DD151309A5 - Verfahren zur herstellung von substituierten aminotriazinen - Google Patents

Verfahren zur herstellung von substituierten aminotriazinen Download PDF

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Publication number
DD151309A5
DD151309A5 DD80221474A DD22147480A DD151309A5 DD 151309 A5 DD151309 A5 DD 151309A5 DD 80221474 A DD80221474 A DD 80221474A DD 22147480 A DD22147480 A DD 22147480A DD 151309 A5 DD151309 A5 DD 151309A5
Authority
DD
German Democratic Republic
Prior art keywords
hydrogen
group
triazine
diamino
trifluoromethyl
Prior art date
Application number
DD80221474A
Other languages
German (de)
English (en)
Inventor
Martin G Baxter
Albert R Elphick
Alistair A Miller
David A Sawyer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD151309(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DD151309A5 publication Critical patent/DD151309A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD80221474A 1979-06-01 1980-05-30 Verfahren zur herstellung von substituierten aminotriazinen DD151309A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
DD151309A5 true DD151309A5 (de) 1981-10-14

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80221474A DD151309A5 (de) 1979-06-01 1980-05-30 Verfahren zur herstellung von substituierten aminotriazinen

Country Status (30)

Country Link
US (2) US4486354A (ru)
EP (2) EP0059987B1 (ru)
JP (2) JPS5625169A (ru)
AR (1) AR227521A1 (ru)
AT (1) AT370097B (ru)
AU (2) AU530999B2 (ru)
BG (1) BG60427B2 (ru)
CA (1) CA1112643A (ru)
CS (1) CS234018B2 (ru)
CZ (1) CZ384891A3 (ru)
DD (1) DD151309A5 (ru)
DK (1) DK153787C (ru)
ES (1) ES491998A0 (ru)
FI (1) FI67844C (ru)
GE (1) GEP19960470B (ru)
GR (1) GR68380B (ru)
HU (1) HU182086B (ru)
IE (1) IE49823B1 (ru)
IL (1) IL60201A (ru)
IT (1) IT1147087B (ru)
MX (1) MX9202962A (ru)
MY (1) MY8500062A (ru)
NL (1) NL950007I2 (ru)
NZ (1) NZ193890A (ru)
PL (1) PL124029B1 (ru)
SU (1) SU1055331A3 (ru)
UA (1) UA5576A1 (ru)
YU (1) YU145680A (ru)
ZA (1) ZA803250B (ru)
ZW (1) ZW12980A1 (ru)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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EP0024351B1 (en) * 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines
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GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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AU653203B2 (en) * 1991-01-30 1994-09-22 Wellcome Foundation Limited, The Water-dispersible tablets
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
GB2282326A (en) * 1992-06-12 1995-04-05 Wellcome Found Use of 3,5-diamino-6-(2,3 dichlorophenyl)-1,2,4-triazine isethionate for the treatment and prevention of dependence,tolerance and sensitization of drugs
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
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GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
AU4311596A (en) * 1994-12-30 1996-07-24 Wellcome Foundation Limited, The Process for the preparation of lamotrigine
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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WO2004083191A1 (en) * 2003-03-17 2004-09-30 Hetero Drugs Limited Novel crystalline forms of lamotrigine
WO2004085426A1 (en) 2003-03-27 2004-10-07 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
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WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
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CA2659290A1 (en) * 2006-08-14 2008-02-21 Jean-Paul Roduit A process for the preparation of lamotrigine
BRPI0807972A2 (pt) 2007-01-24 2014-06-10 Glaxo Group Ltd Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1
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KR101799113B1 (ko) 2009-05-13 2017-11-17 넥타르 테라퓨틱스 올리고머를 함유하는 치환된 방향족 트리아진 화합물
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CN115737651A (zh) 2015-06-12 2023-03-07 格林威治大学 作为干扰素-γ抑制剂的三嗪衍生物
EA201991428A1 (ru) 2016-12-16 2019-12-30 Идорсия Фармасьютиклз Лтд Фармацевтическая комбинация, содержащая блокатор кальциевых каналов т-типа
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (ru) * 1964-05-05
BE722109A (ru) * 1967-10-12 1969-04-10
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
EP0024351B1 (en) * 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines

Also Published As

Publication number Publication date
IL60201A (en) 1984-05-31
MY8500062A (en) 1985-12-31
EP0021121B1 (en) 1983-05-11
FI67844C (fi) 1985-06-10
IT1147087B (it) 1986-11-19
ES8104993A1 (es) 1981-05-16
FI801758A (fi) 1980-12-02
IT8048848A0 (it) 1980-05-30
HU182086B (en) 1983-12-28
EP0021121A1 (en) 1981-01-07
JPS5625169A (en) 1981-03-10
YU145680A (en) 1983-02-28
DK153787C (da) 1989-01-16
GR68380B (ru) 1981-12-28
UA5576A1 (uk) 1994-12-28
ES491998A0 (es) 1981-05-16
SU1055331A3 (ru) 1983-11-15
AU5890680A (en) 1980-12-04
GEP19960470B (en) 1996-08-29
AU530999B2 (en) 1983-08-04
DK153787B (da) 1988-09-05
AT370097B (de) 1983-02-25
NL950007I2 (nl) 1997-02-03
NZ193890A (en) 1984-07-06
IL60201A0 (en) 1980-07-31
EP0059987B1 (en) 1985-08-14
EP0059987A1 (en) 1982-09-15
CZ384891A3 (en) 1993-10-13
ZW12980A1 (en) 1982-01-06
CS234018B2 (en) 1985-03-14
JPS6133163A (ja) 1986-02-17
PL224633A1 (ru) 1981-02-13
US4602017A (en) 1986-07-22
US4486354A (en) 1984-12-04
AU566870B2 (en) 1987-11-05
CA1112643A (en) 1981-11-17
PL124029B1 (en) 1982-12-31
BG60427B2 (bg) 1995-03-31
IE49823B1 (en) 1985-12-25
ZA803250B (en) 1982-01-27
AR227521A1 (es) 1982-11-15
NL950007I1 (nl) 1995-06-16
JPH0144179B2 (ru) 1989-09-26
IE801126L (en) 1980-12-01
FI67844B (fi) 1985-02-28
JPH0144706B2 (ru) 1989-09-29
ATA289680A (de) 1982-07-15
DK233880A (da) 1980-12-02
MX9202962A (es) 1992-07-01

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