DE602007003830D1 - Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid - Google Patents
Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchloridInfo
- Publication number
- DE602007003830D1 DE602007003830D1 DE602007003830T DE602007003830T DE602007003830D1 DE 602007003830 D1 DE602007003830 D1 DE 602007003830D1 DE 602007003830 T DE602007003830 T DE 602007003830T DE 602007003830 T DE602007003830 T DE 602007003830T DE 602007003830 D1 DE602007003830 D1 DE 602007003830D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- chloride
- lamotrigin
- dichlorbenzoyl
- lamotrigine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06290888 | 2006-05-31 | ||
PCT/EP2007/055251 WO2007138075A1 (en) | 2006-05-31 | 2007-05-30 | Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007003830D1 true DE602007003830D1 (de) | 2010-01-28 |
Family
ID=36928567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007003830T Active DE602007003830D1 (de) | 2006-05-31 | 2007-05-30 | Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090312544A1 (de) |
EP (1) | EP2024345B1 (de) |
JP (1) | JP2009538878A (de) |
AT (1) | ATE452125T1 (de) |
DE (1) | DE602007003830D1 (de) |
ES (1) | ES2337415T3 (de) |
WO (1) | WO2007138075A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120142919A1 (en) * | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
SG11201402074RA (en) | 2011-11-07 | 2014-09-26 | Kaneka Corp | Method for producing chlorinated vinyl chloride resin |
CN104098464A (zh) * | 2013-04-15 | 2014-10-15 | 江苏新瀚有限公司 | 对氟苯甲酰氯的制备方法 |
CN103570637A (zh) * | 2013-09-13 | 2014-02-12 | 盐城凯利药业有限公司 | 一种拉莫三嗪的制备方法 |
CN103833660B (zh) * | 2014-03-26 | 2016-07-13 | 成都医路康医学技术服务有限公司 | 拉莫三嗪及其中间体的制备方法 |
CN106277514B (zh) * | 2015-06-05 | 2019-02-15 | 西南大学 | 回收处理糖精钠废水的方法 |
CN114948868B (zh) | 2021-04-16 | 2023-04-14 | 上海奥科达医药科技股份有限公司 | 一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物 |
CN114907232B (zh) * | 2022-04-28 | 2024-02-23 | 青岛和兴精细化学有限公司 | 2-硝基-4-三氟甲基苯腈的合成工艺 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3691217A (en) * | 1970-03-16 | 1972-09-12 | Argus Chem | Process for the preparation of acyl chlorides and benzaldehydes |
HU182086B (en) * | 1979-06-01 | 1983-12-28 | Wellcome Found | Process for preparing new 1,2,4-triazine derivatives |
US4268457A (en) * | 1979-06-28 | 1981-05-19 | Hooker Chemicals & Plastics Corp. | Process for the preparation of paraphenoxybenzoylchloride |
DE3142856A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid |
JPH0327334A (ja) * | 1989-06-23 | 1991-02-05 | Ihara Chem Ind Co Ltd | 2,5―ジハロゲン化ベンゾトリクロリド類の製造法 |
DE4301247A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride |
IT1263960B (it) * | 1993-02-24 | 1996-09-05 | Enichem Sintesi | Procedimento per la fotoclorurazione di composti alchilaromatici |
JPH07330663A (ja) * | 1994-06-08 | 1995-12-19 | Nippon Light Metal Co Ltd | 2−クロロテレフタル酸クロライドの製造方法 |
EP1140872B1 (de) * | 1998-12-14 | 2003-09-17 | Torrent Pharmaceuticals Ltd | Ein verbessertes verfahren zur herstellung von 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin |
HU225667B1 (en) * | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
-
2007
- 2007-05-30 ES ES07729664T patent/ES2337415T3/es active Active
- 2007-05-30 AT AT07729664T patent/ATE452125T1/de not_active IP Right Cessation
- 2007-05-30 DE DE602007003830T patent/DE602007003830D1/de active Active
- 2007-05-30 US US12/301,747 patent/US20090312544A1/en not_active Abandoned
- 2007-05-30 WO PCT/EP2007/055251 patent/WO2007138075A1/en active Application Filing
- 2007-05-30 EP EP07729664A patent/EP2024345B1/de active Active
- 2007-05-30 JP JP2009512586A patent/JP2009538878A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE452125T1 (de) | 2010-01-15 |
WO2007138075A1 (en) | 2007-12-06 |
EP2024345B1 (de) | 2009-12-16 |
EP2024345A1 (de) | 2009-02-18 |
ES2337415T3 (es) | 2010-04-23 |
JP2009538878A (ja) | 2009-11-12 |
US20090312544A1 (en) | 2009-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |