ATE452125T1 - Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid - Google Patents

Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid

Info

Publication number
ATE452125T1
ATE452125T1 AT07729664T AT07729664T ATE452125T1 AT E452125 T1 ATE452125 T1 AT E452125T1 AT 07729664 T AT07729664 T AT 07729664T AT 07729664 T AT07729664 T AT 07729664T AT E452125 T1 ATE452125 T1 AT E452125T1
Authority
AT
Austria
Prior art keywords
dichlorobenzoyl chloride
lamotrigine
producing
producing lamotrigine
preparing
Prior art date
Application number
AT07729664T
Other languages
English (en)
Inventor
Deynse Dirk Van
Marc Belmans
Frank Boers
Michel Dumur
Alain Laconi
Original Assignee
Calaire Chimie Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calaire Chimie Sas filed Critical Calaire Chimie Sas
Application granted granted Critical
Publication of ATE452125T1 publication Critical patent/ATE452125T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07729664T 2006-05-31 2007-05-30 Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid ATE452125T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06290888 2006-05-31
PCT/EP2007/055251 WO2007138075A1 (en) 2006-05-31 2007-05-30 Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride

Publications (1)

Publication Number Publication Date
ATE452125T1 true ATE452125T1 (de) 2010-01-15

Family

ID=36928567

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07729664T ATE452125T1 (de) 2006-05-31 2007-05-30 Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid

Country Status (7)

Country Link
US (1) US20090312544A1 (de)
EP (1) EP2024345B1 (de)
JP (1) JP2009538878A (de)
AT (1) ATE452125T1 (de)
DE (1) DE602007003830D1 (de)
ES (1) ES2337415T3 (de)
WO (1) WO2007138075A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142919A1 (en) * 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
EP2778180B1 (de) 2011-11-07 2017-03-29 Kaneka Corporation Verfahren zur herstellung von chloriertem vinylchloridharz
CN104098464A (zh) * 2013-04-15 2014-10-15 江苏新瀚有限公司 对氟苯甲酰氯的制备方法
CN103570637A (zh) * 2013-09-13 2014-02-12 盐城凯利药业有限公司 一种拉莫三嗪的制备方法
CN103833660B (zh) * 2014-03-26 2016-07-13 成都医路康医学技术服务有限公司 拉莫三嗪及其中间体的制备方法
CN106277514B (zh) * 2015-06-05 2019-02-15 西南大学 回收处理糖精钠废水的方法
CN114948868B (zh) 2021-04-16 2023-04-14 上海奥科达医药科技股份有限公司 一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物
CN114907232B (zh) * 2022-04-28 2024-02-23 青岛和兴精细化学有限公司 2-硝基-4-三氟甲基苯腈的合成工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691217A (en) * 1970-03-16 1972-09-12 Argus Chem Process for the preparation of acyl chlorides and benzaldehydes
JPS5625169A (en) * 1979-06-01 1981-03-10 Wellcome Found Triazine derivative
US4268457A (en) * 1979-06-28 1981-05-19 Hooker Chemicals & Plastics Corp. Process for the preparation of paraphenoxybenzoylchloride
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
JPH0327334A (ja) * 1989-06-23 1991-02-05 Ihara Chem Ind Co Ltd ２，５―ジハロゲン化ベンゾトリクロリド類の製造法
DE4301247A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride
IT1263960B (it) * 1993-02-24 1996-09-05 Enichem Sintesi Procedimento per la fotoclorurazione di composti alchilaromatici
JPH07330663A (ja) * 1994-06-08 1995-12-19 Nippon Light Metal Co Ltd ２−クロロテレフタル酸クロライドの製造方法
CZ20011949A3 (cs) * 1998-12-14 2001-09-12 Torrent Pharmacauticals Ltd Zlepšený způsob výroby 3,5-diamino-6-(2,3-dichlorfenyl)-1,2,4-triazinu
HU225667B1 (en) * 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

Also Published As

Publication number Publication date
ES2337415T3 (es) 2010-04-23
EP2024345A1 (de) 2009-02-18
DE602007003830D1 (de) 2010-01-28
US20090312544A1 (en) 2009-12-17
JP2009538878A (ja) 2009-11-12
EP2024345B1 (de) 2009-12-16
WO2007138075A1 (en) 2007-12-06

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