AT370097B - Verfahren zur herstellung von neuen 3,5-diamino-6-(substituierten phenyl)-1,2,4-triazinen und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen 3,5-diamino-6-(substituierten phenyl)-1,2,4-triazinen und deren saeureadditionssalzen

Info

Publication number
AT370097B
AT370097B AT0289680A AT289680A AT370097B AT 370097 B AT370097 B AT 370097B AT 0289680 A AT0289680 A AT 0289680A AT 289680 A AT289680 A AT 289680A AT 370097 B AT370097 B AT 370097B
Authority
AT
Austria
Prior art keywords
triazines
diamino
acid addition
addition salts
substituted phenyl
Prior art date
Application number
AT0289680A
Other languages
English (en)
Other versions
ATA289680A (de
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT370097(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ATA289680A publication Critical patent/ATA289680A/de
Application granted granted Critical
Publication of AT370097B publication Critical patent/AT370097B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0289680A 1979-06-01 1980-05-30 Verfahren zur herstellung von neuen 3,5-diamino-6-(substituierten phenyl)-1,2,4-triazinen und deren saeureadditionssalzen AT370097B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
ATA289680A ATA289680A (de) 1982-07-15
AT370097B true AT370097B (de) 1983-02-25

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0289680A AT370097B (de) 1979-06-01 1980-05-30 Verfahren zur herstellung von neuen 3,5-diamino-6-(substituierten phenyl)-1,2,4-triazinen und deren saeureadditionssalzen

Country Status (30)

Country Link
US (2) US4486354A (de)
EP (2) EP0059987B1 (de)
JP (2) JPS5625169A (de)
AR (1) AR227521A1 (de)
AT (1) AT370097B (de)
AU (2) AU530999B2 (de)
BG (1) BG60427B2 (de)
CA (1) CA1112643A (de)
CS (1) CS234018B2 (de)
CZ (1) CZ384891A3 (de)
DD (1) DD151309A5 (de)
DK (1) DK153787C (de)
ES (1) ES491998A0 (de)
FI (1) FI67844C (de)
GE (1) GEP19960470B (de)
GR (1) GR68380B (de)
HU (1) HU182086B (de)
IE (1) IE49823B1 (de)
IL (1) IL60201A (de)
IT (1) IT1147087B (de)
MX (1) MX9202962A (de)
MY (1) MY8500062A (de)
NL (1) NL950007I2 (de)
NZ (1) NZ193890A (de)
PL (1) PL124029B1 (de)
SU (1) SU1055331A3 (de)
UA (1) UA5576A1 (de)
YU (1) YU145680A (de)
ZA (1) ZA803250B (de)
ZW (1) ZW12980A1 (de)

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* Cited by examiner, † Cited by third party
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IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
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GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
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FI895821A0 (fi) 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
FR2671970B1 (fr) * 1991-01-30 1995-06-23 Wellcome Found Comprimes dispersables dans l'eau.
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
SK279730B6 (sk) * 1992-06-12 1999-02-11 The Wellcome Foundation Ltd Iazínu a jehofarmaceuticky a veterinárne prijateľn
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
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GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
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GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
PT800520E (pt) * 1994-12-30 2002-11-29 Wellcome Found Processo para a preparacao de lamotrigina
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
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WO2004083191A1 (en) * 2003-03-17 2004-09-30 Hetero Drugs Limited Novel crystalline forms of lamotrigine
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MXPA05012317A (es) 2003-05-16 2006-01-30 Pfizer Prod Inc Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores del gaba anticonvulsivos o benzodiazepinas.
WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
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EP1737473A4 (de) * 2004-04-19 2009-08-26 Noven Therapeutics Llc Lithium-kombinationen und relevante verwendungen
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US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
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US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
MY148863A (en) * 2005-09-23 2013-06-14 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
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US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
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EP2024345B1 (de) * 2006-05-31 2009-12-16 Calaire Chimie SAS Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid
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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
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GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti

Also Published As

Publication number Publication date
US4486354A (en) 1984-12-04
JPH0144179B2 (de) 1989-09-26
UA5576A1 (uk) 1994-12-28
BG60427B2 (bg) 1995-03-31
EP0021121B1 (de) 1983-05-11
FI67844C (fi) 1985-06-10
EP0059987B1 (de) 1985-08-14
FI801758A (fi) 1980-12-02
AU566870B2 (en) 1987-11-05
YU145680A (en) 1983-02-28
JPS6133163A (ja) 1986-02-17
DK233880A (da) 1980-12-02
IT8048848A0 (it) 1980-05-30
DK153787B (da) 1988-09-05
IT1147087B (it) 1986-11-19
IL60201A (en) 1984-05-31
AU530999B2 (en) 1983-08-04
DD151309A5 (de) 1981-10-14
IE801126L (en) 1980-12-01
GEP19960470B (en) 1996-08-29
IL60201A0 (en) 1980-07-31
HU182086B (en) 1983-12-28
AU5890680A (en) 1980-12-04
ES8104993A1 (es) 1981-05-16
US4602017A (en) 1986-07-22
MX9202962A (es) 1992-07-01
ES491998A0 (es) 1981-05-16
DK153787C (da) 1989-01-16
EP0059987A1 (de) 1982-09-15
JPH0144706B2 (de) 1989-09-29
ZA803250B (en) 1982-01-27
EP0021121A1 (de) 1981-01-07
JPS5625169A (en) 1981-03-10
ZW12980A1 (en) 1982-01-06
NL950007I2 (nl) 1997-02-03
CS234018B2 (en) 1985-03-14
GR68380B (de) 1981-12-28
ATA289680A (de) 1982-07-15
FI67844B (fi) 1985-02-28
PL224633A1 (de) 1981-02-13
PL124029B1 (en) 1982-12-31
NZ193890A (en) 1984-07-06
IE49823B1 (en) 1985-12-25
MY8500062A (en) 1985-12-31
NL950007I1 (nl) 1995-06-16
AR227521A1 (es) 1982-11-15
SU1055331A3 (ru) 1983-11-15
CA1112643A (en) 1981-11-17
CZ384891A3 (en) 1993-10-13

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