IT8048848A0 - Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione - Google Patents

Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione

Info

Publication number
IT8048848A0
IT8048848A0 IT8048848A IT4884880A IT8048848A0 IT 8048848 A0 IT8048848 A0 IT 8048848A0 IT 8048848 A IT8048848 A IT 8048848A IT 4884880 A IT4884880 A IT 4884880A IT 8048848 A0 IT8048848 A0 IT 8048848A0
Authority
IT
Italy
Prior art keywords
disorders
procedure
preparation
treatment
nervous system
Prior art date
Application number
IT8048848A
Other languages
English (en)
Other versions
IT1147087B (it
Inventor
Martin George Baxter
Albert Reginald Elphick
Alistair Ainslie Miller
David Alan Sawyer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT8048848(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IT8048848A0 publication Critical patent/IT8048848A0/it
Application granted granted Critical
Publication of IT1147087B publication Critical patent/IT1147087B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48848/80A 1979-06-01 1980-05-30 Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione IT1147087B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
IT8048848A0 true IT8048848A0 (it) 1980-05-30
IT1147087B IT1147087B (it) 1986-11-19

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48848/80A IT1147087B (it) 1979-06-01 1980-05-30 Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione

Country Status (30)

Country Link
US (2) US4486354A (it)
EP (2) EP0021121B1 (it)
JP (2) JPS5625169A (it)
AR (1) AR227521A1 (it)
AT (1) AT370097B (it)
AU (2) AU530999B2 (it)
BG (1) BG60427B2 (it)
CA (1) CA1112643A (it)
CS (1) CS234018B2 (it)
CZ (1) CZ384891A3 (it)
DD (1) DD151309A5 (it)
DK (1) DK153787C (it)
ES (1) ES8104993A1 (it)
FI (1) FI67844C (it)
GE (1) GEP19960470B (it)
GR (1) GR68380B (it)
HU (1) HU182086B (it)
IE (1) IE49823B1 (it)
IL (1) IL60201A (it)
IT (1) IT1147087B (it)
MX (1) MX9202962A (it)
MY (1) MY8500062A (it)
NL (1) NL950007I2 (it)
NZ (1) NZ193890A (it)
PL (1) PL124029B1 (it)
SU (1) SU1055331A3 (it)
UA (1) UA5576A1 (it)
YU (1) YU145680A (it)
ZA (1) ZA803250B (it)
ZW (1) ZW12980A1 (it)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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DE3069556D1 (en) * 1979-08-16 1984-12-06 Wellcome Found Solid pharmaceutical formulation containing substitued phenyl-triazines
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
KR100190254B1 (ko) * 1991-01-30 1999-06-01 레슬리 에드워즈 수-분산성 정제
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
DK0644763T3 (da) * 1992-06-12 1997-07-28 Wellcome Found Anvendelse af 3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triacin-isethionat til behandlingen og forebyggelsen af afhængighed, tolerance og sensitivering af medikamenter
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
DE69527153T2 (de) * 1994-12-30 2002-12-19 Wellcome Found Verfahren zur herstellung von lamotrigine
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
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HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
AU2003217437A1 (en) * 2003-03-17 2004-10-11 Hetero Drugs Limited Novel crystalline forms of lamotrigine
AU2003230193A1 (en) 2003-03-27 2004-10-18 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
MXPA05012317A (es) 2003-05-16 2006-01-30 Pfizer Prod Inc Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores del gaba anticonvulsivos o benzodiazepinas.
WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
EP1737466A1 (en) * 2004-01-29 2007-01-03 Pfizer Products Inc. COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS
WO2005102366A2 (en) * 2004-04-19 2005-11-03 Philip Maxwell Satow Lithium combinations, and uses related thereto
CN101018546B (zh) * 2004-09-10 2013-06-12 纽朗制药有限公司 作为钠和/或钙通道选择性调节剂的(卤代苄氧基)苄氨基-丙酰胺类
ATE534387T1 (de) * 2005-09-23 2011-12-15 Janssen Pharmaceutica Nv Hexahydro-cycloheptapyrazol-cannabinoid- modulatoren
PL1931335T3 (pl) * 2005-09-23 2010-07-30 Janssen Pharmaceutica Nv Modulatory heksahydrocyklooktylopirazolokannabinoidowe
US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
CN101312952B (zh) 2005-09-23 2012-12-26 詹森药业有限公司 四氢-环戊二烯并吡唑大麻素调节剂
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WO2007138075A1 (en) * 2006-05-31 2007-12-06 Calaire Chimie Sas Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride
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CA2676357A1 (en) * 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
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US20090076010A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched lamotrigine
US8486927B2 (en) * 2007-11-09 2013-07-16 Thar Pharmaceuticals Crystalline forms of lamotrigine
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Family Cites Families (8)

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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (it) * 1964-05-05
FR7689M (it) * 1967-10-12 1970-02-16
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
DE3069556D1 (en) * 1979-08-16 1984-12-06 Wellcome Found Solid pharmaceutical formulation containing substitued phenyl-triazines

Also Published As

Publication number Publication date
JPS6133163A (ja) 1986-02-17
YU145680A (en) 1983-02-28
ES491998A0 (es) 1981-05-16
JPS5625169A (en) 1981-03-10
GR68380B (it) 1981-12-28
EP0059987B1 (en) 1985-08-14
IE801126L (en) 1980-12-01
AT370097B (de) 1983-02-25
DD151309A5 (de) 1981-10-14
JPH0144706B2 (it) 1989-09-29
IE49823B1 (en) 1985-12-25
ZW12980A1 (en) 1982-01-06
IT1147087B (it) 1986-11-19
DK153787B (da) 1988-09-05
DK153787C (da) 1989-01-16
AU566870B2 (en) 1987-11-05
MY8500062A (en) 1985-12-31
PL124029B1 (en) 1982-12-31
AU5890680A (en) 1980-12-04
PL224633A1 (it) 1981-02-13
EP0021121A1 (en) 1981-01-07
NL950007I1 (nl) 1995-06-16
IL60201A0 (en) 1980-07-31
GEP19960470B (en) 1996-08-29
US4602017A (en) 1986-07-22
UA5576A1 (uk) 1994-12-28
ATA289680A (de) 1982-07-15
CA1112643A (en) 1981-11-17
BG60427B2 (bg) 1995-03-31
JPH0144179B2 (it) 1989-09-26
DK233880A (da) 1980-12-02
MX9202962A (es) 1992-07-01
US4486354A (en) 1984-12-04
AU530999B2 (en) 1983-08-04
ES8104993A1 (es) 1981-05-16
IL60201A (en) 1984-05-31
CZ384891A3 (en) 1993-10-13
EP0059987A1 (en) 1982-09-15
CS234018B2 (en) 1985-03-14
HU182086B (en) 1983-12-28
FI67844C (fi) 1985-06-10
FI67844B (fi) 1985-02-28
AR227521A1 (es) 1982-11-15
SU1055331A3 (ru) 1983-11-15
NL950007I2 (nl) 1997-02-03
FI801758A (fi) 1980-12-02
NZ193890A (en) 1984-07-06
EP0021121B1 (en) 1983-05-11
ZA803250B (en) 1982-01-27

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