NL950007I2 - 1,2,4-Triazinederivaten, werkwijze voor de bereiding van deze verbindingen, en deze verbindingen bevattende farmaceutische preparaten. - Google Patents

1,2,4-Triazinederivaten, werkwijze voor de bereiding van deze verbindingen, en deze verbindingen bevattende farmaceutische preparaten.

Info

Publication number
NL950007I2
NL950007I2 NL950007C NL950007C NL950007I2 NL 950007 I2 NL950007 I2 NL 950007I2 NL 950007 C NL950007 C NL 950007C NL 950007 C NL950007 C NL 950007C NL 950007 I2 NL950007 I2 NL 950007I2
Authority
NL
Netherlands
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
triazine derivatives
Prior art date
Application number
NL950007C
Other languages
English (en)
Other versions
NL950007I1 (nl
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL950007(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NL950007I1 publication Critical patent/NL950007I1/nl
Publication of NL950007I2 publication Critical patent/NL950007I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
NL950007C 1979-06-01 1995-04-28 1,2,4-Triazinederivaten, werkwijze voor de bereiding van deze verbindingen, en deze verbindingen bevattende farmaceutische preparaten. NL950007I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
NL950007I1 NL950007I1 (nl) 1995-06-16
NL950007I2 true NL950007I2 (nl) 1997-02-03

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
NL950007C NL950007I2 (nl) 1979-06-01 1995-04-28 1,2,4-Triazinederivaten, werkwijze voor de bereiding van deze verbindingen, en deze verbindingen bevattende farmaceutische preparaten.

Country Status (30)

Country Link
US (2) US4486354A (nl)
EP (2) EP0059987B1 (nl)
JP (2) JPS5625169A (nl)
AR (1) AR227521A1 (nl)
AT (1) AT370097B (nl)
AU (2) AU530999B2 (nl)
BG (1) BG60427B2 (nl)
CA (1) CA1112643A (nl)
CS (1) CS234018B2 (nl)
CZ (1) CZ384891A3 (nl)
DD (1) DD151309A5 (nl)
DK (1) DK153787C (nl)
ES (1) ES491998A0 (nl)
FI (1) FI67844C (nl)
GE (1) GEP19960470B (nl)
GR (1) GR68380B (nl)
HU (1) HU182086B (nl)
IE (1) IE49823B1 (nl)
IL (1) IL60201A (nl)
IT (1) IT1147087B (nl)
MX (1) MX9202962A (nl)
MY (1) MY8500062A (nl)
NL (1) NL950007I2 (nl)
NZ (1) NZ193890A (nl)
PL (1) PL124029B1 (nl)
SU (1) SU1055331A3 (nl)
UA (1) UA5576A1 (nl)
YU (1) YU145680A (nl)
ZA (1) ZA803250B (nl)
ZW (1) ZW12980A1 (nl)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
FR2671970B1 (fr) * 1991-01-30 1995-06-23 Wellcome Found Comprimes dispersables dans l'eau.
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
DE69307705T2 (de) * 1992-06-12 1997-05-22 Wellcome Found Verwendung von 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4,-triazinisethionat zur behandlung und vorbeugung von drogenabhaengigkeit,-toleranz und- sensibilisierung
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
RU2145602C1 (ru) * 1994-12-30 2000-02-20 Де Вэллкам Фаундейшн Лимитед Способы получения ламотриджина, промежуточные соединения и способ получения фармацевтической композиции
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6202491B1 (en) 1997-07-22 2001-03-20 Skf Condition Monitoring, Inc. Digital vibration coupling stud
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US6124500A (en) * 1998-03-09 2000-09-26 Rohm And Haas Company Process for synthesizing benzoic acids
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
EP1140872B1 (en) * 1998-12-14 2003-09-17 Torrent Pharmaceuticals Ltd An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
US20020055177A1 (en) * 1999-03-10 2002-05-09 Glaxo Wellcome Inc. Compound and its use
WO2000061188A1 (en) * 1999-04-09 2000-10-19 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
GB9907965D0 (en) * 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
GB2372988B (en) * 2000-01-03 2004-04-07 Rpg Life Sciences Ltd A process for the preparation of 6-(2,3-Dichlorophenyl)-1,2,4- Triazine-3,5-Diamine, commonly known as Lamotrigine
IL134730A (en) * 2000-02-25 2003-10-31 Chemagis Ltd Process for preparing substituted benzoyl cyanide amidinohydrazones
AU2002215159A1 (en) 2000-11-30 2002-06-11 Pfizer Products Inc. Combination of GABA agonists and sorbitol dehydrogenase inhibitors
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CA2439468A1 (en) * 2001-02-27 2002-09-06 Teva Pharmaceutical Industries Ltd. New crystal forms of lamotrigine and processes for their preparations
PT1423168E (pt) 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
CA2366521C (en) 2001-12-24 2007-03-06 Brantford Chemicals Inc. A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
AU2003234240A1 (en) * 2002-04-23 2003-11-10 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing lamotrigine particles of defined morphology
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
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WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
AU2004305563C1 (en) 2003-12-11 2011-07-07 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
JP2007537151A (ja) * 2004-01-29 2007-12-20 ファイザー・プロダクツ・インク γ−アミノ酪酸モジュレータと５−ＨＴ１Ｂ受容体アンタゴニストとの組合せ
EP1737473A4 (en) * 2004-04-19 2009-08-26 Noven Therapeutics Llc COMBINATIONS OF LITHIUM AND USES THEREOF
RU2391973C2 (ru) * 2004-09-10 2010-06-20 Ньюрон Фармасьютикалс С.П.А. Применение (галобензилокси)бензиламино-пропанамидов для производства лекарственных средств, действующих как селективные модуляторы натриевых и/или кальциевых каналов
US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
AU2006295121B2 (en) * 2005-09-23 2011-10-27 Janssen Pharmaceutica, N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
EA200800889A1 (ru) * 2005-09-23 2008-12-30 Янссен Фармацевтика, Н. В. Гексагидроциклооктилпиразольные каннабиноидные модуляторы
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
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US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
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US20090076010A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched lamotrigine
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GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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HUE058360T2 (hu) 2016-12-16 2022-07-28 Idorsia Pharmaceuticals Ltd T-típusú kalcium-csatorna blokkolót tartalmazó gyógyszerészeti kombináció
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (nl) * 1964-05-05
BE722109A (nl) * 1967-10-12 1969-04-10
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti

Also Published As

Publication number Publication date
AR227521A1 (es) 1982-11-15
US4486354A (en) 1984-12-04
JPS5625169A (en) 1981-03-10
IT8048848A0 (it) 1980-05-30
SU1055331A3 (ru) 1983-11-15
MY8500062A (en) 1985-12-31
AU566870B2 (en) 1987-11-05
FI67844C (fi) 1985-06-10
EP0021121A1 (en) 1981-01-07
DK233880A (da) 1980-12-02
ES8104993A1 (es) 1981-05-16
FI67844B (fi) 1985-02-28
DK153787B (da) 1988-09-05
FI801758A (fi) 1980-12-02
EP0059987B1 (en) 1985-08-14
CZ384891A3 (en) 1993-10-13
ZW12980A1 (en) 1982-01-06
BG60427B2 (bg) 1995-03-31
IE49823B1 (en) 1985-12-25
IE801126L (en) 1980-12-01
PL124029B1 (en) 1982-12-31
AU530999B2 (en) 1983-08-04
AU5890680A (en) 1980-12-04
AT370097B (de) 1983-02-25
ATA289680A (de) 1982-07-15
HU182086B (en) 1983-12-28
NL950007I1 (nl) 1995-06-16
ES491998A0 (es) 1981-05-16
US4602017A (en) 1986-07-22
IT1147087B (it) 1986-11-19
PL224633A1 (nl) 1981-02-13
ZA803250B (en) 1982-01-27
EP0021121B1 (en) 1983-05-11
CA1112643A (en) 1981-11-17
NZ193890A (en) 1984-07-06
JPS6133163A (ja) 1986-02-17
DK153787C (da) 1989-01-16
GR68380B (nl) 1981-12-28
MX9202962A (es) 1992-07-01
UA5576A1 (uk) 1994-12-28
GEP19960470B (en) 1996-08-29
IL60201A0 (en) 1980-07-31
IL60201A (en) 1984-05-31
JPH0144179B2 (nl) 1989-09-26
EP0059987A1 (en) 1982-09-15
JPH0144706B2 (nl) 1989-09-29
YU145680A (en) 1983-02-28
CS234018B2 (en) 1985-03-14
DD151309A5 (de) 1981-10-14

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