DD151309A5 - Verfahren zur herstellung von substituierten aminotriazinen - Google Patents

Verfahren zur herstellung von substituierten aminotriazinen Download PDF

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Publication number
DD151309A5
DD151309A5 DD80221474A DD22147480A DD151309A5 DD 151309 A5 DD151309 A5 DD 151309A5 DD 80221474 A DD80221474 A DD 80221474A DD 22147480 A DD22147480 A DD 22147480A DD 151309 A5 DD151309 A5 DD 151309A5
Authority
DD
German Democratic Republic
Prior art keywords
hydrogen
group
triazine
diamino
trifluoromethyl
Prior art date
Application number
DD80221474A
Other languages
German (de)
English (en)
Inventor
Martin G Baxter
Albert R Elphick
Alistair A Miller
David A Sawyer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD151309(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DD151309A5 publication Critical patent/DD151309A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD80221474A 1979-06-01 1980-05-30 Verfahren zur herstellung von substituierten aminotriazinen DD151309A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
DD151309A5 true DD151309A5 (de) 1981-10-14

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80221474A DD151309A5 (de) 1979-06-01 1980-05-30 Verfahren zur herstellung von substituierten aminotriazinen

Country Status (30)

Country Link
US (2) US4486354A (cs)
EP (2) EP0021121B1 (cs)
JP (2) JPS5625169A (cs)
AR (1) AR227521A1 (cs)
AT (1) AT370097B (cs)
AU (2) AU530999B2 (cs)
BG (1) BG60427B2 (cs)
CA (1) CA1112643A (cs)
CS (1) CS234018B2 (cs)
CZ (1) CZ384891A3 (cs)
DD (1) DD151309A5 (cs)
DK (1) DK153787C (cs)
ES (1) ES491998A0 (cs)
FI (1) FI67844C (cs)
GE (1) GEP19960470B (cs)
GR (1) GR68380B (cs)
HU (1) HU182086B (cs)
IE (1) IE49823B1 (cs)
IL (1) IL60201A (cs)
IT (1) IT1147087B (cs)
MX (1) MX9202962A (cs)
MY (1) MY8500062A (cs)
NL (1) NL950007I2 (cs)
NZ (1) NZ193890A (cs)
PL (1) PL124029B1 (cs)
SU (1) SU1055331A3 (cs)
UA (1) UA5576A1 (cs)
YU (1) YU145680A (cs)
ZA (1) ZA803250B (cs)
ZW (1) ZW12980A1 (cs)

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* Cited by examiner, † Cited by third party
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GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
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GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
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US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
HU221677B1 (hu) * 1991-01-30 2002-12-28 Wellcome Foundation Ltd. Vízben diszpergálható tablettakészítmények és eljárás előállításukra
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
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GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
ATE219487T1 (de) * 1994-12-30 2002-07-15 Wellcome Found Verfahren zur herstellung von lamotrigine
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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WO2004083191A1 (en) * 2003-03-17 2004-09-30 Hetero Drugs Limited Novel crystalline forms of lamotrigine
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GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
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US8772479B2 (en) 2009-05-13 2014-07-08 Nektar Therapeutics Oligomer-containing substituted aromatic triazine compounds
EP2564836A1 (en) 2009-05-20 2013-03-06 Ranbaxy Laboratories Limited Controlled release lamotrigine formulations
GB2471713A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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US10576086B2 (en) 2015-06-12 2020-03-03 University Of Greenwich Triazine derivatives as interferon-gamma inhibitors
RS62980B1 (sr) 2016-12-16 2022-03-31 Idorsia Pharmaceuticals Ltd Farmaceutska kombinacija koja obuhvata blokator kalcijumskih kanala t-tipa
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (cs) * 1964-05-05
GB1204631A (en) * 1967-10-12 1970-09-09 Shell Int Research Pharmacologically active benzylideneamino guanidines and their use
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
US4311701A (en) * 1979-08-16 1982-01-19 Barbara Roth Treatment of convulsions with triazines

Also Published As

Publication number Publication date
EP0021121A1 (en) 1981-01-07
ES8104993A1 (es) 1981-05-16
FI801758A7 (fi) 1980-12-02
PL124029B1 (en) 1982-12-31
FI67844B (fi) 1985-02-28
CS234018B2 (en) 1985-03-14
PL224633A1 (cs) 1981-02-13
NL950007I1 (nl) 1995-06-16
US4602017A (en) 1986-07-22
ZA803250B (en) 1982-01-27
IL60201A0 (en) 1980-07-31
JPH0144179B2 (cs) 1989-09-26
MX9202962A (es) 1992-07-01
NZ193890A (en) 1984-07-06
FI67844C (fi) 1985-06-10
DK233880A (da) 1980-12-02
BG60427B2 (bg) 1995-03-31
AR227521A1 (es) 1982-11-15
DK153787B (da) 1988-09-05
AU5890680A (en) 1980-12-04
CZ384891A3 (en) 1993-10-13
JPH0144706B2 (cs) 1989-09-29
CA1112643A (en) 1981-11-17
EP0059987B1 (en) 1985-08-14
AU530999B2 (en) 1983-08-04
JPS6133163A (ja) 1986-02-17
AT370097B (de) 1983-02-25
DK153787C (da) 1989-01-16
JPS5625169A (en) 1981-03-10
YU145680A (en) 1983-02-28
UA5576A1 (uk) 1994-12-28
GR68380B (cs) 1981-12-28
EP0059987A1 (en) 1982-09-15
IE49823B1 (en) 1985-12-25
AU566870B2 (en) 1987-11-05
IE801126L (en) 1980-12-01
SU1055331A3 (ru) 1983-11-15
MY8500062A (en) 1985-12-31
IT8048848A0 (it) 1980-05-30
US4486354A (en) 1984-12-04
IL60201A (en) 1984-05-31
NL950007I2 (nl) 1997-02-03
ATA289680A (de) 1982-07-15
IT1147087B (it) 1986-11-19
HU182086B (en) 1983-12-28
EP0021121B1 (en) 1983-05-11
ES491998A0 (es) 1981-05-16
ZW12980A1 (en) 1982-01-06
GEP19960470B (en) 1996-08-29

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