FI67844C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat Download PDF

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Publication number
FI67844C
FI67844C FI801758A FI801758A FI67844C FI 67844 C FI67844 C FI 67844C FI 801758 A FI801758 A FI 801758A FI 801758 A FI801758 A FI 801758A FI 67844 C FI67844 C FI 67844C
Authority
FI
Finland
Prior art keywords
diamino
hydrogen
triazine
compound
methyl
Prior art date
Application number
FI801758A
Other languages
English (en)
Finnish (fi)
Other versions
FI801758A7 (fi
FI67844B (fi
Inventor
Martin George Baxter
Albert Reginald Elphick
Alistair Ainslie Miller
David Alan Sawyer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI67844(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI801758A7 publication Critical patent/FI801758A7/fi
Priority to FI840888A priority Critical patent/FI73203C/fi
Publication of FI67844B publication Critical patent/FI67844B/fi
Application granted granted Critical
Publication of FI67844C publication Critical patent/FI67844C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI801758A 1979-06-01 1980-05-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat FI67844C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI840888A FI73203C (fi) 1979-06-01 1984-03-06 Mellanprodukt foer anvaendning vid framstaellning av terapeutiskt anvaendbara 3,5-diamino-6-fenyl-1,2,4- triazinderivat och foerfarande foer dess framstaellning.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01
GB7919257 1979-06-01

Publications (3)

Publication Number Publication Date
FI801758A7 FI801758A7 (fi) 1980-12-02
FI67844B FI67844B (fi) 1985-02-28
FI67844C true FI67844C (fi) 1985-06-10

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
FI801758A FI67844C (fi) 1979-06-01 1980-05-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat

Country Status (30)

Country Link
US (2) US4486354A (cs)
EP (2) EP0021121B1 (cs)
JP (2) JPS5625169A (cs)
AR (1) AR227521A1 (cs)
AT (1) AT370097B (cs)
AU (2) AU530999B2 (cs)
BG (1) BG60427B2 (cs)
CA (1) CA1112643A (cs)
CS (1) CS234018B2 (cs)
CZ (1) CZ384891A3 (cs)
DD (1) DD151309A5 (cs)
DK (1) DK153787C (cs)
ES (1) ES491998A0 (cs)
FI (1) FI67844C (cs)
GE (1) GEP19960470B (cs)
GR (1) GR68380B (cs)
HU (1) HU182086B (cs)
IE (1) IE49823B1 (cs)
IL (1) IL60201A (cs)
IT (1) IT1147087B (cs)
MX (1) MX9202962A (cs)
MY (1) MY8500062A (cs)
NL (1) NL950007I2 (cs)
NZ (1) NZ193890A (cs)
PL (1) PL124029B1 (cs)
SU (1) SU1055331A3 (cs)
UA (1) UA5576A1 (cs)
YU (1) YU145680A (cs)
ZA (1) ZA803250B (cs)
ZW (1) ZW12980A1 (cs)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
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US4311701A (en) * 1979-08-16 1982-01-19 Barbara Roth Treatment of convulsions with triazines
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A7 (fi) 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
HU221677B1 (hu) * 1991-01-30 2002-12-28 Wellcome Foundation Ltd. Vízben diszpergálható tablettakészítmények és eljárás előállításukra
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
CZ284061B6 (cs) * 1992-06-12 1998-08-12 The Wellcome Foundation Limited Použití isethionátu 3,5-diamino-6-(2,3-dichlorfenyl)-1,2,4-triazinu pro výrobu léčiva pro ošetřování a prevenci závislosti, tolerance a citlivosti k drogám
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
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GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
ATE219487T1 (de) * 1994-12-30 2002-07-15 Wellcome Found Verfahren zur herstellung von lamotrigine
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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GB2471713A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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Family Cites Families (8)

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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (cs) * 1964-05-05
GB1204631A (en) * 1967-10-12 1970-09-09 Shell Int Research Pharmacologically active benzylideneamino guanidines and their use
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
US4311701A (en) * 1979-08-16 1982-01-19 Barbara Roth Treatment of convulsions with triazines

Also Published As

Publication number Publication date
EP0021121A1 (en) 1981-01-07
ES8104993A1 (es) 1981-05-16
FI801758A7 (fi) 1980-12-02
PL124029B1 (en) 1982-12-31
FI67844B (fi) 1985-02-28
CS234018B2 (en) 1985-03-14
PL224633A1 (cs) 1981-02-13
NL950007I1 (nl) 1995-06-16
US4602017A (en) 1986-07-22
ZA803250B (en) 1982-01-27
IL60201A0 (en) 1980-07-31
JPH0144179B2 (cs) 1989-09-26
DD151309A5 (de) 1981-10-14
MX9202962A (es) 1992-07-01
NZ193890A (en) 1984-07-06
DK233880A (da) 1980-12-02
BG60427B2 (bg) 1995-03-31
AR227521A1 (es) 1982-11-15
DK153787B (da) 1988-09-05
AU5890680A (en) 1980-12-04
CZ384891A3 (en) 1993-10-13
JPH0144706B2 (cs) 1989-09-29
CA1112643A (en) 1981-11-17
EP0059987B1 (en) 1985-08-14
AU530999B2 (en) 1983-08-04
JPS6133163A (ja) 1986-02-17
AT370097B (de) 1983-02-25
DK153787C (da) 1989-01-16
JPS5625169A (en) 1981-03-10
YU145680A (en) 1983-02-28
UA5576A1 (uk) 1994-12-28
GR68380B (cs) 1981-12-28
EP0059987A1 (en) 1982-09-15
IE49823B1 (en) 1985-12-25
AU566870B2 (en) 1987-11-05
IE801126L (en) 1980-12-01
SU1055331A3 (ru) 1983-11-15
MY8500062A (en) 1985-12-31
IT8048848A0 (it) 1980-05-30
US4486354A (en) 1984-12-04
IL60201A (en) 1984-05-31
NL950007I2 (nl) 1997-02-03
ATA289680A (de) 1982-07-15
IT1147087B (it) 1986-11-19
HU182086B (en) 1983-12-28
EP0021121B1 (en) 1983-05-11
ES491998A0 (es) 1981-05-16
ZW12980A1 (en) 1982-01-06
GEP19960470B (en) 1996-08-29

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