CZ308081B6 - Rekombinantní glykoproteiny a způsob jejich výroby - Google Patents
Rekombinantní glykoproteiny a způsob jejich výroby Download PDFInfo
- Publication number
- CZ308081B6 CZ308081B6 CZ2008-404A CZ2008404A CZ308081B6 CZ 308081 B6 CZ308081 B6 CZ 308081B6 CZ 2008404 A CZ2008404 A CZ 2008404A CZ 308081 B6 CZ308081 B6 CZ 308081B6
- Authority
- CZ
- Czechia
- Prior art keywords
- fucosyltransferase
- glcnac
- sequence
- activity
- plant cells
- Prior art date
Links
- 108090000288 Glycoproteins Proteins 0.000 title claims abstract 5
- 102000003886 Glycoproteins Human genes 0.000 title claims abstract 5
- 230000000694 effects Effects 0.000 claims abstract 9
- 108020004414 DNA Proteins 0.000 claims abstract 5
- 102000053602 DNA Human genes 0.000 claims abstract 4
- 108091033319 polynucleotide Proteins 0.000 claims abstract 4
- 102000040430 polynucleotide Human genes 0.000 claims abstract 4
- 239000002157 polynucleotide Substances 0.000 claims abstract 4
- 230000000295 complement effect Effects 0.000 claims abstract 3
- 230000002068 genetic effect Effects 0.000 claims abstract 2
- 108010001671 galactoside 3-fucosyltransferase Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 102000006471 Fucosyltransferases Human genes 0.000 abstract 1
- 108010019236 Fucosyltransferases Proteins 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- 108010064851 Plant Proteins Proteins 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 235000021118 plant-derived protein Nutrition 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0027099A AT408446B (de) | 1999-02-18 | 1999-02-18 | Fucosyltransferase-gen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ308081B6 true CZ308081B6 (cs) | 2019-12-27 |
Family
ID=3486087
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2008-404A CZ308081B6 (cs) | 1999-02-18 | 2000-02-17 | Rekombinantní glykoproteiny a způsob jejich výroby |
| CZ20012943A CZ299622B6 (cs) | 1999-02-18 | 2000-02-17 | Molekula DNA kódující fukosyltransferázu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20012943A CZ299622B6 (cs) | 1999-02-18 | 2000-02-17 | Molekula DNA kódující fukosyltransferázu |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20080234471A1 (enExample) |
| EP (3) | EP2062977B1 (enExample) |
| JP (2) | JP5514386B2 (enExample) |
| KR (1) | KR20010108234A (enExample) |
| CN (1) | CN1360633A (enExample) |
| AT (2) | AT408446B (enExample) |
| AU (1) | AU771995B2 (enExample) |
| BG (1) | BG65140B1 (enExample) |
| BR (1) | BR0010114A (enExample) |
| CA (1) | CA2362964C (enExample) |
| CZ (2) | CZ308081B6 (enExample) |
| DE (1) | DE50011116D1 (enExample) |
| DK (2) | DK2062977T3 (enExample) |
| EE (1) | EE200100432A (enExample) |
| ES (2) | ES2246222T3 (enExample) |
| HR (1) | HRP20010681A2 (enExample) |
| HU (1) | HU230075B1 (enExample) |
| IL (2) | IL144777A0 (enExample) |
| IS (1) | IS6041A (enExample) |
| MX (1) | MXPA01008372A (enExample) |
| NO (1) | NO20013993L (enExample) |
| NZ (1) | NZ513685A (enExample) |
| PL (2) | PL205710B1 (enExample) |
| PT (1) | PT2062977E (enExample) |
| SK (1) | SK286416B6 (enExample) |
| TR (1) | TR200102393T2 (enExample) |
| WO (1) | WO2000049153A1 (enExample) |
| YU (1) | YU58901A (enExample) |
| ZA (1) | ZA200106735B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2350063T3 (es) | 1998-12-09 | 2011-01-17 | Phyton Holdings, Llc | Método para fabricación de glicoproteínas que tienen glicosilación de tipo humano. |
| AT408446B (de) * | 1999-02-18 | 2001-11-26 | Altmann Friedrich Dr | Fucosyltransferase-gen |
| ES2568899T3 (es) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| NZ518532A (en) | 1999-10-26 | 2004-02-27 | Plant Res Internat B | Transgenic plant expressing mammalian beta-1,4- galactosyltransferase |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CA2434364C (en) | 2001-01-19 | 2013-03-19 | The Dow Chemical Company | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
| WO2003078614A2 (en) | 2002-03-19 | 2003-09-25 | Plant Research International B.V. | Gntiii (udp-n-acethylglucosamine:beta-d mannoside beta (1,4)-n-acethylglucosaminy ltransferase iii) expression in plants |
| CA2799805C (en) | 2002-03-19 | 2016-05-17 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| AU2003236020B2 (en) * | 2002-04-09 | 2009-03-19 | Kyowa Hakko Kirin Co., Ltd. | Cell with depression or deletion of the activity of protein participating in GDP-fucose transport |
| CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
| ATE426033T1 (de) | 2003-08-11 | 2009-04-15 | Greenovation Biotech Gmbh | Promoter sequenzen aus moos und dessen verwendung |
| FI20055398A0 (fi) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Menetelmä solupopulaatioiden evaluoimiseksi |
| US20090060921A1 (en) * | 2006-01-17 | 2009-03-05 | Biolex Therapeutics, Inc. | Glycan-optimized anti-cd20 antibodies |
| MX2008009220A (es) | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| CN102094019B (zh) * | 2007-01-15 | 2012-11-28 | 燕秋 | 用于抑制LeY糖抗原合成的岩藻糖基转移酶Ⅳ的RNA干涉序列及重组干涉质粒 |
| CN102094020B (zh) * | 2007-01-15 | 2012-11-28 | 燕秋 | 用于抑制LeY糖抗原合成的岩藻糖基转移酶I的RNA干涉序列及重组干涉质粒 |
| CN101702919B (zh) | 2007-04-17 | 2014-08-13 | 基金会农业研究服务中心 | 植物通过表达非哺乳动物糖基转移酶而表现出哺乳动物类型的糖基化作用 |
| JP5766947B2 (ja) * | 2007-09-07 | 2015-08-19 | チルドレンズ ホスピタル メディカル センター | 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用 |
| WO2009056155A1 (en) * | 2007-10-31 | 2009-05-07 | Bayer Bioscience N.V. | Method to produce modified plants with altered n-glycosylation pattern |
| EP2166085A1 (en) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalent modified cells |
| PL2944690T3 (pl) | 2010-10-11 | 2018-05-30 | Jennewein Biotechnologie Gmbh | Nowe fukozylotransferazy i ich zastosowanie |
| KR101293658B1 (ko) * | 2010-12-30 | 2013-08-07 | 대한민국 | 알파-1,3-푸코실트랜스퍼라아제 및/또는 베타-1,2-자일로실트렌스퍼라아제 유전자를 포함하는 벼 형질전환용 벡터 및 형질전환된 벼 |
| ES2439507T3 (es) * | 2011-01-20 | 2014-01-23 | Jennewein Biotechnologie Gmbh | Fucosiltransferasas novedosas y sus aplicaciones |
| EP2789686A1 (en) | 2013-04-11 | 2014-10-15 | Greenovation Biotech GmbH | Expression of phosphorylated glycoproteins in plants |
| EP3050973A1 (en) * | 2015-01-30 | 2016-08-03 | Jennewein Biotechnologie GmbH | Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars |
| CN110317799A (zh) * | 2019-07-18 | 2019-10-11 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| EP3871687A1 (en) | 2020-02-27 | 2021-09-01 | eleva GmbH | Enzyme replacement therapy for treating pompe disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009421A1 (en) * | 1995-09-08 | 1997-03-13 | The Regents Of The University Of Michigan | Chimeric fucosyltransferase polypeptides and nucleic acid sequences encoding them |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272066A (en) | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
| DE69434749T2 (de) | 1993-03-29 | 2007-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Alpha-1,3-Fucosyltransferase |
| US6509149B2 (en) * | 1995-06-06 | 2003-01-21 | Hybridon, Inc. | HPV-specific oligonucleotides |
| AT408446B (de) * | 1999-02-18 | 2001-11-26 | Altmann Friedrich Dr | Fucosyltransferase-gen |
-
1999
- 1999-02-18 AT AT0027099A patent/AT408446B/de not_active IP Right Cessation
-
2000
- 2000-02-17 DK DK09154489.0T patent/DK2062977T3/da active
- 2000-02-17 TR TR2001/02393T patent/TR200102393T2/xx unknown
- 2000-02-17 EP EP09154489.0A patent/EP2062977B1/de not_active Expired - Lifetime
- 2000-02-17 ES ES00904677T patent/ES2246222T3/es not_active Expired - Lifetime
- 2000-02-17 CN CN00805192A patent/CN1360633A/zh active Pending
- 2000-02-17 HU HU0200394A patent/HU230075B1/hu unknown
- 2000-02-17 MX MXPA01008372A patent/MXPA01008372A/es active IP Right Grant
- 2000-02-17 EP EP00904677A patent/EP1151109B1/de not_active Expired - Lifetime
- 2000-02-17 KR KR1020017010518A patent/KR20010108234A/ko not_active Ceased
- 2000-02-17 ES ES09154489.0T patent/ES2444126T3/es not_active Expired - Lifetime
- 2000-02-17 BR BR0010114-1A patent/BR0010114A/pt not_active Application Discontinuation
- 2000-02-17 HR HR20010681A patent/HRP20010681A2/hr not_active Application Discontinuation
- 2000-02-17 PT PT91544890T patent/PT2062977E/pt unknown
- 2000-02-17 WO PCT/AT2000/000040 patent/WO2000049153A1/de not_active Ceased
- 2000-02-17 DE DE50011116T patent/DE50011116D1/de not_active Expired - Lifetime
- 2000-02-17 EP EP05108012A patent/EP1642979A1/de not_active Withdrawn
- 2000-02-17 CZ CZ2008-404A patent/CZ308081B6/cs not_active IP Right Cessation
- 2000-02-17 YU YU58901A patent/YU58901A/sh unknown
- 2000-02-17 NZ NZ513685A patent/NZ513685A/en unknown
- 2000-02-17 AT AT00904677T patent/ATE304053T1/de active
- 2000-02-17 EE EEP200100432A patent/EE200100432A/xx unknown
- 2000-02-17 DK DK00904677T patent/DK1151109T3/da active
- 2000-02-17 CZ CZ20012943A patent/CZ299622B6/cs not_active IP Right Cessation
- 2000-02-17 CA CA2362964A patent/CA2362964C/en not_active Expired - Lifetime
- 2000-02-17 IL IL14477700A patent/IL144777A0/xx active IP Right Grant
- 2000-02-17 PL PL385768A patent/PL205710B1/pl unknown
- 2000-02-17 SK SK1118-2001A patent/SK286416B6/sk not_active IP Right Cessation
- 2000-02-17 AU AU26460/00A patent/AU771995B2/en not_active Expired
- 2000-02-17 JP JP2000599878A patent/JP5514386B2/ja not_active Expired - Lifetime
- 2000-02-17 PL PL363438A patent/PL205785B1/pl unknown
-
2001
- 2001-08-07 IL IL144777A patent/IL144777A/en not_active IP Right Cessation
- 2001-08-08 IS IS6041A patent/IS6041A/is unknown
- 2001-08-15 ZA ZA200106735A patent/ZA200106735B/en unknown
- 2001-08-16 NO NO20013993A patent/NO20013993L/no unknown
- 2001-09-13 BG BG105899A patent/BG65140B1/bg unknown
-
2007
- 2007-06-06 US US11/808,096 patent/US20080234471A1/en not_active Abandoned
- 2007-06-06 US US11/808,097 patent/US8198078B2/en not_active Expired - Fee Related
-
2011
- 2011-01-04 JP JP2011000049A patent/JP2011120592A/ja active Pending
-
2012
- 2012-05-15 US US13/471,759 patent/US8895806B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009421A1 (en) * | 1995-09-08 | 1997-03-13 | The Regents Of The University Of Michigan | Chimeric fucosyltransferase polypeptides and nucleic acid sequences encoding them |
Non-Patent Citations (4)
| Title |
|---|
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