CZ300764B6 - Opticky aktivní derivát pyridyl-4H-1,2,4-oxadiazinu, jeho použití pri lécbe vaskulárních onemocnení a farmaceutické kompozice ho obsahující - Google Patents
Opticky aktivní derivát pyridyl-4H-1,2,4-oxadiazinu, jeho použití pri lécbe vaskulárních onemocnení a farmaceutické kompozice ho obsahující Download PDFInfo
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- CZ300764B6 CZ300764B6 CZ20011550A CZ20011550A CZ300764B6 CZ 300764 B6 CZ300764 B6 CZ 300764B6 CZ 20011550 A CZ20011550 A CZ 20011550A CZ 20011550 A CZ20011550 A CZ 20011550A CZ 300764 B6 CZ300764 B6 CZ 300764B6
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- pyridyl
- oxadiazine
- dihydro
- methyl
- piperidinyl
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- 230000002666 vasoprotective effect Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802897A HU226617B1 (en) | 1998-12-14 | 1998-12-14 | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20011550A3 CZ20011550A3 (cs) | 2001-08-15 |
| CZ300764B6 true CZ300764B6 (cs) | 2009-08-05 |
Family
ID=10991166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20011550A CZ300764B6 (cs) | 1998-12-14 | 1999-12-07 | Opticky aktivní derivát pyridyl-4H-1,2,4-oxadiazinu, jeho použití pri lécbe vaskulárních onemocnení a farmaceutické kompozice ho obsahující |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6384029B1 (https=) |
| EP (1) | EP1147105B1 (https=) |
| JP (2) | JP2002532498A (https=) |
| KR (1) | KR100661774B1 (https=) |
| AT (1) | ATE266027T1 (https=) |
| AU (1) | AU765336B2 (https=) |
| BG (1) | BG65179B1 (https=) |
| BR (1) | BR9913982A (https=) |
| CA (1) | CA2340734C (https=) |
| CZ (1) | CZ300764B6 (https=) |
| DE (1) | DE69917074T2 (https=) |
| DK (1) | DK1147105T3 (https=) |
| EE (1) | EE04551B1 (https=) |
| ES (1) | ES2219091T3 (https=) |
| HR (1) | HRP20010133B1 (https=) |
| HU (1) | HU226617B1 (https=) |
| IL (1) | IL141515A (https=) |
| NO (1) | NO317649B1 (https=) |
| PL (1) | PL196584B1 (https=) |
| PT (1) | PT1147105E (https=) |
| RS (1) | RS50129B (https=) |
| RU (1) | RU2222538C2 (https=) |
| SI (1) | SI1147105T1 (https=) |
| SK (1) | SK285582B6 (https=) |
| UA (1) | UA70340C2 (https=) |
| WO (1) | WO2000035914A1 (https=) |
| ZA (1) | ZA200101182B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005514418A (ja) | 2002-01-11 | 2005-05-19 | ビオレックス クタトー エス フェイレストェー アールテー． | カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 |
| KR100678577B1 (ko) * | 2006-09-11 | 2007-02-06 | 조만규 | 가정용 분전함 |
| US8540985B2 (en) | 2008-06-26 | 2013-09-24 | Orphazyme Aps | Use of Hsp70 as a regulator of enzymatic activity |
| EP2356988A4 (en) | 2008-11-18 | 2012-05-09 | Santen Pharmaceutical Co Ltd | THERAPEUTIC FOR CHORIORETINAL DEGENERATION WITH PYRIDINE-3-CARBALDEHYDE O- (PIPERIDIN-1-YL-PROPYL) OXIM DERIVATIVE AS ACTIVE SUBSTANCE |
| RU2013125923A (ru) | 2010-11-30 | 2015-01-10 | Орфазиме Апс | СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| EP3442530A1 (en) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| KR20210059796A (ko) | 2016-04-29 | 2021-05-25 | 오르파짐 에이/에스 | 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰 |
| WO2018215597A1 (en) | 2017-05-24 | 2018-11-29 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
| KR20210015790A (ko) | 2018-05-28 | 2021-02-10 | 오르파짐 에이/에스 | 질환의 바이오마커로서 pbmc 샘플에서 hsp70 단백질 수준 |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997016439A1 (en) * | 1995-11-02 | 1997-05-09 | Biorex Kutató és Fejlesztó Rt. | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
| WO1998006400A2 (en) * | 1996-08-09 | 1998-02-19 | Biorex Kutató És Fejleszto^' Rt. | Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| WO1997016349A1 (en) * | 1995-11-03 | 1997-05-09 | Global Trading Uk Limited | Apparatus for dispensing and filling bags at a checkout counter of a supermarket |
-
1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/hu not_active IP Right Cessation
-
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/uk unknown
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/pt not_active Application Discontinuation
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/ko not_active Expired - Fee Related
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
- 1999-12-07 DE DE69917074T patent/DE69917074T2/de not_active Expired - Lifetime
- 1999-12-07 AT AT99961225T patent/ATE266027T1/de active
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en not_active Ceased
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/ja not_active Withdrawn
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/ru not_active IP Right Cessation
- 1999-12-07 HR HR20010133A patent/HRP20010133B1/xx not_active IP Right Cessation
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
- 1999-12-07 IL IL14151599A patent/IL141515A/xx not_active IP Right Cessation
- 1999-12-07 SK SK234-2001A patent/SK285582B6/sk not_active IP Right Cessation
- 1999-12-07 EP EP99961225A patent/EP1147105B1/en not_active Expired - Lifetime
- 1999-12-07 ES ES99961225T patent/ES2219091T3/es not_active Expired - Lifetime
- 1999-12-07 PT PT99961225T patent/PT1147105E/pt unknown
- 1999-12-07 SI SI9930566T patent/SI1147105T1/xx unknown
- 1999-12-07 EE EEP200100188A patent/EE04551B1/xx not_active IP Right Cessation
- 1999-12-07 DK DK99961225T patent/DK1147105T3/da active
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/cs not_active IP Right Cessation
- 1999-12-07 PL PL346767A patent/PL196584B1/pl not_active IP Right Cessation
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
- 1999-12-07 RS YUP-250/01A patent/RS50129B/sr unknown
-
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-03-14 BG BG105342A patent/BG65179B1/bg unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/no not_active IP Right Cessation
-
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/ja not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997016439A1 (en) * | 1995-11-02 | 1997-05-09 | Biorex Kutató és Fejlesztó Rt. | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
| WO1998006400A2 (en) * | 1996-08-09 | 1998-02-19 | Biorex Kutató És Fejleszto^' Rt. | Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20111207 |