NO317649B1 - Optisk aktiv pyridyl-4H-1,2,4-oksazdiazinderivat og dets anvendelse ved behandling av karsykdommer - Google Patents

Optisk aktiv pyridyl-4H-1,2,4-oksazdiazinderivat og dets anvendelse ved behandling av karsykdommer Download PDF

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Publication number
NO317649B1
NO317649B1 NO20012310A NO20012310A NO317649B1 NO 317649 B1 NO317649 B1 NO 317649B1 NO 20012310 A NO20012310 A NO 20012310A NO 20012310 A NO20012310 A NO 20012310A NO 317649 B1 NO317649 B1 NO 317649B1
Authority
NO
Norway
Prior art keywords
pyridyl
piperidinyl
methyl
oxadiazine
dihydro
Prior art date
Application number
NO20012310A
Other languages
English (en)
Norwegian (no)
Other versions
NO20012310L (no
NO20012310D0 (no
Inventor
Jeno Szilbereky
Peter Krajcsi
Zoltan Nagy
Ede Marvanyos
Mihaly Barabas
Laszlo Uerogdi
Andrea Jednakovits
Istvan Kurucz
Erno Bacsy
Magdolna Torok
Zita Jegesne Csakai
Laszlo Denes
Zsuzsanna Korom
Laszlo Uerge
Karoly Acsai
Original Assignee
Biorex Kutato Fejlesztoe Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft
Publication of NO20012310L publication Critical patent/NO20012310L/no
Publication of NO20012310D0 publication Critical patent/NO20012310D0/no
Publication of NO317649B1 publication Critical patent/NO317649B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20012310A 1998-12-14 2001-05-10 Optisk aktiv pyridyl-4H-1,2,4-oksazdiazinderivat og dets anvendelse ved behandling av karsykdommer NO317649B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
PCT/HU1999/000095 WO2000035914A1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases

Publications (3)

Publication Number Publication Date
NO20012310L NO20012310L (no) 2001-05-10
NO20012310D0 NO20012310D0 (no) 2001-05-10
NO317649B1 true NO317649B1 (no) 2004-11-29

Family

ID=10991166

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012310A NO317649B1 (no) 1998-12-14 2001-05-10 Optisk aktiv pyridyl-4H-1,2,4-oksazdiazinderivat og dets anvendelse ved behandling av karsykdommer

Country Status (27)

Country Link
US (1) US6384029B1 (https=)
EP (1) EP1147105B1 (https=)
JP (2) JP2002532498A (https=)
KR (1) KR100661774B1 (https=)
AT (1) ATE266027T1 (https=)
AU (1) AU765336B2 (https=)
BG (1) BG65179B1 (https=)
BR (1) BR9913982A (https=)
CA (1) CA2340734C (https=)
CZ (1) CZ300764B6 (https=)
DE (1) DE69917074T2 (https=)
DK (1) DK1147105T3 (https=)
EE (1) EE04551B1 (https=)
ES (1) ES2219091T3 (https=)
HR (1) HRP20010133B1 (https=)
HU (1) HU226617B1 (https=)
IL (1) IL141515A (https=)
NO (1) NO317649B1 (https=)
PL (1) PL196584B1 (https=)
PT (1) PT1147105E (https=)
RS (1) RS50129B (https=)
RU (1) RU2222538C2 (https=)
SI (1) SI1147105T1 (https=)
SK (1) SK285582B6 (https=)
UA (1) UA70340C2 (https=)
WO (1) WO2000035914A1 (https=)
ZA (1) ZA200101182B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514418A (ja) 2002-01-11 2005-05-19 ビオレックス クタトー エス フェイレストェー アールテー． カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用
KR100678577B1 (ko) * 2006-09-11 2007-02-06 조만규 가정용 분전함
US8540985B2 (en) 2008-06-26 2013-09-24 Orphazyme Aps Use of Hsp70 as a regulator of enzymatic activity
EP2356988A4 (en) 2008-11-18 2012-05-09 Santen Pharmaceutical Co Ltd THERAPEUTIC FOR CHORIORETINAL DEGENERATION WITH PYRIDINE-3-CARBALDEHYDE O- (PIPERIDIN-1-YL-PROPYL) OXIM DERIVATIVE AS ACTIVE SUBSTANCE
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
US10709700B2 (en) 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
KR20210059796A (ko) 2016-04-29 2021-05-25 오르파짐 에이/에스 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰
WO2018215597A1 (en) 2017-05-24 2018-11-29 Orphazyme A/S Heat shock protein inducers and frontotemporal disorders
KR20210015790A (ko) 2018-05-28 2021-02-10 오르파짐 에이/에스 질환의 바이오마커로서 pbmc 샘플에서 hsp70 단백질 수준
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT395853B (de) * 1991-01-31 1993-03-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
WO1997016349A1 (en) * 1995-11-03 1997-05-09 Global Trading Uk Limited Apparatus for dispensing and filling bags at a checkout counter of a supermarket
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Also Published As

Publication number Publication date
HUP9802897A2 (hu) 2000-11-28
IL141515A0 (en) 2002-03-10
CZ300764B6 (cs) 2009-08-05
BG105342A (en) 2001-12-29
AU1790600A (en) 2000-07-03
SK285582B6 (sk) 2007-04-05
DK1147105T3 (da) 2004-06-01
JP5620340B2 (ja) 2014-11-05
PL196584B1 (pl) 2008-01-31
UA70340C2 (en) 2004-10-15
CA2340734C (en) 2008-10-21
RU2222538C2 (ru) 2004-01-27
SI1147105T1 (en) 2004-08-31
DE69917074D1 (de) 2004-06-09
KR100661774B1 (ko) 2006-12-28
ZA200101182B (en) 2002-02-12
CZ20011550A3 (cs) 2001-08-15
ES2219091T3 (es) 2004-11-16
IL141515A (en) 2005-09-25
HU226617B1 (en) 2009-04-28
RS50129B (sr) 2009-03-25
BR9913982A (pt) 2001-06-12
KR20010073129A (ko) 2001-07-31
NO20012310L (no) 2001-05-10
ATE266027T1 (de) 2004-05-15
CA2340734A1 (en) 2000-06-22
EP1147105B1 (en) 2004-05-06
AU765336B2 (en) 2003-09-18
HRP20010133A2 (en) 2002-02-28
JP2011201916A (ja) 2011-10-13
US6384029B1 (en) 2002-05-07
PL346767A1 (en) 2002-02-25
HU9802897D0 (en) 1999-02-01
HUP9802897A3 (en) 2001-08-28
NO20012310D0 (no) 2001-05-10
PT1147105E (pt) 2004-07-30
JP2002532498A (ja) 2002-10-02
YU25001A (sh) 2004-07-15
SK2342001A3 (en) 2001-08-06
WO2000035914A1 (en) 2000-06-22
EE04551B1 (et) 2005-10-17
EE200100188A (et) 2002-08-15
HRP20010133B1 (en) 2005-02-28
EP1147105A1 (en) 2001-10-24
BG65179B1 (bg) 2007-05-31
DE69917074T2 (de) 2005-05-12

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