KR100661774B1 - 광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도 - Google Patents

광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도 Download PDF

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Publication number
KR100661774B1
KR100661774B1 KR1020017002870A KR20017002870A KR100661774B1 KR 100661774 B1 KR100661774 B1 KR 100661774B1 KR 1020017002870 A KR1020017002870 A KR 1020017002870A KR 20017002870 A KR20017002870 A KR 20017002870A KR 100661774 B1 KR100661774 B1 KR 100661774B1
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KR
South Korea
Prior art keywords
pyridyl
piperidinyl
dihydro
methyl
oxadiazine
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020017002870A
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English (en)
Korean (ko)
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KR20010073129A (ko
Inventor
안드레아 제드나코비츠
라스즐로 유로그디
라스즐로 데네스
이스트반 쿠르츠
에데 마르반요오스
미할리 바라바스
에르노 박시
즈스즈산나 코롬
졸탄 나기
라스즐로 유르게
제노 스질베레키
카롤리 악사이
피터 크라즈시
지타 스사카이
마그돌나 토로크
Original Assignee
비오렉스 쿠타토 에쉬 훼레스테 에르테
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Publication of KR20010073129A publication Critical patent/KR20010073129A/ko
Application granted granted Critical
Publication of KR100661774B1 publication Critical patent/KR100661774B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020017002870A 1998-12-14 1999-12-07 광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도 Expired - Fee Related KR100661774B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9802897 1998-12-14
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient

Publications (2)

Publication Number Publication Date
KR20010073129A KR20010073129A (ko) 2001-07-31
KR100661774B1 true KR100661774B1 (ko) 2006-12-28

Family

ID=10991166

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017002870A Expired - Fee Related KR100661774B1 (ko) 1998-12-14 1999-12-07 광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도

Country Status (27)

Country Link
US (1) US6384029B1 (https=)
EP (1) EP1147105B1 (https=)
JP (2) JP2002532498A (https=)
KR (1) KR100661774B1 (https=)
AT (1) ATE266027T1 (https=)
AU (1) AU765336B2 (https=)
BG (1) BG65179B1 (https=)
BR (1) BR9913982A (https=)
CA (1) CA2340734C (https=)
CZ (1) CZ300764B6 (https=)
DE (1) DE69917074T2 (https=)
DK (1) DK1147105T3 (https=)
EE (1) EE04551B1 (https=)
ES (1) ES2219091T3 (https=)
HR (1) HRP20010133B1 (https=)
HU (1) HU226617B1 (https=)
IL (1) IL141515A (https=)
NO (1) NO317649B1 (https=)
PL (1) PL196584B1 (https=)
PT (1) PT1147105E (https=)
RS (1) RS50129B (https=)
RU (1) RU2222538C2 (https=)
SI (1) SI1147105T1 (https=)
SK (1) SK285582B6 (https=)
UA (1) UA70340C2 (https=)
WO (1) WO2000035914A1 (https=)
ZA (1) ZA200101182B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514418A (ja) 2002-01-11 2005-05-19 ビオレックス クタトー エス フェイレストェー アールテー． カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用
KR100678577B1 (ko) * 2006-09-11 2007-02-06 조만규 가정용 분전함
US8540985B2 (en) 2008-06-26 2013-09-24 Orphazyme Aps Use of Hsp70 as a regulator of enzymatic activity
EP2356988A4 (en) 2008-11-18 2012-05-09 Santen Pharmaceutical Co Ltd THERAPEUTIC FOR CHORIORETINAL DEGENERATION WITH PYRIDINE-3-CARBALDEHYDE O- (PIPERIDIN-1-YL-PROPYL) OXIM DERIVATIVE AS ACTIVE SUBSTANCE
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
US10709700B2 (en) 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
KR20210059796A (ko) 2016-04-29 2021-05-25 오르파짐 에이/에스 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰
WO2018215597A1 (en) 2017-05-24 2018-11-29 Orphazyme A/S Heat shock protein inducers and frontotemporal disorders
KR20210015790A (ko) 2018-05-28 2021-02-10 오르파짐 에이/에스 질환의 바이오마커로서 pbmc 샘플에서 hsp70 단백질 수준
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT395853B (de) * 1991-01-31 1993-03-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
WO1997016349A1 (en) * 1995-11-03 1997-05-09 Global Trading Uk Limited Apparatus for dispensing and filling bags at a checkout counter of a supermarket
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Also Published As

Publication number Publication date
HUP9802897A2 (hu) 2000-11-28
IL141515A0 (en) 2002-03-10
CZ300764B6 (cs) 2009-08-05
BG105342A (en) 2001-12-29
AU1790600A (en) 2000-07-03
SK285582B6 (sk) 2007-04-05
DK1147105T3 (da) 2004-06-01
JP5620340B2 (ja) 2014-11-05
PL196584B1 (pl) 2008-01-31
UA70340C2 (en) 2004-10-15
CA2340734C (en) 2008-10-21
RU2222538C2 (ru) 2004-01-27
SI1147105T1 (en) 2004-08-31
DE69917074D1 (de) 2004-06-09
ZA200101182B (en) 2002-02-12
CZ20011550A3 (cs) 2001-08-15
NO317649B1 (no) 2004-11-29
ES2219091T3 (es) 2004-11-16
IL141515A (en) 2005-09-25
HU226617B1 (en) 2009-04-28
RS50129B (sr) 2009-03-25
BR9913982A (pt) 2001-06-12
KR20010073129A (ko) 2001-07-31
NO20012310L (no) 2001-05-10
ATE266027T1 (de) 2004-05-15
CA2340734A1 (en) 2000-06-22
EP1147105B1 (en) 2004-05-06
AU765336B2 (en) 2003-09-18
HRP20010133A2 (en) 2002-02-28
JP2011201916A (ja) 2011-10-13
US6384029B1 (en) 2002-05-07
PL346767A1 (en) 2002-02-25
HU9802897D0 (en) 1999-02-01
HUP9802897A3 (en) 2001-08-28
NO20012310D0 (no) 2001-05-10
PT1147105E (pt) 2004-07-30
JP2002532498A (ja) 2002-10-02
YU25001A (sh) 2004-07-15
SK2342001A3 (en) 2001-08-06
WO2000035914A1 (en) 2000-06-22
EE04551B1 (et) 2005-10-17
EE200100188A (et) 2002-08-15
HRP20010133B1 (en) 2005-02-28
EP1147105A1 (en) 2001-10-24
BG65179B1 (bg) 2007-05-31
DE69917074T2 (de) 2005-05-12

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