RU2222538C2 - Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция - Google Patents

Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция Download PDF

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Publication number
RU2222538C2
RU2222538C2 RU2001118854/04A RU2001118854A RU2222538C2 RU 2222538 C2 RU2222538 C2 RU 2222538C2 RU 2001118854/04 A RU2001118854/04 A RU 2001118854/04A RU 2001118854 A RU2001118854 A RU 2001118854A RU 2222538 C2 RU2222538 C2 RU 2222538C2
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RU
Russia
Prior art keywords
oxadiazine
pyridyl
pharmaceutical composition
optically active
vascular
Prior art date
Application number
RU2001118854/04A
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English (en)
Russian (ru)
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RU2001118854A (ru
Inventor
Андреа ЙЕДНАКОВИТШ (HU)
Андреа Йеднаковитш
Ласло ИРЕГДИ (HU)
Ласло ИРЕГДИ
Ласло ДЕНЕШ (HU)
Ласло ДЕНЕШ
Иштван КУРУЦ (HU)
Иштван Куруц
Эде МАРВАНЬОШ (HU)
Эде Марваньош
Михай БАРАБАШ (HU)
Михай Барабаш
Эрне БАЧИ (HU)
Эрне БАЧИ
Жужанна КОРОМ (HU)
Жужанна КОРОМ
Зольтан НАДЬ (HU)
Зольтан НАДЬ
Ласло ИРГЕ (HU)
Ласло ИРГЕ
Йене СИЛЬБЕРЕКИ (HU)
Йене СИЛЬБЕРЕКИ
Карой АЧАИ (HU)
Карой АЧАИ
Петер КРАЙЧИ (HU)
Петер КРАЙЧИ
Зита ЧАКАИ (HU)
Зита ЧАКАИ
Магдольна ТЕРЕК (HU)
Магдольна ТЕРЕК
Original Assignee
Биорекс Кутато Еш Фейлесте Рт.
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Application filed by Биорекс Кутато Еш Фейлесте Рт. filed Critical Биорекс Кутато Еш Фейлесте Рт.
Publication of RU2001118854A publication Critical patent/RU2001118854A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2001118854/04A 1998-12-14 1999-12-07 Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция RU2222538C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9802897 1998-12-14
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient

Publications (2)

Publication Number Publication Date
RU2001118854A RU2001118854A (ru) 2003-11-20
RU2222538C2 true RU2222538C2 (ru) 2004-01-27

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Family Applications (1)

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RU2001118854/04A RU2222538C2 (ru) 1998-12-14 1999-12-07 Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция

Country Status (27)

Country Link
US (1) US6384029B1 (https=)
EP (1) EP1147105B1 (https=)
JP (2) JP2002532498A (https=)
KR (1) KR100661774B1 (https=)
AT (1) ATE266027T1 (https=)
AU (1) AU765336B2 (https=)
BG (1) BG65179B1 (https=)
BR (1) BR9913982A (https=)
CA (1) CA2340734C (https=)
CZ (1) CZ300764B6 (https=)
DE (1) DE69917074T2 (https=)
DK (1) DK1147105T3 (https=)
EE (1) EE04551B1 (https=)
ES (1) ES2219091T3 (https=)
HR (1) HRP20010133B1 (https=)
HU (1) HU226617B1 (https=)
IL (1) IL141515A (https=)
NO (1) NO317649B1 (https=)
PL (1) PL196584B1 (https=)
PT (1) PT1147105E (https=)
RS (1) RS50129B (https=)
RU (1) RU2222538C2 (https=)
SI (1) SI1147105T1 (https=)
SK (1) SK285582B6 (https=)
UA (1) UA70340C2 (https=)
WO (1) WO2000035914A1 (https=)
ZA (1) ZA200101182B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514418A (ja) 2002-01-11 2005-05-19 ビオレックス クタトー エス フェイレストェー アールテー． カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用
KR100678577B1 (ko) * 2006-09-11 2007-02-06 조만규 가정용 분전함
US8540985B2 (en) 2008-06-26 2013-09-24 Orphazyme Aps Use of Hsp70 as a regulator of enzymatic activity
EP2356988A4 (en) 2008-11-18 2012-05-09 Santen Pharmaceutical Co Ltd THERAPEUTIC FOR CHORIORETINAL DEGENERATION WITH PYRIDINE-3-CARBALDEHYDE O- (PIPERIDIN-1-YL-PROPYL) OXIM DERIVATIVE AS ACTIVE SUBSTANCE
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
US10709700B2 (en) 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
KR20210059796A (ko) 2016-04-29 2021-05-25 오르파짐 에이/에스 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰
WO2018215597A1 (en) 2017-05-24 2018-11-29 Orphazyme A/S Heat shock protein inducers and frontotemporal disorders
KR20210015790A (ko) 2018-05-28 2021-02-10 오르파짐 에이/에스 질환의 바이오마커로서 pbmc 샘플에서 hsp70 단백질 수준
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2078764C1 (ru) * 1991-01-31 1997-05-10 Хемиш Фармацойтише Форшунгсгезельшафт мбХ Производные тетразола, способ их получения и фармацевтическая композиция, обладающая свойствами антагониста рецептора ангиотензина п

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
WO1997016349A1 (en) * 1995-11-03 1997-05-09 Global Trading Uk Limited Apparatus for dispensing and filling bags at a checkout counter of a supermarket
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2078764C1 (ru) * 1991-01-31 1997-05-10 Хемиш Фармацойтише Форшунгсгезельшафт мбХ Производные тетразола, способ их получения и фармацевтическая композиция, обладающая свойствами антагониста рецептора ангиотензина п

Also Published As

Publication number Publication date
HUP9802897A2 (hu) 2000-11-28
IL141515A0 (en) 2002-03-10
CZ300764B6 (cs) 2009-08-05
BG105342A (en) 2001-12-29
AU1790600A (en) 2000-07-03
SK285582B6 (sk) 2007-04-05
DK1147105T3 (da) 2004-06-01
JP5620340B2 (ja) 2014-11-05
PL196584B1 (pl) 2008-01-31
UA70340C2 (en) 2004-10-15
CA2340734C (en) 2008-10-21
SI1147105T1 (en) 2004-08-31
DE69917074D1 (de) 2004-06-09
KR100661774B1 (ko) 2006-12-28
ZA200101182B (en) 2002-02-12
CZ20011550A3 (cs) 2001-08-15
NO317649B1 (no) 2004-11-29
ES2219091T3 (es) 2004-11-16
IL141515A (en) 2005-09-25
HU226617B1 (en) 2009-04-28
RS50129B (sr) 2009-03-25
BR9913982A (pt) 2001-06-12
KR20010073129A (ko) 2001-07-31
NO20012310L (no) 2001-05-10
ATE266027T1 (de) 2004-05-15
CA2340734A1 (en) 2000-06-22
EP1147105B1 (en) 2004-05-06
AU765336B2 (en) 2003-09-18
HRP20010133A2 (en) 2002-02-28
JP2011201916A (ja) 2011-10-13
US6384029B1 (en) 2002-05-07
PL346767A1 (en) 2002-02-25
HU9802897D0 (en) 1999-02-01
HUP9802897A3 (en) 2001-08-28
NO20012310D0 (no) 2001-05-10
PT1147105E (pt) 2004-07-30
JP2002532498A (ja) 2002-10-02
YU25001A (sh) 2004-07-15
SK2342001A3 (en) 2001-08-06
WO2000035914A1 (en) 2000-06-22
EE04551B1 (et) 2005-10-17
EE200100188A (et) 2002-08-15
HRP20010133B1 (en) 2005-02-28
EP1147105A1 (en) 2001-10-24
BG65179B1 (bg) 2007-05-31
DE69917074T2 (de) 2005-05-12

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Effective date: 20111208