CZ219999A3 - Nové sloučeniny s analgetickým účinkem - Google Patents

Nové sloučeniny s analgetickým účinkem

Info

Publication number
CZ219999A3
CZ219999A3 CZ992199A CZ219999A CZ219999A3 CZ 219999 A3 CZ219999 A3 CZ 219999A3 CZ 992199 A CZ992199 A CZ 992199A CZ 219999 A CZ219999 A CZ 219999A CZ 219999 A3 CZ219999 A3 CZ 219999A3
Authority
CZ
Czechia
Prior art keywords
novel compounds
compounds exhibiting
analgetic activity
analgetic
activity
Prior art date
Application number
CZ992199A
Other languages
English (en)
Other versions
CZ295557B6 (cs
Inventor
Daniel Delorme
Edward Roberts
Zhongyong Wei
Original Assignee
Astra Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9604785A external-priority patent/SE9604785D0/xx
Priority claimed from SE9702535A external-priority patent/SE9702535D0/xx
Application filed by Astra Pharma Inc. filed Critical Astra Pharma Inc.
Publication of CZ219999A3 publication Critical patent/CZ219999A3/cs
Publication of CZ295557B6 publication Critical patent/CZ295557B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ19992199A 1996-12-20 1997-12-09 Piperidinylidenový derivát, způsob a meziprodukt pro jeho přípravu a diagnostické činidlo a farmaceutický prostředek s obsahem tohoto derivátu CZ295557B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604785A SE9604785D0 (sv) 1996-12-20 1996-12-20 New compounds
SE9702535A SE9702535D0 (sv) 1997-07-01 1997-07-01 New compounds

Publications (2)

Publication Number Publication Date
CZ219999A3 true CZ219999A3 (cs) 1999-11-17
CZ295557B6 CZ295557B6 (cs) 2005-08-17

Family

ID=26662830

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19992199A CZ295557B6 (cs) 1996-12-20 1997-12-09 Piperidinylidenový derivát, způsob a meziprodukt pro jeho přípravu a diagnostické činidlo a farmaceutický prostředek s obsahem tohoto derivátu

Country Status (28)

Country Link
US (5) US6187792B1 (cs)
EP (1) EP0946511B1 (cs)
JP (1) JP4324652B2 (cs)
KR (1) KR100549144B1 (cs)
CN (2) CN100519528C (cs)
AR (1) AR010376A1 (cs)
AT (1) ATE296288T1 (cs)
AU (1) AU737999B2 (cs)
BR (1) BR9714055B1 (cs)
CA (1) CA2274074C (cs)
CZ (1) CZ295557B6 (cs)
DE (1) DE69733362T2 (cs)
EE (1) EE03824B1 (cs)
ES (1) ES2241060T3 (cs)
HU (1) HU226724B1 (cs)
ID (1) ID22074A (cs)
IL (2) IL130535A0 (cs)
IS (1) IS2210B (cs)
MY (1) MY119403A (cs)
NO (1) NO313670B1 (cs)
NZ (1) NZ336029A (cs)
PL (1) PL189196B1 (cs)
PT (1) PT946511E (cs)
RU (1) RU2193029C2 (cs)
SK (1) SK283211B6 (cs)
TR (1) TR199901417T2 (cs)
TW (1) TW548271B (cs)
WO (1) WO1998028275A1 (cs)

Families Citing this family (70)

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SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
WO2000071518A2 (en) * 1999-05-25 2000-11-30 Sepracor, Inc. Heterocyclic analgesic compounds and their use
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
EP1242421A1 (en) 1999-12-22 2002-09-25 Ortho-McNeil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1] octan-3-yl)] aminobenzoic acid derivatives
ATE302184T1 (de) * 2000-02-18 2005-09-15 Meiji Seika Kaisha Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors
KR20030009376A (ko) 2000-03-03 2003-01-29 오르토-맥네일 파마슈티칼, 인코퍼레이티드 3-(디아릴메틸렌)-8-아자비사이클로[3.2.1]옥탄 유도체
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AU2001216218A1 (en) 2000-05-25 2001-12-11 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
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US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
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Also Published As

Publication number Publication date
ATE296288T1 (de) 2005-06-15
BR9714055B1 (pt) 2010-02-23
CN100519528C (zh) 2009-07-29
US20040171612A1 (en) 2004-09-02
BR9714055A (pt) 2000-05-09
CN1146540C (zh) 2004-04-21
DE69733362T2 (de) 2006-02-02
WO1998028275A1 (en) 1998-07-02
IL130535A (en) 2006-04-10
HUP0000610A2 (hu) 2000-09-28
AU737999B2 (en) 2001-09-06
SK283211B6 (sk) 2003-03-04
NZ336029A (en) 2001-03-30
NO993022D0 (no) 1999-06-18
US20080176903A1 (en) 2008-07-24
KR20000069599A (ko) 2000-11-25
SK76299A3 (en) 1999-11-08
PL189196B1 (pl) 2005-07-29
JP4324652B2 (ja) 2009-09-02
ID22074A (id) 1999-09-02
NO313670B1 (no) 2002-11-11
PL334374A1 (en) 2000-02-28
US20010021715A1 (en) 2001-09-13
CN1246111A (zh) 2000-03-01
RU2193029C2 (ru) 2002-11-20
US6187792B1 (en) 2001-02-13
EE9900256A (et) 1999-12-15
HUP0000610A3 (en) 2000-10-30
TR199901417T2 (xx) 1999-10-21
US7312336B2 (en) 2007-12-25
HK1022689A1 (en) 2000-08-18
US6693117B2 (en) 2004-02-17
EP0946511A1 (en) 1999-10-06
KR100549144B1 (ko) 2006-02-03
JP2001507350A (ja) 2001-06-05
TW548271B (en) 2003-08-21
IS5071A (is) 1999-06-07
US20030149023A1 (en) 2003-08-07
MY119403A (en) 2005-05-31
CN1524852A (zh) 2004-09-01
PT946511E (pt) 2005-09-30
ES2241060T3 (es) 2005-10-16
IL130535A0 (en) 2000-06-01
AU5351298A (en) 1998-07-17
AR010376A1 (es) 2000-06-07
DE69733362D1 (de) 2005-06-30
IS2210B (is) 2007-02-15
NO993022L (no) 1999-08-20
US6455545B2 (en) 2002-09-24
CA2274074C (en) 2006-07-11
EP0946511B1 (en) 2005-05-25
CA2274074A1 (en) 1998-07-02
HU226724B1 (en) 2009-08-28
CZ295557B6 (cs) 2005-08-17
EE03824B1 (et) 2002-08-15

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