HUP0000610A2 - Fájdalomcsillapító hatású piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Fájdalomcsillapító hatású piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0000610A2 HUP0000610A2 HU0000610A HUP0000610A HUP0000610A2 HU P0000610 A2 HUP0000610 A2 HU P0000610A2 HU 0000610 A HU0000610 A HU 0000610A HU P0000610 A HUP0000610 A HU P0000610A HU P0000610 A2 HUP0000610 A2 HU P0000610A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- producing
- pharmaceutical compositions
- compositions containing
- analgesic effect
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- -1 isomers Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az (I) általánős képletű, új vegyületek -, ahőlelőnyösen A jelentése általánős képletű csőpőrt, amelyben R4 és R9egyaránt etilcsőpőrt, Z1 és Z2 pedig az arőmás gyűrűk szőkásősszűbsztitűensei: R1 hidrőgénatőm, alkil-, alkenil-, ciklőalkil-metil,aril-metil, vagy heterőaril-metil-csőpőrt; B adőtt esetbenszűbsztitűált aril- vagy heterőarilcsőpőrt; és R2 és R3 hidrőgénatőmvagy metilcsőpőrt - és ezeket tartalmazó gyógyszerkészítmények, azelőállításűkra szőlgáló eljárás és alkalmazásűk - elsősőrban fájdalőmenyhítésére - képezik. ŕ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9604785A SE9604785D0 (sv) | 1996-12-20 | 1996-12-20 | New compounds |
SE9702535A SE9702535D0 (sv) | 1997-07-01 | 1997-07-01 | New compounds |
PCT/SE1997/002050 WO1998028275A1 (en) | 1996-12-20 | 1997-12-09 | Novel compounds with analgesic effect |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0000610A2 true HUP0000610A2 (hu) | 2000-09-28 |
HUP0000610A3 HUP0000610A3 (en) | 2000-10-30 |
HU226724B1 HU226724B1 (en) | 2009-08-28 |
Family
ID=26662830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0000610A HU226724B1 (en) | 1996-12-20 | 1997-12-09 | Piperidine derivatives, with analgesic effect, process for producing them and pharmaceutical compositions containing them |
Country Status (29)
Country | Link |
---|---|
US (5) | US6187792B1 (hu) |
EP (1) | EP0946511B1 (hu) |
JP (1) | JP4324652B2 (hu) |
KR (1) | KR100549144B1 (hu) |
CN (2) | CN100519528C (hu) |
AR (1) | AR010376A1 (hu) |
AT (1) | ATE296288T1 (hu) |
AU (1) | AU737999B2 (hu) |
BR (1) | BR9714055B1 (hu) |
CA (1) | CA2274074C (hu) |
CZ (1) | CZ295557B6 (hu) |
DE (1) | DE69733362T2 (hu) |
EE (1) | EE03824B1 (hu) |
ES (1) | ES2241060T3 (hu) |
HK (1) | HK1022689A1 (hu) |
HU (1) | HU226724B1 (hu) |
ID (1) | ID22074A (hu) |
IL (2) | IL130535A0 (hu) |
IS (1) | IS2210B (hu) |
MY (1) | MY119403A (hu) |
NO (1) | NO313670B1 (hu) |
NZ (1) | NZ336029A (hu) |
PL (1) | PL189196B1 (hu) |
PT (1) | PT946511E (hu) |
RU (1) | RU2193029C2 (hu) |
SK (1) | SK283211B6 (hu) |
TR (1) | TR199901417T2 (hu) |
TW (1) | TW548271B (hu) |
WO (1) | WO1998028275A1 (hu) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
WO2000071518A2 (en) * | 1999-05-25 | 2000-11-30 | Sepracor, Inc. | Heterocyclic analgesic compounds and their use |
US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
WO2001046191A1 (en) | 1999-12-22 | 2001-06-28 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives |
ES2248281T3 (es) * | 2000-02-18 | 2006-03-16 | Meiji Seika Kaisha, Ltd. | Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta. |
JP2003525938A (ja) * | 2000-03-03 | 2003-09-02 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 3−(ジアリールメチレン)−8−アザビシクロ[3.2.1]オクタン誘導体 |
EP1277737A4 (en) | 2000-03-24 | 2003-05-07 | Meiji Seika Kaisha | DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR |
SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
AU2001216218A1 (en) | 2000-05-25 | 2001-12-11 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
WO2002048122A2 (en) * | 2000-12-14 | 2002-06-20 | Ortho-Mcneil Pharmaceutical, Inc. | Benzamidine derivatives |
SE0101765D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101769D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
WO2002094794A1 (en) | 2001-05-18 | 2002-11-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
SE0103313D0 (sv) * | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
PL367967A1 (en) | 2001-10-15 | 2005-03-07 | Janssen Pharmaceutica N.V. | Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
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US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
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SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203301D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
EP1615920A1 (en) * | 2003-04-15 | 2006-01-18 | Pfizer Products Inc. | 3-benzhydrylidene-8-aza-bicyclo [3.2.1] octane derivatives with opioid receptor activity |
SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0301443D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
MXPA05012117A (es) * | 2003-05-16 | 2006-02-08 | Astrazeneca Ab | Derivados de diarilmetiliden piperidina, preparaciones de los mismos y usos de los mismos. |
SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
WO2004103972A1 (ja) * | 2003-05-20 | 2004-12-02 | Ajinomoto Co.,Inc. | 新規ピペリジン誘導体 |
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SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0400025D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
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SE0402485D0 (sv) | 2004-10-13 | 2004-10-13 | Astrazeneca Ab | Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt |
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WO2006069277A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC δ-OPIOID MODULATORS |
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SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類 |
SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
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1997
- 1997-12-08 TW TW086118465A patent/TW548271B/zh not_active IP Right Cessation
- 1997-12-09 ES ES97950538T patent/ES2241060T3/es not_active Expired - Lifetime
- 1997-12-09 AT AT97950538T patent/ATE296288T1/de not_active IP Right Cessation
- 1997-12-09 KR KR1019997005585A patent/KR100549144B1/ko not_active IP Right Cessation
- 1997-12-09 PL PL97334374A patent/PL189196B1/pl not_active IP Right Cessation
- 1997-12-09 CZ CZ19992199A patent/CZ295557B6/cs not_active IP Right Cessation
- 1997-12-09 CN CNB2004100082366A patent/CN100519528C/zh not_active Expired - Fee Related
- 1997-12-09 CA CA002274074A patent/CA2274074C/en not_active Expired - Fee Related
- 1997-12-09 RU RU99115750/04A patent/RU2193029C2/ru not_active IP Right Cessation
- 1997-12-09 IL IL13053597A patent/IL130535A0/xx active IP Right Grant
- 1997-12-09 WO PCT/SE1997/002050 patent/WO1998028275A1/en active IP Right Grant
- 1997-12-09 EE EEP199900256A patent/EE03824B1/xx not_active IP Right Cessation
- 1997-12-09 TR TR1999/01417T patent/TR199901417T2/xx unknown
- 1997-12-09 EP EP97950538A patent/EP0946511B1/en not_active Expired - Lifetime
- 1997-12-09 ID IDW990508A patent/ID22074A/id unknown
- 1997-12-09 AU AU53512/98A patent/AU737999B2/en not_active Ceased
- 1997-12-09 SK SK762-99A patent/SK283211B6/sk not_active IP Right Cessation
- 1997-12-09 US US09/029,633 patent/US6187792B1/en not_active Expired - Lifetime
- 1997-12-09 HU HU0000610A patent/HU226724B1/hu not_active IP Right Cessation
- 1997-12-09 JP JP52866998A patent/JP4324652B2/ja not_active Expired - Fee Related
- 1997-12-09 PT PT97950538T patent/PT946511E/pt unknown
- 1997-12-09 BR BRPI9714055-4A patent/BR9714055B1/pt not_active IP Right Cessation
- 1997-12-09 NZ NZ336029A patent/NZ336029A/en unknown
- 1997-12-09 CN CNB971818142A patent/CN1146540C/zh not_active Expired - Fee Related
- 1997-12-09 DE DE69733362T patent/DE69733362T2/de not_active Expired - Lifetime
- 1997-12-19 AR ARP970106074A patent/AR010376A1/es active IP Right Grant
- 1997-12-19 MY MYPI97006173A patent/MY119403A/en unknown
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1999
- 1999-06-07 IS IS5071A patent/IS2210B/is unknown
- 1999-06-17 IL IL130535A patent/IL130535A/en not_active IP Right Cessation
- 1999-06-18 NO NO19993022A patent/NO313670B1/no not_active IP Right Cessation
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2000
- 2000-03-11 HK HK00101528A patent/HK1022689A1/xx not_active IP Right Cessation
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2001
- 2001-01-18 US US09/761,833 patent/US6455545B2/en not_active Expired - Fee Related
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2002
- 2002-08-19 US US10/222,990 patent/US6693117B2/en not_active Expired - Fee Related
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2003
- 2003-12-09 US US10/730,265 patent/US7312336B2/en not_active Expired - Fee Related
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2007
- 2007-12-05 US US11/951,014 patent/US20080176903A1/en not_active Abandoned
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