YU46767B - POSTUPAK ZA DOBIJANJE 3,4-DIHIDRO-2-ALKIL-3-OKSO-N-ARIL-2H-/1/ BENZOTIENO/3,2-e/-1,2-TIAZIN4-KARBOKSAMID-1,1-DIOKSIDA - Google Patents
POSTUPAK ZA DOBIJANJE 3,4-DIHIDRO-2-ALKIL-3-OKSO-N-ARIL-2H-/1/ BENZOTIENO/3,2-e/-1,2-TIAZIN4-KARBOKSAMID-1,1-DIOKSIDAInfo
- Publication number
- YU46767B YU46767B YU111988A YU111988A YU46767B YU 46767 B YU46767 B YU 46767B YU 111988 A YU111988 A YU 111988A YU 111988 A YU111988 A YU 111988A YU 46767 B YU46767 B YU 46767B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- benzothieno
- thiazine
- carboxamide
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
POSTUPAK ZA DOBIJANJE 3,4-DIHIDRO-2-ALKIL-3-OKSO-N-ARIL-2H-/1/ BENZOTIENO/3,2-e/-1,2-TIAZIN4-KARBOKSAMID-1,1-DIOKSIDA, formule: ili njihovih farmaceutski prihvatljivih soli, u kojoj R1 predstavlja vodonik, halogen ili C1-C4alkil, R2 je vodonik ili C1-C4 alkil, a Ar je fenil ili fenil supstituisan sa jednim ili vise supstituenata odabranih izmedju C1-C4alkil, halogen, treifluorometil, nitro, hidroksil, halofenil ili C1-C4alkoksi, naznacen time, sto obuhvata reaguvanje jedinjenja formule R2NH2 u kojem je R2 kao sto je definisano sa prethodno hlorsulfonovanim jedinjenjem formule u kojem je R1 kao sto je prethodno odredjeno, kada nastaje jedinjenje formule III, ili sa jedinjenjem formule III; u kojem je R1 kao sto je prethodno odredjeno gradeci jedinjenje formule IV u kojem su R1 i R2 kao sto je odredjeno, pri cemu se gornje reakcije izvode u hlorovanom rastvaracu, pogodno u metilenhloridu ili dih-loretanu, na temperaturi od -20° do 50°C, pogodno na 0°C i pritisku od 0,1 do 10 bara, pogodno atmosferskom, koje se litiira, a dobijeni dianjon razlaze sa gasovitim ugljen dioksidom i reakciona smesa zakiseli dajuci jedinjenje formule V: u kojoj se R1 i R2 kao sto je prethodno odredjeno, pri cemu je rastvarac za reakciju litacije aprotican, pogodno etiletar, temperatura izmedju -50° i 50°C, pogodno -20° do 0°C, a pritisak izmedju 0,1 i 10 bara, pogodno atmosferski, sto se na jedinjenju formule V vrsi ciklodehidratacija uz nagradjivanje jedinjenja formule VI: u kojoj su R1 i R2 kao sto je prethodno odredjeno, u prisustvu kiseline, pogodno p-toluensulfonske kiseline, u rastvaracu kao sto je benzen, toluen ili ksilen, na temperaturi od oko -25° do oko 250°C, pogodno na temperaturi refluksa rastvaraca, i na pritisku od 0,1 do 10 bara, pogodno atmosferskom, i sto jedinjenje formule VI reaguje jedinjenjem formule ArNCO, u kojem je Ar kao sto je prethodno odredjeno u polarnom rastvaracu kao sto je dimetilsulfoksid ili dimetilfor-mamid, pri temperaturi od -20° do 100°C, pogodno na sobnoj temperaturi, i pritisku od 0,1 do 10 bara, pogodno atmosferskom, i sto se, po potrebi, dobijeno jedinjenje formule I konvertuje u far-maceutski prihvatljivu so. Prijava sadrzi jos 2 zavisna zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/001357 WO1988009793A1 (en) | 1987-06-10 | 1987-06-10 | 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES |
| EP88304975A EP0294994B1 (en) | 1987-06-10 | 1988-06-01 | 3-4-Dihydro-2-alkyl-3-oxo-N-aryl-2H-[1]benzothieno[3,2-el]-1,2-thiazine-4-carboxamide-1,1-dioxides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU111988A YU111988A (en) | 1989-12-31 |
| YU46767B true YU46767B (sh) | 1994-05-10 |
Family
ID=55448100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU111988A YU46767B (sh) | 1987-06-10 | 1988-06-09 | POSTUPAK ZA DOBIJANJE 3,4-DIHIDRO-2-ALKIL-3-OKSO-N-ARIL-2H-/1/ BENZOTIENO/3,2-e/-1,2-TIAZIN4-KARBOKSAMID-1,1-DIOKSIDA |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4914101A (sh) |
| EP (1) | EP0294994B1 (sh) |
| JP (1) | JPH078874B2 (sh) |
| KR (1) | KR900006758B1 (sh) |
| CN (1) | CN1019576B (sh) |
| AT (1) | ATE105561T1 (sh) |
| AU (1) | AU593743B2 (sh) |
| CA (1) | CA1300625C (sh) |
| CZ (1) | CZ281857B6 (sh) |
| DD (1) | DD281602A5 (sh) |
| DE (1) | DE3889497T2 (sh) |
| DK (1) | DK313388A (sh) |
| EG (1) | EG18525A (sh) |
| ES (1) | ES2051846T3 (sh) |
| FI (1) | FI89802C (sh) |
| HU (1) | HU203762B (sh) |
| IE (1) | IE63214B1 (sh) |
| IL (1) | IL86602A (sh) |
| MX (1) | MX174093B (sh) |
| MY (1) | MY103572A (sh) |
| NO (2) | NO176277C (sh) |
| NZ (1) | NZ224956A (sh) |
| PH (1) | PH25187A (sh) |
| PL (1) | PL158994B1 (sh) |
| PT (1) | PT87678B (sh) |
| WO (1) | WO1988009793A1 (sh) |
| YU (1) | YU46767B (sh) |
| ZA (1) | ZA884115B (sh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007970A1 (en) * | 1989-11-30 | 1991-06-13 | Nippon Hypox Laboratories Incorporated | Medicine containing thiazine dioxide derivative |
| US6340659B1 (en) | 1995-12-13 | 2002-01-22 | The Lubrizol Corporation | Metal salts of lactones as lubricant additives |
| JP4250344B2 (ja) | 2001-01-29 | 2009-04-08 | インターナショナル・ビジネス・マシーンズ・コーポレーション | ワークフローシステム、ワークフローサーバ、および記憶媒体 |
| US8741299B2 (en) | 2011-06-20 | 2014-06-03 | The Feinstein Institute For Medical Research | Method for treating pathologies associated with hypoxia using MIF inhibitors |
| US9666805B2 (en) * | 2014-11-25 | 2017-05-30 | Northwestern University | Bithiophene sulfonamide-based molecular and polymeric semiconductors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| CA1066711A (en) * | 1974-08-26 | 1979-11-20 | Hoffmann-La Roche Limited | Thiophene derivatives |
| LU78009A1 (de) * | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
| AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| DE2838377A1 (de) * | 1978-09-02 | 1980-03-20 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung |
| AU5811280A (en) * | 1979-06-13 | 1980-12-18 | F. Hoffmann-La Roche Ag | Thiazine derivatives |
| ZA803401B (en) * | 1979-06-13 | 1981-05-27 | Hoffmann La Roche | Thiazine derivatives |
-
1987
- 1987-06-10 WO PCT/US1987/001357 patent/WO1988009793A1/en active IP Right Grant
- 1987-06-10 HU HU873899A patent/HU203762B/hu not_active IP Right Cessation
- 1987-06-10 US US07/382,161 patent/US4914101A/en not_active Expired - Lifetime
- 1987-06-10 MX MX011827A patent/MX174093B/es unknown
-
1988
- 1988-06-01 ES ES88304975T patent/ES2051846T3/es not_active Expired - Lifetime
- 1988-06-01 DE DE3889497T patent/DE3889497T2/de not_active Expired - Fee Related
- 1988-06-01 EP EP88304975A patent/EP0294994B1/en not_active Expired - Lifetime
- 1988-06-01 AT AT8888304975T patent/ATE105561T1/de not_active IP Right Cessation
- 1988-06-02 IL IL86602A patent/IL86602A/xx not_active IP Right Cessation
- 1988-06-06 MY MYPI88000605A patent/MY103572A/en unknown
- 1988-06-06 JP JP13920488A patent/JPH078874B2/ja not_active Expired - Lifetime
- 1988-06-07 CZ CS883925A patent/CZ281857B6/cs not_active IP Right Cessation
- 1988-06-08 PH PH37029A patent/PH25187A/en unknown
- 1988-06-08 PT PT87678A patent/PT87678B/pt not_active IP Right Cessation
- 1988-06-08 CA CA000568893A patent/CA1300625C/en not_active Expired - Fee Related
- 1988-06-08 DD DD88316546A patent/DD281602A5/de not_active IP Right Cessation
- 1988-06-08 PL PL1988272928A patent/PL158994B1/pl unknown
- 1988-06-09 AU AU17535/88A patent/AU593743B2/en not_active Ceased
- 1988-06-09 IE IE173388A patent/IE63214B1/en not_active IP Right Cessation
- 1988-06-09 NZ NZ224956A patent/NZ224956A/xx unknown
- 1988-06-09 YU YU111988A patent/YU46767B/sh unknown
- 1988-06-09 EG EG32188A patent/EG18525A/xx active
- 1988-06-09 ZA ZA884115A patent/ZA884115B/xx unknown
- 1988-06-09 DK DK313388A patent/DK313388A/da not_active Application Discontinuation
- 1988-06-09 CN CN88103539A patent/CN1019576B/zh not_active Expired
- 1988-06-09 KR KR1019880006909A patent/KR900006758B1/ko not_active IP Right Cessation
-
1989
- 1989-02-08 NO NO890531A patent/NO176277C/no unknown
- 1989-02-09 FI FI890620A patent/FI89802C/fi not_active IP Right Cessation
-
1992
- 1992-07-03 NO NO922636A patent/NO922636D0/no unknown
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