KR890000500A - 3,4-디하이드로-2-알킬-3-옥소-N-아릴-2H-[1]벤조티에노-[3,2-e]-1,2- 티아진-4-카복스 아미드-1, 1-디옥사이드 - Google Patents
3,4-디하이드로-2-알킬-3-옥소-N-아릴-2H-[1]벤조티에노-[3,2-e]-1,2- 티아진-4-카복스 아미드-1, 1-디옥사이드 Download PDFInfo
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- KR890000500A KR890000500A KR1019880006909A KR880006909A KR890000500A KR 890000500 A KR890000500 A KR 890000500A KR 1019880006909 A KR1019880006909 A KR 1019880006909A KR 880006909 A KR880006909 A KR 880006909A KR 890000500 A KR890000500 A KR 890000500A
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- alkyl
- hydrogen
- thiazine
- dihydro
- oxo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 다음 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염.상기식에서, R1은 수소, 할로겐 또는 C1내지 C4알킬이고 ; R2는 수소 또는 C1내지 C4알킬이며 ; Ar은 페닐이거나 C1내지 C4알킬, 할로, 트리플루오로메틸, 니트로, 하이드록실, 할로페닐 또는 C1내지 C4알콕시 중에서 선택된 치환체 하나 이상에 의해 치환된 페닐이다.
- 제 1 항에 있어서, R1이 수소인 화합물.
- 제 1 항 또는 2항에 있어서, R2가 메틸인 화합물.
- 제 1 항 내지 3항중 어느 한 항에 있어서, 3,4-디하이드로-2-메틸-1,3-옥소-N-페닐-2H-[1]벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드,N-(4-플루올페닐)-3,4-디하이드로-2-메틸-1,3-옥소-2H-[1]벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드,N-(4-브로모페닐)-3,4-디하이드로-2-메틸-1,3-옥소-2H-[1] 벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드,N-(4-트리플루오로메틸페닐)-3,4-디하이드로-2-메틸-1,3-옥소-2H-[1]벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드,N-(2-메틸-4-니트로페닐)-3,4-디하이드로-2-메틸-1,3-옥소-2H-[1]벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드 및 N-(2,3-디플루오로페닐)-3,4-디하이드로-2-메틸-1,3-옥소-2H-[1]벤조티에노 [3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드 및 이들 화합물의 약제학적으로 허용되는 염으로 이루어진 그룹 중에서 선택된 화합물.
- 염증, 관절염, 알러지증세, 건선, 천식, 기관지염, 폐순환승압, 폐산소저하증, 소화성궤양, 장염 또는 심혈관경축 증상을 치료하는데 효과적인 양의 제 1 항 내지 4항 중의 어느 한 항에 따른 화합물과 약제학적으로 허용되는 담체를 함유하는, 언급한 질환중 어느 하나를치료하기 위한 약학 조성물.
- 염증, 관절염, 알러지증세, 기관지염, 폐순환승압, 폐산소저하증, 소화성궤양, 장염, 심혈관경축, 건선 또는 천식의 치료를 필요로 하는 환자에게 언급한 질환중의 어느 하나를 치료하는데 효과적인 양의 제 1 항 내지 4항 중의 어느 한 항에 따른 화합물을 투여하여, 언급한 질환중의 어느 하나를 치료하는 방법.
- 다음 일반식(Ⅵ)의 화합물.상기식에서, R1은 수소, 할로겐 또는 C1내지 C4알킬이고, R2는 수소 또는 C1내지 C4알킬이다.
- 다음 일반식(Ⅴ)의 화합물.상기식에서, R1은 수소, 할로겐 또는 C1내지 C4알킬이고, R2는 수소 또는 C1내지 C4알킬이다.
- 다음 일반식(Ⅳ)의 화합물.상기식에서, R1은 수소, 할로겐 또는 C1내지 C4알킬이고, R2는 수소 또는 C1내지 C4알킬이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US87/01357 | 1987-06-10 | ||
PCT/US1987/001357 WO1988009793A1 (en) | 1987-06-10 | 1987-06-10 | 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES |
EP88304975A EP0294994B1 (en) | 1987-06-10 | 1988-06-01 | 3-4-Dihydro-2-alkyl-3-oxo-N-aryl-2H-[1]benzothieno[3,2-el]-1,2-thiazine-4-carboxamide-1,1-dioxides |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890000500A true KR890000500A (ko) | 1989-03-15 |
KR900006758B1 KR900006758B1 (ko) | 1990-09-20 |
Family
ID=55448100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880006909A KR900006758B1 (ko) | 1987-06-10 | 1988-06-09 | 3,4-디하이드로-2-알킬-3-옥소-N-아릴-2H-[1]벤조 티에노-[3,2-e]-1,2-티아진-4-카복스아미드-1,1-디옥사이드 |
Country Status (28)
Country | Link |
---|---|
US (1) | US4914101A (ko) |
EP (1) | EP0294994B1 (ko) |
JP (1) | JPH078874B2 (ko) |
KR (1) | KR900006758B1 (ko) |
CN (1) | CN1019576B (ko) |
AT (1) | ATE105561T1 (ko) |
AU (1) | AU593743B2 (ko) |
CA (1) | CA1300625C (ko) |
CZ (1) | CZ281857B6 (ko) |
DD (1) | DD281602A5 (ko) |
DE (1) | DE3889497T2 (ko) |
DK (1) | DK313388A (ko) |
EG (1) | EG18525A (ko) |
ES (1) | ES2051846T3 (ko) |
FI (1) | FI89802C (ko) |
HU (1) | HU203762B (ko) |
IE (1) | IE63214B1 (ko) |
IL (1) | IL86602A (ko) |
MX (1) | MX174093B (ko) |
MY (1) | MY103572A (ko) |
NO (2) | NO176277C (ko) |
NZ (1) | NZ224956A (ko) |
PH (1) | PH25187A (ko) |
PL (1) | PL158994B1 (ko) |
PT (1) | PT87678B (ko) |
WO (1) | WO1988009793A1 (ko) |
YU (1) | YU46767B (ko) |
ZA (1) | ZA884115B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69027594T2 (de) * | 1989-11-30 | 1996-10-31 | Nippon Hypox Lab Inc | Ein thiazindioxidderivat enthaltendes medikament |
US6340659B1 (en) | 1995-12-13 | 2002-01-22 | The Lubrizol Corporation | Metal salts of lactones as lubricant additives |
JP4250344B2 (ja) | 2001-01-29 | 2009-04-08 | インターナショナル・ビジネス・マシーンズ・コーポレーション | ワークフローシステム、ワークフローサーバ、および記憶媒体 |
US8741299B2 (en) | 2011-06-20 | 2014-06-03 | The Feinstein Institute For Medical Research | Method for treating pathologies associated with hypoxia using MIF inhibitors |
US9666805B2 (en) * | 2014-11-25 | 2017-05-30 | Northwestern University | Bithiophene sulfonamide-based molecular and polymeric semiconductors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
CA1066711A (en) * | 1974-08-26 | 1979-11-20 | Hoffmann-La Roche Limited | Thiophene derivatives |
LU78009A1 (de) * | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
DE2838377A1 (de) * | 1978-09-02 | 1980-03-20 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung |
AU5811280A (en) * | 1979-06-13 | 1980-12-18 | F. Hoffmann-La Roche Ag | Thiazine derivatives |
ZA803401B (en) * | 1979-06-13 | 1981-05-27 | Hoffmann La Roche | Thiazine derivatives |
-
1987
- 1987-06-10 US US07/382,161 patent/US4914101A/en not_active Expired - Lifetime
- 1987-06-10 MX MX011827A patent/MX174093B/es unknown
- 1987-06-10 WO PCT/US1987/001357 patent/WO1988009793A1/en active IP Right Grant
- 1987-06-10 HU HU873899A patent/HU203762B/hu not_active IP Right Cessation
-
1988
- 1988-06-01 AT AT8888304975T patent/ATE105561T1/de not_active IP Right Cessation
- 1988-06-01 EP EP88304975A patent/EP0294994B1/en not_active Expired - Lifetime
- 1988-06-01 ES ES88304975T patent/ES2051846T3/es not_active Expired - Lifetime
- 1988-06-01 DE DE3889497T patent/DE3889497T2/de not_active Expired - Fee Related
- 1988-06-02 IL IL86602A patent/IL86602A/xx not_active IP Right Cessation
- 1988-06-06 MY MYPI88000605A patent/MY103572A/en unknown
- 1988-06-06 JP JP13920488A patent/JPH078874B2/ja not_active Expired - Lifetime
- 1988-06-07 CZ CS883925A patent/CZ281857B6/cs not_active IP Right Cessation
- 1988-06-08 DD DD88316546A patent/DD281602A5/de not_active IP Right Cessation
- 1988-06-08 PT PT87678A patent/PT87678B/pt not_active IP Right Cessation
- 1988-06-08 PH PH37029A patent/PH25187A/en unknown
- 1988-06-08 PL PL1988272928A patent/PL158994B1/pl unknown
- 1988-06-08 CA CA000568893A patent/CA1300625C/en not_active Expired - Fee Related
- 1988-06-09 AU AU17535/88A patent/AU593743B2/en not_active Ceased
- 1988-06-09 KR KR1019880006909A patent/KR900006758B1/ko not_active IP Right Cessation
- 1988-06-09 DK DK313388A patent/DK313388A/da not_active Application Discontinuation
- 1988-06-09 IE IE173388A patent/IE63214B1/en not_active IP Right Cessation
- 1988-06-09 NZ NZ224956A patent/NZ224956A/xx unknown
- 1988-06-09 CN CN88103539A patent/CN1019576B/zh not_active Expired
- 1988-06-09 YU YU111988A patent/YU46767B/sh unknown
- 1988-06-09 EG EG32188A patent/EG18525A/xx active
- 1988-06-09 ZA ZA884115A patent/ZA884115B/xx unknown
-
1989
- 1989-02-08 NO NO890531A patent/NO176277C/no unknown
- 1989-02-09 FI FI890620A patent/FI89802C/fi not_active IP Right Cessation
-
1992
- 1992-07-03 NO NO922636A patent/NO922636D0/no unknown
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