NO922636L - Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder - Google Patents

Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder

Info

Publication number
NO922636L
NO922636L NO92922636A NO922636A NO922636L NO 922636 L NO922636 L NO 922636L NO 92922636 A NO92922636 A NO 92922636A NO 922636 A NO922636 A NO 922636A NO 922636 L NO922636 L NO 922636L
Authority
NO
Norway
Prior art keywords
alkyl
thiazine
dihydro
oxo
benzotieno
Prior art date
Application number
NO92922636A
Other languages
English (en)
Other versions
NO922636D0 (no
Inventor
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO922636L publication Critical patent/NO922636L/no
Application filed by Pfizer filed Critical Pfizer
Priority to NO922636A priority Critical patent/NO922636D0/no
Publication of NO922636D0 publication Critical patent/NO922636D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Fremgangsmåte for fremstilling av en forbindelse med formelen O VI hvor R1 er hydrogen, halogen eller GI til C4 alkyl, og R2 er hydrogen eller C til C. alkyl, ved cyklodehydratisering av en forbindelse med formelen ¿>" SO,NKR' hvor R1 og R2 er som angitt ovenfor. De fremstilte forbindelser er egnet som mellomprodukter ved fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H- [l]benzotieno[3,2-e]-l,2-tiazin-4-karboksamid-l,1-dioksyder.
NO922636A 1987-06-10 1992-07-03 Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder NO922636D0 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO922636A NO922636D0 (no) 1987-06-10 1992-07-03 Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1987/001357 WO1988009793A1 (en) 1987-06-10 1987-06-10 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES
NO890531A NO176277C (no) 1987-06-10 1989-02-08 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder
NO922636A NO922636D0 (no) 1987-06-10 1992-07-03 Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder

Publications (2)

Publication Number Publication Date
NO922636L true NO922636L (no) 1989-02-08
NO922636D0 NO922636D0 (no) 1992-07-03

Family

ID=55448100

Family Applications (2)

Application Number Title Priority Date Filing Date
NO890531A NO176277C (no) 1987-06-10 1989-02-08 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder
NO922636A NO922636D0 (no) 1987-06-10 1992-07-03 Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO890531A NO176277C (no) 1987-06-10 1989-02-08 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder

Country Status (28)

Country Link
US (1) US4914101A (no)
EP (1) EP0294994B1 (no)
JP (1) JPH078874B2 (no)
KR (1) KR900006758B1 (no)
CN (1) CN1019576B (no)
AT (1) ATE105561T1 (no)
AU (1) AU593743B2 (no)
CA (1) CA1300625C (no)
CZ (1) CZ281857B6 (no)
DD (1) DD281602A5 (no)
DE (1) DE3889497T2 (no)
DK (1) DK313388A (no)
EG (1) EG18525A (no)
ES (1) ES2051846T3 (no)
FI (1) FI89802C (no)
HU (1) HU203762B (no)
IE (1) IE63214B1 (no)
IL (1) IL86602A (no)
MX (1) MX174093B (no)
MY (1) MY103572A (no)
NO (2) NO176277C (no)
NZ (1) NZ224956A (no)
PH (1) PH25187A (no)
PL (1) PL158994B1 (no)
PT (1) PT87678B (no)
WO (1) WO1988009793A1 (no)
YU (1) YU46767B (no)
ZA (1) ZA884115B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69027594T2 (de) * 1989-11-30 1996-10-31 Nippon Hypox Lab Inc Ein thiazindioxidderivat enthaltendes medikament
US6340659B1 (en) 1995-12-13 2002-01-22 The Lubrizol Corporation Metal salts of lactones as lubricant additives
JP4250344B2 (ja) 2001-01-29 2009-04-08 インターナショナル・ビジネス・マシーンズ・コーポレーション ワークフローシステム、ワークフローサーバ、および記憶媒体
US8741299B2 (en) 2011-06-20 2014-06-03 The Feinstein Institute For Medical Research Method for treating pathologies associated with hypoxia using MIF inhibitors
US9666805B2 (en) * 2014-11-25 2017-05-30 Northwestern University Bithiophene sulfonamide-based molecular and polymeric semiconductors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
LU78009A1 (de) * 1977-08-22 1979-05-23 Hoffmann La Roche Verfahren zur herstellung von thiazinderivaten
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
DE2838377A1 (de) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
ZA803401B (en) * 1979-06-13 1981-05-27 Hoffmann La Roche Thiazine derivatives

Also Published As

Publication number Publication date
MY103572A (en) 1993-08-28
ZA884115B (en) 1990-02-28
US4914101A (en) 1990-04-03
EP0294994A1 (en) 1988-12-14
KR890000500A (ko) 1989-03-15
NO176277C (no) 1995-03-08
PT87678B (pt) 1992-10-30
DK313388A (da) 1988-12-11
NZ224956A (en) 1990-07-26
EG18525A (en) 1994-04-30
IL86602A0 (en) 1988-11-30
CA1300625C (en) 1992-05-12
NO890531L (no) 1989-02-08
NO922636D0 (no) 1992-07-03
DD281602A5 (de) 1990-08-15
CZ281857B6 (cs) 1997-03-12
MX11827A (es) 1993-04-01
MX174093B (es) 1994-04-21
PH25187A (en) 1991-03-27
PT87678A (pt) 1988-07-01
FI890620A0 (fi) 1989-02-09
FI89802C (fi) 1993-11-25
ES2051846T3 (es) 1994-07-01
WO1988009793A1 (en) 1988-12-15
KR900006758B1 (ko) 1990-09-20
CN1019576B (zh) 1992-12-23
DE3889497D1 (de) 1994-06-16
CZ392588A3 (en) 1996-11-13
JPH078874B2 (ja) 1995-02-01
PL272928A1 (en) 1989-07-10
FI890620A (fi) 1989-02-09
AU593743B2 (en) 1990-02-15
HUT54376A (en) 1991-02-28
FI89802B (fi) 1993-08-13
CN88103539A (zh) 1988-12-28
IE63214B1 (en) 1995-04-05
AU1753588A (en) 1988-12-15
ATE105561T1 (de) 1994-05-15
JPS6413093A (en) 1989-01-17
NO890531D0 (no) 1989-02-08
IL86602A (en) 1992-06-21
DK313388D0 (da) 1988-06-09
NO176277B (no) 1994-11-28
YU111988A (en) 1989-12-31
HU203762B (en) 1991-09-30
YU46767B (sh) 1994-05-10
EP0294994B1 (en) 1994-05-11
IE881733L (en) 1988-12-10
PL158994B1 (pl) 1992-10-30
DE3889497T2 (de) 1994-08-25

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