MX174093B - 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA - Google Patents

1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA

Info

Publication number
MX174093B
MX174093B MX011827A MX1182788A MX174093B MX 174093 B MX174093 B MX 174093B MX 011827 A MX011827 A MX 011827A MX 1182788 A MX1182788 A MX 1182788A MX 174093 B MX174093 B MX 174093B
Authority
MX
Mexico
Prior art keywords
compounds
thiazino
dihydro
oxo
aryl
Prior art date
Application number
MX011827A
Other languages
English (en)
Other versions
MX11827A (es
Inventor
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX11827A publication Critical patent/MX11827A/es
Publication of MX174093B publication Critical patent/MX174093B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a 1,1-dióxidos de 3,4-dihidro-2-alquil-3-oxo-N-aril-2H-[1]benzotieno[3,2-e] 1,2-tiazino-4-carboxiamida, a metodos de preparación de estos compuestos, a composiciones farmaceuticas que contienen estos compuestos y al uso de dichos compuestos en el tratamiento de la inflamación (v.g., artritis) u otras enfermedades mediadas por prostaglandinas o leucotrienos. Los compuestos de la presente invención son compuestos de fórmula y sus sales farmaceuticamente aceptables.
MX011827A 1987-06-10 1987-06-10 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA MX174093B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1987/001357 WO1988009793A1 (en) 1987-06-10 1987-06-10 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES
EP88304975A EP0294994B1 (en) 1987-06-10 1988-06-01 3-4-Dihydro-2-alkyl-3-oxo-N-aryl-2H-[1]benzothieno[3,2-el]-1,2-thiazine-4-carboxamide-1,1-dioxides

Publications (2)

Publication Number Publication Date
MX11827A MX11827A (es) 1993-04-01
MX174093B true MX174093B (es) 1994-04-21

Family

ID=55448100

Family Applications (1)

Application Number Title Priority Date Filing Date
MX011827A MX174093B (es) 1987-06-10 1987-06-10 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA

Country Status (28)

Country Link
US (1) US4914101A (es)
EP (1) EP0294994B1 (es)
JP (1) JPH078874B2 (es)
KR (1) KR900006758B1 (es)
CN (1) CN1019576B (es)
AT (1) ATE105561T1 (es)
AU (1) AU593743B2 (es)
CA (1) CA1300625C (es)
CZ (1) CZ281857B6 (es)
DD (1) DD281602A5 (es)
DE (1) DE3889497T2 (es)
DK (1) DK313388A (es)
EG (1) EG18525A (es)
ES (1) ES2051846T3 (es)
FI (1) FI89802C (es)
HU (1) HU203762B (es)
IE (1) IE63214B1 (es)
IL (1) IL86602A (es)
MX (1) MX174093B (es)
MY (1) MY103572A (es)
NO (2) NO176277C (es)
NZ (1) NZ224956A (es)
PH (1) PH25187A (es)
PL (1) PL158994B1 (es)
PT (1) PT87678B (es)
WO (1) WO1988009793A1 (es)
YU (1) YU46767B (es)
ZA (1) ZA884115B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69027594T2 (de) * 1989-11-30 1996-10-31 Nippon Hypox Lab Inc Ein thiazindioxidderivat enthaltendes medikament
US6340659B1 (en) 1995-12-13 2002-01-22 The Lubrizol Corporation Metal salts of lactones as lubricant additives
JP4250344B2 (ja) 2001-01-29 2009-04-08 インターナショナル・ビジネス・マシーンズ・コーポレーション ワークフローシステム、ワークフローサーバ、および記憶媒体
US8741299B2 (en) * 2011-06-20 2014-06-03 The Feinstein Institute For Medical Research Method for treating pathologies associated with hypoxia using MIF inhibitors
US9666805B2 (en) * 2014-11-25 2017-05-30 Northwestern University Bithiophene sulfonamide-based molecular and polymeric semiconductors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
LU78009A1 (de) * 1977-08-22 1979-05-23 Hoffmann La Roche Verfahren zur herstellung von thiazinderivaten
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
DE2838377A1 (de) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
ZA803401B (en) * 1979-06-13 1981-05-27 Hoffmann La Roche Thiazine derivatives

Also Published As

Publication number Publication date
CZ281857B6 (cs) 1997-03-12
CN88103539A (zh) 1988-12-28
IE63214B1 (en) 1995-04-05
EP0294994A1 (en) 1988-12-14
IE881733L (en) 1988-12-10
KR890000500A (ko) 1989-03-15
DE3889497T2 (de) 1994-08-25
AU593743B2 (en) 1990-02-15
NO176277B (no) 1994-11-28
PL158994B1 (pl) 1992-10-30
FI89802B (fi) 1993-08-13
DK313388D0 (da) 1988-06-09
MX11827A (es) 1993-04-01
PH25187A (en) 1991-03-27
WO1988009793A1 (en) 1988-12-15
HUT54376A (en) 1991-02-28
CZ392588A3 (en) 1996-11-13
PT87678A (pt) 1988-07-01
JPS6413093A (en) 1989-01-17
HU203762B (en) 1991-09-30
IL86602A0 (en) 1988-11-30
PL272928A1 (en) 1989-07-10
US4914101A (en) 1990-04-03
ATE105561T1 (de) 1994-05-15
ES2051846T3 (es) 1994-07-01
EP0294994B1 (en) 1994-05-11
IL86602A (en) 1992-06-21
DD281602A5 (de) 1990-08-15
NO922636L (no) 1989-02-08
MY103572A (en) 1993-08-28
ZA884115B (en) 1990-02-28
NO922636D0 (no) 1992-07-03
FI890620A0 (fi) 1989-02-09
CA1300625C (en) 1992-05-12
YU46767B (sh) 1994-05-10
NZ224956A (en) 1990-07-26
DE3889497D1 (de) 1994-06-16
PT87678B (pt) 1992-10-30
NO890531D0 (no) 1989-02-08
AU1753588A (en) 1988-12-15
KR900006758B1 (ko) 1990-09-20
YU111988A (en) 1989-12-31
NO890531L (no) 1989-02-08
NO176277C (no) 1995-03-08
JPH078874B2 (ja) 1995-02-01
FI890620A7 (fi) 1989-02-09
EG18525A (en) 1994-04-30
CN1019576B (zh) 1992-12-23
FI89802C (fi) 1993-11-25
DK313388A (da) 1988-12-11

Similar Documents

Publication Publication Date Title
MX9301929A (es) Derivados de pirimidina y procedimientos para su preparacion.
MY103850A (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
ES2071621T3 (es) Enantiomero dextrogiro del alfa-(tetrahidro-4,5,6,7-tieno-(3,2-c)-piridil-5)(cloro-2-fenil) acetato de metilo, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen.
ES2040261T3 (es) Procedimiento para preparar acidos 6-fluor-4-oxo-1,4-dihidroquinolina-3-carboxilicos sustituidos y acidos 9-fluor-3-metil-7-oxo-2,3-dihidro-7h-pirido(1,2,3-de)(1,4)benzoxazina-6-carboxilico sustituidos.
ES2084944T3 (es) Amidas terapeuticas.
LV5503A3 (lv) Panemiens omeprazola salu iegusanai
ATE184598T1 (de) Enniatine und enniatinderivate zur bekämpfung von endoparasiten
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
MX9300407A (es) Derivados azabiciclicos usados en la fabricacion de medicamentos, composiciones que los contienen y procedimiento para su preparacion.
AR004700A1 (es) 1alfa, 26 dihidroxi-d-homo-vitamina d3, una composicion farmaceutica que la comprende, un procedimiento para su preparacion y el uso de los mismos en laelaboracion de un medicamento
LV10954A (lv) Benzimidazola atvasinajumi to iegusanas panemiens un tos saturosa farmaceitiska kompozicija
FR2361901A1 (fr) Derives de substitution de nucleotides et medicament contenant ces substances
ATE45153T1 (de) Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte.
NO178923C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 24-homo-vitamin-D-derivater
ES8404361A1 (es) Un procedimiento para la preparacion de un derivado de cefalosporina.
ES460098A1 (es) Metodo para producir derivados de acido penicilanico.
ES2043863T3 (es) Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina.
ES2073393T3 (es) Derivados de acidos 2,4- y 2,5-dicarboxilicos, procedimiento para su preparacion, utilizacion de los mismos asi como medicamentos a base de estos compuestos.
ES2173195T3 (es) Derivados de antraciclina.
SE8405588D0 (sv) New compounds
MX174093B (es) 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA
MX9306394A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
IT1151953B (it) Composizione farmaceutica per la cura di affezioni della cavita' orale
ES2062997T3 (es) Vinilcefalosporinas sustituidas, procedimiento para su fabricacion y su uso como medicamento.
ES2077473T3 (es) Nuevos compuestos tiocromanicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.