ES2062997T3 - Vinilcefalosporinas sustituidas, procedimiento para su fabricacion y su uso como medicamento. - Google Patents

Vinilcefalosporinas sustituidas, procedimiento para su fabricacion y su uso como medicamento.

Info

Publication number
ES2062997T3
ES2062997T3 ES88107686T ES88107686T ES2062997T3 ES 2062997 T3 ES2062997 T3 ES 2062997T3 ES 88107686 T ES88107686 T ES 88107686T ES 88107686 T ES88107686 T ES 88107686T ES 2062997 T3 ES2062997 T3 ES 2062997T3
Authority
ES
Spain
Prior art keywords
vinylcephalosporins
substituted
procedure
manufacture
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88107686T
Other languages
English (en)
Inventor
Gunter Dr Schmidt
Karl Georg Dr Metzger
Hans-Joachim Dr Zeiler
Rainer Dr Endermann
Ingo Dr Haller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2062997T3 publication Critical patent/ES2062997T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A VINILCEFALOSPORINAS DE FORMULA (I) EN LA QUE R1, R2, R3, R4 Y R5 TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION, SU OBTENCION Y SU EMPLEO COMO MEDICAMENTOS O EN LA OBTENCION DE LOS MISMOS.
ES88107686T 1987-05-26 1988-05-13 Vinilcefalosporinas sustituidas, procedimiento para su fabricacion y su uso como medicamento. Expired - Lifetime ES2062997T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3717664 1987-05-26
DE19873734004 DE3734004A1 (de) 1987-05-26 1987-10-08 Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2062997T3 true ES2062997T3 (es) 1995-01-01

Family

ID=25856024

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88107686T Expired - Lifetime ES2062997T3 (es) 1987-05-26 1988-05-13 Vinilcefalosporinas sustituidas, procedimiento para su fabricacion y su uso como medicamento.

Country Status (14)

Country Link
EP (1) EP0292808B1 (es)
JP (1) JPH0645627B2 (es)
KR (1) KR880013950A (es)
CN (1) CN88103202A (es)
AU (1) AU1630188A (es)
CA (1) CA1340154C (es)
DE (2) DE3734004A1 (es)
DK (1) DK284688A (es)
ES (1) ES2062997T3 (es)
FI (1) FI882443A7 (es)
HU (1) HU205937B (es)
IL (1) IL86478A (es)
NO (1) NO170020C (es)
PT (1) PT87564B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734005A1 (de) * 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3933934A1 (de) * 1989-10-03 1991-04-11 Bayer Ag Verfahren zur herstellung von 7-amino-3-((z)-1-propen-1-yl)-3-cephem-4-carbonsaeure
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
EP0503453B1 (en) 1991-03-08 2001-05-09 Biochemie Gesellschaft M.B.H. New process for the production of cephalosporines and novel intermediates in this process
KR930007261B1 (ko) * 1991-04-19 1993-08-04 한국과학기술연구원 7β-아미노-3-[3-(4-치환된 테트라졸린-5-티온-1-일)프로펜-1-일]-3-세펨-4-카르복실산 유도체 및 그 제조방법
JP3224279B2 (ja) * 1992-07-27 2001-10-29 大塚化学株式会社 セフエム化合物の製造法
KR20000002217A (ko) * 1998-06-18 2000-01-15 김종인 신규 세팔로스포린계 항생제 및 이의 제조 방법
CA2935651A1 (en) * 2007-10-09 2009-04-16 Gladius Pharmaceuticals Corporation Broad spectrum beta-lactamase inhibitors
EP3441071A1 (en) 2013-03-12 2019-02-13 Gladius Pharmaceuticals Corporation Derivatized cephalosporins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
US4390693A (en) * 1977-07-27 1983-06-28 Merck & Co., Inc. Cephalosporin compounds
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
GB8406231D0 (en) * 1984-03-09 1984-04-11 Fujisawa Pharmaceutical Co Cephem compounds
DE3508258A1 (de) * 1985-03-08 1986-09-18 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln
JPS63126023A (ja) * 1986-11-14 1988-05-30 Fujitsu Ltd 表示装置
DE3734005A1 (de) * 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
FI882443A7 (fi) 1988-11-27
HU205937B (en) 1992-07-28
NO170020C (no) 1992-09-02
JPS63307885A (ja) 1988-12-15
CN88103202A (zh) 1988-12-21
AU1630188A (en) 1988-12-01
DK284688D0 (da) 1988-05-25
DE3734004A1 (de) 1988-12-15
PT87564B (pt) 1992-09-30
JPH0645627B2 (ja) 1994-06-15
IL86478A (en) 1993-02-21
KR880013950A (ko) 1988-12-22
FI882443A0 (fi) 1988-05-24
NO882112L (no) 1988-11-28
DK284688A (da) 1988-11-27
PT87564A (pt) 1989-05-31
CA1340154C (en) 1998-12-01
IL86478A0 (en) 1988-11-15
NO882112D0 (no) 1988-05-13
DE3888018D1 (de) 1994-04-07
EP0292808B1 (de) 1994-03-02
NO170020B (no) 1992-05-25
EP0292808A3 (en) 1990-09-19
HUT47940A (en) 1989-04-28
EP0292808A2 (de) 1988-11-30

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