CY2314B1 - Liquid ophthalmic sustained release delivery system. - Google Patents

Liquid ophthalmic sustained release delivery system.

Info

Publication number
CY2314B1
CY2314B1 CY0300008A CY0300008A CY2314B1 CY 2314 B1 CY2314 B1 CY 2314B1 CY 0300008 A CY0300008 A CY 0300008A CY 0300008 A CY0300008 A CY 0300008A CY 2314 B1 CY2314 B1 CY 2314B1
Authority
CY
Cyprus
Prior art keywords
sustained release
ophthalmic
delivery system
polymer
mammal
Prior art date
Application number
CY0300008A
Other languages
English (en)
Inventor
Shau-Fong Yen
Kenneth W Reed
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2314B1 publication Critical patent/CY2314B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CY0300008A 1994-02-18 2003-02-03 Liquid ophthalmic sustained release delivery system. CY2314B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/198,924 US5422116A (en) 1994-02-18 1994-02-18 Liquid ophthalmic sustained release delivery system

Publications (1)

Publication Number Publication Date
CY2314B1 true CY2314B1 (en) 2003-11-14

Family

ID=22735469

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300008A CY2314B1 (en) 1994-02-18 2003-02-03 Liquid ophthalmic sustained release delivery system.

Country Status (21)

Country Link
US (1) US5422116A (pt)
EP (1) EP0744938B1 (pt)
JP (1) JP3720359B2 (pt)
CN (1) CN1138530C (pt)
AT (1) ATE205079T1 (pt)
AU (1) AU704353B2 (pt)
CA (1) CA2181715C (pt)
CY (1) CY2314B1 (pt)
DE (1) DE69522550T2 (pt)
DK (1) DK0744938T3 (pt)
ES (1) ES2163495T3 (pt)
FI (1) FI117851B (pt)
GR (1) GR3036884T3 (pt)
IL (1) IL112674A (pt)
MX (1) MX9603435A (pt)
NO (1) NO313861B1 (pt)
NZ (1) NZ278668A (pt)
PT (1) PT744938E (pt)
TW (1) TW317501B (pt)
WO (1) WO1995022315A1 (pt)
ZA (1) ZA951323B (pt)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762903A (en) * 1995-03-10 1998-06-09 Korea Atomic Energy Research Institute Radioactive chitosan complex for radiation therapy
MX9701731A (es) * 1995-06-06 1997-10-31 Bayer Ag Composiciones anti-bacterianas oticas, no-irritantes, no-sensibles y no-toxicas para el oido.
US5843930A (en) * 1995-06-06 1998-12-01 Bayer Corporation Method of treating otitis with ciprofloxacin-hydrocortisone suspension
TW389694B (en) * 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
WO1997007139A2 (en) * 1995-08-17 1997-02-27 Novartis Ag Stabilized chitin derivative compounds
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US6071904A (en) * 1996-12-11 2000-06-06 Alcon Laboratories, Inc. Process for manufacturing ophthalmic suspensions
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US7288532B1 (en) * 1998-08-21 2007-10-30 The University Of Maryland Biotechnology Institute Modified chitosan polymers and enzymatic methods for the production thereof
US20040152664A1 (en) * 1998-09-02 2004-08-05 Allergan, Inc. Prednisolone compositions
US6214381B1 (en) 1998-09-08 2001-04-10 Effcon, Inc. Methazolamide composition and method of use
WO2000030609A1 (en) * 1998-11-20 2000-06-02 Laboratoire Medidom S.A. Aqueous ophthalmic formulations comprising chitosan
BR0014203A (pt) * 1999-09-24 2002-05-21 Alcon Inc Formulações de suspensão tópicas contendo ciprofloxacina e dexametasona
WO2001032181A2 (en) 1999-11-01 2001-05-10 Alcon Universal Ltd. Pharmaceutical compositions containing a fluoroquinolone antibiotic drug and xanthan gum
DK1229940T3 (da) * 1999-11-15 2014-08-18 Piramal Healthcare Canada Ltd Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning
WO2001041821A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
KR100371092B1 (ko) * 1999-12-09 2003-02-05 주식회사대성미생물연구소 동물용 복합항균제 조성물
US6348508B1 (en) * 2000-04-04 2002-02-19 Bausch & Lomb Incorporated Method for treating dry eye
US6716970B2 (en) * 2000-04-21 2004-04-06 Adjuvant Pharmaceuticals, Llc Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof
DE60002448T2 (de) * 2000-05-26 2004-03-25 Laboratoire Medidom S.A. Antibakterielle wässerige ophtalmische Formulierungen mit Ofloxacin und Chitosan
BR0112109A (pt) * 2000-06-29 2007-05-29 Biosyntech Canada Inc composição e método para a correção e regeneração de cartilagem e outros tecidos
ES2225573T3 (es) 2000-07-28 2005-03-16 Alcon, Inc Composiciones farmaceuticas que contienen tobramicina y goma xantana.
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
AR034372A1 (es) * 2001-06-08 2004-02-18 Novartis Ag Composiciones farmaceuticas
AU2002316467A1 (en) * 2001-06-27 2003-03-03 Diversa Corporation Glycosylated kinamycins and methods of making and using them
ATA13842001A (de) 2001-08-31 2002-10-15 Mucobiomer Biotechnologische F Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung
AU2003249805A1 (en) * 2002-07-16 2004-02-02 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
AU2003262800A1 (en) * 2002-08-23 2004-03-11 University Of Maryland Baltimore County Assembly of chitosan onto an electrode surface
AU2003275289A1 (en) * 2002-09-26 2004-04-19 University Of Maryland Baltimore County Polysaccharide-based polymers and methods of making the same
US7790010B2 (en) * 2002-12-20 2010-09-07 University Of Maryland, College Park Spatially selective deposition of polysaccharide layer onto patterned template
TW200416046A (en) * 2002-12-23 2004-09-01 Alcon Inc Contact lens care compositions containing chitin derivatives
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
ATE451915T1 (de) * 2003-01-24 2010-01-15 Psivida Inc Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren
US7883615B2 (en) * 2003-02-12 2011-02-08 University Of Maryland, College Park Controlled electrochemical deposition of polysaccharide films and hydrogels, and materials formed therefrom
US20070148192A1 (en) * 2003-02-21 2007-06-28 Laddha Ritu N Stable ophthalmic composition
US20040202687A1 (en) * 2003-04-14 2004-10-14 Babu M.K. Manoj Ciprofloxacin formulations and methods of making and using the same
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
US7125967B2 (en) * 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
US20050101582A1 (en) * 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US7375404B2 (en) * 2003-12-05 2008-05-20 University Of Maryland Biotechnology Institute Fabrication and integration of polymeric bioMEMS
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
KR101080056B1 (ko) * 2004-12-01 2011-11-04 한국원자력연구원 체내 주사시 겔화 안정성이 개선된 방사성물질-키토산복합체용액 조성물 및 그 제조 방법
ATE397439T1 (de) * 2005-02-17 2008-06-15 Jordanian Pharmaceutical Mfg Zubereitung zur kontinuierlichen arzneimittelfreisetzung chitosan enthaltend
US8088773B2 (en) 2005-05-12 2012-01-03 The Texas A&M University System Therapeutic compositions and methods
EP1945712A4 (en) * 2005-11-04 2013-05-01 Piramal Healthcare Canada Ltd BINDING OF AQUEOUS POLYELECTROLYTE SOLUTIONS BY THERMALLY INDUCED CHANGES IN THE IONIZATION CONDITION
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
US20070154523A1 (en) * 2005-12-30 2007-07-05 Rick Lewis Controlled pupil dilation for diagnostic and treatment of visual anomalies
US7785624B2 (en) * 2006-03-02 2010-08-31 Inspire Pharmaceuticals, Inc. Pharmaceutical latrunculin formulations
DK1938839T3 (da) * 2006-12-18 2009-11-30 Jorge Luis Benozzi Oftalmiske sammensætninger af parasympatiske stimulanter og anti-inflammatoriske midler til anvendelse i behandlingen af presbyopi
US8252771B2 (en) * 2007-01-31 2012-08-28 Allergan, Inc. Biomaterials and a method for making and using same
WO2008109397A2 (en) * 2007-03-02 2008-09-12 Saint Simeon Lda Novel ophthalmic compositions containing human recombinant lysozyme and use thereof for treating eye conditions and as contact lens solutions
CA2698812A1 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
CN101780105B (zh) * 2009-01-20 2011-09-28 沈阳兴齐制药有限公司 小牛血去蛋白提取物的滴眼液
WO2010135731A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2011018800A2 (en) 2009-08-13 2011-02-17 Fdc Limited A novel in-situ gel forming solution for ocular drug delivery
DE102010009475B4 (de) 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions
TR201903465T4 (tr) 2011-09-20 2019-04-22 Allergan Inc Presbiyopi, hafif hiperopi ve düzensiz astigmatizmin tedavi edilmesine yönelik bileşimler ve yöntemler.
JP2015519398A (ja) * 2012-06-11 2015-07-09 マククリア・インコーポレイテッド 治療用製剤および処置の方法
EP3973954A1 (en) * 2013-10-15 2022-03-30 Pharmathen S.A. Preservative free pharmaceutical compositions for ophthalmic administration
TWI609701B (zh) 2016-01-05 2018-01-01 國立交通大學 滴點式複合藥物凝膠及其製備方法
CA3031370A1 (en) 2016-08-19 2018-02-22 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
CN106511268A (zh) * 2017-01-22 2017-03-22 吉林省始祖生物波医学研究院有限公司 治疗眼病的溶液及其应用、眼贴及其制作方法
US9980946B1 (en) 2017-01-25 2018-05-29 Effcon Laboratories, Inc. Extended release methazolamide formulation
SG11202007977RA (en) * 2018-02-28 2020-09-29 Santen Pharmaceutical Co Ltd Ophthalmic composition comprising diquafosol and cationic polymer
WO2019193513A1 (en) * 2018-04-03 2019-10-10 Hyderabad Eye Research Foundation Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics
SG11202010472XA (en) 2018-04-24 2020-11-27 Allergan Inc Use of pilocarpine hydrochloride for the treatment of ocular conditions
WO2020146353A1 (en) 2019-01-08 2020-07-16 Alumend, Llc Topical compositions containing low molecular weight chitosan derivatives
IT201900006104A1 (it) 2019-04-18 2020-10-18 S I I T S R L Servizio Int Imballaggi Termosaldanti Metodo di preparazione di un prodotto a base di chitosano
CN111848830A (zh) * 2019-04-30 2020-10-30 苏州大学 含氟化合物修饰的壳聚糖作为药物载体的用途及其制备方法
CN117771172A (zh) * 2019-08-27 2024-03-29 参天制药株式会社 含有地夸磷索或其盐、及聚乙烯吡咯烷酮的水性眼科用组合物
CN114073670B (zh) * 2020-08-11 2023-02-24 武汉科福新药有限责任公司 马来酸噻吗洛尔凝胶滴眼液及其制备方法
WO2022165178A1 (en) * 2021-01-28 2022-08-04 Glaukos Corporation Formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
EP0244178A3 (en) * 1986-04-28 1989-02-08 Iolab, Inc Intraocular dosage compositions and method of use
IT1190347B (it) * 1986-06-16 1988-02-16 Franco Conti Processo per la preparazione dell'n-dimetilchitosano e suoi impieghi farmacologici
JPS6471822A (en) * 1987-09-12 1989-03-16 Rohto Pharma Ophthalmic sustained release preparation
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
FR2653021A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
JPH0418022A (ja) * 1990-05-10 1992-01-22 Fujikawa Kk ピロキシカムの安定水溶液ならびにその製造法
JP2536806B2 (ja) * 1991-03-27 1996-09-25 アルコン ラボラトリーズ インコーポレイテッド ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels

Also Published As

Publication number Publication date
FI963217A (fi) 1996-08-16
MX9603435A (es) 1997-03-29
CN1140988A (zh) 1997-01-22
IL112674A (en) 1999-12-22
ES2163495T3 (es) 2002-02-01
AU1464995A (en) 1995-09-04
PT744938E (pt) 2001-12-28
ATE205079T1 (de) 2001-09-15
GR3036884T3 (en) 2002-01-31
DE69522550T2 (de) 2002-05-02
CA2181715A1 (en) 1995-08-24
IL112674A0 (en) 1995-05-26
FI117851B (fi) 2007-03-30
US5422116A (en) 1995-06-06
ZA951323B (en) 1995-08-18
DK0744938T3 (da) 2001-12-31
WO1995022315A1 (en) 1995-08-24
CA2181715C (en) 2006-05-30
CN1138530C (zh) 2004-02-18
AU704353B2 (en) 1999-04-22
NZ278668A (en) 1998-01-26
NO963431L (no) 1996-10-09
EP0744938B1 (en) 2001-09-05
EP0744938A1 (en) 1996-12-04
FI963217A0 (fi) 1996-08-16
JPH09509166A (ja) 1997-09-16
NO313861B1 (no) 2002-12-16
TW317501B (pt) 1997-10-11
DE69522550D1 (de) 2001-10-11
JP3720359B2 (ja) 2005-11-24
NO963431D0 (no) 1996-08-16

Similar Documents

Publication Publication Date Title
CY2314B1 (en) Liquid ophthalmic sustained release delivery system.
ATE192332T1 (de) Alkalische ophthalmische suspensionen
CN1762381B (zh) 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
KR100379881B1 (ko) 하드 콘택트 렌즈 보호용 컨디셔닝 용액
EP0590655B1 (en) Muco-adhesive polymers
US5075104A (en) Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
EP0799615B1 (en) Liposome eye drops
US5209927A (en) Ophthalmic solution
CN101312711B (zh) 不含右泛醇、钙离子和磷酸盐的药物组合物以及钙螯合剂和眼科相容粘度调节剂的应用
ATE204745T1 (de) Mit tamarindensamenpolysacchariden verdickte opthalmische lösungen
IL114193A0 (en) Ophthalmic pharmaceutical compositions
ES2192560T3 (es) Material viscoelastico sintetico para aplicaciones oftalmicas.
WO1984004680A1 (en) Ophthalmic gel
FR2742336B1 (fr) Collyre destine notamment au traitement de l'oeil sec
WO2007007076A1 (en) Contact lens care solution