CY1126998T1 - Πολυμορφικες μορφες rad1901-2hcl - Google Patents

Πολυμορφικες μορφες rad1901-2hcl

Info

Publication number
CY1126998T1
CY1126998T1 CY20241100491T CY241100491T CY1126998T1 CY 1126998 T1 CY1126998 T1 CY 1126998T1 CY 20241100491 T CY20241100491 T CY 20241100491T CY 241100491 T CY241100491 T CY 241100491T CY 1126998 T1 CY1126998 T1 CY 1126998T1
Authority
CY
Cyprus
Prior art keywords
rad1901
2hcl
polymorphic forms
polymorphic
forms
Prior art date
Application number
CY20241100491T
Other languages
Greek (el)
English (en)
Inventor
Michael Paul CRUSKIE
Joshua Kyle BOLGER
Jonathan Blake MCKENZIE
Pratik SHETH
Richard Edwards
Alex Eberlin
Michael MARKEY
Original Assignee
Radius Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62709319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1126998(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Radius Pharmaceuticals, Inc. filed Critical Radius Pharmaceuticals, Inc.
Publication of CY1126998T1 publication Critical patent/CY1126998T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Conductive Materials (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Indole Compounds (AREA)
CY20241100491T 2017-01-05 2024-07-09 Πολυμορφικες μορφες rad1901-2hcl CY1126998T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762442921P 2017-01-05 2017-01-05

Publications (1)

Publication Number Publication Date
CY1126998T1 true CY1126998T1 (el) 2026-02-25

Family

ID=62709319

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20241100491T CY1126998T1 (el) 2017-01-05 2024-07-09 Πολυμορφικες μορφες rad1901-2hcl

Country Status (22)

Country Link
US (6) US10385008B2 (https=)
EP (2) EP3565542B1 (https=)
JP (3) JP7481115B2 (https=)
KR (4) KR102707399B1 (https=)
CN (2) CN110191707A (https=)
AU (3) AU2018205285C9 (https=)
CA (1) CA3047411A1 (https=)
CY (1) CY1126998T1 (https=)
DK (1) DK3565542T3 (https=)
ES (1) ES2981967T3 (https=)
FI (1) FI3565542T3 (https=)
HR (1) HRP20240923T1 (https=)
HU (1) HUE067541T2 (https=)
IL (3) IL316617A (https=)
LT (1) LT3565542T (https=)
MX (3) MX383786B (https=)
PL (1) PL3565542T3 (https=)
PT (1) PT3565542T (https=)
RS (1) RS65694B1 (https=)
SI (1) SI3565542T1 (https=)
SM (1) SMT202400280T1 (https=)
WO (1) WO2018129419A1 (https=)

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KR102707399B1 (ko) * 2017-01-05 2024-09-13 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
IL279853B2 (en) * 2018-07-04 2025-01-01 Radius Pharmaceuticals Inc Polymorphic forms of RAD 1901-2HCL
CN113164779A (zh) * 2018-12-06 2021-07-23 雷迪厄斯制药公司 治疗cdk4/6抑制剂耐药性癌症的方法
CN113348163B (zh) 2019-02-12 2024-10-08 雷迪厄斯制药公司 方法和化合物
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
WO2023224961A1 (en) 2022-05-16 2023-11-23 Exelixis, Inc. Cancer therapy using a combination of a cdk7 inhibitor with an oral serd
US20250282711A1 (en) 2022-05-25 2025-09-11 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystalline form of elacestrant and preparation method and use thereof
WO2024104268A1 (zh) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 艾拉司群二盐酸盐的共晶及其制备方法和用途
EP4719360A1 (en) 2023-06-05 2026-04-08 Berlin-Chemie AG Solid elacestrant dihydrochloride compositions, methods of making the same, and methods of treatment using the same
EP4574811A1 (en) 2023-12-22 2025-06-25 Sandoz Ag Crystalline forms of elacestrant dihydrochloride
WO2025158416A1 (en) 2024-01-25 2025-07-31 Assia Chemical Industries Ltd. Solid state forms of elacestrant and processes for preparation thereof
WO2025181825A2 (en) * 2024-02-26 2025-09-04 Msn Laboratories Private Limited, R&D Center Solid state forms of Elacestrant dihydrochloride and their processes for the preparation
WO2025210676A1 (en) * 2024-03-30 2025-10-09 Msn Laboratories Private Limited, R&D Center Novel crystalline forms of Elacestrant dihydrochloride and processes for their preparation
CN118652186A (zh) * 2024-05-23 2024-09-17 奥锐特药业(天津)有限公司 艾拉司群二盐酸盐的新晶型及其制备方法和用途
WO2026009173A1 (en) * 2024-07-02 2026-01-08 Hetero Labs Limited Polymorphic forms of rad1901-2hcl

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