CY1124071T1 - Συζευγμα αντισωματος anti-her3 φapmakoy - Google Patents
Συζευγμα αντισωματος anti-her3 φapmakoyInfo
- Publication number
- CY1124071T1 CY1124071T1 CY20211100356T CY211100356T CY1124071T1 CY 1124071 T1 CY1124071 T1 CY 1124071T1 CY 20211100356 T CY20211100356 T CY 20211100356T CY 211100356 T CY211100356 T CY 211100356T CY 1124071 T1 CY1124071 T1 CY 1124071T1
- Authority
- CY
- Cyprus
- Prior art keywords
- her3 antibody
- antitumor
- fapmakoy
- antibody conjugate
- terminus
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 1
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Abstract
Να παρασχεθεί ένα φάρμακο κατά των όγκων που να έχει εξαιρετική θεραπευτική επίδραση, το οποίο να είναι εξαιρετικό από την άποψη της επίδρασης κατά των όγκων και της ασφάλειας. Παρέχεται ένα σύζευγμα αντισώματος-φαρμάκου στο οποίο μια ένωση κατά των όγκων που αναπαρίσταται από τον ακόλουθο χημικό τύπο συζεύγνυται σε ένα αντίσωμα αντι-ΗΕΡ3 μέσω ενός συνδέτη έχοντας μια δομή που αναπαρίσταται από τον χημικό τύπο: -L1-L2-LΡ-ΝΗ- (CH2)n1-La-(CH2)n2-C(=O)- ή –L1-L2-LP- (το αντίσωμα αντι-HER3 συνδέεται στο τερματικό του L1, η ένωση κατά των όγκων συνδέεται στην ομάδα καρβονυλίου της μερίδας -(CH2)n2-C(=O)- ή στο τερματικό C του LP, με το άτομο αζώτου της αμινομάδας στη θέση 1 ως μια συνδετική θέση).
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JP2014081454 | 2014-04-10 | ||
PCT/JP2015/002020 WO2015155998A1 (en) | 2014-04-10 | 2015-04-10 | Anti-her3 antibody-drug conjugate |
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