BR112016017893A2 - conjugado de anticorpo-fármaco anti-her3 - Google Patents

conjugado de anticorpo-fármaco anti-her3

Info

Publication number
BR112016017893A2
BR112016017893A2 BR112016017893A BR112016017893A BR112016017893A2 BR 112016017893 A2 BR112016017893 A2 BR 112016017893A2 BR 112016017893 A BR112016017893 A BR 112016017893A BR 112016017893 A BR112016017893 A BR 112016017893A BR 112016017893 A2 BR112016017893 A2 BR 112016017893A2
Authority
BR
Brazil
Prior art keywords
her3 antibody
drug conjugate
antitumor
terminus
attached
Prior art date
Application number
BR112016017893A
Other languages
English (en)
Other versions
BR112016017893B1 (pt
Inventor
Abraham Reimar
Blum Sabine
Ueno Suguru
Hettmann Thore
Original Assignee
Daiichi Sankyo Co Ltd
U3 Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53008825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016017893(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd, U3 Pharma Gmbh filed Critical Daiichi Sankyo Co Ltd
Publication of BR112016017893A2 publication Critical patent/BR112016017893A2/pt
Publication of BR112016017893B1 publication Critical patent/BR112016017893B1/pt

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Classifications

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

proporcionar um fármaco antitumor tendo excelente efeito terapêutico, o qual é excelente em termos de efeito antitumor e segurança. é fornecido um conjugado de anticorpo-fármaco no qual um composto antitumor representado pela fórmula a seguir é conjugado a um anticorpo anti-her3 através de um ligante tendo uma estrutura representada pela fórmula: -l1-l2-lp-nh-(ch2)n1-la-(ch2)n2-c(=o)- ou -l1-l2-lp- (o anticorpo anti-her3 é conectado ao término de l1, o composto antitumor é conectado ao grupo carbonila da porção -(ch2)n2-c(=o)- ou ao c-término de lp, com o átomo de nitrogênio do grupo amino na posição 1 como uma posição de conexão).
BR112016017893-9A 2014-04-10 2015-04-10 Conjugado de anticorpo-fármaco, medicamento antitumoral e/ou anticancerígeno, e composição farmacêutica BR112016017893B1 (pt)

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