CY1123164T1 - Διεργασια για τη συνθεση ενος αναστολεα ινδολαμινης 2,3-διοξυγενασης - Google Patents

Διεργασια για τη συνθεση ενος αναστολεα ινδολαμινης 2,3-διοξυγενασης

Info

Publication number
CY1123164T1
CY1123164T1 CY20201100726T CY201100726T CY1123164T1 CY 1123164 T1 CY1123164 T1 CY 1123164T1 CY 20201100726 T CY20201100726 T CY 20201100726T CY 201100726 T CY201100726 T CY 201100726T CY 1123164 T1 CY1123164 T1 CY 1123164T1
Authority
CY
Cyprus
Prior art keywords
indolamine
synthesis
dioxygenase inhibitor
dioxygenase
inhibitor
Prior art date
Application number
CY20201100726T
Other languages
English (en)
Inventor
Ming Tao
William Frietze
David J. Meloni
Lingkai Weng
Jiacheng Zhou
Yongchun Pan
Original Assignee
Incyte Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of CY1123164T1 publication Critical patent/CY1123164T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Η παρούσα αίτηση αφορά διεργασίες και ενδιάμεσες ενώσεις για τη δημιουργία
CY20201100726T 2013-11-08 2020-08-05 Διεργασια για τη συνθεση ενος αναστολεα ινδολαμινης 2,3-διοξυγενασης CY1123164T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361901689P 2013-11-08 2013-11-08
PCT/US2014/064531 WO2015070007A1 (en) 2013-11-08 2014-11-07 Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

Publications (1)

Publication Number Publication Date
CY1123164T1 true CY1123164T1 (el) 2021-10-29

Family

ID=52023608

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100726T CY1123164T1 (el) 2013-11-08 2020-08-05 Διεργασια για τη συνθεση ενος αναστολεα ινδολαμινης 2,3-διοξυγενασης

Country Status (31)

Country Link
US (3) US9321755B2 (el)
EP (2) EP3066085B1 (el)
JP (4) JP6461953B2 (el)
KR (2) KR102370067B1 (el)
CN (2) CN105899498B (el)
AR (1) AR098343A1 (el)
AU (2) AU2014346647B2 (el)
BR (2) BR122020009912B1 (el)
CA (1) CA2929552C (el)
CL (1) CL2016001082A1 (el)
CR (2) CR20160252A (el)
CY (1) CY1123164T1 (el)
DK (1) DK3066085T3 (el)
EA (2) EA201991770A1 (el)
ES (1) ES2799582T3 (el)
HR (1) HRP20201089T1 (el)
HU (1) HUE049337T2 (el)
IL (2) IL245314B (el)
LT (1) LT3066085T (el)
ME (1) ME03792B (el)
MX (2) MX366874B (el)
MY (1) MY174254A (el)
PE (2) PE20220430A1 (el)
PH (2) PH12016500818A1 (el)
PL (1) PL3066085T3 (el)
PT (1) PT3066085T (el)
RS (1) RS60598B1 (el)
SG (2) SG10201803874PA (el)
SI (1) SI3066085T1 (el)
TW (4) TW202309014A (el)
WO (1) WO2015070007A1 (el)

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WO2017181849A1 (zh) * 2016-04-20 2017-10-26 江苏豪森药业集团有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
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CN109206380A (zh) * 2017-07-03 2019-01-15 上海时莱生物技术有限公司 吲哚胺2，3-双加氧酶抑制剂化合物及其制备方法和用途
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CN108101899B (zh) * 2018-02-11 2021-01-26 中国药科大学 IDO1抑制剂Epacadostat中间体的制备方法
CN109180603A (zh) * 2018-10-10 2019-01-11 中国药科大学 Epacadostat关键中间体的制备方法
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CN112341403B (zh) * 2020-11-10 2022-06-28 南京工业大学 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法
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Also Published As

Publication number Publication date
CA2929552A1 (en) 2015-05-14
IL267773B (en) 2020-04-30
EP3066085A1 (en) 2016-09-14
US9321755B2 (en) 2016-04-26
PH12016500818B1 (en) 2016-06-20
US20180244663A1 (en) 2018-08-30
SI3066085T1 (sl) 2020-08-31
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