PT3066085T - Processo para a síntese de um inibidor de indoleamina 2,3-dioxigenase - Google Patents

Processo para a síntese de um inibidor de indoleamina 2,3-dioxigenase

Info

Publication number
PT3066085T
PT3066085T PT148120157T PT14812015T PT3066085T PT 3066085 T PT3066085 T PT 3066085T PT 148120157 T PT148120157 T PT 148120157T PT 14812015 T PT14812015 T PT 14812015T PT 3066085 T PT3066085 T PT 3066085T
Authority
PT
Portugal
Prior art keywords
indoleamine
synthesis
dioxygenase inhibitor
dioxygenase
inhibitor
Prior art date
Application number
PT148120157T
Other languages
English (en)
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of PT3066085T publication Critical patent/PT3066085T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT148120157T 2013-11-08 2014-11-07 Processo para a síntese de um inibidor de indoleamina 2,3-dioxigenase PT3066085T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361901689P 2013-11-08 2013-11-08

Publications (1)

Publication Number Publication Date
PT3066085T true PT3066085T (pt) 2020-07-16

Family

ID=52023608

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148120157T PT3066085T (pt) 2013-11-08 2014-11-07 Processo para a síntese de um inibidor de indoleamina 2,3-dioxigenase

Country Status (31)

Country Link
US (3) US9321755B2 (pt)
EP (2) EP3066085B1 (pt)
JP (4) JP6461953B2 (pt)
KR (2) KR102617531B1 (pt)
CN (2) CN105899498B (pt)
AR (1) AR098343A1 (pt)
AU (2) AU2014346647B2 (pt)
BR (2) BR112016009786B1 (pt)
CA (1) CA2929552C (pt)
CL (1) CL2016001082A1 (pt)
CR (2) CR20190351A (pt)
CY (1) CY1123164T1 (pt)
DK (1) DK3066085T3 (pt)
EA (2) EA201991770A1 (pt)
ES (1) ES2799582T3 (pt)
HR (1) HRP20201089T1 (pt)
HU (1) HUE049337T2 (pt)
IL (2) IL245314B (pt)
LT (1) LT3066085T (pt)
ME (1) ME03792B (pt)
MX (2) MX366874B (pt)
MY (1) MY174254A (pt)
PE (2) PE20160863A1 (pt)
PH (2) PH12016500818A1 (pt)
PL (1) PL3066085T3 (pt)
PT (1) PT3066085T (pt)
RS (1) RS60598B1 (pt)
SG (2) SG10201803874PA (pt)
SI (1) SI3066085T1 (pt)
TW (4) TWI696618B (pt)
WO (1) WO2015070007A1 (pt)

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PT2559690T (pt) 2005-05-10 2016-07-07 Incyte Holdings Corp Moduladores de indolamina-2,3-dioxigenase e métodos de utilização dos mesmos
KR101847107B1 (ko) 2008-07-08 2018-04-10 인사이트 홀딩스 코포레이션 인돌아민 ２,３-디옥시게나아제의 억제제로서의 １,２,５-옥사디아졸
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GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
EP3066085B1 (en) 2013-11-08 2020-05-13 Incyte Holdings Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US20170037125A1 (en) * 2014-02-04 2017-02-09 Incyte Corporation Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer
WO2017010106A1 (en) * 2015-07-14 2017-01-19 Kyowa Hakko Kirin Co., Ltd. A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody
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WO2017106062A1 (en) * 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Novel compounds as indoleamine 2,3-dioxygenase inhibitors
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CN105646389B (zh) * 2016-01-28 2019-06-28 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途
WO2017181849A1 (zh) * 2016-04-20 2017-10-26 江苏豪森药业集团有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
CN107304191B (zh) * 2016-04-20 2023-09-29 上海翰森生物医药科技有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
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CN109952300B (zh) 2016-09-24 2022-01-18 百济神州有限公司 5或8-取代的咪唑并[1,5-a]吡啶
EP3544965A4 (en) * 2016-11-28 2020-05-20 Shanghai Fochon Pharmaceutical Co., Ltd. SULFOXIMIN, SULFONIMIDAMID, SULFONDIIMIN AND DIIMIDOSULFONAMID COMPOUNDS AS INHIBITORS OF INDOLAMINE-2,3-DIOXYGENASE
PT3559009T (pt) 2016-12-22 2021-05-04 Calithera Biosciences Inc Composições e métodos para inibir a atividade da arginase
CN109206380A (zh) * 2017-07-03 2019-01-15 上海时莱生物技术有限公司 吲哚胺2，3-双加氧酶抑制剂化合物及其制备方法和用途
CN110066253B (zh) * 2018-01-24 2023-06-23 江苏柯菲平医药股份有限公司 1,2,5-噁二唑类衍生物，其制备方法及其在医药中的应用
CN108101899B (zh) * 2018-02-11 2021-01-26 中国药科大学 IDO1抑制剂Epacadostat中间体的制备方法
CN109180603A (zh) * 2018-10-10 2019-01-11 中国药科大学 Epacadostat关键中间体的制备方法
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EP4057818A4 (en) * 2019-11-14 2023-11-22 Nova Southeastern University METHODS AND COMPOSITIONS FOR TREATING SOLID TUMORS USING ISOINDOLE F16 SMALL MOLECULES
CN112341403B (zh) * 2020-11-10 2022-06-28 南京工业大学 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法
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US20240091202A1 (en) 2021-03-05 2024-03-21 Universität Basel Compositions for the treatment of ebv associated diseases or conditions

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Also Published As

Publication number Publication date
TW201605817A (zh) 2016-02-16
PE20220430A1 (es) 2022-03-29
CN109810104A (zh) 2019-05-28
MY174254A (en) 2020-04-01
SG11201603433UA (en) 2016-05-30
HRP20201089T1 (hr) 2020-10-30
EP3066085A1 (en) 2016-09-14
HUE049337T2 (hu) 2020-09-28
MX366874B (es) 2019-07-29
PH12019500770A1 (en) 2020-09-21
SG10201803874PA (en) 2018-07-30
TWI775079B (zh) 2022-08-21
MX2019008378A (es) 2019-09-09
AR098343A1 (es) 2016-05-26
CR20160252A (es) 2016-09-19
CA2929552A1 (en) 2015-05-14
KR20160094971A (ko) 2016-08-10
US10280157B2 (en) 2019-05-07
EA201690959A1 (ru) 2016-08-31
EA033667B1 (ru) 2019-11-14
US9321755B2 (en) 2016-04-26
TW202100523A (zh) 2021-01-01
JP2020019805A (ja) 2020-02-06
IL267773B (en) 2020-04-30
CY1123164T1 (el) 2021-10-29
AU2019200404A1 (en) 2019-02-07
KR102617531B1 (ko) 2023-12-27
JP2020019806A (ja) 2020-02-06
TW202309014A (zh) 2023-03-01
CN105899498B (zh) 2019-01-25
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US20160221996A1 (en) 2016-08-04
BR122020009912B1 (pt) 2022-11-01
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PH12016500818B1 (en) 2016-06-20
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US9873688B2 (en) 2018-01-23
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IL267773A (en) 2019-09-26
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