HK1218414A1 - 用於合成手性犬尿氨酸化合物的方法 - Google Patents

用於合成手性犬尿氨酸化合物的方法

Info

Publication number
HK1218414A1
HK1218414A1 HK16106379.0A HK16106379A HK1218414A1 HK 1218414 A1 HK1218414 A1 HK 1218414A1 HK 16106379 A HK16106379 A HK 16106379A HK 1218414 A1 HK1218414 A1 HK 1218414A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
methods
chiral
kynurenine compounds
compounds
Prior art date
Application number
HK16106379.0A
Other languages
English (en)
Inventor
斯蒂芬‧阿貝爾
克勞斯‧勞厄
羅蘭‧
‧布瑞坦莫瑟
Original Assignee
Vistagen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vistagen Therapeutics Inc filed Critical Vistagen Therapeutics Inc
Publication of HK1218414A1 publication Critical patent/HK1218414A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01014—Aminoacylase (3.5.1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK16106379.0A 2013-03-14 2016-06-03 用於合成手性犬尿氨酸化合物的方法 HK1218414A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361785807P 2013-03-14 2013-03-14
PCT/US2014/027694 WO2014152752A1 (en) 2013-03-14 2014-03-14 Methods for the synthesis of chiral kynurenine compounds

Publications (1)

Publication Number Publication Date
HK1218414A1 true HK1218414A1 (zh) 2017-02-17

Family

ID=51581307

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16106379.0A HK1218414A1 (zh) 2013-03-14 2016-06-03 用於合成手性犬尿氨酸化合物的方法

Country Status (7)

Country Link
US (2) US9834801B2 (zh)
EP (1) EP2970097B1 (zh)
JP (2) JP6340409B2 (zh)
CN (2) CN107417558A (zh)
CA (1) CA2941559A1 (zh)
HK (1) HK1218414A1 (zh)
WO (1) WO2014152752A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152752A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Methods for the synthesis of chiral kynurenine compounds
CA3024783A1 (en) 2015-05-22 2016-12-01 Vistagen Therapeutics, Inc. Therapeutic uses of l-4-chlorokynurenine
WO2017044516A1 (en) * 2015-09-08 2017-03-16 Cephalon, Inc. Prodrugs of chlorokynurenines
WO2018044724A1 (en) * 2016-08-31 2018-03-08 Ampio Pharmaceuticals, Inc. Treatment of disease with n-acetyl kynurenine
WO2018180116A1 (ja) 2017-03-29 2018-10-04 富士フイルム株式会社 構造体および光センサ
JP7431163B2 (ja) 2018-02-09 2024-02-14 ヴィスタゲン セラピューティクス、インコーポレイテッド ４－クロロキヌレニンおよび中間体の合成
CN113549661B (zh) * 2020-04-26 2022-08-30 赤壁生合元科技有限公司 生物催化合成L-4-Cl-犬尿氨酸或L-4-Br-犬尿氨酸的方法及应用
CN113549662B (zh) * 2020-04-26 2022-06-03 赤壁市高质量发展研究院有限公司 一种用MOF载酶技术高效制备抗抑郁药前药L-4-Cl-犬尿氨酸的方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766261A (en) 1970-08-21 1973-10-16 Us Agriculture Process of producing kynurenine
US3702255A (en) * 1970-08-21 1972-11-07 Us Agriculture Kynurenine derivatives as sweetening agents
US3765261A (en) * 1973-01-02 1973-10-16 Hurst Performance Unitary stick transfer case shifter
US5519055A (en) 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
GB9522615D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
ITMI20041626A1 (it) 2004-08-06 2004-11-06 Roberto Pellicciari Inibitori della chinurenina-ammino-trasferasi
US7622495B2 (en) * 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
JP5232247B2 (ja) * 2008-12-11 2013-07-10 東洋紡株式会社 Ｌ−サクシニルアミノアシラーゼ、およびこれを用いたｌ−アミノ酸の製造方法
WO2014152752A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Methods for the synthesis of chiral kynurenine compounds

Also Published As

Publication number Publication date
CN105164100B (zh) 2017-09-15
US10294502B2 (en) 2019-05-21
EP2970097A1 (en) 2016-01-20
CN107417558A (zh) 2017-12-01
JP2016513709A (ja) 2016-05-16
WO2014152752A1 (en) 2014-09-25
US20180171372A1 (en) 2018-06-21
EP2970097A4 (en) 2016-11-16
JP2018139608A (ja) 2018-09-13
US20160032334A1 (en) 2016-02-04
CN105164100A (zh) 2015-12-16
CA2941559A1 (en) 2014-09-25
JP6340409B2 (ja) 2018-06-06
US9834801B2 (en) 2017-12-05
JP6618569B2 (ja) 2019-12-11
EP2970097B1 (en) 2018-10-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220312