PE20160863A1 - Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa - Google Patents
Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasaInfo
- Publication number
- PE20160863A1 PE20160863A1 PE2016000604A PE2016000604A PE20160863A1 PE 20160863 A1 PE20160863 A1 PE 20160863A1 PE 2016000604 A PE2016000604 A PE 2016000604A PE 2016000604 A PE2016000604 A PE 2016000604A PE 20160863 A1 PE20160863 A1 PE 20160863A1
- Authority
- PE
- Peru
- Prior art keywords
- indolamine
- dioxygenase
- inhibitor
- synthesis
- amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a procesos e intermedios para elaborar 4-({2-[(aminosulfonil)amino]etil}amino)-N-(3-bromo-4-fluorofenil)-N'-hidroxi-1, 2, 5-oxadiazol- 3-carboximidamida. Dicho compuesto es un inhibidor de indolamina 2, 3-dioxigenasa, siendo util en el tratamiento del cancer y otros trastornos
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361901689P | 2013-11-08 | 2013-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160863A1 true PE20160863A1 (es) | 2016-09-03 |
Family
ID=52023608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021001747A PE20220430A1 (es) | 2013-11-08 | 2014-11-07 | PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA |
PE2016000604A PE20160863A1 (es) | 2013-11-08 | 2014-11-07 | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021001747A PE20220430A1 (es) | 2013-11-08 | 2014-11-07 | PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA |
Country Status (31)
Country | Link |
---|---|
US (3) | US9321755B2 (es) |
EP (2) | EP3744715A1 (es) |
JP (4) | JP6461953B2 (es) |
KR (2) | KR102617531B1 (es) |
CN (2) | CN109810104B (es) |
AR (1) | AR098343A1 (es) |
AU (2) | AU2014346647B2 (es) |
BR (2) | BR112016009786B1 (es) |
CA (1) | CA2929552C (es) |
CL (1) | CL2016001082A1 (es) |
CR (2) | CR20160252A (es) |
CY (1) | CY1123164T1 (es) |
DK (1) | DK3066085T3 (es) |
EA (2) | EA201991770A1 (es) |
ES (1) | ES2799582T3 (es) |
HR (1) | HRP20201089T1 (es) |
HU (1) | HUE049337T2 (es) |
IL (2) | IL245314B (es) |
LT (1) | LT3066085T (es) |
ME (1) | ME03792B (es) |
MX (2) | MX366874B (es) |
MY (1) | MY174254A (es) |
PE (2) | PE20220430A1 (es) |
PH (2) | PH12016500818B1 (es) |
PL (1) | PL3066085T3 (es) |
PT (1) | PT3066085T (es) |
RS (1) | RS60598B1 (es) |
SG (2) | SG10201803874PA (es) |
SI (1) | SI3066085T1 (es) |
TW (4) | TWI696618B (es) |
WO (1) | WO2015070007A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS54876B1 (sr) | 2005-05-10 | 2016-10-31 | Incyte Holdings Corp | Modulatori indoleamina 2,3-dioksigenaze i metode za upotrebu istih |
MY171866A (en) | 2008-07-08 | 2019-11-05 | Incyte Holdings Corp | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
BR112016009786B1 (pt) | 2013-11-08 | 2021-01-05 | Incyte Holdings Corporation | compostos inibidores de indoleamina 2,3-dioxigenase e seus processos de síntese |
CN106456753B (zh) * | 2014-02-04 | 2021-05-11 | 因塞特公司 | 用于治疗癌症的pd-1拮抗剂和ido1抑制剂的组合 |
CA2992238A1 (en) * | 2015-07-14 | 2017-01-19 | Kyowa Hakko Kirin Co., Ltd. | A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody |
CN114748474A (zh) | 2015-11-04 | 2022-07-15 | 因赛特公司 | 用于吲哚胺2,3-双加氧酶抑制及其适应症的药物组合物和方法 |
WO2017106062A1 (en) * | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Novel compounds as indoleamine 2,3-dioxygenase inhibitors |
US9624185B1 (en) * | 2016-01-20 | 2017-04-18 | Yong Xu | Method for preparing IDO inhibitor epacadostat |
CN105646389B (zh) * | 2016-01-28 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途 |
WO2017181849A1 (zh) * | 2016-04-20 | 2017-10-26 | 江苏豪森药业集团有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
CN107304191B (zh) * | 2016-04-20 | 2023-09-29 | 上海翰森生物医药科技有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
CN109689652B (zh) | 2016-08-23 | 2022-04-26 | 北京诺诚健华医药科技有限公司 | 稠杂环类衍生物、其制备方法及其在医学上的应用 |
CN109952300B (zh) | 2016-09-24 | 2022-01-18 | 百济神州有限公司 | 5或8-取代的咪唑并[1,5-a]吡啶 |
US11168078B2 (en) | 2016-11-28 | 2021-11-09 | Shanghai Fochon Pharmaceutical Co., Ltd. | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase |
AU2017382405B2 (en) | 2016-12-22 | 2021-12-16 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
CN109206380A (zh) * | 2017-07-03 | 2019-01-15 | 上海时莱生物技术有限公司 | 吲哚胺2,3-双加氧酶抑制剂化合物及其制备方法和用途 |
CN110066253B (zh) * | 2018-01-24 | 2023-06-23 | 江苏柯菲平医药股份有限公司 | 1,2,5-噁二唑类衍生物,其制备方法及其在医药中的应用 |
CN108101899B (zh) * | 2018-02-11 | 2021-01-26 | 中国药科大学 | IDO1抑制剂Epacadostat中间体的制备方法 |
CN109180603A (zh) * | 2018-10-10 | 2019-01-11 | 中国药科大学 | Epacadostat关键中间体的制备方法 |
AU2020319875A1 (en) | 2019-08-01 | 2022-02-17 | Incyte Corporation | A dosing regimen for an IDO inhibitor |
US20220409581A1 (en) * | 2019-11-14 | 2022-12-29 | Nova Southeastern University | Methods and compositions for treatment of solid tumors using f16 isoindole small molecules |
CN112341403B (zh) * | 2020-11-10 | 2022-06-28 | 南京工业大学 | 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法 |
AU2022228701A1 (en) | 2021-03-05 | 2023-09-14 | Universität Basel | Compositions for the treatment of ebv associated diseases or conditions |
EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236855A (en) | 1964-01-17 | 1966-02-22 | Merck & Co Inc | Certain n-phenyl(thiazole-hydroxamidine) compounds and their preparation |
US3354174A (en) | 1964-02-19 | 1967-11-21 | Sterling Drug Inc | 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines |
US3553228A (en) | 1967-09-26 | 1971-01-05 | Colgate Palmolive Co | 3-substituted-4h(1)benzopyrano(3,4-d) isoxazoles |
DE2040628A1 (de) | 1970-08-17 | 1972-02-24 | Fahlberg List Veb | Neue herbizide Mittel |
US3948928A (en) | 1972-03-17 | 1976-04-06 | Dainippon Pharmaceutical Co., Ltd. | 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof |
JPS5621033B2 (es) | 1973-09-05 | 1981-05-16 | ||
DE2640484A1 (de) | 1975-09-11 | 1977-04-07 | Philagro Sa | Amidoxim-derivate, ihre herstellung und verwendung |
FR2323683A1 (fr) | 1975-09-11 | 1977-04-08 | Philagro Sa | Nouveaux derives d'amidoximes, leur preparation et les compositions qui les contiennent |
US4323681A (en) | 1980-09-29 | 1982-04-06 | American Home Products Corporation | 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides |
JPS58208275A (ja) | 1982-05-20 | 1983-12-03 | Lion Corp | 5−アミノ−ピラゾ−ル誘導体及び該化合物を含有する抗腫瘍剤 |
DE3462259D1 (de) | 1983-07-22 | 1987-03-05 | Bayer Ag | Substituted furazans |
US4507485A (en) | 1984-01-23 | 1985-03-26 | Bristol-Myers Company | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity |
JPS60193968A (ja) | 1984-03-13 | 1985-10-02 | Toyo Jozo Co Ltd | シクロペンテン環を有するイミダゾ−ルアミドオキシムおよびその製造法 |
JPS6259283A (ja) | 1985-09-10 | 1987-03-14 | Kaken Pharmaceut Co Ltd | セフアロスポリン化合物 |
JP2696342B2 (ja) | 1988-06-27 | 1998-01-14 | 日本曹達株式会社 | アミジン誘導体、その製造方法及び殺ダニ剤・農園芸用殺菌剤 |
EP0352832B1 (en) | 1988-07-05 | 1992-05-06 | Akzo N.V. | Compounds with bronchodilator activity |
JPH04297449A (ja) | 1991-03-27 | 1992-10-21 | Hokko Chem Ind Co Ltd | N−ヒドロキシベンジルグアニジン誘導体および農園芸用殺菌剤 |
JPH05186458A (ja) | 1991-04-26 | 1993-07-27 | Japan Tobacco Inc | 新規なベンゾピラン誘導体 |
FR2677019B1 (fr) | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
JP2709677B2 (ja) | 1992-06-19 | 1998-02-04 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
FR2720396B1 (fr) | 1994-05-27 | 1996-06-28 | Adir | Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5731315A (en) | 1995-06-07 | 1998-03-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds |
BR9610988A (pt) | 1995-10-17 | 1999-04-06 | Astra Pharma Prod | Composto uso do mesmo fomulação farmacêutica e processo para produção do composto |
WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
US5955495A (en) | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
JPH11171702A (ja) | 1997-09-24 | 1999-06-29 | Takeda Chem Ind Ltd | 害虫防除方法 |
WO1999029310A2 (en) | 1997-12-05 | 1999-06-17 | Medical College Of Georgia Research Institute, Inc. | Regulation of t cell-mediated immunity by tryptophan and its analogs |
ES2213929T3 (es) | 1997-12-10 | 2004-09-01 | Dainippon Ink And Chemicals, Inc. | Derivados de oximas y productos quimicos para uso agricola que incluyen los mismos. |
ES2177275T3 (es) | 1998-06-02 | 2002-12-01 | Takeda Chemical Industries Ltd | Derivados de oxadiazolina y su uso como insecticidas. |
FR2784678B1 (fr) | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
CA2330942C (en) | 1999-03-03 | 2004-11-23 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
KR20010108481A (ko) | 1999-04-09 | 2001-12-07 | 스타르크, 카르크 | 트롬빈 억제제의 프로드럭 |
KR100799134B1 (ko) | 1999-05-24 | 2008-01-29 | 미츠비시 웰파마 가부시키가이샤 | 페녹시프로필아민 화합물 |
JP2001158785A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 農薬組成物 |
JP2001158786A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 哺乳動物の外部寄生虫防除剤 |
US6780858B2 (en) | 2000-01-13 | 2004-08-24 | Tularik Inc. | Antibacterial agents |
JP2001233861A (ja) | 2000-02-22 | 2001-08-28 | Ube Ind Ltd | ピラゾールオキシム化合物、その製法及び用途 |
CA2413330A1 (en) | 2000-06-28 | 2002-01-03 | Smithkline Beecham P.L.C. | Wet milling process |
GB0108102D0 (en) | 2001-03-30 | 2001-05-23 | Pfizer Ltd | Compounds |
EA006212B1 (ru) | 2001-06-18 | 2005-10-27 | Апплайд Резеч Системз Арс Холдинг Н.В. | Оксадиазольные и тиадиазольные производные пирролидина |
CA2476822A1 (en) | 2002-02-19 | 2003-08-28 | Pharmacia Italia S.P.A. | Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents |
GB0208224D0 (en) | 2002-04-10 | 2002-05-22 | Celltech R&D Ltd | Chemical compounds |
EP1501918A4 (en) | 2002-04-12 | 2006-03-29 | Med College Georgia Res Inst | ANTIGEN PRESENTING CELL POPULATIONS AND THEIR USE AS REAGENTS TO INCREASE OR REDUCE IMMUNO TOLERANCE |
US7109354B2 (en) | 2002-05-28 | 2006-09-19 | 3-Dimensional Pharmaceuticals, Inc. | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7015321B2 (en) * | 2002-10-12 | 2006-03-21 | The Scripps Research Institute | Synthesis of non-symmetrical sulfamides using burgess-type reagents |
EP1613308A4 (en) | 2003-03-27 | 2008-02-20 | Lankenau Inst Medical Res | CANCER TREATMENT METHODS |
US7598287B2 (en) | 2003-04-01 | 2009-10-06 | Medical College Of Georgia Research Institute, Inc. | Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities |
AU2004267094A1 (en) | 2003-08-20 | 2005-03-03 | Vertex Pharmaceuticals Incorporated | (4 -amino -1,2, 5-oxadiazol-4-yl) -hetxiroaromatic compounds useful as protein kinase inhibitors |
DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
DE10348022A1 (de) | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
PT1801108E (pt) | 2004-09-08 | 2012-12-03 | Mitsubishi Tanabe Pharma Corp | Composto de morfolina para o tratamento de inflamações |
JP5065908B2 (ja) | 2004-12-24 | 2012-11-07 | プロシディオン・リミテッド | Gタンパク質結合受容体作動薬 |
US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
RS54876B1 (sr) | 2005-05-10 | 2016-10-31 | Incyte Holdings Corp | Modulatori indoleamina 2,3-dioksigenaze i metode za upotrebu istih |
WO2006133417A1 (en) | 2005-06-07 | 2006-12-14 | Valeant Pharmaceuticals International | Phenylamino isothiazole carboxamidines as mek inhibitors |
JP2008544818A (ja) | 2005-06-30 | 2008-12-11 | アントフロゲネシス コーポレーション | 胎盤由来コラーゲンバイオ線維を用いた鼓膜の修復 |
DE102005060466A1 (de) | 2005-12-17 | 2007-06-28 | Bayer Cropscience Ag | Carboxamide |
JP5294874B2 (ja) | 2005-12-20 | 2013-09-18 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロ環 |
US20070203140A1 (en) | 2006-02-09 | 2007-08-30 | Combs Andrew P | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
JP4297449B2 (ja) | 2006-05-12 | 2009-07-15 | 株式会社サクラクレパス | 墨汁 |
US20080119491A1 (en) | 2006-09-19 | 2008-05-22 | Incyte Corporation | Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
US20080146624A1 (en) | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
US20080125470A1 (en) | 2006-09-19 | 2008-05-29 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
US20080182882A1 (en) | 2006-11-08 | 2008-07-31 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
CN101679297B (zh) | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
EP2219646A4 (en) | 2007-12-21 | 2010-12-22 | Univ Rochester | METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS |
WO2009128521A1 (ja) * | 2008-04-15 | 2009-10-22 | 帝人ファーマ株式会社 | システインプロテアーゼ阻害剤 |
MY171866A (en) | 2008-07-08 | 2019-11-05 | Incyte Holdings Corp | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
BR112016009786B1 (pt) | 2013-11-08 | 2021-01-05 | Incyte Holdings Corporation | compostos inibidores de indoleamina 2,3-dioxigenase e seus processos de síntese |
-
2014
- 2014-11-07 BR BR112016009786-6A patent/BR112016009786B1/pt active IP Right Grant
- 2014-11-07 PE PE2021001747A patent/PE20220430A1/es unknown
- 2014-11-07 RS RS20200798A patent/RS60598B1/sr unknown
- 2014-11-07 TW TW108102217A patent/TWI696618B/zh active
- 2014-11-07 KR KR1020217032616A patent/KR102617531B1/ko active IP Right Grant
- 2014-11-07 ME MEP-2020-146A patent/ME03792B/me unknown
- 2014-11-07 DK DK14812015.7T patent/DK3066085T3/da active
- 2014-11-07 AR ARP140104196A patent/AR098343A1/es unknown
- 2014-11-07 TW TW109116698A patent/TWI775079B/zh active
- 2014-11-07 PL PL14812015T patent/PL3066085T3/pl unknown
- 2014-11-07 AU AU2014346647A patent/AU2014346647B2/en active Active
- 2014-11-07 SI SI201431604T patent/SI3066085T1/sl unknown
- 2014-11-07 CR CR20160252A patent/CR20160252A/es unknown
- 2014-11-07 LT LTEP14812015.7T patent/LT3066085T/lt unknown
- 2014-11-07 EA EA201991770A patent/EA201991770A1/ru unknown
- 2014-11-07 WO PCT/US2014/064531 patent/WO2015070007A1/en active Application Filing
- 2014-11-07 EP EP20169098.9A patent/EP3744715A1/en active Pending
- 2014-11-07 US US14/535,781 patent/US9321755B2/en active Active
- 2014-11-07 CR CR20190351A patent/CR20190351A/es unknown
- 2014-11-07 TW TW111127236A patent/TW202309014A/zh unknown
- 2014-11-07 MX MX2016005954A patent/MX366874B/es active IP Right Grant
- 2014-11-07 PE PE2016000604A patent/PE20160863A1/es unknown
- 2014-11-07 SG SG10201803874PA patent/SG10201803874PA/en unknown
- 2014-11-07 HU HUE14812015A patent/HUE049337T2/hu unknown
- 2014-11-07 CN CN201910026055.2A patent/CN109810104B/zh active Active
- 2014-11-07 BR BR122020009912-7A patent/BR122020009912B1/pt active IP Right Grant
- 2014-11-07 MY MYPI2016000827A patent/MY174254A/en unknown
- 2014-11-07 SG SG11201603433UA patent/SG11201603433UA/en unknown
- 2014-11-07 KR KR1020167015077A patent/KR102370067B1/ko active IP Right Grant
- 2014-11-07 ES ES14812015T patent/ES2799582T3/es active Active
- 2014-11-07 TW TW103138838A patent/TWI651311B/zh active
- 2014-11-07 CA CA2929552A patent/CA2929552C/en active Active
- 2014-11-07 EA EA201690959A patent/EA033667B1/ru unknown
- 2014-11-07 PT PT148120157T patent/PT3066085T/pt unknown
- 2014-11-07 JP JP2016528055A patent/JP6461953B2/ja active Active
- 2014-11-07 EP EP14812015.7A patent/EP3066085B1/en active Active
- 2014-11-07 CN CN201480071825.0A patent/CN105899498B/zh active Active
-
2016
- 2016-04-07 US US15/093,486 patent/US9873688B2/en active Active
- 2016-04-27 IL IL245314A patent/IL245314B/en active IP Right Grant
- 2016-05-02 PH PH12016500818A patent/PH12016500818B1/en unknown
- 2016-05-05 CL CL2016001082A patent/CL2016001082A1/es unknown
- 2016-05-06 MX MX2019008378A patent/MX2019008378A/es unknown
-
2017
- 2017-12-22 US US15/852,995 patent/US10280157B2/en active Active
-
2018
- 2018-10-02 JP JP2018187218A patent/JP6633163B2/ja active Active
-
2019
- 2019-01-21 AU AU2019200404A patent/AU2019200404B2/en active Active
- 2019-04-10 PH PH12019500770A patent/PH12019500770A1/en unknown
- 2019-07-01 IL IL267773A patent/IL267773B/en active IP Right Grant
- 2019-10-07 JP JP2019184577A patent/JP6913725B2/ja active Active
- 2019-10-07 JP JP2019184589A patent/JP6883079B2/ja active Active
-
2020
- 2020-07-13 HR HRP20201089TT patent/HRP20201089T1/hr unknown
- 2020-08-05 CY CY20201100726T patent/CY1123164T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20160863A1 (es) | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa | |
EA201690153A1 (ru) | Замещенные бензофуранильные и бензоксазолильные соединения и их применения | |
CY1119533T1 (el) | Νεοι θεραπευτικοι παραγοντες | |
EA201990001A1 (ru) | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 | |
GT201500334A (es) | Compuestos de 3,4- dihidroisoquinolin-2-(1h)-ilo | |
CU24411B1 (es) | Compuesto derivado de benzamida sustituida con 1,3-tiazol-2-ilo útil para el tratamiento de trastornos neurogénicos | |
EA201691447A1 (ru) | 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 для лечения болезни альцгеймера | |
CO2017009298A2 (es) | Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 | |
CU20150129A7 (es) | Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos | |
PE20151542A1 (es) | Compuestos de tetrahidropirrolotiazina | |
EA201490453A1 (ru) | Замещенные аналоги (e)-n-(1-фенилэтилиден)бензогидразида в качестве ингибиторов деметилазы гистонов | |
CO6680645A2 (es) | Inhibidores de oxadiazol de la producción de leucotrieno | |
CU20160183A7 (es) | Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida | |
EA201591360A1 (ru) | Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств | |
PE20140966A1 (es) | Quinazolincarboxamida azetidinas | |
DOP2016000120A (es) | Nuevos inhibidores de dgat2 | |
EA201590827A1 (ru) | Новые производные пиразина в качестве агонистов каннабиноидного рецептора 2 | |
MX2017012960A (es) | Metodo para producir acilsulfamoilbenzamidas. | |
AR098134A1 (es) | Compuestos de urea | |
TH166656B (th) | กระบวนการสำหรับการสังเคราะห์สารยับยั้งอินโดลเอมีน 2,3-ไดออกซีจีเนสชนิดหนึ่ง | |
TH166656A (th) | กระบวนการสำหรับการสังเคราะห์สารยับยั้งอินโดลเอมีน 2,3-ไดออกซีจีเนสชนิดหนึ่ง | |
UY36023A (es) | “derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil) tetrahidrofuran-2-il)-3-aminopropan-2-ol “. | |
AR099931A1 (es) | Combinaciones de agentes terapéuticos contra cáncer | |
FR2977492B1 (fr) | Nouvelle association entre le n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl) benzofuran-2-ylcarbonylamino]ethoxy}benzamide et le folfox | |
CL2017002313A1 (es) | Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 |