MX2019008378A - Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa. - Google Patents

Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa.

Info

Publication number
MX2019008378A
MX2019008378A MX2019008378A MX2019008378A MX2019008378A MX 2019008378 A MX2019008378 A MX 2019008378A MX 2019008378 A MX2019008378 A MX 2019008378A MX 2019008378 A MX2019008378 A MX 2019008378A MX 2019008378 A MX2019008378 A MX 2019008378A
Authority
MX
Mexico
Prior art keywords
indoleamine
synthesis
dioxygenase inhibitor
dioxygenase
inhibitor
Prior art date
Application number
MX2019008378A
Other languages
English (en)
Inventor
Weng Lingkai
Zhou Jiacheng
Tao Ming
Pan Yongchun
Frietze William
J Meloni David
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX2019008378A publication Critical patent/MX2019008378A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente solicitud se refiere a procesos e intermedios para elaborar 4-({2-[(aminosulfonil)amino]etil}amino)-N-(3-bromo-4-fluo rofenil)-N'-hidroxi-1,2,5-oxadiazol-3-carboximidamida, que es un inhibidor de indolamina 2,3-dioxigenasa útil en el tratamiento del cáncer y otros trastornos.
MX2019008378A 2013-11-08 2016-05-06 Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa. MX2019008378A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361901689P 2013-11-08 2013-11-08

Publications (1)

Publication Number Publication Date
MX2019008378A true MX2019008378A (es) 2019-09-09

Family

ID=52023608

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005954A MX366874B (es) 2013-11-08 2014-11-07 Proceso para la síntesis de un inhibidor de indolamina 2,3-dioxigenasa.
MX2019008378A MX2019008378A (es) 2013-11-08 2016-05-06 Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016005954A MX366874B (es) 2013-11-08 2014-11-07 Proceso para la síntesis de un inhibidor de indolamina 2,3-dioxigenasa.

Country Status (31)

Country Link
US (3) US9321755B2 (es)
EP (2) EP3066085B1 (es)
JP (4) JP6461953B2 (es)
KR (2) KR102370067B1 (es)
CN (2) CN105899498B (es)
AR (1) AR098343A1 (es)
AU (2) AU2014346647B2 (es)
BR (2) BR122020009912B1 (es)
CA (1) CA2929552C (es)
CL (1) CL2016001082A1 (es)
CR (2) CR20160252A (es)
CY (1) CY1123164T1 (es)
DK (1) DK3066085T3 (es)
EA (2) EA201991770A1 (es)
ES (1) ES2799582T3 (es)
HR (1) HRP20201089T1 (es)
HU (1) HUE049337T2 (es)
IL (2) IL245314B (es)
LT (1) LT3066085T (es)
ME (1) ME03792B (es)
MX (2) MX366874B (es)
MY (1) MY174254A (es)
PE (2) PE20220430A1 (es)
PH (2) PH12016500818A1 (es)
PL (1) PL3066085T3 (es)
PT (1) PT3066085T (es)
RS (1) RS60598B1 (es)
SG (2) SG10201803874PA (es)
SI (1) SI3066085T1 (es)
TW (4) TW202309014A (es)
WO (1) WO2015070007A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1879573T1 (sl) 2005-05-10 2013-04-30 Incyte Corporation Experimental Station Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te
NO2824100T3 (es) 2008-07-08 2018-07-21
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
ME03792B (me) 2013-11-08 2021-04-20 Incyte Holdings Corp Postupak sinteze inhibitora indolamin 2,3-dioksigenaze
KR20220153677A (ko) * 2014-02-04 2022-11-18 인사이트 코포레이션 암을 치료하기 위한 pd-1 길항제 및 ido1 억제제의 조합
CA2992238A1 (en) * 2015-07-14 2017-01-19 Kyowa Hakko Kirin Co., Ltd. A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody
MX2018005600A (es) 2015-11-04 2018-11-09 Incyte Corp Composiciones farmaceuticas y metodos para la inhibicion de indolamina 2,3-dioxigenasa e indicaciones para ello.
EP3389783A4 (en) * 2015-12-15 2019-05-15 Merck Sharp & Dohme Corp. NOVEL COMPOUNDS THAN INDOLAMINE-2,3-DIOXYGENASE INHIBITORS
US9624185B1 (en) * 2016-01-20 2017-04-18 Yong Xu Method for preparing IDO inhibitor epacadostat
CN105646389B (zh) * 2016-01-28 2019-06-28 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途
CN107304191B (zh) * 2016-04-20 2023-09-29 上海翰森生物医药科技有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
WO2017181849A1 (zh) * 2016-04-20 2017-10-26 江苏豪森药业集团有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
EP3505517A4 (en) 2016-08-23 2020-01-15 Beijing InnoCare Pharma Tech Co., Ltd. FUSED HETEROCYCLIC DERIVATIVE, ITS PREPARATION METHOD AND ITS MEDICAL USE
CN109952300B (zh) 2016-09-24 2022-01-18 百济神州有限公司 5或8-取代的咪唑并[1,5-a]吡啶
US11168078B2 (en) * 2016-11-28 2021-11-09 Shanghai Fochon Pharmaceutical Co., Ltd. Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase
CN110382508B (zh) 2016-12-22 2022-08-02 卡里塞拉生物科学股份公司 用于抑制精氨酸酶活性的组合物和方法
CN109206380A (zh) * 2017-07-03 2019-01-15 上海时莱生物技术有限公司 吲哚胺2，3-双加氧酶抑制剂化合物及其制备方法和用途
CN110066253B (zh) * 2018-01-24 2023-06-23 江苏柯菲平医药股份有限公司 1,2,5-噁二唑类衍生物，其制备方法及其在医药中的应用
CN108101899B (zh) * 2018-02-11 2021-01-26 中国药科大学 IDO1抑制剂Epacadostat中间体的制备方法
CN109180603A (zh) * 2018-10-10 2019-01-11 中国药科大学 Epacadostat关键中间体的制备方法
AU2020319875A1 (en) 2019-08-01 2022-02-17 Incyte Corporation A dosing regimen for an IDO inhibitor
JP2023501496A (ja) * 2019-11-14 2023-01-18 ノバ サウスイースタン ユニバーシティー Ｆ１６イソインドール小分子を使用する固形腫瘍の治療のための方法及び組成物
CN112341403B (zh) * 2020-11-10 2022-06-28 南京工业大学 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236855A (en) 1964-01-17 1966-02-22 Merck & Co Inc Certain n-phenyl(thiazole-hydroxamidine) compounds and their preparation
US3354174A (en) 1964-02-19 1967-11-21 Sterling Drug Inc 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
US3553228A (en) 1967-09-26 1971-01-05 Colgate Palmolive Co 3-substituted-4h(1)benzopyrano(3,4-d) isoxazoles
DE2040628A1 (de) 1970-08-17 1972-02-24 Fahlberg List Veb Neue herbizide Mittel
US3948928A (en) 1972-03-17 1976-04-06 Dainippon Pharmaceutical Co., Ltd. 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof
JPS5621033B2 (es) 1973-09-05 1981-05-16
GB1501529A (en) 1975-09-11 1978-02-15 Philagro Sa Derivatives of amidoximes
FR2323683A1 (fr) 1975-09-11 1977-04-08 Philagro Sa Nouveaux derives d'amidoximes, leur preparation et les compositions qui les contiennent
US4323681A (en) 1980-09-29 1982-04-06 American Home Products Corporation 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides
JPS58208275A (ja) 1982-05-20 1983-12-03 Lion Corp ５−アミノ−ピラゾ−ル誘導体及び該化合物を含有する抗腫瘍剤
DE3462259D1 (de) 1983-07-22 1987-03-05 Bayer Ag Substituted furazans
US4507485A (en) 1984-01-23 1985-03-26 Bristol-Myers Company 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity
JPS60193968A (ja) 1984-03-13 1985-10-02 Toyo Jozo Co Ltd シクロペンテン環を有するイミダゾ−ルアミドオキシムおよびその製造法
JPS6259283A (ja) 1985-09-10 1987-03-14 Kaken Pharmaceut Co Ltd セフアロスポリン化合物
JP2696342B2 (ja) 1988-06-27 1998-01-14 日本曹達株式会社 アミジン誘導体、その製造方法及び殺ダニ剤・農園芸用殺菌剤
EP0352832B1 (en) 1988-07-05 1992-05-06 Akzo N.V. Compounds with bronchodilator activity
JPH04297449A (ja) 1991-03-27 1992-10-21 Hokko Chem Ind Co Ltd Ｎ−ヒドロキシベンジルグアニジン誘導体および農園芸用殺菌剤
JPH05186458A (ja) 1991-04-26 1993-07-27 Japan Tobacco Inc 新規なベンゾピラン誘導体
FR2677019B1 (fr) 1991-05-27 1994-11-25 Pf Medicament Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
JP2709677B2 (ja) 1992-06-19 1998-02-04 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
FR2720396B1 (fr) 1994-05-27 1996-06-28 Adir Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5731315A (en) 1995-06-07 1998-03-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds
BR9610988A (pt) 1995-10-17 1999-04-06 Astra Pharma Prod Composto uso do mesmo fomulação farmacêutica e processo para produção do composto
WO1997030047A1 (en) 1996-02-17 1997-08-21 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
US5955495A (en) 1996-05-03 1999-09-21 Hoffmann-La Roche Inc. Method of treating diseases of the CNS
JPH11171702A (ja) 1997-09-24 1999-06-29 Takeda Chem Ind Ltd 害虫防除方法
AU1628599A (en) 1997-12-05 1999-06-28 Medical College Of Georgia Research Institute, Inc. Regulation of t cell-mediated immunity by tryptophan
ES2213929T3 (es) 1997-12-10 2004-09-01 Dainippon Ink And Chemicals, Inc. Derivados de oximas y productos quimicos para uso agricola que incluyen los mismos.
AR018424A1 (es) 1998-06-02 2001-11-14 Sumitomo Chem Takeda Agro Co Compuesto oxadiazolina, composicion agroquimica que lo comprende y uso del mismo para la preparacion de dicha composicion
FR2784678B1 (fr) 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
CN100354271C (zh) 1999-03-03 2007-12-12 三进制药株式会社 哌嗪衍生物及其制备方法
EP1165601A2 (de) 1999-04-09 2002-01-02 Basf Aktiengesellschaft Prodrugs von thrombininhibitoren
CN1164574C (zh) 1999-05-24 2004-09-01 三菱制药株式会社 苯氧基丙胺类化合物
JP2001158785A (ja) 1999-11-30 2001-06-12 Takeda Chem Ind Ltd 農薬組成物
JP2001158786A (ja) 1999-11-30 2001-06-12 Takeda Chem Ind Ltd 哺乳動物の外部寄生虫防除剤
CA2397575A1 (en) 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
JP2001233861A (ja) 2000-02-22 2001-08-28 Ube Ind Ltd ピラゾールオキシム化合物、その製法及び用途
PT1294358E (pt) 2000-06-28 2004-12-31 Smithkline Beecham Plc Processo de moagem por via humida
GB0108102D0 (en) 2001-03-30 2001-05-23 Pfizer Ltd Compounds
CZ20033475A3 (en) 2001-06-18 2004-05-12 Appliedáresearchásystemsáarsáholdingán@V Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists.
JP2005529850A (ja) 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
GB0208224D0 (en) 2002-04-10 2002-05-22 Celltech R&D Ltd Chemical compounds
WO2003087347A1 (en) 2002-04-12 2003-10-23 Medical College Of Georgia Research Institute, Inc. Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
BR0311419A (pt) 2002-05-28 2005-04-05 Dimensional Pharm Inc Amidinas de tiofeno suas composições e métodos de tratamento de doenças e condições mediadas por complemento
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7015321B2 (en) * 2002-10-12 2006-03-21 The Scripps Research Institute Synthesis of non-symmetrical sulfamides using burgess-type reagents
JP2006521377A (ja) 2003-03-27 2006-09-21 ランケナー インスティテュート フォー メディカル リサーチ 新型ｉｄｏ阻害剤とその使用方法
US7598287B2 (en) 2003-04-01 2009-10-06 Medical College Of Georgia Research Institute, Inc. Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
US7157476B2 (en) 2003-08-20 2007-01-02 Vertex Pharmaceuticals Incorporated Aminofurazan compounds useful as protein kinase inhibitors
DE10348022A1 (de) 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
DE10348023A1 (de) 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
US7151097B2 (en) * 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
PL1801108T3 (pl) 2004-09-08 2013-04-30 Mitsubishi Tanabe Pharma Corp Związki morfolinowe do leczenia stanów zapalnych
US8193359B2 (en) 2004-12-24 2012-06-05 Prosidion Limited G-protein coupled receptor agonists
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
SI1879573T1 (sl) * 2005-05-10 2013-04-30 Incyte Corporation Experimental Station Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te
WO2006133417A1 (en) 2005-06-07 2006-12-14 Valeant Pharmaceuticals International Phenylamino isothiazole carboxamidines as mek inhibitors
KR20080026198A (ko) 2005-06-30 2008-03-24 안트로제네시스 코포레이션 태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원
DE102005060466A1 (de) 2005-12-17 2007-06-28 Bayer Cropscience Ag Carboxamide
ES2540561T3 (es) 2005-12-20 2015-07-10 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa
US20070203140A1 (en) 2006-02-09 2007-08-30 Combs Andrew P N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
JP4297449B2 (ja) 2006-05-12 2009-07-15 株式会社サクラクレパス 墨汁
US20080146624A1 (en) 2006-09-19 2008-06-19 Incyte Corporation Amidines as modulators of indoleamine 2,3-dioxygenase
WO2008036643A2 (en) 2006-09-19 2008-03-27 Incyte Corporation Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
JP5319532B2 (ja) 2006-09-19 2013-10-16 インサイト・コーポレイション インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロサイクル
WO2008058178A1 (en) * 2006-11-08 2008-05-15 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
CA2709784A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009128521A1 (ja) * 2008-04-15 2009-10-22 帝人ファーマ株式会社 システインプロテアーゼ阻害剤
NO2824100T3 (es) 2008-07-08 2018-07-21
ME03792B (me) 2013-11-08 2021-04-20 Incyte Holdings Corp Postupak sinteze inhibitora indolamin 2,3-dioksigenaze

Also Published As

Publication number Publication date
CA2929552A1 (en) 2015-05-14
IL267773B (en) 2020-04-30
EP3066085A1 (en) 2016-09-14
US9321755B2 (en) 2016-04-26
PH12016500818B1 (en) 2016-06-20
US20180244663A1 (en) 2018-08-30
SI3066085T1 (sl) 2020-08-31
PE20220430A1 (es) 2022-03-29
AU2019200404A1 (en) 2019-02-07
CN105899498B (zh) 2019-01-25
JP2019038811A (ja) 2019-03-14
MX366874B (es) 2019-07-29
AU2014346647A1 (en) 2016-05-26
CA2929552C (en) 2022-05-17
SG11201603433UA (en) 2016-05-30
SG10201803874PA (en) 2018-07-30
RS60598B1 (sr) 2020-08-31
CR20160252A (es) 2016-09-19
US9873688B2 (en) 2018-01-23
AU2019200404B2 (en) 2021-03-04
MX2016005954A (es) 2016-12-07
KR102370067B1 (ko) 2022-03-04
DK3066085T3 (da) 2020-06-02
JP2020019805A (ja) 2020-02-06
KR102617531B1 (ko) 2023-12-27
CL2016001082A1 (es) 2016-12-09
KR20210126157A (ko) 2021-10-19
EA033667B1 (ru) 2019-11-14
US20150133674A1 (en) 2015-05-14
ME03792B (me) 2021-04-20
JP6633163B2 (ja) 2020-01-22
AU2014346647B2 (en) 2018-10-25
US10280157B2 (en) 2019-05-07
TW202309014A (zh) 2023-03-01
EP3066085B1 (en) 2020-05-13
BR122020009912B1 (pt) 2022-11-01
MY174254A (en) 2020-04-01
TWI696618B (zh) 2020-06-21
IL245314B (en) 2019-07-31
JP6913725B2 (ja) 2021-08-04
TWI775079B (zh) 2022-08-21
TW201920158A (zh) 2019-06-01
KR20160094971A (ko) 2016-08-10
EA201991770A1 (ru) 2019-12-30
CN109810104A (zh) 2019-05-28
NZ719822A (en) 2021-11-26
PE20160863A1 (es) 2016-09-03
CR20190351A (es) 2019-10-07
PH12019500770A1 (en) 2020-09-21
CN109810104B (zh) 2022-05-03
TW201605817A (zh) 2016-02-16
JP6461953B2 (ja) 2019-01-30
EA201690959A1 (ru) 2016-08-31
ES2799582T3 (es) 2020-12-18
CN105899498A (zh) 2016-08-24
TW202100523A (zh) 2021-01-01
PL3066085T3 (pl) 2020-11-02
WO2015070007A1 (en) 2015-05-14
JP2020019806A (ja) 2020-02-06
PH12016500818A1 (en) 2016-06-20
EP3744715A1 (en) 2020-12-02
AR098343A1 (es) 2016-05-26
HRP20201089T1 (hr) 2020-10-30
IL267773A (en) 2019-09-26
HUE049337T2 (hu) 2020-09-28
LT3066085T (lt) 2020-06-25
TWI651311B (zh) 2019-02-21
US20160221996A1 (en) 2016-08-04
JP6883079B2 (ja) 2021-06-09
IL245314A0 (en) 2016-06-30
JP2017500284A (ja) 2017-01-05
PT3066085T (pt) 2020-07-16
BR112016009786B1 (pt) 2021-01-05
CY1123164T1 (el) 2021-10-29

Similar Documents

Publication Publication Date Title
PH12019500770A1 (en) Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
SA519401020B1 (ar) مركبات n-(فينيل سلفونيل)بنزاميد والمركبات ذات الصلة كمثبطات لبروتين ليمفوما الخلية البائية 2
MX2019002303A (es) Inhibidores de procesos metabolicos celulares.
NZ630196A (en) Cyclic amides as metap-2 inhibitors
MY165620A (en) Cyclopropylamines as lsd1 inhibitors
MD20160106A2 (ro) Compuşi aril sau heteroaril biciclici condensaţi şi utilizarea acestora ca inhibitori IRAK4
EA201792028A1 (ru) Альфа-цинамидные соединения и композиции как ингибиторы hdac8
MX2017006048A (es) 2-amino-3,5-difluoro-3,6-dimetil-6-fenil-3,4,5,6-tetrahidropiridi nas en calidad de inhibidores de bace1 para tratar enfermedad de alzheimer.
EA201790085A1 (ru) Ингибиторы лизин-специфической деметилазы-1
EA201490493A1 (ru) Пирано[3,2-d][1,3]тиазол в качестве ингибиторов гликозидазы
GEP20196949B (en) 2-amino-6-(difluoromethyl)-5, 5-difluoro-6-phenyl-3, 4, 5, 6-tetra- hydropyridines as bace1 inhibitors
MX2011006006A (es) Compuestos, composicion farmaceutica y metodos para utilizarse en el tratamiento de trastornos metabolicos.
EA201791030A1 (ru) 2-амино-5,5-дифтор-6-(фторметил)-6-фенил-3,4,5,6-тетрагидпропиридины в качестве ингибиторов bace1
MX2021015656A (es) Formas amorfas y cristalinas de inhibidores de indolamina 2,3-dioxigenasa (ido).
MD20160105A2 (ro) 2-Amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8H)-il-1,3-tiazol-4-il amide
DOP2016000120A (es) Nuevos inhibidores de dgat2
BR112015011974A2 (pt) derivados de azaquinazolina carboxamida
EA201170672A1 (ru) Соединения, пригодные для лечения целлюлита
MX359556B (es) Acido 2-[5-[n-(4-fluorofenil)carbamoíl]pirimidin-2-ilsulfanilmetil ]-4-(trifluorometoxi)fenil]borónico.
EA201891761A1 (ru) Новые биароматические соединения пропинила, фармацевтические и косметические композиции, их содержащие, и их применение
AR099931A1 (es) Combinaciones de agentes terapéuticos contra cáncer
TH166656A (th) กระบวนการสำหรับการสังเคราะห์สารยับยั้งอินโดลเอมีน 2,3-ไดออกซีจีเนสชนิดหนึ่ง
EA201990556A1 (ru) Ингибиторы клеточных метаболических процессов
EA202092082A1 (ru) Соединения аминопиразиндиола как ингибиторы pi3k-
PH12019500368A1 (en) Inhibitors of cellular metabolic processes