PE20220430A1 - PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA - Google Patents
PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASAInfo
- Publication number
- PE20220430A1 PE20220430A1 PE2021001747A PE2021001747A PE20220430A1 PE 20220430 A1 PE20220430 A1 PE 20220430A1 PE 2021001747 A PE2021001747 A PE 2021001747A PE 2021001747 A PE2021001747 A PE 2021001747A PE 20220430 A1 PE20220430 A1 PE 20220430A1
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- compound
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- amino
- carboximidamide
- oxadiazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente solicitud se refiere a procesos e intermedios para elaborar 4-({2-[(aminosulfonil)amino]etil}amino)-N-(3- bromo-4-fluorofenil)-N'-hidroxi-1,2,5-oxadiazol-3- carboximidamida (compuesto de Fomula I), que es un inhibidor de indolamina 2,3- dioxigenasa util en el tratamiento del cancer y otros trastornos. Esta referida a un proceso que comprende hacer reaccionar un compuesto de la Formula F5 con un aldehido de la Formula F6, donde Pg1 es etoxicarbonilo, terc-butoxicarbonilo, benciloxicarbonilo o 9-fluorenilmetiloxicarbonilo, para proporcionar un compuesto de la Formula F7. Tambien comprende adicionalmente desproteger dicho compuesto de la Formula F7 para proporcionar un compuesto de la Formula F8, el que se hace reaccionar posteriormente con Pg2 -NH-SO2-X, en presencia de una base organica para proporcionar un compuesto de la Formula F9. Este compuesto es desprotegido para proporcionar un compuesto de la Formula F10, el cual se hace reaccionar con hidroxido de sodio para proporcionar un compuesto de la Formula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201361901689P | 2013-11-08 | 2013-11-08 | |
PCT/US2014/064531 WO2015070007A1 (en) | 2013-11-08 | 2014-11-07 | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
Publications (1)
Publication Number | Publication Date |
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PE20220430A1 true PE20220430A1 (es) | 2022-03-29 |
Family
ID=52023608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021001747A PE20220430A1 (es) | 2013-11-08 | 2014-11-07 | PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA |
PE2016000604A PE20160863A1 (es) | 2013-11-08 | 2014-11-07 | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000604A PE20160863A1 (es) | 2013-11-08 | 2014-11-07 | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
Country Status (31)
Country | Link |
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US (3) | US9321755B2 (es) |
EP (2) | EP3744715A1 (es) |
JP (4) | JP6461953B2 (es) |
KR (2) | KR102617531B1 (es) |
CN (2) | CN109810104B (es) |
AR (1) | AR098343A1 (es) |
AU (2) | AU2014346647B2 (es) |
BR (2) | BR122020009912B1 (es) |
CA (1) | CA2929552C (es) |
CL (1) | CL2016001082A1 (es) |
CR (2) | CR20190351A (es) |
CY (1) | CY1123164T1 (es) |
DK (1) | DK3066085T3 (es) |
EA (2) | EA201991770A1 (es) |
ES (1) | ES2799582T3 (es) |
HR (1) | HRP20201089T1 (es) |
HU (1) | HUE049337T2 (es) |
IL (2) | IL245314B (es) |
LT (1) | LT3066085T (es) |
ME (1) | ME03792B (es) |
MX (2) | MX366874B (es) |
MY (1) | MY174254A (es) |
PE (2) | PE20220430A1 (es) |
PH (2) | PH12016500818B1 (es) |
PL (1) | PL3066085T3 (es) |
PT (1) | PT3066085T (es) |
RS (1) | RS60598B1 (es) |
SG (2) | SG11201603433UA (es) |
SI (1) | SI3066085T1 (es) |
TW (4) | TWI696618B (es) |
WO (1) | WO2015070007A1 (es) |
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CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
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CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
WO2009128521A1 (ja) * | 2008-04-15 | 2009-10-22 | 帝人ファーマ株式会社 | システインプロテアーゼ阻害剤 |
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