PE20220430A1 - PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA - Google Patents
PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASAInfo
- Publication number
- PE20220430A1 PE20220430A1 PE2021001747A PE2021001747A PE20220430A1 PE 20220430 A1 PE20220430 A1 PE 20220430A1 PE 2021001747 A PE2021001747 A PE 2021001747A PE 2021001747 A PE2021001747 A PE 2021001747A PE 20220430 A1 PE20220430 A1 PE 20220430A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- amino
- carboximidamide
- oxadiazole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente solicitud se refiere a procesos e intermedios para elaborar 4-({2-[(aminosulfonil)amino]etil}amino)-N-(3- bromo-4-fluorofenil)-N'-hidroxi-1,2,5-oxadiazol-3- carboximidamida (compuesto de Fomula I), que es un inhibidor de indolamina 2,3- dioxigenasa util en el tratamiento del cancer y otros trastornos. Esta referida a un proceso que comprende hacer reaccionar un compuesto de la Formula F5 con un aldehido de la Formula F6, donde Pg1 es etoxicarbonilo, terc-butoxicarbonilo, benciloxicarbonilo o 9-fluorenilmetiloxicarbonilo, para proporcionar un compuesto de la Formula F7. Tambien comprende adicionalmente desproteger dicho compuesto de la Formula F7 para proporcionar un compuesto de la Formula F8, el que se hace reaccionar posteriormente con Pg2 -NH-SO2-X, en presencia de una base organica para proporcionar un compuesto de la Formula F9. Este compuesto es desprotegido para proporcionar un compuesto de la Formula F10, el cual se hace reaccionar con hidroxido de sodio para proporcionar un compuesto de la Formula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361901689P | 2013-11-08 | 2013-11-08 | |
PCT/US2014/064531 WO2015070007A1 (en) | 2013-11-08 | 2014-11-07 | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20220430A1 true PE20220430A1 (es) | 2022-03-29 |
Family
ID=52023608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021001747A PE20220430A1 (es) | 2013-11-08 | 2014-11-07 | PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA |
PE2016000604A PE20160863A1 (es) | 2013-11-08 | 2014-11-07 | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000604A PE20160863A1 (es) | 2013-11-08 | 2014-11-07 | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
Country Status (31)
Country | Link |
---|---|
US (3) | US9321755B2 (es) |
EP (2) | EP3066085B1 (es) |
JP (4) | JP6461953B2 (es) |
KR (2) | KR102370067B1 (es) |
CN (2) | CN105899498B (es) |
AR (1) | AR098343A1 (es) |
AU (2) | AU2014346647B2 (es) |
BR (2) | BR122020009912B1 (es) |
CA (1) | CA2929552C (es) |
CL (1) | CL2016001082A1 (es) |
CR (2) | CR20160252A (es) |
CY (1) | CY1123164T1 (es) |
DK (1) | DK3066085T3 (es) |
EA (2) | EA201991770A1 (es) |
ES (1) | ES2799582T3 (es) |
HR (1) | HRP20201089T1 (es) |
HU (1) | HUE049337T2 (es) |
IL (2) | IL245314B (es) |
LT (1) | LT3066085T (es) |
ME (1) | ME03792B (es) |
MX (2) | MX366874B (es) |
MY (1) | MY174254A (es) |
PE (2) | PE20220430A1 (es) |
PH (2) | PH12016500818A1 (es) |
PL (1) | PL3066085T3 (es) |
PT (1) | PT3066085T (es) |
RS (1) | RS60598B1 (es) |
SG (2) | SG10201803874PA (es) |
SI (1) | SI3066085T1 (es) |
TW (4) | TW202309014A (es) |
WO (1) | WO2015070007A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1879573T1 (sl) | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
NO2824100T3 (es) | 2008-07-08 | 2018-07-21 | ||
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
ME03792B (me) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Postupak sinteze inhibitora indolamin 2,3-dioksigenaze |
KR20220153677A (ko) * | 2014-02-04 | 2022-11-18 | 인사이트 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 ido1 억제제의 조합 |
CA2992238A1 (en) * | 2015-07-14 | 2017-01-19 | Kyowa Hakko Kirin Co., Ltd. | A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody |
MX2018005600A (es) | 2015-11-04 | 2018-11-09 | Incyte Corp | Composiciones farmaceuticas y metodos para la inhibicion de indolamina 2,3-dioxigenasa e indicaciones para ello. |
EP3389783A4 (en) * | 2015-12-15 | 2019-05-15 | Merck Sharp & Dohme Corp. | NOVEL COMPOUNDS THAN INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
US9624185B1 (en) * | 2016-01-20 | 2017-04-18 | Yong Xu | Method for preparing IDO inhibitor epacadostat |
CN105646389B (zh) * | 2016-01-28 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途 |
CN107304191B (zh) * | 2016-04-20 | 2023-09-29 | 上海翰森生物医药科技有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
WO2017181849A1 (zh) * | 2016-04-20 | 2017-10-26 | 江苏豪森药业集团有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
EP3505517A4 (en) | 2016-08-23 | 2020-01-15 | Beijing InnoCare Pharma Tech Co., Ltd. | FUSED HETEROCYCLIC DERIVATIVE, ITS PREPARATION METHOD AND ITS MEDICAL USE |
CN109952300B (zh) | 2016-09-24 | 2022-01-18 | 百济神州有限公司 | 5或8-取代的咪唑并[1,5-a]吡啶 |
US11168078B2 (en) * | 2016-11-28 | 2021-11-09 | Shanghai Fochon Pharmaceutical Co., Ltd. | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase |
CN110382508B (zh) | 2016-12-22 | 2022-08-02 | 卡里塞拉生物科学股份公司 | 用于抑制精氨酸酶活性的组合物和方法 |
CN109206380A (zh) * | 2017-07-03 | 2019-01-15 | 上海时莱生物技术有限公司 | 吲哚胺2,3-双加氧酶抑制剂化合物及其制备方法和用途 |
CN110066253B (zh) * | 2018-01-24 | 2023-06-23 | 江苏柯菲平医药股份有限公司 | 1,2,5-噁二唑类衍生物,其制备方法及其在医药中的应用 |
CN108101899B (zh) * | 2018-02-11 | 2021-01-26 | 中国药科大学 | IDO1抑制剂Epacadostat中间体的制备方法 |
CN109180603A (zh) * | 2018-10-10 | 2019-01-11 | 中国药科大学 | Epacadostat关键中间体的制备方法 |
AU2020319875A1 (en) | 2019-08-01 | 2022-02-17 | Incyte Corporation | A dosing regimen for an IDO inhibitor |
JP2023501496A (ja) * | 2019-11-14 | 2023-01-18 | ノバ サウスイースタン ユニバーシティー | F16イソインドール小分子を使用する固形腫瘍の治療のための方法及び組成物 |
CN112341403B (zh) * | 2020-11-10 | 2022-06-28 | 南京工业大学 | 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法 |
EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
BR112023017582A2 (pt) | 2021-03-05 | 2023-12-05 | Univ Basel | Composições para o tratamento de doenças ou condições associadas ao ebv |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236855A (en) | 1964-01-17 | 1966-02-22 | Merck & Co Inc | Certain n-phenyl(thiazole-hydroxamidine) compounds and their preparation |
US3354174A (en) | 1964-02-19 | 1967-11-21 | Sterling Drug Inc | 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines |
US3553228A (en) | 1967-09-26 | 1971-01-05 | Colgate Palmolive Co | 3-substituted-4h(1)benzopyrano(3,4-d) isoxazoles |
DE2040628A1 (de) | 1970-08-17 | 1972-02-24 | Fahlberg List Veb | Neue herbizide Mittel |
US3948928A (en) | 1972-03-17 | 1976-04-06 | Dainippon Pharmaceutical Co., Ltd. | 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof |
JPS5621033B2 (es) | 1973-09-05 | 1981-05-16 | ||
GB1501529A (en) | 1975-09-11 | 1978-02-15 | Philagro Sa | Derivatives of amidoximes |
FR2323683A1 (fr) | 1975-09-11 | 1977-04-08 | Philagro Sa | Nouveaux derives d'amidoximes, leur preparation et les compositions qui les contiennent |
US4323681A (en) | 1980-09-29 | 1982-04-06 | American Home Products Corporation | 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides |
JPS58208275A (ja) | 1982-05-20 | 1983-12-03 | Lion Corp | 5−アミノ−ピラゾ−ル誘導体及び該化合物を含有する抗腫瘍剤 |
DE3462259D1 (de) | 1983-07-22 | 1987-03-05 | Bayer Ag | Substituted furazans |
US4507485A (en) | 1984-01-23 | 1985-03-26 | Bristol-Myers Company | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity |
JPS60193968A (ja) | 1984-03-13 | 1985-10-02 | Toyo Jozo Co Ltd | シクロペンテン環を有するイミダゾ−ルアミドオキシムおよびその製造法 |
JPS6259283A (ja) | 1985-09-10 | 1987-03-14 | Kaken Pharmaceut Co Ltd | セフアロスポリン化合物 |
JP2696342B2 (ja) | 1988-06-27 | 1998-01-14 | 日本曹達株式会社 | アミジン誘導体、その製造方法及び殺ダニ剤・農園芸用殺菌剤 |
EP0352832B1 (en) | 1988-07-05 | 1992-05-06 | Akzo N.V. | Compounds with bronchodilator activity |
JPH04297449A (ja) | 1991-03-27 | 1992-10-21 | Hokko Chem Ind Co Ltd | N−ヒドロキシベンジルグアニジン誘導体および農園芸用殺菌剤 |
JPH05186458A (ja) | 1991-04-26 | 1993-07-27 | Japan Tobacco Inc | 新規なベンゾピラン誘導体 |
FR2677019B1 (fr) | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
JP2709677B2 (ja) | 1992-06-19 | 1998-02-04 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
FR2720396B1 (fr) | 1994-05-27 | 1996-06-28 | Adir | Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5731315A (en) | 1995-06-07 | 1998-03-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds |
BR9610988A (pt) | 1995-10-17 | 1999-04-06 | Astra Pharma Prod | Composto uso do mesmo fomulação farmacêutica e processo para produção do composto |
WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
US5955495A (en) | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
JPH11171702A (ja) | 1997-09-24 | 1999-06-29 | Takeda Chem Ind Ltd | 害虫防除方法 |
AU1628599A (en) | 1997-12-05 | 1999-06-28 | Medical College Of Georgia Research Institute, Inc. | Regulation of t cell-mediated immunity by tryptophan |
ES2213929T3 (es) | 1997-12-10 | 2004-09-01 | Dainippon Ink And Chemicals, Inc. | Derivados de oximas y productos quimicos para uso agricola que incluyen los mismos. |
AR018424A1 (es) | 1998-06-02 | 2001-11-14 | Sumitomo Chem Takeda Agro Co | Compuesto oxadiazolina, composicion agroquimica que lo comprende y uso del mismo para la preparacion de dicha composicion |
FR2784678B1 (fr) | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
CN100354271C (zh) | 1999-03-03 | 2007-12-12 | 三进制药株式会社 | 哌嗪衍生物及其制备方法 |
EP1165601A2 (de) | 1999-04-09 | 2002-01-02 | Basf Aktiengesellschaft | Prodrugs von thrombininhibitoren |
CN1164574C (zh) | 1999-05-24 | 2004-09-01 | 三菱制药株式会社 | 苯氧基丙胺类化合物 |
JP2001158785A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 農薬組成物 |
JP2001158786A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 哺乳動物の外部寄生虫防除剤 |
CA2397575A1 (en) | 2000-01-13 | 2001-07-19 | Tularik Inc. | Antibacterial agents |
JP2001233861A (ja) | 2000-02-22 | 2001-08-28 | Ube Ind Ltd | ピラゾールオキシム化合物、その製法及び用途 |
PT1294358E (pt) | 2000-06-28 | 2004-12-31 | Smithkline Beecham Plc | Processo de moagem por via humida |
GB0108102D0 (en) | 2001-03-30 | 2001-05-23 | Pfizer Ltd | Compounds |
CZ20033475A3 (en) | 2001-06-18 | 2004-05-12 | Appliedáresearchásystemsáarsáholdingán@V | Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists. |
JP2005529850A (ja) | 2002-02-19 | 2005-10-06 | ファルマシア・イタリア・エス・ピー・エー | 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用 |
GB0208224D0 (en) | 2002-04-10 | 2002-05-22 | Celltech R&D Ltd | Chemical compounds |
WO2003087347A1 (en) | 2002-04-12 | 2003-10-23 | Medical College Of Georgia Research Institute, Inc. | Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance |
BR0311419A (pt) | 2002-05-28 | 2005-04-05 | Dimensional Pharm Inc | Amidinas de tiofeno suas composições e métodos de tratamento de doenças e condições mediadas por complemento |
US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7015321B2 (en) * | 2002-10-12 | 2006-03-21 | The Scripps Research Institute | Synthesis of non-symmetrical sulfamides using burgess-type reagents |
JP2006521377A (ja) | 2003-03-27 | 2006-09-21 | ランケナー インスティテュート フォー メディカル リサーチ | 新型ido阻害剤とその使用方法 |
US7598287B2 (en) | 2003-04-01 | 2009-10-06 | Medical College Of Georgia Research Institute, Inc. | Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities |
US7157476B2 (en) | 2003-08-20 | 2007-01-02 | Vertex Pharmaceuticals Incorporated | Aminofurazan compounds useful as protein kinase inhibitors |
DE10348022A1 (de) | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
PL1801108T3 (pl) | 2004-09-08 | 2013-04-30 | Mitsubishi Tanabe Pharma Corp | Związki morfolinowe do leczenia stanów zapalnych |
US8193359B2 (en) | 2004-12-24 | 2012-06-05 | Prosidion Limited | G-protein coupled receptor agonists |
US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
SI1879573T1 (sl) * | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
WO2006133417A1 (en) | 2005-06-07 | 2006-12-14 | Valeant Pharmaceuticals International | Phenylamino isothiazole carboxamidines as mek inhibitors |
KR20080026198A (ko) | 2005-06-30 | 2008-03-24 | 안트로제네시스 코포레이션 | 태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원 |
DE102005060466A1 (de) | 2005-12-17 | 2007-06-28 | Bayer Cropscience Ag | Carboxamide |
ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
US20070203140A1 (en) | 2006-02-09 | 2007-08-30 | Combs Andrew P | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
JP4297449B2 (ja) | 2006-05-12 | 2009-07-15 | 株式会社サクラクレパス | 墨汁 |
US20080146624A1 (en) | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
WO2008036643A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
JP5319532B2 (ja) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロサイクル |
WO2008058178A1 (en) * | 2006-11-08 | 2008-05-15 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
KR20090094125A (ko) | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Lxr 및 fxr 조절자 |
CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
WO2009128521A1 (ja) * | 2008-04-15 | 2009-10-22 | 帝人ファーマ株式会社 | システインプロテアーゼ阻害剤 |
NO2824100T3 (es) | 2008-07-08 | 2018-07-21 | ||
ME03792B (me) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Postupak sinteze inhibitora indolamin 2,3-dioksigenaze |
-
2014
- 2014-11-07 ME MEP-2020-146A patent/ME03792B/me unknown
- 2014-11-07 US US14/535,781 patent/US9321755B2/en active Active
- 2014-11-07 RS RS20200798A patent/RS60598B1/sr unknown
- 2014-11-07 ES ES14812015T patent/ES2799582T3/es active Active
- 2014-11-07 LT LTEP14812015.7T patent/LT3066085T/lt unknown
- 2014-11-07 CN CN201480071825.0A patent/CN105899498B/zh active Active
- 2014-11-07 CR CR20160252A patent/CR20160252A/es unknown
- 2014-11-07 EA EA201991770A patent/EA201991770A1/ru unknown
- 2014-11-07 HU HUE14812015A patent/HUE049337T2/hu unknown
- 2014-11-07 JP JP2016528055A patent/JP6461953B2/ja active Active
- 2014-11-07 BR BR122020009912-7A patent/BR122020009912B1/pt active IP Right Grant
- 2014-11-07 CR CR20190351A patent/CR20190351A/es unknown
- 2014-11-07 WO PCT/US2014/064531 patent/WO2015070007A1/en active Application Filing
- 2014-11-07 TW TW111127236A patent/TW202309014A/zh unknown
- 2014-11-07 TW TW108102217A patent/TWI696618B/zh active
- 2014-11-07 MX MX2016005954A patent/MX366874B/es active IP Right Grant
- 2014-11-07 MY MYPI2016000827A patent/MY174254A/en unknown
- 2014-11-07 PE PE2021001747A patent/PE20220430A1/es unknown
- 2014-11-07 KR KR1020167015077A patent/KR102370067B1/ko active IP Right Grant
- 2014-11-07 SG SG10201803874PA patent/SG10201803874PA/en unknown
- 2014-11-07 BR BR112016009786-6A patent/BR112016009786B1/pt active IP Right Grant
- 2014-11-07 SG SG11201603433UA patent/SG11201603433UA/en unknown
- 2014-11-07 PL PL14812015T patent/PL3066085T3/pl unknown
- 2014-11-07 TW TW109116698A patent/TWI775079B/zh active
- 2014-11-07 CN CN201910026055.2A patent/CN109810104B/zh active Active
- 2014-11-07 EP EP14812015.7A patent/EP3066085B1/en active Active
- 2014-11-07 PE PE2016000604A patent/PE20160863A1/es unknown
- 2014-11-07 TW TW103138838A patent/TWI651311B/zh active
- 2014-11-07 EP EP20169098.9A patent/EP3744715A1/en active Pending
- 2014-11-07 EA EA201690959A patent/EA033667B1/ru unknown
- 2014-11-07 KR KR1020217032616A patent/KR102617531B1/ko active IP Right Grant
- 2014-11-07 DK DK14812015.7T patent/DK3066085T3/da active
- 2014-11-07 SI SI201431604T patent/SI3066085T1/sl unknown
- 2014-11-07 AR ARP140104196A patent/AR098343A1/es unknown
- 2014-11-07 AU AU2014346647A patent/AU2014346647B2/en active Active
- 2014-11-07 CA CA2929552A patent/CA2929552C/en active Active
- 2014-11-07 PT PT148120157T patent/PT3066085T/pt unknown
-
2016
- 2016-04-07 US US15/093,486 patent/US9873688B2/en active Active
- 2016-04-27 IL IL245314A patent/IL245314B/en active IP Right Grant
- 2016-05-02 PH PH12016500818A patent/PH12016500818A1/en unknown
- 2016-05-05 CL CL2016001082A patent/CL2016001082A1/es unknown
- 2016-05-06 MX MX2019008378A patent/MX2019008378A/es unknown
-
2017
- 2017-12-22 US US15/852,995 patent/US10280157B2/en active Active
-
2018
- 2018-10-02 JP JP2018187218A patent/JP6633163B2/ja active Active
-
2019
- 2019-01-21 AU AU2019200404A patent/AU2019200404B2/en active Active
- 2019-04-10 PH PH12019500770A patent/PH12019500770A1/en unknown
- 2019-07-01 IL IL267773A patent/IL267773B/en active IP Right Grant
- 2019-10-07 JP JP2019184589A patent/JP6883079B2/ja active Active
- 2019-10-07 JP JP2019184577A patent/JP6913725B2/ja active Active
-
2020
- 2020-07-13 HR HRP20201089TT patent/HRP20201089T1/hr unknown
- 2020-08-05 CY CY20201100726T patent/CY1123164T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20220430A1 (es) | PROCESO PARA LA SINTESIS DE 4-({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENILl)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA UN INHIBIDOR DE INDOLAMINA 2,3-DIOXIGENASA | |
PE20160654A1 (es) | Compuestos de inhibidor de autotaxina | |
CO6430460A2 (es) | Compuestos tetraciclicos | |
SV2016005229A (es) | Inhibidores de syk | |
UY30588A1 (es) | Compuestos de 4-metilpiridopirimidinona | |
CO6680645A2 (es) | Inhibidores de oxadiazol de la producción de leucotrieno | |
SV2009002865A (es) | Uso de oxazolidinonas para el tratamiento y profilaxis de microangiopatias | |
EA201690153A1 (ru) | Замещенные бензофуранильные и бензоксазолильные соединения и их применения | |
PE20151542A1 (es) | Compuestos de tetrahidropirrolotiazina | |
ECSP10010271A (es) | Derivados de tiazol usados como inhibidores de pi 3-cinasa | |
UY32096A (es) | Derivados de 2-carboxamida - cicloamino - urea especìficos, sus sales farmacèuticamente aceptables, composiciones contenièndolos, pro-farmacos de los mismos, procesos para su produciòn y aplicaciones | |
PE20210549A1 (es) | Derivado de amino-metil piperidina como inhibidor de quinasa | |
EA201000884A1 (ru) | Производные 1,2-дизамещенного 4-бензиламинопирролидина в качестве ингибиторов белка-переносчика холестерилового эфира, используемые для лечения заболеваний, таких как гиперлипидемия или артериосклероз | |
AR077080A1 (es) | Compuestos de 2,3-dihidro-1h-indeno | |
CL2014000441A1 (es) | Una entidad quimica que comprende el compuesto sulfamato de {(1s,2s,4r)-4-[(6-{[(1r,2s)-5-cloro-2-metoxi-2,3-dihidro-1h-inden-1-il]amino}pirimidin-4-il)oxi]-2-hidroxiciclopentil}metilo; inhibidor de la activacion de la enzima nedd-8; forma cristalina i; profarmaco del compuesto; composicion farmaceutica; un metodo para tratar el cancer. | |
AR085308A1 (es) | Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzimidazol-2-il]urea | |
AR080204A1 (es) | Procesos para preparar ciclopropilamidas e intermedios asociados con estas | |
BR112023012947A2 (pt) | Inibidores de lrrk2 | |
UY32042A (es) | Compuestos de 2-aminopirimidina como potentes inhibidores de hsp-90 | |
GT200600102A (es) | Procedimiento para la preparacion de compuestos benzoxazol sustituidos | |
AR076407A1 (es) | Un proceso para la preparacion de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamilmetil)piperidin-4-il]oxi}quinazolina e intermediarios utilizados en el mismo. | |
AR107672A1 (es) | Proceso para la fabricación de derivados de 3-piperazin-1-il-propilamina | |
TH166656A (th) | กระบวนการสำหรับการสังเคราะห์สารยับยั้งอินโดลเอมีน 2,3-ไดออกซีจีเนสชนิดหนึ่ง | |
TH166656B (th) | กระบวนการสำหรับการสังเคราะห์สารยับยั้งอินโดลเอมีน 2,3-ไดออกซีจีเนสชนิดหนึ่ง | |
CU20200020A7 (es) | Composición farmacéutica que comprende abx196 |