CY1118815T1 - Συνθεσεις, φαρμακοτεχνικες μορφες και μεθοδοι λιπιδιωμενων ενωσεων τροποποιητων ανοσολογικης απαντησης - Google Patents

Συνθεσεις, φαρμακοτεχνικες μορφες και μεθοδοι λιπιδιωμενων ενωσεων τροποποιητων ανοσολογικης απαντησης

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Publication number
CY1118815T1
CY1118815T1 CY20171100425T CY171100425T CY1118815T1 CY 1118815 T1 CY1118815 T1 CY 1118815T1 CY 20171100425 T CY20171100425 T CY 20171100425T CY 171100425 T CY171100425 T CY 171100425T CY 1118815 T1 CY1118815 T1 CY 1118815T1
Authority
CY
Cyprus
Prior art keywords
immune response
compositions
methods
pharmaceutical forms
modified immune
Prior art date
Application number
CY20171100425T
Other languages
Greek (el)
English (en)
Inventor
Paul D Wightman
Original Assignee
3M Innovative Properties Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Company filed Critical 3M Innovative Properties Company
Publication of CY1118815T1 publication Critical patent/CY1118815T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16311—Influenzavirus C, i.e. influenza C virus
    • C12N2760/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY20171100425T 2010-08-17 2017-04-10 Συνθεσεις, φαρμακοτεχνικες μορφες και μεθοδοι λιπιδιωμενων ενωσεων τροποποιητων ανοσολογικης απαντησης CY1118815T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37451210P 2010-08-17 2010-08-17
PCT/US2011/047901 WO2012024284A1 (en) 2010-08-17 2011-08-16 Lipidated immune response modifier compound compositions, formulations, and methods

Publications (1)

Publication Number Publication Date
CY1118815T1 true CY1118815T1 (el) 2018-01-10

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Family Applications (1)

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CY20171100425T CY1118815T1 (el) 2010-08-17 2017-04-10 Συνθεσεις, φαρμακοτεχνικες μορφες και μεθοδοι λιπιδιωμενων ενωσεων τροποποιητων ανοσολογικης απαντησης

Country Status (20)

Country Link
US (9) US9242980B2 (OSRAM)
EP (2) EP3222621B1 (OSRAM)
JP (5) JP2013534248A (OSRAM)
CN (2) CN103097386A (OSRAM)
AU (1) AU2011292146B2 (OSRAM)
BR (1) BR112013003772A2 (OSRAM)
CA (2) CA3021114C (OSRAM)
CY (1) CY1118815T1 (OSRAM)
DK (1) DK2606047T3 (OSRAM)
ES (2) ES2943385T3 (OSRAM)
HR (1) HRP20170433T1 (OSRAM)
HU (1) HUE033901T2 (OSRAM)
LT (1) LT2606047T (OSRAM)
MX (1) MX359517B (OSRAM)
PL (1) PL2606047T3 (OSRAM)
PT (1) PT2606047T (OSRAM)
RS (1) RS55819B1 (OSRAM)
SI (1) SI2606047T1 (OSRAM)
SM (1) SMT201700182T1 (OSRAM)
WO (1) WO2012024284A1 (OSRAM)

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AU2015296214B2 (en) * 2014-08-01 2019-11-07 Board Of Regents, The University Of Texas System Methods and therapeutic combinations for treating tumors
WO2016183371A1 (en) 2015-05-13 2016-11-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for the treatment or prevention of ischemic tissue damage
EP3316874A4 (en) 2015-06-30 2019-03-06 The Trustees Of The University Of Pennsylvania TOPICAL AND INJECTABLE RESIQUIMOD COMPOSITIONS FOR THE TREATMENT OF NEOPLASTIC GUM DISEASES
JP6956071B2 (ja) 2015-08-31 2021-10-27 スリーエム イノベイティブ プロパティズ カンパニー 置換グアニジン基を含有するイミダゾ［４，５−ｃ］環状化合物
US10150768B2 (en) 2015-08-31 2018-12-11 3M Innovative Properties Company Guanidine substituted imidazo[4,5-c] ring compounds
CN108348618B (zh) 2015-09-29 2021-06-15 大日本住友制药株式会社 腺嘌呤缀合物化合物及其作为疫苗佐剂的用途
CA3001283C (en) * 2015-10-07 2023-10-10 Sumitomo Dainippon Pharma Co., Ltd. Pyrimidine compound
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EP4112638A1 (en) * 2016-05-16 2023-01-04 Access to Advanced Health Institute Formulation containing tlr agonist and methods of use
JP7195147B2 (ja) 2016-05-16 2022-12-23 アクセス ツー アドバンスト ヘルス インスティチュート Ｐｅｇ化リポソームおよび使用方法
TW201840316A (zh) * 2017-01-12 2018-11-16 美商麥迪紐有限責任公司 Ｔｏｌｌ樣受體７／８激動劑之安全性和藥物活性
EP3589631B1 (en) 2017-03-01 2021-07-21 3M Innovative Properties Company Imidazo[4,5-c]ring compounds containing guanidine substituted benzamide groups
US11032816B2 (en) * 2017-08-10 2021-06-08 Qualcomm Incorporated Techniques and apparatuses for variable timing adjustment granularity
CA3086439A1 (en) 2017-12-20 2019-06-27 3M Innovative Properties Company Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
ES3003782T3 (en) 2018-02-28 2025-03-11 Solventum Intellectual Properties Company Substituted imidazo[4,5-c]quinoline compounds with an n-1 branched group
EP3802536B1 (en) 2018-05-24 2022-07-13 3M Innovative Properties Company N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods
US12059462B2 (en) 2018-07-23 2024-08-13 Japan As Represented By Director General Of National Institute Of Infectious Diseases Composition containing influenza vaccine
CN117462549A (zh) * 2019-02-01 2024-01-30 康威(广州)生物科技有限公司 咪唑并喹啉胺衍生物、及其药物组合物和应用
CA3161668A1 (en) 2019-12-20 2021-06-24 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof
TW202510879A (zh) * 2023-06-01 2025-03-16 日商聯合免疫股份有限公司 複合體
EP4578448A4 (en) * 2023-06-01 2025-10-15 United Immunity Co Ltd COMPLEX
CN119320387B (zh) * 2024-12-19 2025-06-27 杭州天龙药业有限公司 基于Toll样受体激动剂的疫苗佐剂脂质化合物及其应用

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