JP2006523212A - 皮膚病変の診断方法 - Google Patents
皮膚病変の診断方法 Download PDFInfo
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- JP2006523212A JP2006523212A JP2006507225A JP2006507225A JP2006523212A JP 2006523212 A JP2006523212 A JP 2006523212A JP 2006507225 A JP2006507225 A JP 2006507225A JP 2006507225 A JP2006507225 A JP 2006507225A JP 2006523212 A JP2006523212 A JP 2006523212A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/446—Scalp evaluation or scalp disorder diagnosis, e.g. dandruff
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- Heart & Thoracic Surgery (AREA)
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- Dermatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Description
25cm2処理領域内に位置する4〜8箇所の臨床的に診断されたAK病変を有する志願者が研究のため登録された。この研究は、事前研究期間、16週の処理期間、および8週の後処理期間からなる。登録された参加者には、無作為に、5%イミキモドクリーム(アルダラ(ALDARA)、ミネソタ州、セントポール(St.Paul,MN)の3M ファーマシューティカルズ(3M Pharmaceuticals))、または生物学的活性成分を含有しないプラシーボクリームのいずれかを受けさせた。
病変の外科的切除前に、アルダラ(ALDARA)(ミネソタ州、セントポール(St.Paul,MN)の3M ファーマシューティカルズ(3M Pharmaceuticals))として市販される5%イミキモドクリームによって、BCC病変を有する患者を前処理する。5〜7週間、週5〜7回のBCC病変への5%イミキモドクリームの局所的適用によって、BCC病変の顕著なびらん、紅斑および/または浮腫が生じ、それによって病変の辺縁が強調される。
病変の外科的切除前に、アルダラ(ALDARA)(ミネソタ州、セントポール(St.Paul,MN)の3M ファーマシューティカルズ(3M Pharmaceuticals))として市販される5%イミキモドクリームによって、ボーエン病を有する患者を前処理する。1〜3週間、週2〜3回の病変への5%イミキモドクリームの局所的適用によって、病変の顕著なびらん、紅斑および/または浮腫が生じ、それによって病変の辺縁が強調される。
病変の外科的切除前に、アルダラ(ALDARA)(ミネソタ州、セントポール(St.Paul,MN)の3M ファーマシューティカルズ(3M Pharmaceuticals))として市販される5%イミキモドクリームによって、悪性ほくろを有する患者を前処理する。1〜3週間、週2〜3回の病変への5%イミキモドクリームの局所的適用によって、病変の顕著なびらん、紅斑および/または浮腫が生じ、それによって病変の辺縁が強調される。
Claims (30)
- 処理領域における皮膚病変の視覚化を可能にするために十分な期間および量で、IRM化合物を皮膚の上記処理領域に投与する工程を含んでなる、皮膚病変の診断方法。
- 前記皮膚病変の切除をさらに含んでなる、請求項1に記載の方法。
- 前記皮膚病変の切除が、モース・マイクログラフィック外科手術、外科的切除、寒冷療法または放射線療法による、請求項2に記載の方法。
- 前記皮膚病変の切除がモース・マイクログラフィック外科手術による、請求項3に記載の方法。
- 前記皮膚病変が腫瘍性皮膚病変である、請求項1に記載の方法。
- 前記皮膚病変が無症状性病変である、請求項1に記載の方法。
- 前記皮膚病変が非メラノーマ皮膚癌である、請求項1に記載の方法。
- 前記皮膚病変が前悪性皮膚病変である、請求項1に記載の方法。
- 前記皮膚病変が、基底細胞癌、扁平上皮癌、悪性ほくろ、ボーエン病および日光性角化症よりなる群から選択される、請求項1に記載の方法。
- 前記IRM化合物が、少なくとも1つのTLRの作動薬である、請求項1に記載の方法。
- 前記IRM化合物が、TLR7、TLR8、またはTLR7およびTLR8の両方の作動薬である、請求項1に記載の方法。
- 前記IRM化合物が、局所適用媒体を介して投与される、請求項1に記載の方法。
- 前記IRM化合物が、イミダゾキノリンアミン、テトラヒドロイミダゾキノリンアミン、イミダゾピリジンアミン、1,2−架橋イミダゾキノリンアミン、6,7−縮合シクロアルキルイミダゾピリジンアミン、イミダゾナフチリジンアミン、テトラヒドロイミダゾナフチリジンアミン、オキサゾロキノリンアミン、チアゾロキノリンアミン、オキサゾロピリジンアミン、チアゾロピリジンアミン、オキサゾロナフチリジンアミンまたはチアゾロナフチリジンアミンである、請求項1に記載の方法。
- 前記IRM化合物が少なくとも1回投与される、請求項1に記載の方法。
- 前記IRM化合物が週に2回投与される、請求項1に記載の方法。
- 前記IRM化合物が週に3回投与される、請求項1に記載の方法。
- 前記IRM化合物が1週間投与される、請求項1に記載の方法。
- 前記IRM化合物が4週間投与される、請求項1に記載の方法。
- 前記IRM化合物が8週間投与される、請求項1に記載の方法。
- 皮膚病変の辺縁の視覚化法であって、
処理領域における皮膚病変の辺縁の視覚化を可能にするために十分な期間および量で、IRM化合物を前記処理領域に投与する工程と、
前記皮膚病変の辺縁を視覚化する工程と、
を含んでなる方法。 - 前記IRM化合物を投与する工程が、前記皮膚病変の辺縁の視覚化を可能にする局在性免疫応答を誘導する、請求項20に記載の方法。
- 皮膚病変の辺縁を可視的に強調する方法であって、皮膚病変の辺縁を可視的に強調するために十分な期間および量で、IRM化合物を、少なくとも1つの臨床的に可視の皮膚病変を含んでなる処理領域に投与する工程を含んでなる方法。
- 皮膚病変の切除の前に皮膚病変を前処理する方法であって、皮膚病変の辺縁を可視的に強調するために十分な期間および量で、IRM化合物を、少なくとも1つの臨床的に可視の皮膚病変を含んでなる処理領域に投与する工程を含んでなる方法。
- 皮膚病変に切除手順を施す工程をさらに含んでなる、請求項23に記載の方法。
- 前記切除手順が、モース・マイクログラフィック外科手術、外科的切除、寒冷療法および放射線療法よりなる群から選択される、請求項24に記載の方法。
- 前記切除手順がモース・マイクログラフィック外科手術である、請求項25に記載の方法。
- 無症状性皮膚病変の視覚化法であって、
処理領域における無症状性皮膚病変を明白にさせるために十分な期間および量で、IRM化合物を前記処理領域に投与する工程と、
前記無症状性皮膚病変を視覚化する工程と、
を含んでなる方法。 - 前記皮膚病変が日光性角化症である、請求項27に記載の方法。
- 皮膚病変の処理法であって、
前記皮膚病変の辺縁の視覚化を可能にするために十分な期間および量で、IRM化合物を、少なくとも1つの皮膚病変を含んでなる処理領域に投与する工程と、
前記皮膚病変に切除手順を施す工程と、
を含んでなる方法。 - 前記切除手順が、モース・マイクログラフィック外科手術、外科的切除、寒冷療法および放射線療法よりなる群から選択される、請求項29に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45424403P | 2003-03-13 | 2003-03-13 | |
PCT/US2004/007946 WO2004080293A2 (en) | 2003-03-13 | 2004-03-12 | Methods for diagnosing skin lesions |
Publications (2)
Publication Number | Publication Date |
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JP2006523212A true JP2006523212A (ja) | 2006-10-12 |
JP2006523212A5 JP2006523212A5 (ja) | 2007-04-26 |
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JP2006507225A Pending JP2006523212A (ja) | 2003-03-13 | 2004-03-12 | 皮膚病変の診断方法 |
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US (2) | US7699057B2 (ja) |
EP (1) | EP1608282A4 (ja) |
JP (1) | JP2006523212A (ja) |
AU (1) | AU2004220466A1 (ja) |
CA (1) | CA2518082C (ja) |
WO (1) | WO2004080293A2 (ja) |
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US20100180902A1 (en) | 2010-07-22 |
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CA2518082A1 (en) | 2004-09-23 |
CA2518082C (en) | 2013-02-12 |
WO2004080293A2 (en) | 2004-09-23 |
WO2004080293A3 (en) | 2005-05-19 |
AU2004220466A2 (en) | 2004-09-23 |
US7699057B2 (en) | 2010-04-20 |
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