CY1117575T1 - Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων - Google Patents
Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτωνInfo
- Publication number
- CY1117575T1 CY1117575T1 CY20161100126T CY161100126T CY1117575T1 CY 1117575 T1 CY1117575 T1 CY 1117575T1 CY 20161100126 T CY20161100126 T CY 20161100126T CY 161100126 T CY161100126 T CY 161100126T CY 1117575 T1 CY1117575 T1 CY 1117575T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aav
- reduced
- isosomatia
- immunoactivity
- reduced immunoreactivity
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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Abstract
Περιγράφονται μέθοδοι κατασκευής και χρήσης ιοσωματίων ανασυνδυασμένου AAV με μειωμένη ανοσοαντιδραστικότητα. Τα ιοσωμάτια ανασυνδυασμένου AAV περιλαμβάνουν μεταλλαγμένες καψιδιακές πρωτεΐνες ή προέρχονται από ορότυπους AAV μη πρωτεύοντος θηλαστικού και προϊόντα απομόνωσης τα οποία εμφανίζουν μειωμένη ανοσοαντιδραστικότητα σε σχέση με τον AAV-2.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48039503P | 2003-06-19 | 2003-06-19 | |
US56731004P | 2004-04-30 | 2004-04-30 | |
US57650104P | 2004-06-03 | 2004-06-03 | |
EP04755800.2A EP1633772B1 (en) | 2003-06-19 | 2004-06-21 | Aav virions with decreased immunoreactivity and uses therefor |
Publications (1)
Publication Number | Publication Date |
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CY1117575T1 true CY1117575T1 (el) | 2017-04-26 |
Family
ID=33545345
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100126T CY1117575T1 (el) | 2003-06-19 | 2016-02-16 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100603T CY1119222T1 (el) | 2003-06-19 | 2017-06-08 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100649T CY1119279T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100650T CY1119241T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20211100317T CY1124371T1 (el) | 2003-06-19 | 2021-04-13 | Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100603T CY1119222T1 (el) | 2003-06-19 | 2017-06-08 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100649T CY1119279T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100650T CY1119241T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20211100317T CY1124371T1 (el) | 2003-06-19 | 2021-04-13 | Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
Country Status (11)
Country | Link |
---|---|
US (6) | US7259151B2 (el) |
EP (5) | EP2657247B1 (el) |
JP (7) | JP2007524386A (el) |
CY (5) | CY1117575T1 (el) |
DK (5) | DK2657248T3 (el) |
ES (5) | ES2629087T3 (el) |
HU (5) | HUE029556T2 (el) |
PL (5) | PL1633772T3 (el) |
PT (5) | PT2657248T (el) |
SI (5) | SI2657247T1 (el) |
WO (1) | WO2004112727A2 (el) |
Families Citing this family (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030215422A1 (en) | 1996-09-11 | 2003-11-20 | John A. Chiorini | Aav4 vector and uses thereof |
ATE402254T1 (de) | 1998-05-28 | 2008-08-15 | Us Gov Health & Human Serv | Aav5 vektoren und deren verwendung |
JP4969002B2 (ja) | 1999-06-08 | 2012-07-04 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | rAAV形質導入を増加するための化合物および方法 |
NZ600121A (en) | 2001-11-13 | 2013-12-20 | Univ Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
US7419817B2 (en) | 2002-05-17 | 2008-09-02 | The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. | Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography |
WO2004090145A2 (en) | 2003-03-31 | 2004-10-21 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
US8927269B2 (en) | 2003-05-19 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Avian adenoassociated virus and uses thereof |
PL1633772T3 (pl) | 2003-06-19 | 2016-10-31 | Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowanie | |
US9233131B2 (en) * | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US8137960B2 (en) | 2003-12-04 | 2012-03-20 | The United States Of America As Represented By The Department Of Health And Human Services | Bovine adeno-associated viral (BAAV) vector and uses thereof |
US20080188431A1 (en) * | 2004-09-08 | 2008-08-07 | Chiorini John A | Transcytosis of Adeno-Associated Viruses |
AU2005316476A1 (en) * | 2004-12-15 | 2006-06-22 | University Of Florida Research Foundation, Inc. | Chimeric vectors |
JP5702519B2 (ja) * | 2005-04-07 | 2015-04-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Aavベクターの機能を上げる方法 |
WO2006119432A2 (en) | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
EP2019964A2 (en) * | 2006-04-28 | 2009-02-04 | University of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection. method to identify a viral receptor or co-receptor |
EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
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- 2004-06-21 SI SI200432399A patent/SI2657247T1/sl unknown
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2007
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2010
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2013
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2016
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2017
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2019
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2020
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2021
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2023
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