CY1124371T1 - Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων - Google Patents
Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτωνInfo
- Publication number
- CY1124371T1 CY1124371T1 CY20211100317T CY211100317T CY1124371T1 CY 1124371 T1 CY1124371 T1 CY 1124371T1 CY 20211100317 T CY20211100317 T CY 20211100317T CY 211100317 T CY211100317 T CY 211100317T CY 1124371 T1 CY1124371 T1 CY 1124371T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aav
- vizones
- immunoreactively
- reduced
- reduced aav
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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Abstract
Περιγράφονται μέθοδοι παρασκευής και χρήσης ιοσωματίων ανασυνδυασμένου AAV με μειωμένη ανοσοαντιδραστικότητα. Τα ιοσωμάτια ανασυνδυασμένου AAV περιλαμβάνουν μεταλλαγμένες καψιδικές πρωτείνες ή προέρχονται από ορότυπους και απομονώματα AAV μη πρωτευόντων θηλαστικών που παρουσιάζουν μειωμένη ανοσοδραστικότητα σχετικώς προς τον AAV-2.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48039503P | 2003-06-19 | 2003-06-19 | |
US56731004P | 2004-04-30 | 2004-04-30 | |
US57650104P | 2004-06-03 | 2004-06-03 | |
EP13163182.2A EP2657248B1 (en) | 2003-06-19 | 2004-06-21 | AAV virions with decreased immunoreactivity and uses therefor |
EP04755800.2A EP1633772B1 (en) | 2003-06-19 | 2004-06-21 | Aav virions with decreased immunoreactivity and uses therefor |
PCT/US2004/019884 WO2004112727A2 (en) | 2003-06-19 | 2004-06-21 | Aav virions with decreased immunoreactivity and uses therefor |
Publications (1)
Publication Number | Publication Date |
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CY1124371T1 true CY1124371T1 (el) | 2022-07-22 |
Family
ID=33545345
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100126T CY1117575T1 (el) | 2003-06-19 | 2016-02-16 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100603T CY1119222T1 (el) | 2003-06-19 | 2017-06-08 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100649T CY1119279T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100650T CY1119241T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20211100317T CY1124371T1 (el) | 2003-06-19 | 2021-04-13 | Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100126T CY1117575T1 (el) | 2003-06-19 | 2016-02-16 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100603T CY1119222T1 (el) | 2003-06-19 | 2017-06-08 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100649T CY1119279T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
CY20171100650T CY1119241T1 (el) | 2003-06-19 | 2017-06-21 | Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων |
Country Status (11)
Country | Link |
---|---|
US (6) | US7259151B2 (el) |
EP (5) | EP2657247B1 (el) |
JP (7) | JP2007524386A (el) |
CY (5) | CY1117575T1 (el) |
DK (5) | DK2357189T3 (el) |
ES (5) | ES2629380T3 (el) |
HU (5) | HUE054046T2 (el) |
PL (5) | PL2357189T3 (el) |
PT (5) | PT3235827T (el) |
SI (5) | SI2657247T1 (el) |
WO (1) | WO2004112727A2 (el) |
Families Citing this family (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4645697A (en) | 1996-09-11 | 1998-04-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Aav4 vector and uses thereof |
CA2745131C (en) | 1998-05-28 | 2016-08-09 | John A. Chiorini | Aav5 vector and uses thereof |
WO2000075365A2 (en) | 1999-06-08 | 2000-12-14 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
PL222683B1 (pl) | 2001-11-13 | 2016-08-31 | Univ Pennsylvania | Rekombinowane wirusy stowarzyszone z adenowirusem (AAV), sposoby ich wytwarzania, pakująca komórka gospodarza, kompozycja zawierająca wirus, zastosowanie wirusa, wyizolowane wirusy AAV, białka,sztuczne białka kapsydu, cząsteczki, komórki gospodarza, sposoby dostarczania transgenu, sposób identyfikacji serotypu, zestaw diagnostyczny, sposób izolacji nowych wirusów, rekombinowana komórka |
US7419817B2 (en) | 2002-05-17 | 2008-09-02 | The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. | Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography |
AU2004227915A1 (en) | 2003-03-31 | 2004-10-21 | John F. Engelhardt | Pharmico-gene theraphy of epithelial sodium channel associated disoders |
US8927269B2 (en) | 2003-05-19 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Avian adenoassociated virus and uses thereof |
WO2004112727A2 (en) | 2003-06-19 | 2004-12-29 | Avigen, Inc. | Aav virions with decreased immunoreactivity and uses therefor |
US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9233131B2 (en) * | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
WO2005056807A2 (en) * | 2003-12-04 | 2005-06-23 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health | Bovine adeno-associated viral (baav) vector and uses thereof |
US20080188431A1 (en) * | 2004-09-08 | 2008-08-07 | Chiorini John A | Transcytosis of Adeno-Associated Viruses |
AU2005316476A1 (en) * | 2004-12-15 | 2006-06-22 | University Of Florida Research Foundation, Inc. | Chimeric vectors |
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