CY1119279T1 - Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων - Google Patents

Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

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Publication number
CY1119279T1
CY1119279T1 CY20171100649T CY171100649T CY1119279T1 CY 1119279 T1 CY1119279 T1 CY 1119279T1 CY 20171100649 T CY20171100649 T CY 20171100649T CY 171100649 T CY171100649 T CY 171100649T CY 1119279 T1 CY1119279 T1 CY 1119279T1
Authority
CY
Cyprus
Prior art keywords
aav
reduced
isosomatia
immunoactivity
reduced immunoreactivity
Prior art date
Application number
CY20171100649T
Other languages
English (en)
Inventor
Alejandra Elena Arbetman
Peter C Colosi
Michael A Lochrie
Richard T Surosky
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1119279T1 publication Critical patent/CY1119279T1/el

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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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Abstract

Περιγράφονται μέθοδοι κατασκευής και χρήσης ιοσωματίων ανασυνδυασμένου AAV με μειωμένη ανοσοαντιδραστικότητα. Τα ιοσωμάτια ανασυνδυασμένου AAV συμπεριλαμβάνουν μεταλλαγμένες πρωτεΐνες καψιδίου ή προέρχονται από ορότυπους AAV μη πρωτεύοντος θηλαστικού και προϊόντα απομόνωσης, τα οποία εμφανίζουν μειωμένη ανοσοαντιδραστικότητα σε σχέση με τον AAV-2.
CY20171100649T 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων CY1119279T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48039503P 2003-06-19 2003-06-19
US56731004P 2004-04-30 2004-04-30
US57650104P 2004-06-03 2004-06-03
EP04755800.2A EP1633772B1 (en) 2003-06-19 2004-06-21 Aav virions with decreased immunoreactivity and uses therefor

Publications (1)

Publication Number Publication Date
CY1119279T1 true CY1119279T1 (el) 2018-02-14

Family

ID=33545345

Family Applications (5)

Application Number Title Priority Date Filing Date
CY20161100126T CY1117575T1 (el) 2003-06-19 2016-02-16 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100603T CY1119222T1 (el) 2003-06-19 2017-06-08 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100649T CY1119279T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100650T CY1119241T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20211100317T CY1124371T1 (el) 2003-06-19 2021-04-13 Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

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CY20161100126T CY1117575T1 (el) 2003-06-19 2016-02-16 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20171100603T CY1119222T1 (el) 2003-06-19 2017-06-08 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

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CY20171100650T CY1119241T1 (el) 2003-06-19 2017-06-21 Ιοσωματια aav με μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
CY20211100317T CY1124371T1 (el) 2003-06-19 2021-04-13 Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων

Country Status (11)

Country Link
US (6) US7259151B2 (el)
EP (5) EP2657247B1 (el)
JP (7) JP2007524386A (el)
CY (5) CY1117575T1 (el)
DK (5) DK2357189T3 (el)
ES (5) ES2629380T3 (el)
HU (5) HUE054046T2 (el)
PL (5) PL2357189T3 (el)
PT (5) PT3235827T (el)
SI (5) SI2657247T1 (el)
WO (1) WO2004112727A2 (el)

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WO2000075365A2 (en) 1999-06-08 2000-12-14 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
PL222683B1 (pl) 2001-11-13 2016-08-31 Univ Pennsylvania Rekombinowane wirusy stowarzyszone z adenowirusem (AAV), sposoby ich wytwarzania, pakująca komórka gospodarza, kompozycja zawierająca wirus, zastosowanie wirusa, wyizolowane wirusy AAV, białka,sztuczne białka kapsydu, cząsteczki, komórki gospodarza, sposoby dostarczania transgenu, sposób identyfikacji serotypu, zestaw diagnostyczny, sposób izolacji nowych wirusów, rekombinowana komórka
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US9441244B2 (en) 2003-06-30 2016-09-13 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
US9233131B2 (en) * 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
WO2005056807A2 (en) * 2003-12-04 2005-06-23 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Bovine adeno-associated viral (baav) vector and uses thereof
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