CY1110521T1 - Υποκατεστημενα ινδολια για τη διαμορφωση της nfkb-ενεργοτητας - Google Patents
Υποκατεστημενα ινδολια για τη διαμορφωση της nfkb-ενεργοτηταςInfo
- Publication number
- CY1110521T1 CY1110521T1 CY20091101115T CY091101115T CY1110521T1 CY 1110521 T1 CY1110521 T1 CY 1110521T1 CY 20091101115 T CY20091101115 T CY 20091101115T CY 091101115 T CY091101115 T CY 091101115T CY 1110521 T1 CY1110521 T1 CY 1110521T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nfkb
- sub
- energy construction
- indicators
- substitute
- Prior art date
Links
- 238000010276 construction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 abstract 1
- 239000003458 I kappa b kinase inhibitor Substances 0.000 abstract 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
Abstract
Οι ενώσεις του τύπου (I) είναι κατάλληλες για την παραγωγή φαρμακευτικών μέσων για την προφύλαξη και θεραπεία παθήσεων, στην εξέλιξη των οποίων εμπλέκεται ενισχυμένη ενεργότητα του NFκB. Οι ενώσεις είναι ειδικοί αναστολείς της ΙκΒ-κινάσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19951360A DE19951360A1 (de) | 1999-10-26 | 1999-10-26 | Substituierte Indole |
EP00974405A EP1261601B1 (de) | 1999-10-26 | 2000-10-17 | Substituierte indole zur modulierung von nfkb-aktivität |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110521T1 true CY1110521T1 (el) | 2015-04-29 |
Family
ID=7926798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091101115T CY1110521T1 (el) | 1999-10-26 | 2009-10-26 | Υποκατεστημενα ινδολια για τη διαμορφωση της nfkb-ενεργοτητας |
Country Status (32)
Country | Link |
---|---|
US (3) | US20030119820A1 (el) |
EP (1) | EP1261601B1 (el) |
JP (1) | JP3843012B2 (el) |
KR (1) | KR100795709B1 (el) |
CN (1) | CN1172929C (el) |
AT (1) | ATE437867T1 (el) |
AU (1) | AU781553B2 (el) |
BR (1) | BR0015026B1 (el) |
CA (1) | CA2389165C (el) |
CY (1) | CY1110521T1 (el) |
CZ (1) | CZ304885B6 (el) |
DE (2) | DE19951360A1 (el) |
DK (1) | DK1261601T3 (el) |
EE (1) | EE05036B1 (el) |
ES (1) | ES2329871T3 (el) |
HK (1) | HK1049671A1 (el) |
HR (1) | HRP20020357B1 (el) |
HU (1) | HU229215B1 (el) |
IL (2) | IL149272A0 (el) |
ME (1) | ME00434B (el) |
MX (1) | MXPA02003998A (el) |
NO (1) | NO323952B1 (el) |
NZ (1) | NZ518587A (el) |
PL (1) | PL200115B1 (el) |
PT (1) | PT1261601E (el) |
RS (1) | RS50424B (el) |
RU (1) | RU2255087C2 (el) |
SI (1) | SI1261601T1 (el) |
SK (1) | SK287116B6 (el) |
TR (1) | TR200201144T2 (el) |
WO (1) | WO2001030774A1 (el) |
ZA (1) | ZA200203204B (el) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE05180B1 (et) | 1999-12-24 | 2009-06-15 | Aventis Pharma Limited | Asaindooli sisaldav farmatseutiline kompositsioon raviotstarbeliseks kasutamiseks, asaindoolid ning nende kasutamine ravimite valmistamiseks, mis on ette nhtud proteiinikinaasi kataltilise toime prssimiseks |
DE60133758T2 (de) | 2000-10-26 | 2009-07-02 | Amgen Inc., Thousand Oaks | Antiphlogistische mittel |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
JP4448327B2 (ja) * | 2001-08-13 | 2010-04-07 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 新規置換1h−ジヒドロピラゾール、それらの製造および使用 |
WO2003039545A2 (en) * | 2001-11-07 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
US7176314B2 (en) | 2001-12-05 | 2007-02-13 | Amgen, Inc. | Inflammation modulators |
PT1474425E (pt) | 2002-01-07 | 2006-09-29 | Eisai Co Ltd | Desazapurinas e sua utilizacao |
AU2003237330A1 (en) | 2002-06-06 | 2003-12-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
DE10237723A1 (de) * | 2002-08-17 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie |
US7462638B2 (en) * | 2002-08-17 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Use of IκB-kinase inhibitors in pain therapy |
DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
CA2502429A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP1462105A1 (en) * | 2003-03-28 | 2004-09-29 | Procorde GmbH | Activation specific inhibitors of NF-kB and method of treating inflammatory processes in cardio-vascular diseases |
KR20060006031A (ko) * | 2003-04-09 | 2006-01-18 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질환 치료에 유용한 베타-카르볼린 |
US20050004164A1 (en) * | 2003-04-30 | 2005-01-06 | Caggiano Thomas J. | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use |
CN102911161A (zh) | 2004-02-20 | 2013-02-06 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
BRPI0509660A (pt) | 2004-04-09 | 2007-10-09 | Millennium Pharm Inc | compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias |
US7425580B2 (en) | 2004-05-19 | 2008-09-16 | Wyeth | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
DE102005025225A1 (de) * | 2005-06-01 | 2006-12-07 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
BRPI0611674A2 (pt) | 2005-06-30 | 2009-04-28 | Smithkline Beecham Corp | compostos quÍmicos |
JP5015154B2 (ja) | 2005-08-12 | 2012-08-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | 2−アリール−ベンゾイミダゾール−5−カルボキサミド誘導体 |
US7592353B2 (en) | 2006-06-06 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
DK2119703T3 (da) * | 2007-01-15 | 2013-01-14 | Santen Pharmaceutical Co Ltd | Nyt indolderivat med inhiberende virkning på I-B-kinase. |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
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1999
- 1999-10-26 DE DE19951360A patent/DE19951360A1/de not_active Withdrawn
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2000
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- 2000-10-17 IL IL14927200A patent/IL149272A0/xx active IP Right Grant
- 2000-10-17 DK DK00974405T patent/DK1261601T3/da active
- 2000-10-17 RS YUP-217/02A patent/RS50424B/sr unknown
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- 2000-10-17 CZ CZ2002-1413A patent/CZ304885B6/cs not_active IP Right Cessation
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- 2000-10-17 BR BRPI0015026-6A patent/BR0015026B1/pt not_active IP Right Cessation
- 2000-10-17 ME MEP-2008-655A patent/ME00434B/me unknown
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- 2000-10-17 KR KR1020027005395A patent/KR100795709B1/ko not_active IP Right Cessation
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- 2000-10-17 WO PCT/EP2000/010210 patent/WO2001030774A1/de active IP Right Grant
- 2000-10-17 AU AU12728/01A patent/AU781553B2/en not_active Ceased
- 2000-10-17 AT AT00974405T patent/ATE437867T1/de active
- 2000-10-17 RU RU2002113651/04A patent/RU2255087C2/ru not_active IP Right Cessation
- 2000-10-17 DE DE50015700T patent/DE50015700D1/de not_active Expired - Lifetime
- 2000-10-17 JP JP2001533128A patent/JP3843012B2/ja not_active Expired - Fee Related
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2002
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- 2002-10-04 US US10/263,691 patent/US20030119820A1/en not_active Abandoned
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2003
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2004
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