CY1110234T1 - Κρυσταλλικη και καθαρη μοδαφινιλη, και διεργασια παρασκευης της ιδιας - Google Patents

Κρυσταλλικη και καθαρη μοδαφινιλη, και διεργασια παρασκευης της ιδιας

Info

Publication number
CY1110234T1
CY1110234T1 CY20101100255T CY101100255T CY1110234T1 CY 1110234 T1 CY1110234 T1 CY 1110234T1 CY 20101100255 T CY20101100255 T CY 20101100255T CY 101100255 T CY101100255 T CY 101100255T CY 1110234 T1 CY1110234 T1 CY 1110234T1
Authority
CY
Cyprus
Prior art keywords
modafinil
modafinili
pure
crystal
preparation process
Prior art date
Application number
CY20101100255T
Other languages
Greek (el)
English (en)
Inventor
Claude Singer
Neomi Gershon
Arina Ceausu
Anita Lieberman
Judith Aronhime
Original Assignee
Teva Pharmaceutical Industries, Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries, Ltd filed Critical Teva Pharmaceutical Industries, Ltd
Publication of CY1110234T1 publication Critical patent/CY1110234T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Laminated Bodies (AREA)
  • Glass Compositions (AREA)
CY20101100255T 2000-07-27 2010-03-19 Κρυσταλλικη και καθαρη μοδαφινιλη, και διεργασια παρασκευης της ιδιας CY1110234T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US22649100P 2000-08-18 2000-08-18
US22916000P 2000-08-30 2000-08-30
US23008800P 2000-09-05 2000-09-05
US25933201P 2001-01-02 2001-01-02
EP07000780A EP1787980B1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (1)

Publication Number Publication Date
CY1110234T1 true CY1110234T1 (el) 2015-01-14

Family

ID=27539819

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100255T CY1110234T1 (el) 2000-07-27 2010-03-19 Κρυσταλλικη και καθαρη μοδαφινιλη, και διεργασια παρασκευης της ιδιας

Country Status (24)

Country Link
US (3) US6849120B2 (https=)
EP (3) EP2168946A1 (https=)
JP (2) JP4302977B2 (https=)
KR (8) KR100729292B1 (https=)
CN (2) CN100500651C (https=)
AT (1) ATE453618T1 (https=)
AU (1) AU2001283008A1 (https=)
CA (3) CA2634702C (https=)
CY (1) CY1110234T1 (https=)
CZ (1) CZ2003529A3 (https=)
DE (3) DE60126099T2 (https=)
DK (2) DK1309547T3 (https=)
ES (2) ES2277937T3 (https=)
HR (2) HRP20080373A2 (https=)
HU (1) HUP0400927A3 (https=)
IL (2) IL154122A0 (https=)
IS (1) IS6699A (https=)
MX (1) MXPA03000747A (https=)
NZ (1) NZ524359A (https=)
PL (1) PL206371B1 (https=)
PT (2) PT1787980E (https=)
SK (1) SK2242003A3 (https=)
WO (1) WO2002010125A1 (https=)
ZA (1) ZA200300672B (https=)

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JP4593074B2 (ja) * 2000-10-11 2010-12-08 セフアロン・インコーポレーテツド モダフィニル化合物含有組成物
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
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US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
IL165383A0 (en) 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
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US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) * 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
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US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ES2330321T3 (es) 2003-05-16 2009-12-09 Cephalon France Procedimiento de sintesis de modafinilo.
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
JP4842819B2 (ja) * 2003-09-04 2011-12-21 セフアロン・インコーポレーテツド モダフィニル組成物
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en) * 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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US20090018202A1 (en) * 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
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US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
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US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
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BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007070238A2 (en) * 2005-12-09 2007-06-21 Mallinckrodt Inc. Processes for the preparation of modafinil and analogs thereof
MX2007012605A (es) * 2006-02-21 2008-01-11 Teva Pharma Formas cristalinas novedosas de armodafinil y preparacion de ellas.
AU2007272501A1 (en) * 2006-07-12 2008-01-17 Elan Pharma International Limited Nanoparticulate formulations of modafinil
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WO2009025791A2 (en) * 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
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WO2009045488A2 (en) * 2007-10-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
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CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
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Also Published As

Publication number Publication date
DE60126099T2 (de) 2007-11-15
US7235691B2 (en) 2007-06-26
DE60126099D1 (de) 2007-03-08
HRP20030131B1 (en) 2011-03-31
CN1466570A (zh) 2004-01-07
CA2685310A1 (en) 2002-02-07
DK1787980T3 (da) 2010-04-26
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
AU2001283008A1 (en) 2002-02-13
CA2685310C (en) 2012-10-16
PL206371B1 (pl) 2010-07-30
CA2634702C (en) 2011-07-19
EP1787980B1 (en) 2009-12-30
CN101186590A (zh) 2008-05-28
PL365613A1 (en) 2005-01-10
KR20030029636A (ko) 2003-04-14
CZ2003529A3 (cs) 2003-09-17
CA2634702A1 (en) 2002-02-07
NZ524359A (en) 2005-06-24
KR101098749B1 (ko) 2011-12-23
IS6699A (is) 2003-01-24
IL154122A (en) 2009-07-20
EP1309547A4 (en) 2005-03-02
SK2242003A3 (en) 2003-10-07
KR20090106661A (ko) 2009-10-09
KR20090103962A (ko) 2009-10-01
US20050038124A1 (en) 2005-02-17
EP1309547B1 (en) 2007-01-17
IL154122A0 (en) 2003-07-31
JP2009024006A (ja) 2009-02-05
EP1787980A2 (en) 2007-05-23
CA2416792A1 (en) 2002-02-07
WO2002010125A1 (en) 2002-02-07
KR101081212B1 (ko) 2011-11-07
ATE453618T1 (de) 2010-01-15
ZA200300672B (en) 2004-02-18
KR20060097771A (ko) 2006-09-15
HUP0400927A2 (hu) 2004-07-28
KR20060024028A (ko) 2006-03-15
HUP0400927A3 (en) 2007-11-28
KR101019448B1 (ko) 2011-03-07
KR100729292B1 (ko) 2007-06-18
MXPA03000747A (es) 2003-06-04
CN100500651C (zh) 2009-06-17
US6849120B2 (en) 2005-02-01
EP2168946A1 (en) 2010-03-31
ES2337838T3 (es) 2010-04-29
HRP20080373A2 (hr) 2008-12-31
US20020043207A1 (en) 2002-04-18
KR20100098462A (ko) 2010-09-06
DE60140973D1 (de) 2010-02-11
ES2277937T3 (es) 2007-08-01
CA2416792C (en) 2010-02-09
US8048222B2 (en) 2011-11-01
DK1309547T3 (da) 2007-05-21
US20050034652A1 (en) 2005-02-17
JP4302977B2 (ja) 2009-07-29
EP1787980A3 (en) 2007-08-08
DE20122504U1 (de) 2005-12-29
JP2004509080A (ja) 2004-03-25
EP1309547A1 (en) 2003-05-14
PT1787980E (pt) 2010-03-18
KR20070007970A (ko) 2007-01-16
KR20070097131A (ko) 2007-10-02
HRP20030131A2 (en) 2005-04-30
JP4980309B2 (ja) 2012-07-18

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