CY1105777T1 - Σχηματισμος και ανιοντο-ανταλλαγη των εσωτepικων κρυσταλλικων αλατων αμμωνιου εχινοκανδινης β - Google Patents
Σχηματισμος και ανιοντο-ανταλλαγη των εσωτepικων κρυσταλλικων αλατων αμμωνιου εχινοκανδινης βInfo
- Publication number
- CY1105777T1 CY1105777T1 CY20061101646T CY061101646T CY1105777T1 CY 1105777 T1 CY1105777 T1 CY 1105777T1 CY 20061101646 T CY20061101646 T CY 20061101646T CY 061101646 T CY061101646 T CY 061101646T CY 1105777 T1 CY1105777 T1 CY 1105777T1
- Authority
- CY
- Cyprus
- Prior art keywords
- echinocandin
- salt
- intercrystally
- antion
- exchange
- Prior art date
Links
- 150000003863 ammonium salts Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- FAUOJMHVEYMQQG-HVYQDZECSA-N echinocandin B Chemical class C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](C)O)=CC=C(O)C=C1 FAUOJMHVEYMQQG-HVYQDZECSA-N 0.000 title 1
- 108010062092 echinocandin B Proteins 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- 108010049047 Echinocandins Proteins 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001728 nano-filtration Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
- Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
- Y10S977/898—Enzymatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12307399P | 1999-03-03 | 1999-03-03 | |
| PCT/US2000/005494 WO2000052036A1 (en) | 1999-03-03 | 2000-03-02 | Formation and anion-exchange of crystalline echinocandin ammonium salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105777T1 true CY1105777T1 (el) | 2011-02-02 |
Family
ID=22406562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101646T CY1105777T1 (el) | 1999-03-03 | 2006-11-13 | Σχηματισμος και ανιοντο-ανταλλαγη των εσωτepικων κρυσταλλικων αλατων αμμωνιου εχινοκανδινης β |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6590073B2 (enExample) |
| EP (1) | EP1155034B1 (enExample) |
| JP (1) | JP4063497B2 (enExample) |
| KR (1) | KR20020002476A (enExample) |
| CN (1) | CN1351610A (enExample) |
| AT (1) | ATE338060T1 (enExample) |
| AU (1) | AU767956B2 (enExample) |
| BR (1) | BR0009248A (enExample) |
| CA (1) | CA2362826A1 (enExample) |
| CY (1) | CY1105777T1 (enExample) |
| DE (1) | DE60030415T2 (enExample) |
| DK (1) | DK1155034T3 (enExample) |
| ES (1) | ES2270819T3 (enExample) |
| HK (1) | HK1040087A1 (enExample) |
| IL (1) | IL145186A0 (enExample) |
| PT (1) | PT1155034E (enExample) |
| WO (1) | WO2000052036A1 (enExample) |
| ZA (1) | ZA200107999B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| CN1337968A (zh) | 1998-12-09 | 2002-02-27 | 伊莱利利公司 | 蓝刺菌素环肽化合物的纯化 |
| DK1155034T3 (da) | 1999-03-03 | 2007-01-08 | Lilly Co Eli | Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte |
| JP2002538097A (ja) | 1999-03-03 | 2002-11-12 | イーライ リリー アンド カンパニー | 薬学的経口ｅｃｂ処方物および組成物の作製方法 |
| CN100335122C (zh) * | 1999-03-03 | 2007-09-05 | 伊莱利利公司 | 含有成胶束表面活性剂的棘白菌素药物制剂 |
| KR20020003864A (ko) | 1999-03-03 | 2002-01-15 | 피터 지. 스트링거 | 에키노칸딘/탄수화물 착물 |
| US6991800B2 (en) | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| TW200826957A (en) * | 2006-10-16 | 2008-07-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Purification processes for echinocandin-type compounds |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| US9394340B2 (en) | 2009-03-24 | 2016-07-19 | Cadila Healthcare Limited | Purification process for lipopeptides |
| WO2010108637A1 (en) * | 2009-03-27 | 2010-09-30 | Axellia Pharmaceuticals Aps | Crystalline compound |
| CN102464704B (zh) * | 2010-11-05 | 2013-12-11 | 上海医药工业研究院 | 一种化合物及其制备方法和用途 |
| CN102485879A (zh) * | 2010-12-03 | 2012-06-06 | 上海医药工业研究院 | 一种用于生产wf11899a的发酵培养基 |
| CN102295686A (zh) * | 2011-09-09 | 2011-12-28 | 杭州华东医药集团生物工程研究所有限公司 | 一种纽莫康定b0的提取纯化方法 |
| CN102659930B (zh) * | 2012-03-30 | 2014-04-23 | 上海天伟生物制药有限公司 | 一种高纯度环肽类物质的晶体及其制备方法和用途 |
| CN102627688B (zh) * | 2012-03-30 | 2014-12-31 | 上海天伟生物制药有限公司 | 一种高纯度环肽化合物及其制备方法和用途 |
| CN102627689B (zh) * | 2012-03-30 | 2014-08-06 | 上海天伟生物制药有限公司 | 一种环肽类化合物的水合物及其制备方法和用途 |
| CN105669839B (zh) * | 2014-12-05 | 2019-08-13 | 重庆乾泰生物医药有限公司 | 一种棘白菌素b母核或其盐的水合物及制备方法和用途 |
| CN105669840B (zh) * | 2014-12-05 | 2019-06-04 | 重庆乾泰生物医药有限公司 | 一种高纯度棘白菌素b母核盐酸盐的晶体及其制备方法 |
| US12060439B2 (en) | 2018-10-25 | 2024-08-13 | Napp Pharmaceutical Group Limited | Polymorph of echinocandin antifungal agent |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3293482A (en) | 1962-06-21 | 1966-12-20 | Rca Corp | Plural output traveling wave tube |
| JPS5134916B2 (enExample) | 1974-03-06 | 1976-09-29 | ||
| US4299763A (en) | 1979-12-13 | 1981-11-10 | Eli Lilly And Company | A-30912B Nucleus |
| US4293489A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| CA1170598A (en) * | 1979-12-13 | 1984-07-10 | Bernard J. Abbott | Process for the preparation of cyclic peptide nuclei |
| US4293482A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | A-30912A Nucleus |
| US4320052A (en) | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4293483A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4304716A (en) | 1979-12-13 | 1981-12-08 | Eli Lilly And Company | S 31794/F-1 Nucleus |
| US4876241A (en) | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
| DK173802B1 (da) | 1988-09-12 | 2001-11-05 | Merck & Co Inc | Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner |
| US5166135A (en) | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| CA2037957A1 (en) | 1990-03-12 | 1991-09-13 | Merck & Co., Inc. | N-acylated cyclohexapeptide compounds |
| US5310726A (en) | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| EP0460882B1 (en) | 1990-06-07 | 1996-07-24 | Eli Lilly And Company | Lipopeptide deacylase |
| FI912873L (fi) | 1990-06-18 | 1991-12-19 | Fujisawa Pharmaceutical Co | Ny polypeptidfoerening och foerfarande foer dess framstaellning. |
| US5198421A (en) | 1991-04-26 | 1993-03-30 | Merck & Co., Inc. | Phosphorylated cyclic lipopeptide |
| IL105048A (en) | 1992-03-19 | 2001-06-14 | Eli Lilly And Company U S | Cyclic peptide antifungal agents and process for preparation thereof |
| US5965525A (en) | 1992-03-19 | 1999-10-12 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5541160A (en) | 1994-04-04 | 1996-07-30 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
| US5646111A (en) | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| US5652213A (en) | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5618787A (en) | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5786325A (en) | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| US5629290A (en) | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629289A (en) | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JP2001503015A (ja) * | 1996-02-01 | 2001-03-06 | イーライ・リリー・アンド・カンパニー | 環状ペプチド抗真菌剤 |
| JPH1036284A (ja) * | 1996-07-24 | 1998-02-10 | Sumitomo Pharmaceut Co Ltd | プロテアソーム阻害剤 |
| AU8687798A (en) | 1997-08-04 | 1999-02-22 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US6232290B1 (en) * | 1998-02-09 | 2001-05-15 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic hexapeptides with antimicrobial activity |
| US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| EP1107981B1 (en) | 1998-08-20 | 2005-01-26 | Eli Lilly & Company | Synthesis of ring-modified cyclic peptide analogs |
| ATE267210T1 (de) | 1998-08-28 | 2004-06-15 | Lilly Co Eli | Reversible borkomplexe von 1,2-(cis)-diol zyklischen peptiden |
| CN1337968A (zh) | 1998-12-09 | 2002-02-27 | 伊莱利利公司 | 蓝刺菌素环肽化合物的纯化 |
| JP2002535248A (ja) | 1998-12-16 | 2002-10-22 | イーライ リリー アンド カンパニー | 環式ペプチド抗真菌剤 |
| CA2354055A1 (en) | 1998-12-16 | 2000-06-22 | Eli Lilly And Company | Cyclic peptide antifungal agents having a sugar substituent |
| DK1155034T3 (da) | 1999-03-03 | 2007-01-08 | Lilly Co Eli | Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte |
| KR20020003864A (ko) | 1999-03-03 | 2002-01-15 | 피터 지. 스트링거 | 에키노칸딘/탄수화물 착물 |
| JP2002538097A (ja) | 1999-03-03 | 2002-11-12 | イーライ リリー アンド カンパニー | 薬学的経口ｅｃｂ処方物および組成物の作製方法 |
| CN100335122C (zh) | 1999-03-03 | 2007-09-05 | 伊莱利利公司 | 含有成胶束表面活性剂的棘白菌素药物制剂 |
-
2000
- 2000-03-02 DK DK00916011T patent/DK1155034T3/da active
- 2000-03-02 EP EP00916011A patent/EP1155034B1/en not_active Expired - Lifetime
- 2000-03-02 PT PT00916011T patent/PT1155034E/pt unknown
- 2000-03-02 BR BR0009248-7A patent/BR0009248A/pt not_active IP Right Cessation
- 2000-03-02 JP JP2000602260A patent/JP4063497B2/ja not_active Expired - Lifetime
- 2000-03-02 KR KR1020017011233A patent/KR20020002476A/ko not_active Withdrawn
- 2000-03-02 HK HK02101825.7A patent/HK1040087A1/zh unknown
- 2000-03-02 DE DE60030415T patent/DE60030415T2/de not_active Expired - Lifetime
- 2000-03-02 AT AT00916011T patent/ATE338060T1/de active
- 2000-03-02 IL IL14518600A patent/IL145186A0/xx unknown
- 2000-03-02 ES ES00916011T patent/ES2270819T3/es not_active Expired - Lifetime
- 2000-03-02 CA CA002362826A patent/CA2362826A1/en not_active Abandoned
- 2000-03-02 AU AU37182/00A patent/AU767956B2/en not_active Ceased
- 2000-03-02 CN CN00804419A patent/CN1351610A/zh active Pending
- 2000-03-02 WO PCT/US2000/005494 patent/WO2000052036A1/en not_active Ceased
-
2001
- 2001-08-30 US US09/944,309 patent/US6590073B2/en not_active Expired - Lifetime
- 2001-09-28 ZA ZA200107999A patent/ZA200107999B/xx unknown
-
2006
- 2006-11-13 CY CY20061101646T patent/CY1105777T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1040087A1 (zh) | 2002-05-24 |
| KR20020002476A (ko) | 2002-01-09 |
| DE60030415T2 (de) | 2007-08-30 |
| CA2362826A1 (en) | 2000-09-08 |
| US20020161176A1 (en) | 2002-10-31 |
| DK1155034T3 (da) | 2007-01-08 |
| CN1351610A (zh) | 2002-05-29 |
| JP4063497B2 (ja) | 2008-03-19 |
| WO2000052036A1 (en) | 2000-09-08 |
| BR0009248A (pt) | 2001-11-20 |
| JP2002538165A (ja) | 2002-11-12 |
| ES2270819T3 (es) | 2007-04-16 |
| ZA200107999B (en) | 2003-06-25 |
| ATE338060T1 (de) | 2006-09-15 |
| US6590073B2 (en) | 2003-07-08 |
| AU3718200A (en) | 2000-09-21 |
| EP1155034A1 (en) | 2001-11-21 |
| AU767956B2 (en) | 2003-11-27 |
| DE60030415D1 (de) | 2006-10-12 |
| IL145186A0 (en) | 2002-06-30 |
| EP1155034B1 (en) | 2006-08-30 |
| WO2000052036A8 (en) | 2001-06-21 |
| PT1155034E (pt) | 2007-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1105777T1 (el) | Σχηματισμος και ανιοντο-ανταλλαγη των εσωτepικων κρυσταλλικων αλατων αμμωνιου εχινοκανδινης β | |
| ES8706165A1 (es) | Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida. | |
| YU39292A (sh) | Nove nehigroskopne mono-amonium soli | |
| MX9303441A (es) | Procedimiento para la preparacion de acido clavulanico. | |
| HUP9903454A2 (hu) | Cefditoren-pivoxil kristályos formája, és eljárás annak előállítására | |
| ATE149509T1 (de) | Verfahren zur herstellung von 2-chlor-2'- desoxyadenosin | |
| HUP9800615A2 (hu) | Eljárás bisz(hidroxi-metil)-vegyületek előállítására | |
| CY1110539T1 (el) | Μεθοδος για παραγωγα φαινυλοξικου οξεος | |
| BR0002297A (pt) | Aditivo de gênero alimentìcio que contém ácido d-pantotênico e/ou seus sais e um processo para a sua preparação | |
| UA41904C2 (uk) | Спосіб одержання бензопіранових сполук, проміжні сполуки, спосіб одержання проміжних сполук | |
| EA200100514A1 (ru) | Способ получения метионина | |
| AU8728801A (en) | Method and agents on the basis of 2-mercaptopropionic acid amides for durable hair forming and a method for producing same | |
| BR9102466A (pt) | Processo para a preparacao de um composto quimico e composto de piridina-dicarboxilato | |
| MX2024010008A (es) | Formas polimorficas y metodos de produccion de formas polimorficas de un compuesto. | |
| AR126196A1 (es) | Proceso para preparar inhibidores de egfr | |
| DE3867899D1 (de) | Verfahren zur herstellung von 4-amino-androstendion-derivaten. | |
| ATE267799T1 (de) | Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycin | |
| PL362392A1 (pl) | Sposób wytwarzania pochodnych taksanu | |
| BR9913989A (pt) | Derivados de 6-(4-fenilbutóxi)hexilamina e processo para a obtenção de salmeterol | |
| DE69521887D1 (de) | Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz | |
| EA199900765A1 (ru) | Новые производные эритромицина, способ их получения и их применение в качестве лекарственных средств | |
| NO994083L (no) | Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser | |
| ATE284837T1 (de) | Verfahren zur herstellung einer salzfreien, waessrigen hydroxylaminloesung | |
| BRPI0417300A (pt) | métodos para a preparação de compostos de tiazolpirimidina | |
| ES541215A0 (es) | Un metodo para preparar un cianoimidazol-nucleosido |