ATE338060T1 - Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b - Google Patents

Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b

Info

Publication number
ATE338060T1
ATE338060T1 AT00916011T AT00916011T ATE338060T1 AT E338060 T1 ATE338060 T1 AT E338060T1 AT 00916011 T AT00916011 T AT 00916011T AT 00916011 T AT00916011 T AT 00916011T AT E338060 T1 ATE338060 T1 AT E338060T1
Authority
AT
Austria
Prior art keywords
echinocandin
formation
ammonium salts
anion exchange
salt
Prior art date
Application number
AT00916011T
Other languages
German (de)
English (en)
Inventor
Brian Weston Dalder
Michael Anthony Dotlich
Neil John Kallman
Samuel Dean Larsen
Den Berghe Snorek Sharon Van
Jeffrey Thomas Vicenzi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE338060T1 publication Critical patent/ATE338060T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
    • Y10S977/898—Enzymatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT00916011T 1999-03-03 2000-03-02 Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b ATE338060T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12307399P 1999-03-03 1999-03-03

Publications (1)

Publication Number Publication Date
ATE338060T1 true ATE338060T1 (de) 2006-09-15

Family

ID=22406562

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00916011T ATE338060T1 (de) 1999-03-03 2000-03-02 Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b

Country Status (18)

Country Link
US (1) US6590073B2 (enExample)
EP (1) EP1155034B1 (enExample)
JP (1) JP4063497B2 (enExample)
KR (1) KR20020002476A (enExample)
CN (1) CN1351610A (enExample)
AT (1) ATE338060T1 (enExample)
AU (1) AU767956B2 (enExample)
BR (1) BR0009248A (enExample)
CA (1) CA2362826A1 (enExample)
CY (1) CY1105777T1 (enExample)
DE (1) DE60030415T2 (enExample)
DK (1) DK1155034T3 (enExample)
ES (1) ES2270819T3 (enExample)
HK (1) HK1040087A1 (enExample)
IL (1) IL145186A0 (enExample)
PT (1) PT1155034E (enExample)
WO (1) WO2000052036A1 (enExample)
ZA (1) ZA200107999B (enExample)

Families Citing this family (20)

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US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
EP1137663B1 (en) 1998-12-09 2006-08-30 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
BR0008712A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Complexos equinocandina/carboidrato
KR20010112302A (ko) 1999-03-03 2001-12-20 피터 지. 스트링거 제약학적 경구용 ｅｃｂ 조제물 및 조성물의 제조 방법
PT1582204E (pt) * 1999-03-03 2013-11-25 Lilly Co Eli Formulações farmacêuticas de equinocandina que contêm tensioactivos que formam micelas
ES2270819T3 (es) 1999-03-03 2007-04-16 Eli Lilly And Company Formacion e intercambio anionico de sales de amonio internas cristalinas de equinocandina.
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
WO2010108637A1 (en) * 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN102464704B (zh) * 2010-11-05 2013-12-11 上海医药工业研究院 一种化合物及其制备方法和用途
CN102485879A (zh) * 2010-12-03 2012-06-06 上海医药工业研究院 一种用于生产wf11899a的发酵培养基
CN102295686A (zh) * 2011-09-09 2011-12-28 杭州华东医药集团生物工程研究所有限公司 一种纽莫康定b0的提取纯化方法
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) * 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN102627688B (zh) * 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN105669839B (zh) * 2014-12-05 2019-08-13 重庆乾泰生物医药有限公司 一种棘白菌素b母核或其盐的水合物及制备方法和用途
CN105669840B (zh) * 2014-12-05 2019-06-04 重庆乾泰生物医药有限公司 一种高纯度棘白菌素b母核盐酸盐的晶体及其制备方法
WO2020086931A1 (en) * 2018-10-25 2020-04-30 Cidara Therapeutics, Inc. Polymorph of echinocandin antifungal agent

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US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4299763A (en) 1979-12-13 1981-11-10 Eli Lilly And Company A-30912B Nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293483A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
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CA2037957A1 (en) 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
CA2043762C (en) 1990-06-07 2001-05-29 Adam J. Kreuzman Lipopeptide deacylase
FI912873A7 (fi) 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Uusi polypeptidiyhdiste ja menetelmä sen valmistamiseksi
US5198421A (en) 1991-04-26 1993-03-30 Merck & Co., Inc. Phosphorylated cyclic lipopeptide
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
MY136593A (en) 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0881907A4 (en) * 1996-02-01 2000-05-10 Lilly Co Eli FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES
JPH1036284A (ja) * 1996-07-24 1998-02-10 Sumitomo Pharmaceut Co Ltd プロテアソーム阻害剤
AU8687798A (en) 1997-08-04 1999-02-22 Eli Lilly And Company Cyclic peptide antifungal agents
CA2320416A1 (en) * 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
AU763351B2 (en) 1998-08-28 2003-07-17 Eli Lilly And Company Reversible boronate complexes of 1,2-(cis)-diol cyclic-peptides
EP1137663B1 (en) 1998-12-09 2006-08-30 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
EP1140991A1 (en) 1998-12-16 2001-10-10 Eli Lilly And Company Cyclic peptide antifungal agents
WO2000035945A1 (en) 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
PT1582204E (pt) 1999-03-03 2013-11-25 Lilly Co Eli Formulações farmacêuticas de equinocandina que contêm tensioactivos que formam micelas
ES2270819T3 (es) 1999-03-03 2007-04-16 Eli Lilly And Company Formacion e intercambio anionico de sales de amonio internas cristalinas de equinocandina.
KR20010112302A (ko) 1999-03-03 2001-12-20 피터 지. 스트링거 제약학적 경구용 ｅｃｂ 조제물 및 조성물의 제조 방법
BR0008712A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Complexos equinocandina/carboidrato

Also Published As

Publication number Publication date
CA2362826A1 (en) 2000-09-08
DK1155034T3 (da) 2007-01-08
CN1351610A (zh) 2002-05-29
US20020161176A1 (en) 2002-10-31
EP1155034A1 (en) 2001-11-21
ES2270819T3 (es) 2007-04-16
JP2002538165A (ja) 2002-11-12
BR0009248A (pt) 2001-11-20
US6590073B2 (en) 2003-07-08
CY1105777T1 (el) 2011-02-02
AU3718200A (en) 2000-09-21
AU767956B2 (en) 2003-11-27
HK1040087A1 (zh) 2002-05-24
EP1155034B1 (en) 2006-08-30
DE60030415D1 (de) 2006-10-12
KR20020002476A (ko) 2002-01-09
JP4063497B2 (ja) 2008-03-19
DE60030415T2 (de) 2007-08-30
IL145186A0 (en) 2002-06-30
WO2000052036A8 (en) 2001-06-21
WO2000052036A1 (en) 2000-09-08
PT1155034E (pt) 2007-01-31
ZA200107999B (en) 2003-06-25

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