SI9500039B - Nov kombiniran postopek čiščenja Vankomicin hidroklorida - Google Patents
Nov kombiniran postopek čiščenja Vankomicin hidroklorida Download PDFInfo
- Publication number
- SI9500039B SI9500039B SI9500039A SI9500039A SI9500039B SI 9500039 B SI9500039 B SI 9500039B SI 9500039 A SI9500039 A SI 9500039A SI 9500039 A SI9500039 A SI 9500039A SI 9500039 B SI9500039 B SI 9500039B
- Authority
- SI
- Slovenia
- Prior art keywords
- process according
- antibiotic
- ethanol
- water
- mobile phase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Claims (16)
1 PATENTNI ZAHTEVKI 1. Nov postopek za čiščenje vankomicinskih antibiotikov, značilen po tem, da kombinira preparativno kromatografijo na silikagelni koloni z alkalno vodno-metanolno mobilno fazo in obarjanje z etanolom iz solno-vodno-etanolne raztopine za stranske frakcije, ki obsega naslednje stopnje: a) koncentriranje nakisanih združenih stranskih frakcij antibiotika s koncentracijami do približno 1,5 g/1 z reverzno osmozo b) dodajanje NaCl in mešanje, da dosežemo raztopitev soli in kristalizacijo antibiotika c) dodajanje etanola k nastali suspenziji pri sobni temperaturi, da povzročimo prvo raztapljanje kristaliziranega antibiotika in nadaljnje dodajanje etanola (v celoti štirikrat več etanola kot vode), da povzročimo obarjanje antibiotika d) ohlajevanje dobljene suspenzije na približno 5 °C in centrifugiranje e) razsoljevanje antibiotika na reverzni osmozi in nadaljevanje postopka, kot je uporabljen za glavno frakcijo.
2. Postopek po zahtevku 1, značilen po tem, da pripravimo končni produkt z obarjanjem iz solno-vodno-etanolne raztopine.
3. Postopek po zahtevku 2, značilen po tem, da posušimo končni produkt na razpršilnem sušilniku.
4. Postopek po zahtevku 2, značilen po tem, da pripravimo končni produkt z liofilizacijo iz etanolne raztopine antibiotika. 2
5. Postopek po zahtevku 4, značilen po tem, da liofiliziramo iz raztopine z dodatkom do največ 12 % etanola.
6. Postopek po zahtevku 1, značilen po tem, da ga uporabljamo za čiščenje vankomicina in vankomicin hidroklorida.
7. Postopek po zahtevku 1, značilen po tem, daje koncentracija antibiotika pri nanosu na kolono ter pred začetkom izsoljevanja okrog 50 do okrog 120 g/1.
8. Postopek po zahtevku 7, značilen po tem, daje koncentracija antibiotika pri nanosu na kolono ter pred začetkom izsoljevanja okrog 80 g/1.
9. Postopek po zahtevku 1, značilen po tem, daje masno razmerje med antibiotikom in silikagelom na koloni okrog 1 : 100.
10. Postopek po zahtevku 1, značilen po tem, daje mobilna faza 0,35 %-ni NH4HCO3 v 7 %-nem metanolu.
11. Postopek po zahtevku 1, značilen po tem, daje pretok mobilne faze med okrog 20 in okrog 100 1/min.
12. Postopek po zahtevku 1, značilen po tem, daje pH mobilne faze med okrog 7,9 in okrog 8,5.
13. Postopek po zahtevku 1, značilen po tem, daje temperatura v koloni okrog 15 °C.
14. Postopek po zahtevku 1, značilen po tem, da izsoljujemo z okrog 10 do okrog 20 % NaCl glede na vodo. 3
15. Postopek po zahtevku 1, značilen po tem, da izsoljujemo z okrog 15 % NaCl glede na vodo.
16. Postopek po zahtevku 1, značilen po tem, da pridobimo tako čist antibiotik, daje uporaben tako peroralno kot parenteralno.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9500039A SI9500039B (sl) | 1995-02-07 | 1995-02-07 | Nov kombiniran postopek čiščenja Vankomicin hidroklorida |
| EP96901183A EP0809652B1 (en) | 1995-02-07 | 1996-02-06 | New combined process for the purification of vancomycin hydrochloride |
| ES96901183T ES2205012T3 (es) | 1995-02-07 | 1996-02-06 | Nuevo procedimiento combinado para la purificacion de clorhidrato de vancomicina. |
| DK96901183T DK0809652T3 (da) | 1995-02-07 | 1996-02-06 | Kombineret fremgangsmåde til rensning af vancomycinhydrochlorid |
| JP8524215A JPH10513196A (ja) | 1995-02-07 | 1996-02-06 | バンコマイシン塩酸塩の精製のための新規な組合された方法 |
| AT96901183T ATE247665T1 (de) | 1995-02-07 | 1996-02-06 | Kombinierter prozess zur reinigung von vancomycin hydrochlorid |
| AU45003/96A AU4500396A (en) | 1995-02-07 | 1996-02-06 | New combined process for the purification of vancomycin hydrochloride |
| PCT/SI1996/000003 WO1996024615A1 (en) | 1995-02-07 | 1996-02-06 | New combined process for the purification of vancomycin hydrochloride |
| US08/875,443 US5853720A (en) | 1995-02-07 | 1996-02-06 | Combined process for the purification of vancomycin hydrochloride |
| DE69629551T DE69629551T2 (de) | 1995-02-07 | 1996-02-06 | Kombinierter prozess zur reinigung von vancomycin hydrochlorid |
| CA002210990A CA2210990C (en) | 1995-02-07 | 1996-02-06 | New combined process for the purification of vancomycin hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9500039A SI9500039B (sl) | 1995-02-07 | 1995-02-07 | Nov kombiniran postopek čiščenja Vankomicin hidroklorida |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9500039A SI9500039A (en) | 1996-08-31 |
| SI9500039B true SI9500039B (sl) | 2002-02-28 |
Family
ID=20431542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9500039A SI9500039B (sl) | 1995-02-07 | 1995-02-07 | Nov kombiniran postopek čiščenja Vankomicin hidroklorida |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5853720A (sl) |
| EP (1) | EP0809652B1 (sl) |
| JP (1) | JPH10513196A (sl) |
| AT (1) | ATE247665T1 (sl) |
| AU (1) | AU4500396A (sl) |
| CA (1) | CA2210990C (sl) |
| DE (1) | DE69629551T2 (sl) |
| DK (1) | DK0809652T3 (sl) |
| ES (1) | ES2205012T3 (sl) |
| SI (1) | SI9500039B (sl) |
| WO (1) | WO1996024615A1 (sl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI233932B (en) * | 2001-08-24 | 2005-06-11 | Theravance Inc | Process for purifying glycopeptide phosphonate derivatives |
| CA2506236C (en) * | 2002-11-18 | 2018-07-17 | Vicuron Pharmaceuticals Inc. | Compositions and uses of dalbavancin for treatment of bacterial infections |
| KR100554481B1 (ko) * | 2004-06-30 | 2006-03-03 | 씨제이 주식회사 | 반코마이신 염산염의 정제방법 |
| CN100408596C (zh) * | 2005-11-30 | 2008-08-06 | 上海医药工业研究院 | 供hplc分析的万古霉素发酵液前处理方法 |
| EP1798237A1 (en) * | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Process for the purification of macrolide antibiotics |
| KR101101663B1 (ko) * | 2009-01-13 | 2011-12-30 | (주) 제노텍 | 반코마이신 습체의 정제방법 |
| JP2011153119A (ja) * | 2010-01-27 | 2011-08-11 | Mylan Seiyaku Ltd | バンコマイシンまたはその塩を含有する錠剤 |
| AU2012204462A1 (en) * | 2011-01-05 | 2013-07-11 | Hospira, Inc. | Spray drying vancomycin |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| CN104610434B (zh) * | 2013-11-01 | 2019-06-07 | 浙江医药股份有限公司新昌制药厂 | 一种盐酸万古霉素的分离纯化方法 |
| CN104991028B (zh) * | 2015-07-31 | 2017-10-31 | 北京市药品检验所 | Lc‑ms测试物中不挥发性缓冲盐含量的降低方法 |
| CN105461786B (zh) * | 2016-01-23 | 2018-11-16 | 雅赛利(台州)制药有限公司 | 一种盐酸万古霉素的分离纯化工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2577133B2 (ja) * | 1989-11-27 | 1997-01-29 | スティフティング フォール ド テフニスヘ ウェッテンスハッペン | 船舶のプロペラ |
| US5235037A (en) * | 1991-08-15 | 1993-08-10 | American Cyanamid Company | Vancomycin precipitation process |
-
1995
- 1995-02-07 SI SI9500039A patent/SI9500039B/sl not_active IP Right Cessation
-
1996
- 1996-02-06 AT AT96901183T patent/ATE247665T1/de not_active IP Right Cessation
- 1996-02-06 US US08/875,443 patent/US5853720A/en not_active Expired - Fee Related
- 1996-02-06 EP EP96901183A patent/EP0809652B1/en not_active Expired - Lifetime
- 1996-02-06 CA CA002210990A patent/CA2210990C/en not_active Expired - Fee Related
- 1996-02-06 DE DE69629551T patent/DE69629551T2/de not_active Expired - Fee Related
- 1996-02-06 ES ES96901183T patent/ES2205012T3/es not_active Expired - Lifetime
- 1996-02-06 JP JP8524215A patent/JPH10513196A/ja not_active Withdrawn
- 1996-02-06 DK DK96901183T patent/DK0809652T3/da active
- 1996-02-06 AU AU45003/96A patent/AU4500396A/en not_active Abandoned
- 1996-02-06 WO PCT/SI1996/000003 patent/WO1996024615A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ATE247665T1 (de) | 2003-09-15 |
| DE69629551T2 (de) | 2004-06-17 |
| EP0809652A1 (en) | 1997-12-03 |
| SI9500039A (en) | 1996-08-31 |
| JPH10513196A (ja) | 1998-12-15 |
| US5853720A (en) | 1998-12-29 |
| ES2205012T3 (es) | 2004-05-01 |
| CA2210990A1 (en) | 1996-08-15 |
| WO1996024615A1 (en) | 1996-08-15 |
| DK0809652T3 (da) | 2003-12-08 |
| CA2210990C (en) | 2001-07-03 |
| AU4500396A (en) | 1996-08-27 |
| EP0809652B1 (en) | 2003-08-20 |
| DE69629551D1 (de) | 2003-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI9500039B (sl) | Nov kombiniran postopek čiščenja Vankomicin hidroklorida | |
| AP1709A (en) | Ethanolate of azithromycin, process for manufacure, and pharmaceutical compositions thereof. | |
| NO930885D0 (no) | Framgangsmaate for fremstilling av rhamnose fra rhamnolipider | |
| ATE338060T1 (de) | Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b | |
| KR950032260A (ko) | 티오에테르 결합체의 제조 방법 | |
| JP2002542163A (ja) | 血漿成分の分離 | |
| EP1824874A1 (en) | Pure vancomycin hydrochloride | |
| EP1311535B1 (en) | Metal ion assisted n- n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester isomer resolution | |
| IL122151A0 (en) | Purification of dalbaheptide antibiotics by isoelectric focusing | |
| JPH04352796A (ja) | アスパルテームの晶析法 | |
| JPH10513195A (ja) | 分取ｈｐｌｃの使用によるバンコマイシン塩酸塩のクロマトグラフ精製 | |
| JPH08119916A (ja) | Ｎ−保護グルタミン酸γ−誘導体の選択的製造法 | |
| Kinoshita et al. | Absolute configuration of 4-amino-3-hydroxy-6-methylheptanoic acid present in pepstatin A and stereospecific synthesis of all four isomers | |
| JP3382297B2 (ja) | 高純度デフェロキサミン塩の製造法 | |
| JPH07233147A (ja) | 精製ｌ−ヒドロキシプロリンの製造法 | |
| US5391738A (en) | Process for the separation of folinic acids | |
| Da Settimo et al. | Isosteric replacement of the indole nucleus by benzothiophene and benzofuran in a series of indolylglyoxylylamine derivatives with partial agonist activity at the benzodiazepine receptor | |
| JPH11180948A (ja) | Ｓ−（１，２− ジカルボキシエチル） グルタチオンの製造法 | |
| JPH0812693A (ja) | アスコルビン酸誘導体の製造法 | |
| JPH072747A (ja) | Ｎ−長鎖アシル酸性アミノ酸塩の精製法 | |
| RU2000125238A (ru) | Производные 5-имино-13-дезокси антрациклина и способ их получения (варианты), фармацевтическая композиция, способ лечения рака, аутоиммунных заболеваний или иммунодефицитных нарушений | |
| IT9019913A1 (it) | Separazione di isomeri di derivati della furo/3, 4-c/piridina | |
| SU557794A1 (ru) | Способ очистки рутина | |
| SK281295B6 (sk) | Spôsob separácie aminokyselín a/alebo aminosulfónových kyselín adsorpciou na zeolitoch | |
| IKEDA et al. | Preparation of 13C and 15N labeled bellenamine and its degradation products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20061011 |