BR0308304A - Processo para preparar forma i cristalina de cabergolina - Google Patents

Processo para preparar forma i cristalina de cabergolina

Info

Publication number
BR0308304A
BR0308304A BR0308304-7A BR0308304A BR0308304A BR 0308304 A BR0308304 A BR 0308304A BR 0308304 A BR0308304 A BR 0308304A BR 0308304 A BR0308304 A BR 0308304A
Authority
BR
Brazil
Prior art keywords
cabergoline
heptane
preparing crystalline
cabergoline form
toluene
Prior art date
Application number
BR0308304-7A
Other languages
English (en)
Inventor
Ahmad Y Sheikh
Attilio Tomasi
Original Assignee
Pharmacia Corp
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Pharmacia Italia Spa filed Critical Pharmacia Corp
Publication of BR0308304A publication Critical patent/BR0308304A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Abstract

"PROCESSO PARA PREPARAR FORMA I CRISTALINA DE CABERGOLINA". A presente invenção refere-se a um processo para produção de forma I cristalina de cabergolina, cujo processo compreende a preparação de forma V usando heptano como solvente de precipitação, e sua exclusiva conversão em forma I cristalina de cabergolina. O presente processo de cristalização do sistema solvente tolueno-heptano para forma V, envolve a 'adição reversa' de concentrado tolueno-cabergolina a heptano frio.
BR0308304-7A 2002-03-15 2003-03-10 Processo para preparar forma i cristalina de cabergolina BR0308304A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36456702P 2002-03-15 2002-03-15
US41016302P 2002-09-12 2002-09-12
PCT/EP2003/002628 WO2003078433A1 (en) 2002-03-15 2003-03-10 Process for preparing crystalline form i of cabergoline

Publications (1)

Publication Number Publication Date
BR0308304A true BR0308304A (pt) 2004-12-28

Family

ID=28045414

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308304-7A BR0308304A (pt) 2002-03-15 2003-03-10 Processo para preparar forma i cristalina de cabergolina

Country Status (15)

Country Link
US (1) US20060281777A1 (pt)
EP (1) EP1485383A1 (pt)
JP (1) JP2005529856A (pt)
KR (1) KR100622512B1 (pt)
CN (1) CN1639160A (pt)
AU (1) AU2003218753A1 (pt)
BR (1) BR0308304A (pt)
CA (1) CA2479140A1 (pt)
IL (1) IL163520A0 (pt)
MX (1) MXPA04008915A (pt)
PL (1) PL374503A1 (pt)
RS (1) RS81804A (pt)
RU (1) RU2278118C2 (pt)
TW (1) TW200305573A (pt)
WO (1) WO2003078433A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1507777A4 (en) * 2002-03-15 2007-03-07 Pharmacia Corp PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM I OF CABERGOLIN
IL155545A (en) 2003-04-21 2009-12-24 Finetech Pharmaceutical Ltd Solvate form of cabergoline
CA2525104A1 (en) * 2003-05-08 2004-11-25 Ivax Pharmaceuticals S.R.O. Polymorphs of cabergoline
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
GB0515430D0 (en) * 2005-07-27 2005-08-31 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) * 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US7887234B2 (en) * 2006-10-20 2011-02-15 Siemens Corporation Maximum blade surface temperature estimation for advanced stationary gas turbines in near-infrared (with reflection)
EP1953157A1 (en) * 2007-01-31 2008-08-06 LEK Pharmaceuticals D.D. New crystal form of cabergoline

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
EP0664705B1 (en) * 1993-08-18 2000-10-04 Alcon Laboratories, Inc. Compositions of ergoline derivatives for the treatment of glaucoma
GB0007309D0 (en) * 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Crystalline form V|| of cabergoline
GB0007307D0 (en) * 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Crystalline form || of cabergoline
GB0007308D0 (en) * 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Process for preparing crystalline form | of cabergoline

Also Published As

Publication number Publication date
RS81804A (en) 2006-10-27
KR100622512B1 (ko) 2006-09-13
CA2479140A1 (en) 2003-09-25
AU2003218753A1 (en) 2003-09-29
RU2004127583A (ru) 2006-01-27
US20060281777A1 (en) 2006-12-14
WO2003078433A1 (en) 2003-09-25
KR20050006129A (ko) 2005-01-15
RU2278118C2 (ru) 2006-06-20
CN1639160A (zh) 2005-07-13
MXPA04008915A (es) 2005-06-20
IL163520A0 (en) 2005-12-18
TW200305573A (en) 2003-11-01
JP2005529856A (ja) 2005-10-06
EP1485383A1 (en) 2004-12-15
PL374503A1 (en) 2005-10-31

Similar Documents

Publication Publication Date Title
BR0308304A (pt) Processo para preparar forma i cristalina de cabergolina
HUP0300418A2 (hu) Eljárás klaritromicin (II) típusú kristálymódosulatainak az előállítására
WO2001002297A3 (de) Verfahren zur herstellung von tonerdehydraten durch fällung von aluminiumsalzen in gegenwart von kristallisationskeimen
ES2192165T3 (es) Metodo para preparar cristales en forma ii de claritromicina de la forma ii.
TR200201146T2 (tr) Sertralin hidrokorid polimorfik formları.
BR0315335A (pt) Processo para a preparação de (s,s)-cis-2-benzidril-3-benzilaminoquinuclina
ATE353903T1 (de) Kristalline cefdinirsalze
FR2888849B1 (fr) Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
IT1319234B1 (it) Processo di preparazione di gabapentina.
BR0212542A (pt) Método para a preparação de gluconato de cálcio, e, mistura de sal de glucomato/sal de ácido orgânico
BR0301667A (pt) Processo para a preparação de polìmeros em emulsão com pureza elevada
BR0012631A (pt) Processo para a preparação de compostos de amina
ATE519731T1 (de) Verfahren zur herstellung von memantinhydrochlorid
BRPI0409235A (pt) processo para a produção de sal de amÈnio do ácido 2-hidróxi-4-metiltiobutìrico
PT1102745E (pt) Processo para a preparacao do sal de calcio do zofenopril
BR0314838A (pt) Sistema de liberação controlada, e, processo para preparar comprimidos de liberação controlada de temozolomida
ATE437178T1 (de) Analgetisches antitumorpeptid aus skorpionen und verfahren zu dessen herstellung
DE69521887T2 (de) Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz
BRPI0413741A (pt) métodos para preparar thip e para preparar um composto, e, composto
BRPI0017522B8 (pt) processo para preparação de secretagogos de hormônio de crescimento e polimorfo
BRPI0517810A (pt) composto e respectivo método de produção e processo de preparação de 13-deoxiantraciclinas e de 5-imino-13-deoxiantraciclinas
BR0008566A (pt) Processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxamida
BRPI0409644A (pt) processo para a preparação de nicotinaldeìdos
BR0312672A (pt) Processo para a preparação de compostos
BRPI0407012A (pt) Processo para a produção de um composto e uso do composto

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.