DE69521887T2 - Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz - Google Patents

Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz

Info

Publication number
DE69521887T2
DE69521887T2 DE69521887T DE69521887T DE69521887T2 DE 69521887 T2 DE69521887 T2 DE 69521887T2 DE 69521887 T DE69521887 T DE 69521887T DE 69521887 T DE69521887 T DE 69521887T DE 69521887 T2 DE69521887 T2 DE 69521887T2
Authority
DE
Germany
Prior art keywords
benzo
amino
dione
zaminoethyl
isochinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69521887T
Other languages
English (en)
Other versions
DE69521887D1 (de
Inventor
Silvano Spinelli
Roberto Didomenico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novuspharma SpA
Original Assignee
Novuspharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma SpA filed Critical Novuspharma SpA
Application granted granted Critical
Publication of DE69521887D1 publication Critical patent/DE69521887D1/de
Publication of DE69521887T2 publication Critical patent/DE69521887T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69521887T 1994-03-28 1995-03-27 Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz Expired - Lifetime DE69521887T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
PCT/IB1995/000230 WO1995026189A1 (en) 1994-03-28 1995-03-27 AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT

Publications (2)

Publication Number Publication Date
DE69521887D1 DE69521887D1 (de) 2001-08-30
DE69521887T2 true DE69521887T2 (de) 2001-11-22

Family

ID=22821665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521887T Expired - Lifetime DE69521887T2 (de) 1994-03-28 1995-03-27 Verbessertes verfahren zur herstellung von 6,9[(zaminoethyl)amino]benzo[g]isochinoline-5,10 dione und sein dimaleinsaeure salz

Country Status (24)

Country Link
US (3) US5506232A (de)
EP (1) EP0752857B1 (de)
JP (2) JP3151462B2 (de)
KR (1) KR100224153B1 (de)
CN (2) CN1130199C (de)
AT (1) ATE203408T1 (de)
AU (1) AU679627B2 (de)
BR (1) BR9507257A (de)
CA (1) CA2186485C (de)
CZ (2) CZ285139B6 (de)
DE (1) DE69521887T2 (de)
DK (1) DK0752857T3 (de)
ES (1) ES2159313T3 (de)
FI (1) FI113861B (de)
GR (1) GR3037014T3 (de)
HU (1) HU223311B1 (de)
LU (1) LU92089I2 (de)
NO (2) NO307564B1 (de)
NZ (1) NZ282480A (de)
PT (1) PT752857E (de)
RU (1) RU2144028C1 (de)
TW (1) TW397826B (de)
WO (1) WO1995026189A1 (de)
ZA (1) ZA952477B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
SK281254B6 (sk) * 1995-07-13 2001-01-18 Smithkline Beecham Corporation Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
US20050222190A1 (en) * 2004-03-30 2005-10-06 Curd John G 1,4-bis-N-oxide azaanthracenediones and the use thereof
US20080081041A1 (en) * 2006-09-29 2008-04-03 Jeffrey Nemeth Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920754A1 (en) * 1991-03-08 1992-09-09 Univ Vermont 6,9 BIS(SUBSTITUTED-AMINO) BENZO[g]-ISOQUINOLINE-5,10-DIONES
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
CN1282738A (zh) 2001-02-07
EP0752857B1 (de) 2001-07-25
FI113861B (fi) 2004-06-30
HU9602655D0 (en) 1996-11-28
CZ598A3 (cs) 1999-05-12
US5506232A (en) 1996-04-09
AU1958995A (en) 1995-10-17
NO964082L (no) 1996-09-27
FI963864A (fi) 1996-09-27
CZ285139B6 (cs) 1999-05-12
JP2001089454A (ja) 2001-04-03
FI963864A0 (fi) 1996-09-27
EP0752857A1 (de) 1997-01-15
MX9603994A (es) 1997-12-31
NZ282480A (en) 1997-04-24
ES2159313T3 (es) 2001-10-01
CZ284937B6 (cs) 1999-04-14
BR9507257A (pt) 1997-10-07
NO964082D0 (no) 1996-09-27
NO2012020I1 (no) 2012-12-27
CN1130199C (zh) 2003-12-10
TW397826B (en) 2000-07-11
PT752857E (pt) 2001-11-30
CA2186485C (en) 1999-12-14
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
DE69521887D1 (de) 2001-08-30
NO307564B1 (no) 2000-04-25
RU2144028C1 (ru) 2000-01-10
CZ276796A3 (en) 1997-02-12
AU679627B2 (en) 1997-07-03
GR3037014T3 (en) 2002-01-31
CA2186485A1 (en) 1995-10-05
ZA952477B (en) 1996-09-27
LU92089I2 (fr) 2012-12-27
JP3151462B2 (ja) 2001-04-03
DK0752857T3 (da) 2001-09-24
HUT75654A (en) 1997-05-28
CN1145028A (zh) 1997-03-12
ATE203408T1 (de) 2001-08-15
JP3548099B2 (ja) 2004-07-28
US5717099A (en) 1998-02-10
KR100224153B1 (ko) 1999-10-15
JPH09507674A (ja) 1997-08-05
HU223311B1 (hu) 2004-05-28
WO1995026189A1 (en) 1995-10-05

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