ZA952477B - Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt - Google Patents

Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt

Info

Publication number
ZA952477B
ZA952477B ZA952477A ZA952477A ZA952477B ZA 952477 B ZA952477 B ZA 952477B ZA 952477 A ZA952477 A ZA 952477A ZA 952477 A ZA952477 A ZA 952477A ZA 952477 B ZA952477 B ZA 952477B
Authority
ZA
South Africa
Prior art keywords
aminoethyl
benzo
bis
amino
dione
Prior art date
Application number
ZA952477A
Other languages
English (en)
Inventor
Silvano Spinelli
Roberto Didomenico
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ZA952477B publication Critical patent/ZA952477B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA952477A 1994-03-28 1995-03-27 Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt ZA952477B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Publications (1)

Publication Number Publication Date
ZA952477B true ZA952477B (en) 1996-09-27

Family

ID=22821665

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952477A ZA952477B (en) 1994-03-28 1995-03-27 Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt

Country Status (24)

Country Link
US (3) US5506232A (de)
EP (1) EP0752857B1 (de)
JP (2) JP3151462B2 (de)
KR (1) KR100224153B1 (de)
CN (2) CN1130199C (de)
AT (1) ATE203408T1 (de)
AU (1) AU679627B2 (de)
BR (1) BR9507257A (de)
CA (1) CA2186485C (de)
CZ (2) CZ284937B6 (de)
DE (1) DE69521887T2 (de)
DK (1) DK0752857T3 (de)
ES (1) ES2159313T3 (de)
FI (1) FI113861B (de)
GR (1) GR3037014T3 (de)
HU (1) HU223311B1 (de)
LU (1) LU92089I2 (de)
NO (2) NO307564B1 (de)
NZ (1) NZ282480A (de)
PT (1) PT752857E (de)
RU (1) RU2144028C1 (de)
TW (1) TW397826B (de)
WO (1) WO1995026189A1 (de)
ZA (1) ZA952477B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
US20050222190A1 (en) * 2004-03-30 2005-10-06 Curd John G 1,4-bis-N-oxide azaanthracenediones and the use thereof
WO2008042611A2 (en) * 2006-09-29 2008-04-10 Centocor, Inc. Method of using il6 antagonists with mitoxantrone for prostate cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ241868A (en) * 1991-03-08 1995-05-26 Univ Vermont 6,9-bis(substituted-amino)benzo[g]isoquinoline-5,10-diones, preparation and pharmaceutical compositions thereof
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
NO964082L (no) 1996-09-27
CZ285139B6 (cs) 1999-05-12
NO964082D0 (no) 1996-09-27
CN1145028A (zh) 1997-03-12
RU2144028C1 (ru) 2000-01-10
BR9507257A (pt) 1997-10-07
JP3548099B2 (ja) 2004-07-28
TW397826B (en) 2000-07-11
MX9603994A (es) 1997-12-31
DE69521887T2 (de) 2001-11-22
CZ276796A3 (en) 1997-02-12
CA2186485A1 (en) 1995-10-05
NZ282480A (en) 1997-04-24
ES2159313T3 (es) 2001-10-01
KR100224153B1 (ko) 1999-10-15
CN1130199C (zh) 2003-12-10
GR3037014T3 (en) 2002-01-31
US5506232A (en) 1996-04-09
NO307564B1 (no) 2000-04-25
US5717099A (en) 1998-02-10
FI963864A (fi) 1996-09-27
EP0752857B1 (de) 2001-07-25
JP2001089454A (ja) 2001-04-03
FI113861B (fi) 2004-06-30
PT752857E (pt) 2001-11-30
AU679627B2 (en) 1997-07-03
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
JPH09507674A (ja) 1997-08-05
ATE203408T1 (de) 2001-08-15
NO2012020I1 (no) 2012-12-27
AU1958995A (en) 1995-10-17
DK0752857T3 (da) 2001-09-24
CZ284937B6 (cs) 1999-04-14
HU9602655D0 (en) 1996-11-28
HUT75654A (en) 1997-05-28
CA2186485C (en) 1999-12-14
JP3151462B2 (ja) 2001-04-03
WO1995026189A1 (en) 1995-10-05
EP0752857A1 (de) 1997-01-15
DE69521887D1 (de) 2001-08-30
LU92089I2 (fr) 2012-12-27
CZ598A3 (cs) 1999-05-12
HU223311B1 (hu) 2004-05-28
CN1282738A (zh) 2001-02-07
FI963864A0 (fi) 1996-09-27

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