NO2012020I1 - Piksantron eller salter eller hydrater derav - Google Patents

Piksantron eller salter eller hydrater derav

Info

Publication number
NO2012020I1
NO2012020I1 NO2012020C NO2012020C NO2012020I1 NO 2012020 I1 NO2012020 I1 NO 2012020I1 NO 2012020 C NO2012020 C NO 2012020C NO 2012020 C NO2012020 C NO 2012020C NO 2012020 I1 NO2012020 I1 NO 2012020I1
Authority
NO
Norway
Prior art keywords
piksantron
hydrates
salts
compound
heteroanalogs
Prior art date
Application number
NO2012020C
Other languages
English (en)
Other versions
NO2012020I2 (no
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of NO2012020I1 publication Critical patent/NO2012020I1/no
Publication of NO2012020I2 publication Critical patent/NO2012020I2/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO2012020C 1994-03-28 2012-12-11 Piksantron dimaleatsalt NO2012020I2 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
PCT/IB1995/000230 WO1995026189A1 (en) 1994-03-28 1995-03-27 AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT

Publications (2)

Publication Number Publication Date
NO2012020I1 true NO2012020I1 (no) 2012-12-27
NO2012020I2 NO2012020I2 (no) 2013-11-11

Family

ID=22821665

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19964082A NO307564B1 (no) 1994-03-28 1996-09-27 Fremgangsmate for syntese av 6,9-bis[(2-aminoetyl)amino]benzo[g]isokinolin-5,10-dion og dets dimaleatsalt, samt dimaleatsaltet fremstilt ved fremgangsmaten
NO2012020C NO2012020I2 (no) 1994-03-28 2012-12-11 Piksantron dimaleatsalt

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19964082A NO307564B1 (no) 1994-03-28 1996-09-27 Fremgangsmate for syntese av 6,9-bis[(2-aminoetyl)amino]benzo[g]isokinolin-5,10-dion og dets dimaleatsalt, samt dimaleatsaltet fremstilt ved fremgangsmaten

Country Status (24)

Country Link
US (3) US5506232A (no)
EP (1) EP0752857B1 (no)
JP (2) JP3151462B2 (no)
KR (1) KR100224153B1 (no)
CN (2) CN1130199C (no)
AT (1) ATE203408T1 (no)
AU (1) AU679627B2 (no)
BR (1) BR9507257A (no)
CA (1) CA2186485C (no)
CZ (2) CZ598A3 (no)
DE (1) DE69521887T2 (no)
DK (1) DK0752857T3 (no)
ES (1) ES2159313T3 (no)
FI (1) FI113861B (no)
GR (1) GR3037014T3 (no)
HU (1) HU223311B1 (no)
LU (1) LU92089I2 (no)
NO (2) NO307564B1 (no)
NZ (1) NZ282480A (no)
PT (1) PT752857E (no)
RU (1) RU2144028C1 (no)
TW (1) TW397826B (no)
WO (1) WO1995026189A1 (no)
ZA (1) ZA952477B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
NZ286951A (en) * 1995-07-13 1998-02-26 Anormed Inc Substituted Under N-n-diethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
US20050222190A1 (en) * 2004-03-30 2005-10-06 Curd John G 1,4-bis-N-oxide azaanthracenediones and the use thereof
WO2008042611A2 (en) * 2006-09-29 2008-04-10 Centocor, Inc. Method of using il6 antagonists with mitoxantrone for prostate cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920754A1 (en) * 1991-03-08 1992-09-09 Univ Vermont 6,9 BIS(SUBSTITUTED-AMINO) BENZO[g]-ISOQUINOLINE-5,10-DIONES
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
CZ276796A3 (en) 1997-02-12
JP3151462B2 (ja) 2001-04-03
HU223311B1 (hu) 2004-05-28
CN1130199C (zh) 2003-12-10
MX9603994A (es) 1997-12-31
AU679627B2 (en) 1997-07-03
CA2186485C (en) 1999-12-14
CZ285139B6 (cs) 1999-05-12
US5506232A (en) 1996-04-09
CN1282738A (zh) 2001-02-07
PT752857E (pt) 2001-11-30
HUT75654A (en) 1997-05-28
AU1958995A (en) 1995-10-17
CZ598A3 (cs) 1999-05-12
ES2159313T3 (es) 2001-10-01
DK0752857T3 (da) 2001-09-24
CA2186485A1 (en) 1995-10-05
WO1995026189A1 (en) 1995-10-05
NO307564B1 (no) 2000-04-25
EP0752857A1 (en) 1997-01-15
JP2001089454A (ja) 2001-04-03
GR3037014T3 (en) 2002-01-31
EP0752857B1 (en) 2001-07-25
ATE203408T1 (de) 2001-08-15
KR100224153B1 (ko) 1999-10-15
ZA952477B (en) 1996-09-27
RU2144028C1 (ru) 2000-01-10
LU92089I2 (fr) 2012-12-27
US5717099A (en) 1998-02-10
BR9507257A (pt) 1997-10-07
FI963864A0 (fi) 1996-09-27
NZ282480A (en) 1997-04-24
JPH09507674A (ja) 1997-08-05
JP3548099B2 (ja) 2004-07-28
CZ284937B6 (cs) 1999-04-14
DE69521887T2 (de) 2001-11-22
DE69521887D1 (de) 2001-08-30
FI113861B (fi) 2004-06-30
NO964082D0 (no) 1996-09-27
CN1145028A (zh) 1997-03-12
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
TW397826B (en) 2000-07-11
FI963864A (fi) 1996-09-27
NO964082L (no) 1996-09-27
HU9602655D0 (en) 1996-11-28

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: CTI BIOPHARMA CORP., US