ATE519731T1 - Verfahren zur herstellung von memantinhydrochlorid - Google Patents

Verfahren zur herstellung von memantinhydrochlorid

Info

Publication number
ATE519731T1
ATE519731T1 AT03785457T AT03785457T ATE519731T1 AT E519731 T1 ATE519731 T1 AT E519731T1 AT 03785457 T AT03785457 T AT 03785457T AT 03785457 T AT03785457 T AT 03785457T AT E519731 T1 ATE519731 T1 AT E519731T1
Authority
AT
Austria
Prior art keywords
hydrochloride
formic acid
purity
memantinine
producing
Prior art date
Application number
AT03785457T
Other languages
English (en)
Inventor
Fuli Zhang
Meng Hu
Lizhi Zhao
Mengya Ge
Original Assignee
Shanghai Inst Pharm Industry
Zhejiang Kangyu Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Inst Pharm Industry, Zhejiang Kangyu Pharmaceutical Co Ltd filed Critical Shanghai Inst Pharm Industry
Application granted granted Critical
Publication of ATE519731T1 publication Critical patent/ATE519731T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03785457T 2003-09-10 2003-12-19 Verfahren zur herstellung von memantinhydrochlorid ATE519731T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB031508928A CN1240668C (zh) 2003-09-10 2003-09-10 一种新的盐酸美金刚制备方法
PCT/CN2003/001094 WO2005023753A1 (fr) 2003-09-10 2003-12-19 Procede de preparation de chlorhydrate de memantine

Publications (1)

Publication Number Publication Date
ATE519731T1 true ATE519731T1 (de) 2011-08-15

Family

ID=34240661

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03785457T ATE519731T1 (de) 2003-09-10 2003-12-19 Verfahren zur herstellung von memantinhydrochlorid

Country Status (6)

Country Link
US (1) US7355080B2 (de)
EP (1) EP1674446B1 (de)
CN (1) CN1240668C (de)
AT (1) ATE519731T1 (de)
AU (1) AU2003296199A1 (de)
WO (1) WO2005023753A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1836157T1 (sl) * 2005-01-11 2009-12-31 Teva Pharm Fine Chemicals Srl Postopek priprave 1-amino-3,5-dimetiladamantan hidroklorida
PL1820792T3 (pl) 2006-02-21 2012-06-29 Hexal Ag Sposób otrzymywania adamantanoamin
EP1908748A1 (de) * 2006-10-05 2008-04-09 Krka Verfahren zur Herstellung von Memantin und seinem Hydrochlorid
US20090118376A1 (en) * 2007-11-02 2009-05-07 Ru-Band Lu Memantine Protects Inflammation-Related Degeneration of Dopamine Neurons Through Inhibition of Over-Activated Microglia and Release of Neurotrophic Factors from Astroglia
HRP20090186A2 (hr) 2009-03-31 2010-10-31 Institut Ruđer Bošković Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
WO2012051333A1 (en) 2010-10-12 2012-04-19 The Johns Hopkins University Antitussive compositions comprising memantine
CN102432473A (zh) * 2011-11-23 2012-05-02 广州博济医药生物技术股份有限公司 一种盐酸美金刚的合成方法
CN103833555B (zh) * 2012-11-23 2016-12-21 上海京新生物医药有限公司 一种盐酸美金刚的制备方法
CN104592039B (zh) * 2013-10-31 2018-09-28 江苏万邦生化医药股份有限公司 制备高纯度盐酸美金刚的方法
CN103664640A (zh) * 2013-12-18 2014-03-26 成都医路康医学技术服务有限公司 盐酸美金刚的制备方法
JP6354701B2 (ja) * 2015-08-19 2018-07-11 大日本印刷株式会社 高純度メマンチン塩酸塩の製造法
CN106966909B (zh) * 2016-09-06 2019-04-12 南京优科制药有限公司 一种盐酸美金刚的纯化方法
CN114767700A (zh) * 2022-06-01 2022-07-22 江苏长泰药业有限公司 盐酸美金刚联合用药在制备激活血管性痴呆海马区bdnf蛋白表达的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA974518A (en) * 1972-04-20 1975-09-16 Merz And Co. Procedure for the manufacture of 1,3,5 trisubstituted adamantan compounds
DE10299048I2 (de) * 1989-04-14 2006-07-13 Merz Pharma Gmbh & Co Kgaa Verwendung von Adamantan-Derivaten zur Pr{vention und Behandlung der cerebralen Isch{mie
CZ288445B6 (en) * 1996-06-20 2001-06-13 Lachema Np Process for preparing hydrochloride of 5-amino-1,3-dimethyltricyclo(3,3,1,1 3,7 )decane
CN1125033C (zh) * 2001-08-29 2003-10-22 中国科学院广州化学研究所 美金刚胺盐酸盐的合成方法
CN1400205A (zh) 2002-08-30 2003-03-05 中国科学院广州化学研究所 美金刚胺盐酸盐的制备方法

Also Published As

Publication number Publication date
WO2005023753A1 (fr) 2005-03-17
US7355080B2 (en) 2008-04-08
AU2003296199A1 (en) 2005-03-29
CN1594277A (zh) 2005-03-16
EP1674446A1 (de) 2006-06-28
CN1240668C (zh) 2006-02-08
EP1674446B1 (de) 2011-08-10
US20070078283A1 (en) 2007-04-05
EP1674446A4 (de) 2009-09-09

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