NO994083L - Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser - Google Patents

Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser

Info

Publication number
NO994083L
NO994083L NO994083A NO994083A NO994083L NO 994083 L NO994083 L NO 994083L NO 994083 A NO994083 A NO 994083A NO 994083 A NO994083 A NO 994083A NO 994083 L NO994083 L NO 994083L
Authority
NO
Norway
Prior art keywords
preparation
pharmaceutical compounds
epoxidation method
selective epoxidation
compounds
Prior art date
Application number
NO994083A
Other languages
English (en)
Other versions
NO994083D0 (no
Inventor
David W Hoard
Eric D Moher
Bryan H Norman
Vinod Francis Patel
Original Assignee
Lilly Co Eli
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State filed Critical Lilly Co Eli
Publication of NO994083D0 publication Critical patent/NO994083D0/no
Publication of NO994083L publication Critical patent/NO994083L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Kryptofycinforbindelser som utviser en B-epoksidel kan bli fremstilt med høy stereoselektivitet ved forskjellige trinn i den syntetiske prosessen. Denne oppfmnelsentilveiebringer også nye intermediater nyttige for å fremstille kryptofycinforbindelser.
NO994083A 1997-02-26 1999-08-24 Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser NO994083L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3911497P 1997-02-26 1997-02-26
US3911697P 1997-02-26 1997-02-26
PCT/US1998/003667 WO1998038164A1 (en) 1997-02-26 1998-02-25 Selective epoxidation process for preparing pharmaceutical compounds

Publications (2)

Publication Number Publication Date
NO994083D0 NO994083D0 (no) 1999-08-24
NO994083L true NO994083L (no) 1999-10-25

Family

ID=26715826

Family Applications (2)

Application Number Title Priority Date Filing Date
NO994049A NO994049D0 (no) 1997-02-26 1999-08-23 Metode for å fremstille farmasöytiske forbindelser
NO994083A NO994083L (no) 1997-02-26 1999-08-24 Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO994049A NO994049D0 (no) 1997-02-26 1999-08-23 Metode for å fremstille farmasöytiske forbindelser

Country Status (17)

Country Link
US (1) US6143909A (no)
EP (2) EP0861839A1 (no)
JP (2) JP2002513403A (no)
KR (2) KR20000075623A (no)
CN (2) CN1252788A (no)
AU (2) AU738999B2 (no)
BR (2) BR9811252A (no)
CA (2) CA2281104A1 (no)
CZ (1) CZ9902998A3 (no)
EA (2) EA199900770A1 (no)
ID (2) ID22984A (no)
IL (2) IL131205A0 (no)
NO (2) NO994049D0 (no)
NZ (1) NZ336918A (no)
PL (2) PL335347A1 (no)
TR (2) TR199902064T2 (no)
WO (2) WO1998038164A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008812A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Process for preparing pharmaceutical compounds
EP0929556A4 (en) * 1996-09-06 2001-04-18 Lilly Co Eli PROCESS AND NEW INTERMEDIATES
WO2000023429A2 (en) * 1998-10-16 2000-04-27 Eli Lilly And Company Stereoselective process for producing cryptophycins
WO2000034252A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Process for the preparation of cryptophycin derivatives
WO2000034253A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Intermediates and reaction sequence to produce said intermediates useful for the preparation of antineoplastic and antifungal cryptophycin derivatives
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1751279A4 (en) 2004-05-05 2008-03-19 Univ Minnesota NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN
CN101962323B (zh) * 2010-07-16 2013-06-05 中国人民解放军第二军医大学 2-丙烯酰x基-3-取代苯基丙酸类化合物及其用途
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
EP0458841B1 (en) * 1989-02-17 1995-06-14 Chiron Mimotopes Pty. Ltd. Method for the use and synthesis of peptides
US5256802A (en) * 1990-04-03 1993-10-26 Miles Inc. Process for the production of oxiranes
WO1994011388A1 (en) * 1992-11-06 1994-05-26 Chiron Mimotopes Pty. Ltd. Support for the synthesis of modular polymers
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine
ATE191917T1 (de) * 1994-10-14 2000-05-15 Stratagene Inc Porphyrin-markierung von polynukleotiden
EP0830136B1 (en) * 1995-03-07 2004-10-20 University Of Hawaii New cryptophycins from synthesis
KR100381275B1 (ko) * 1995-03-31 2003-08-19 닛뽕 케미파 가부시키가이샤 에폭시숙신산유도체
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
EP0850316A4 (en) * 1995-08-30 2000-08-23 Univ Hawaii CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS
WO1997023211A1 (en) * 1995-12-22 1997-07-03 Eli Lilly And Company Pharmaceutical compounds
ATE209438T1 (de) * 1996-02-07 2001-12-15 Buckman Labor Inc Synergistische antimikrobielle zusammensetzungen, die ein ionene-polymer und ein dodecylaminsalz enthalten und verfahren zu ihrer verwendung
AU2058197A (en) * 1996-02-27 1997-09-16 Eli Lilly And Company Pharmaceutical compounds
EP0934065B1 (en) * 1996-08-30 2006-06-07 University Of Hawaii Novel cryptophycin derivatives as anti-neoplastic agents
AU4169897A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Pharmaceutical compounds
CA2263420A1 (en) * 1996-08-30 1998-03-05 James Edward Ray Pharmaceutical compounds
US6025506A (en) * 1997-02-21 2000-02-15 Dsm N.V. Process for preparing an optically active phenylglycidyl acid derivative
TW438787B (en) * 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester

Also Published As

Publication number Publication date
US6143909A (en) 2000-11-07
KR20000075623A (ko) 2000-12-26
CA2281108A1 (en) 1998-09-03
IL131205A0 (en) 2001-01-28
NZ336918A (en) 2001-11-30
IL131162A0 (en) 2001-01-28
EP0861838A3 (en) 1998-12-09
NO994083D0 (no) 1999-08-24
AU738999B2 (en) 2001-10-04
EA002547B1 (ru) 2002-06-27
AU6667298A (en) 1998-09-18
ID22984A (id) 1999-12-23
WO1998038164A1 (en) 1998-09-03
CN1255121A (zh) 2000-05-31
NO994049L (no) 1999-08-23
KR20000075671A (ko) 2000-12-26
EA199900770A1 (ru) 2000-04-24
BR9807265A (pt) 2000-05-23
TR199902065T2 (xx) 2000-02-21
EP0861839A1 (en) 1998-09-02
CA2281104A1 (en) 1998-09-03
JP2002513403A (ja) 2002-05-08
AU6667198A (en) 1998-09-18
WO1998038158A1 (en) 1998-09-03
CN1252788A (zh) 2000-05-10
EP0861838A2 (en) 1998-09-02
BR9811252A (pt) 2000-09-26
JP2002512603A (ja) 2002-04-23
EA199900772A1 (ru) 2000-04-24
TR199902064T2 (xx) 2001-10-22
ID24527A (id) 2000-07-20
PL335347A1 (en) 2000-04-25
NO994049D0 (no) 1999-08-23
CZ9902998A3 (cs) 2002-10-16
PL335478A1 (en) 2000-04-25

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FC2A Withdrawal, rejection or dismissal of laid open patent application