CY1105537T1 - Ανιχνευση αυτοαντισωματων απο ασθενεις που πασχουν απο ρευματοειδη αρθριτιδα - Google Patents

Ανιχνευση αυτοαντισωματων απο ασθενεις που πασχουν απο ρευματοειδη αρθριτιδα

Info

Publication number
CY1105537T1
CY1105537T1 CY20061101278T CY061101278T CY1105537T1 CY 1105537 T1 CY1105537 T1 CY 1105537T1 CY 20061101278 T CY20061101278 T CY 20061101278T CY 061101278 T CY061101278 T CY 061101278T CY 1105537 T1 CY1105537 T1 CY 1105537T1
Authority
CY
Cyprus
Prior art keywords
patients suffering
arthritis
rheumato
detection
auto antibodies
Prior art date
Application number
CY20061101278T
Other languages
English (en)
Inventor
Waltherus Jacobus Wilhelmus Van Venrooij
Jan Wouter Drijfhout
Martinus Adrianus Maria Van Boekel
Gerardus Jozef Maria Pruijn
Original Assignee
Stichting Voor De Technische Wetenschappen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Voor De Technische Wetenschappen filed Critical Stichting Voor De Technische Wetenschappen
Publication of CY1105537T1 publication Critical patent/CY1105537T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2410/00—Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Amplifiers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μία μέθοδο ανίχνευσης αυτοαντισωμάτων από ασθενείς που πάσχουν από ρευματοειδή αρθρίτιδα. Προς το σκοπό αυτό, σύμφωνα με την εφεύρεση, χρησιμοποιούνται δύο τουλάχιστον μονάδες πεπτιδίων από τις οποίες μία τουλάχιστον μονάδα πεπτιδίου περιλαμβάνει ένα τμήμα που δεν προέρχεται από (pro)fillaggrin, ινώδες, ινωδογόνο, vimentin, κυτοκερατίνη 1 και κυτοκερατίνη 9, και η οποία μονάδα πεπτιδίου περιλαμβάνει το μοτίφ XG, και μία μονάδα πεπτιδίου που περιλαμβάνει το μοτίφ XnonG, όπου το Χ είναι μία κιτρουλλίνη ή ένα ανάλογο αυτής, και το nonG είναι ένα άλλο αμινοξύ και όχι γλυκίνη.
CY20061101278T 2001-12-11 2006-09-07 Ανιχνευση αυτοαντισωματων απο ασθενεις που πασχουν απο ρευματοειδη αρθριτιδα CY1105537T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1019540A NL1019540C2 (nl) 2001-12-11 2001-12-11 Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
PCT/NL2002/000815 WO2003050542A2 (en) 2001-12-11 2002-12-11 Method of detecting autoantibodies from patients suffering from rheumatoid arthritis, a peptide and an assaykit

Publications (1)

Publication Number Publication Date
CY1105537T1 true CY1105537T1 (el) 2010-07-28

Family

ID=19774384

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101278T CY1105537T1 (el) 2001-12-11 2006-09-07 Ανιχνευση αυτοαντισωματων απο ασθενεις που πασχουν απο ρευματοειδη αρθριτιδα

Country Status (17)

Country Link
US (6) US7888133B2 (el)
EP (3) EP1456662B1 (el)
JP (1) JP4098718B2 (el)
CN (4) CN101408546B (el)
AT (1) ATE329267T1 (el)
AU (3) AU2002354397B2 (el)
BR (1) BRPI0214872B8 (el)
CA (5) CA2489167C (el)
CY (1) CY1105537T1 (el)
DE (1) DE60212186T2 (el)
DK (1) DK1456662T3 (el)
ES (1) ES2266603T3 (el)
HK (4) HK1072805A1 (el)
NL (1) NL1019540C2 (el)
PT (1) PT1456662E (el)
SI (1) SI1456662T1 (el)
WO (1) WO2003050542A2 (el)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1019540C2 (nl) * 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
DK1882946T3 (da) * 2003-12-23 2010-05-31 Hoffmann La Roche Fremgangsmåde til at bedømme rheumatold arthritis ved at måle anti-CCP og interleukin 6
CA2552420A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Method of assessing rheumatoid arthritis by measuring anti-ccp and serum amyloid a
FR2879604B1 (fr) * 2004-12-22 2010-08-13 Biomerieux Sa Peptides citrullines derives de la fibrine reconnus par des auto-anticorps specifiques de la polyarthrite rhumatoide, et leurs utilisations
ES2310853T3 (es) * 2004-11-04 2009-01-16 Biomerieux Peptidos citrulinados derivados de la fibrina reconocidos por autoanticuerpos especificos de la poliartritis reumatoide y usos de los mismos.
US20090075305A1 (en) * 2005-05-02 2009-03-19 The Brigham And Womern's Hospital, Inc. Diagnostic serum antibody profiling
FI20050814A0 (fi) * 2005-08-11 2005-08-11 Procollagen Oy Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
WO2008037420A1 (en) 2006-09-29 2008-04-03 Roche Diagnostics Gmbh Assessing the risk of disease progression for a patient with rheumatoid arthritis
US20100047256A1 (en) 2007-01-25 2010-02-25 Imperial Innovations Limited Methods
ES2307421B1 (es) * 2007-04-30 2009-09-28 Consejo Superiorde Investigaciones Cientificas (Csic) Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
EP2058663A1 (en) 2007-11-12 2009-05-13 Euro-Diagnostica B.V. Method for the immobilization of an analyte on a solid support
JP5611831B2 (ja) * 2007-12-03 2014-10-22 エスキューアイ・ダイアグノスティクス・システムズ・インコーポレイテッドＳＱＩ Ｄｉａｇｎｏｓｔｉｃｓ Ｓｙｓｔｅｍｓ Ｉｎｃ． リウマチ性関節炎自己抗体との免疫反応性合成ペプチド
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
FR2940292B1 (fr) * 2008-12-23 2013-05-10 Isp Investments Inc Peptides derives d'hmg-coa reductase et composition cosmetique et/ou pharmaceutique les contenant
EP2204655A1 (en) 2008-12-23 2010-07-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostic prediction of rheumatoid arthritis and systemic lupus erythematosus
CN102004154B (zh) * 2009-08-28 2013-06-19 上海荣盛生物药业有限公司 斑点金免疫渗滤法检测类风湿关节炎免疫抗体的组合物
CN102012431B (zh) * 2009-09-04 2013-06-19 上海荣盛生物药业有限公司 斑点金免疫渗滤法检测类风湿关节炎免疫抗体的ccp肽
EP2325195A1 (en) 2009-11-23 2011-05-25 Toscana Biomarkers S.r.l. Viral citrullinated peptides and uses thereof
EP2336769A1 (en) 2009-12-18 2011-06-22 F. Hoffmann-La Roche AG Trigger assay for differentiating between rheumatic and non-rheumatic disorders
EP2402368A1 (en) 2010-07-02 2012-01-04 Toscana Biomarkers S.r.l. Histone citrullinated peptides and uses thereof
CA2825765C (en) * 2011-02-02 2020-03-10 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Anti-carbamylated protein antibodies and the risk for arthritis
EP3412680B1 (en) 2011-04-05 2020-11-04 Curara AB Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment
EP2527841A1 (en) 2011-05-25 2012-11-28 Toscana Biomarkers S.r.l. Methods for the diagnosis of rheumatoid arthritis
CN103703370B (zh) * 2011-05-27 2016-08-17 北欧生物科技公司 诊断性肽的检测
CN102590530B (zh) * 2012-03-02 2014-06-25 常晓天 Krt84自我免疫抗体作为诊断、检测类风湿性关节炎的诊断标记物的应用
CA2902209A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
EP3024849A2 (en) 2013-07-24 2016-06-01 Vilara AB Novel antibodies for the diagnosis and treatment of rheumatoid arthritis
JP6543332B2 (ja) 2014-05-05 2019-07-10 ノヴィオ テーハー ベー．フェー．Ｎｏｖｉｏ ＴＨ Ｂ．Ｖ． 関節リウマチの血清学的な診断方法
CN104262489B (zh) * 2014-09-30 2017-01-11 陈仁奋 一种环状瓜氨酸嵌合肽抗原及其应用
EP3056904A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3
JP2018506720A (ja) 2015-02-13 2018-03-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｃｃｐおよび抗ｐｉｋ３ｃｄを測定することによる関節リウマの査定方法
EP3056903A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-Casp8
WO2017072494A1 (en) * 2015-10-30 2017-05-04 Oxford University Innovation Ltd. Peptide and biomarker associated with inflammatory disorders, and uses thereof
EP3523657B1 (en) 2016-10-04 2023-06-21 F. Hoffmann-La Roche AG System and method for identification of a synthetic classifier
CN106543277B (zh) * 2016-10-31 2020-02-14 中南大学 一种与移植排斥相关的内皮细胞抗原及其应用、试剂盒
CN108196073B (zh) * 2018-03-13 2019-09-13 江苏浩欧博生物医药股份有限公司 一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN108948173B (zh) * 2018-05-22 2020-11-03 北京蛋白质组研究中心 一种瓜氨酸修饰肽及其应用
CN108948153B (zh) * 2018-05-22 2020-11-03 北京蛋白质组研究中心 一种瓜氨酸修饰肽抗原组合及其应用
WO2020151631A1 (zh) * 2019-01-27 2020-07-30 中国医药大学 一种类风湿性关节炎自体抗体结合的肽及其应用
CN109929009B (zh) * 2019-03-20 2021-06-04 深圳市新产业生物医学工程股份有限公司 Ccp肽段、包含其的抗原、试剂、试剂盒及应用
WO2020221153A1 (zh) * 2019-04-28 2020-11-05 广州市雷德生物科技有限公司 一种促进蛋白二聚体形成的拉链扣结构及其应用
CN111655734A (zh) * 2019-04-28 2020-09-11 广州市雷德生物科技有限公司 一种促进蛋白二聚体形成的拉链扣结构及其应用
CN114573663B (zh) * 2019-08-27 2023-08-11 广东菲鹏生物有限公司 瓜氨酸肽及其应用、类风湿关节炎的检测试剂与试剂盒

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511116B1 (fr) * 1991-04-26 2004-06-16 Clonatec S.A. Antigènes reconnus par des anticorps de la polyarthrite rhumatoide, leur préparation et leurs applications
US5610297A (en) * 1991-12-27 1997-03-11 Georgia Tech Research Corp. Peptides ketoamides
US5314804A (en) * 1992-03-24 1994-05-24 Serim Research Corporation Test for Helicobacter pylori
CN1153530A (zh) * 1995-03-09 1997-07-02 比奥美希奥公司 相关于类风湿性关节炎的msrv-1病毒和致病性和/或感染性msrv-2因子
KR0182853B1 (ko) * 1995-08-07 1999-05-15 김신규 자가면역 질환의 진단 방법
FR2752842B1 (fr) * 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) * 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
CZ20001963A3 (cs) * 1997-11-28 2002-04-17 Innogenetics N. V. Peptidy obsahující citrulin rozeznaný sérem revmatické artritidy jako prostředky pro diagnózu a léčbu
FR2773157B1 (fr) * 1997-12-30 2001-10-05 Bio Merieux Epitopes peptidiques reconnus par des auto-anticorps antifilaggrine presents dans le serum des patients atteints de polyarthrite rhumatoide
GB9805477D0 (en) * 1998-03-13 1998-05-13 Oxford Glycosciences Limited Methods and compositions for diagnosis of rheumatoid arthritis
GB9822115D0 (en) * 1998-10-09 1998-12-02 King S College London Treatment of inflammatory disease
FR2795735B1 (fr) 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
ES2174770T1 (es) * 1999-12-21 2002-11-16 Innogenetics Nv Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide.
AUPQ776100A0 (en) * 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
NL1019540C2 (nl) * 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.

Also Published As

Publication number Publication date
HK1128329A1 (en) 2009-10-23
BRPI0214872B1 (pt) 2016-12-13
CA2708463A1 (en) 2003-06-19
US20170269078A1 (en) 2017-09-21
DE60212186T2 (de) 2007-04-12
HK1072805A1 (en) 2005-09-09
CN101408546A (zh) 2009-04-15
WO2003050542A3 (en) 2003-12-11
CN101408546B (zh) 2013-10-30
CA2892001A1 (en) 2003-06-19
US20110195861A1 (en) 2011-08-11
EP1693673A2 (en) 2006-08-23
NL1019540C2 (nl) 2003-07-01
SI1456662T1 (sl) 2006-12-31
CA2489167A1 (en) 2003-06-19
PT1456662E (pt) 2006-10-31
HK1191962A1 (zh) 2014-08-08
US10119966B2 (en) 2018-11-06
CN103524603B (zh) 2016-02-24
DK1456662T3 (da) 2006-09-18
EP2071335A2 (en) 2009-06-17
CA2489167C (en) 2010-08-10
ATE329267T1 (de) 2006-06-15
AU2006230702A1 (en) 2006-11-09
CN100424509C (zh) 2008-10-08
CN105699648A (zh) 2016-06-22
BR0214872A (pt) 2004-10-26
AU2002354397A1 (en) 2003-06-23
CN105699648B (zh) 2017-10-20
CN1602426A (zh) 2005-03-30
HK1226143B (zh) 2017-09-22
CA3076702A1 (en) 2003-06-19
US8759114B2 (en) 2014-06-24
US20130267677A1 (en) 2013-10-10
CA3076702C (en) 2022-03-29
CA2892001C (en) 2017-07-18
EP1456662B1 (en) 2006-06-07
CA2969577A1 (en) 2003-06-19
CN103524603A (zh) 2014-01-22
DE60212186D1 (de) 2006-07-20
US20190056393A1 (en) 2019-02-21
US20140336069A1 (en) 2014-11-13
US9689871B2 (en) 2017-06-27
AU2010200648B2 (en) 2012-07-12
US7888133B2 (en) 2011-02-15
BRPI0214872B8 (pt) 2021-07-27
US8481332B2 (en) 2013-07-09
AU2010200648A1 (en) 2010-03-11
ES2266603T3 (es) 2007-03-01
WO2003050542A2 (en) 2003-06-19
CA2708463C (en) 2015-08-11
JP4098718B2 (ja) 2008-06-11
CA2969577C (en) 2020-04-14
JP2005512092A (ja) 2005-04-28
EP1456662A2 (en) 2004-09-15
AU2002354397B2 (en) 2006-07-20
EP2071335A3 (en) 2009-09-02
US20070087380A1 (en) 2007-04-19
EP1693673A3 (en) 2006-12-06

Similar Documents

Publication Publication Date Title
CY1105537T1 (el) Ανιχνευση αυτοαντισωματων απο ασθενεις που πασχουν απο ρευματοειδη αρθριτιδα
ATE262178T1 (de) Identifizierung und charakterisierung von interagierenden molekülen
BR9812783A (pt) "sistemas de detecção para o registro de interações e as relações funcionais de proteìnas"
CY1111006T1 (el) Εκριμματαση ασθενειας alzheimer
CY1105173T1 (el) Πρωτεϊνες συντηξης ιντepφepονης -βητα και χρησεις
CY1113400T1 (el) Αλλαγη των συγγενειων συνδεσης me fcrn ή των ημιζωων ορου αντισωματων με μεταλλαξιγενεση
DE69816350D1 (de) Technik zur Erkennung von Bildstellungsfehlern
DK0941244T3 (da) Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistoffer
EE200100340A (et) Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks
HUP0100697A2 (hu) Szilárdfázisú vizsgálatokhoz használható hegyek és alkalmazásuk
FI962247A (fi) Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden käyttömenetelmät
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
CY1105380T1 (el) Προτιμωμενα τμηματα της νευρικης νηματικης πρωτεϊνης και μεθοδοι χρησης αυτων
PT641861E (pt) Processo de producao de polipeptidos proteinas ou peptidos hidrofobicos
ATE253113T1 (de) Für ein fibroblasten-aktivierungsprotein kodierende nukleinsäure und verwendungen dafür
ATE389881T1 (de) Detektion von kleinen molekülen mit piezo- elektrischem sensor
ATE363070T1 (de) Auswertung von biologischen mitteln in lebenden zielzellen
EP1117682A4 (en) NEW PEPTIDES
DE69433787D1 (de) Von htlv-i und htlv-ii gp21 abgeleitete peptide zur diagnostischen verwendung
WO1996040763A3 (en) Peptides for hiv-1 detection
PT1073676E (pt) Reagente de imunodiagnostico para a deteccao de infeccao pelo virus maedi-visna e caev
ATE213268T1 (de) Fanconi-gen ii
DE60228947D1 (de) Verfahren zur bestimmung sekundärer molekülmodifikationen unter verwendung von arrays
BR9814114A (pt) Uso de quinapril para o tratamento de isquemia miocárdica e angina