EE200100340A - Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks - Google Patents

Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks

Info

Publication number
EE200100340A
EE200100340A EEP200100340A EEP200100340A EE200100340A EE 200100340 A EE200100340 A EE 200100340A EE P200100340 A EEP200100340 A EE P200100340A EE P200100340 A EEP200100340 A EE P200100340A EE 200100340 A EE200100340 A EE 200100340A
Authority
EE
Estonia
Prior art keywords
nucleic acid
acid molecule
target nucleic
sequencing
amplifying
Prior art date
Application number
EEP200100340A
Other languages
English (en)
Inventor
Lexow Preben
Original Assignee
Lexow Preben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexow Preben filed Critical Lexow Preben
Priority claimed from PCT/GB1999/004417 external-priority patent/WO2000039333A1/en
Publication of EE200100340A publication Critical patent/EE200100340A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
EEP200100340A 1998-12-23 1999-12-23 Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks EE200100340A (et)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
NO986133A NO986133D0 (no) 1998-12-23 1998-12-23 FremgangsmÕte for DNA-sekvensering
NO996330A NO996330D0 (no) 1998-12-23 1999-02-26 Metode for sekvensanalyse
NO996331A NO996331D0 (no) 1998-12-23 1999-03-19 Metode for sekvensanalyse
NO996332A NO996332D0 (no) 1998-12-23 1999-04-13 Metode for sekvensanalyse
NO996333A NO996333D0 (no) 1998-12-23 1999-04-14 Metode for sekvensanalyse
NO996334A NO996334D0 (no) 1998-12-23 1999-04-16 Metode for sekvensanalyse
NO996335A NO996335D0 (no) 1998-12-23 1999-04-19 Metode for sekvensanalyse
NO996336A NO996336D0 (no) 1998-12-23 1999-06-11 Metode for sekvensanalyse
NO996337A NO996337D0 (no) 1998-12-23 1999-06-15 Metode for sekvensanalyse
NO996338A NO996338D0 (no) 1998-12-23 1999-08-26 Metode for sekvensanalyse
NO996339A NO996339D0 (no) 1998-12-23 1999-09-10 Metode for sekvensanalyse
PCT/GB1999/004417 WO2000039333A1 (en) 1998-12-23 1999-12-23 Sequencing method using magnifying tags

Publications (1)

Publication Number Publication Date
EE200100340A true EE200100340A (et) 2002-10-15

Family

ID=19902782

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100340A EE200100340A (et) 1998-12-23 1999-12-23 Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks

Country Status (13)

Country Link
US (4) US6723513B2 (et)
EP (2) EP1619259A3 (et)
JP (2) JP4741079B2 (et)
CN (2) CN100351391C (et)
AT (1) ATE302286T1 (et)
AU (1) AU774389B2 (et)
CA (1) CA2354635C (et)
DE (1) DE69926797T2 (et)
DK (1) DK1141399T3 (et)
EE (1) EE200100340A (et)
ES (1) ES2247848T3 (et)
IL (1) IL143732A (et)
NO (12) NO986133D0 (et)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6777187B2 (en) * 2001-05-02 2004-08-17 Rubicon Genomics, Inc. Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates
WO2003002752A2 (en) * 2001-06-29 2003-01-09 Rubicon Genomics Inc. Methods of using nick translate libraries for snp analysis
GB0308851D0 (en) * 2003-04-16 2003-05-21 Lingvitae As Method
US20050095599A1 (en) * 2003-10-30 2005-05-05 Pittaro Richard J. Detection and identification of biopolymers using fluorescence quenching
EP1709203A2 (en) * 2004-01-23 2006-10-11 Lingvitae AS Improving polynucleotide ligation reactions
SE0401270D0 (sv) * 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
US20060019259A1 (en) * 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
EP1784754A4 (en) 2004-08-13 2009-05-27 Harvard College OPTI-NANOPORE DNA READING PLATFORM WITH ULTRAHOLE THROUGHPUT
GB0422730D0 (en) * 2004-10-13 2004-11-17 Lingvitae As Method
GB0422733D0 (en) * 2004-10-13 2004-11-17 Lingvitae As Method
KR101159072B1 (ko) * 2005-01-20 2012-06-25 삼성전자주식회사 나노포어를 이용한 생분자의 분리방법
GB0504182D0 (en) * 2005-03-01 2005-04-06 Lingvitae As Method
GB0504184D0 (en) * 2005-03-01 2005-04-06 Lingvitae As Method
EP1856293A2 (en) * 2005-03-16 2007-11-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
KR100707198B1 (ko) * 2005-06-27 2007-04-13 삼성전자주식회사 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법
WO2007041621A2 (en) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Hybridization assisted nanopore sequencing
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
CA2640385C (en) * 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US7932029B1 (en) * 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US20100291548A1 (en) 2006-03-12 2010-11-18 Applera Corporation Methods of Detecting Target Nucleic Acids
EP3260556B1 (en) * 2006-05-31 2019-07-31 Sequenom, Inc. Methods for the extraction of nucleic acid from a sample
WO2007146158A1 (en) * 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by nanopore using modified nucleotides
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US7892739B2 (en) * 2007-03-27 2011-02-22 Lehigh University Systems, compositions and methods for nucleic acid detection
EP2952587B1 (en) * 2007-06-19 2023-07-05 Stratos Genomics Inc. High throughput nucleic acid sequencing by expansion
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
EP2201136B1 (en) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment
GB2453377A (en) * 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
US8617811B2 (en) 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP4230747A3 (en) 2008-03-28 2023-11-15 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8628940B2 (en) 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
EP2682460B1 (en) 2008-07-07 2017-04-26 Oxford Nanopore Technologies Limited Enzyme-pore constructs
WO2010004273A1 (en) * 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Base-detecting pore
US20100092960A1 (en) * 2008-07-25 2010-04-15 Pacific Biosciences Of California, Inc. Helicase-assisted sequencing with molecular beacons
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
CN102186989B (zh) * 2008-09-03 2021-06-29 纳伯塞斯2.0有限责任公司 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用
EP2329021B1 (en) 2008-09-16 2016-08-10 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
HUE027961T2 (en) * 2008-10-24 2016-11-28 Epicentre Tech Corp Transposon final preparations and methods for modifying nucleic acids
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
CN102257162A (zh) * 2008-10-29 2011-11-23 波士顿大学理事会 保持序列的dna转化
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
CN102439043A (zh) 2009-01-30 2012-05-02 牛津纳米孔技术有限公司 杂交连接物
JP5843614B2 (ja) * 2009-01-30 2016-01-13 オックスフォード ナノポア テクノロジーズ リミテッド 膜貫通配列決定における核酸構築物のためのアダプター
CN104878086A (zh) 2009-02-11 2015-09-02 卡里斯Mpi公司 肿瘤的分子谱分析
WO2010107946A2 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
US8455260B2 (en) * 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
WO2010111605A2 (en) * 2009-03-27 2010-09-30 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
CA2757493C (en) 2009-04-03 2018-11-13 Sequenom, Inc. Nucleic acid preparation compositions and methods
US8246799B2 (en) * 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US8298767B2 (en) 2009-08-20 2012-10-30 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
EP3933402A1 (en) 2010-02-23 2022-01-05 University of Washington Method of making unsupported artificial mycolic acid membranes
EP2539450B1 (en) * 2010-02-25 2016-02-17 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
GB2492729A (en) 2010-05-11 2013-01-09 Univ Boston Use of Nanopore arrays for multiplex sequencing of nucleic acids
EP2390350A1 (en) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Method of DNA sequencing by polymerisation
EP2390351A1 (en) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Method of DNA sequencing by hybridisation
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
WO2012061726A2 (en) * 2010-11-05 2012-05-10 University Of Utah Research Foundation Compositions and methods for sequencing dna
EP2640849B1 (en) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US8845880B2 (en) 2010-12-22 2014-09-30 Genia Technologies, Inc. Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
CA2826374C (en) 2011-02-11 2024-01-23 Oxford Nanopore Technologies Limited Mutant pores
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
WO2012135658A2 (en) * 2011-03-30 2012-10-04 Noblegen Biosciences, Inc. Sequence preserved dna conversion for optical nanopore sequencing
CA2834218C (en) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification of a minority nucleic acid species using inhibitory oligonucleotides
CA2843136C (en) 2011-07-25 2020-12-29 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
HUE056246T2 (hu) 2011-09-23 2022-02-28 Illumina Inc Készítmények nukleinsav-szekvenáláshoz
CA2861457A1 (en) * 2012-01-20 2013-07-25 Genia Technologies, Inc. Nanopore based molecular detection and sequencing
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102083695B1 (ko) 2012-04-10 2020-03-02 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 리세닌 기공
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013188841A1 (en) 2012-06-15 2013-12-19 Genia Technologies, Inc. Chip set-up and high-accuracy nucleic acid sequencing
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2875154B1 (en) 2012-07-19 2017-08-23 Oxford Nanopore Technologies Limited SSB method for characterising a nucleic acid
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
CN111748607A (zh) 2012-08-14 2020-10-09 10X基因组学有限公司 微胶囊组合物及方法
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2887094C (en) 2012-10-04 2021-09-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
EP2956550B1 (en) 2013-01-18 2020-04-08 Nabsys 2.0 LLC Enhanced probe binding
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
CA2900543C (en) 2013-02-08 2023-01-31 10X Genomics, Inc. Partitioning and processing of analytes and other species
FR3001889B1 (fr) 2013-02-11 2021-02-12 Expanscience Lab Utilisation d'une composition comprenant un perseose d'avocat dans la protection des cellules souches epidermiques .
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
CA2901545C (en) 2013-03-08 2019-10-08 Oxford Nanopore Technologies Limited Use of spacer elements in a nucleic acid to control movement of a helicase
WO2014164716A1 (en) * 2013-03-13 2014-10-09 President And Fellows Of Harvard College Methods of elongating dna
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
CA2920250A1 (en) * 2013-08-02 2015-02-05 Stc.Unm Dna sequencing and epigenome analysis
FR3011008B1 (fr) 2013-09-24 2017-12-29 Expanscience Lab Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
CA2926138A1 (en) 2013-10-23 2015-04-30 Genia Technologies, Inc. High speed molecular sensing with nanopores
EP2886663A1 (en) 2013-12-19 2015-06-24 Centre National de la Recherche Scientifique (CNRS) Nanopore sequencing using replicative polymerases and helicases
FR3016373B1 (fr) 2014-01-10 2018-01-19 Laboratoires Expanscience Modele de peau de mammelon reconstitue
CN106103741B (zh) 2014-01-22 2020-03-13 牛津纳米孔技术公司 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
FR3019186B1 (fr) 2014-03-31 2019-06-07 Laboratoires Expanscience Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant
MX2016013156A (es) 2014-04-10 2017-02-14 10X Genomics Inc Dispositivos, sistemas y metodos fluidicos, para encapsular y dividir reactivos, y aplicaciones de los mismos.
US10934581B2 (en) 2014-04-30 2021-03-02 International Business Machines Corporation Bow tie DNA compositions and methods
CN106574300A (zh) 2014-05-02 2017-04-19 牛津纳米孔技术公司 改善目标多核苷酸相对于跨膜孔移动的方法
KR102531677B1 (ko) 2014-06-26 2023-05-10 10엑스 제노믹스, 인크. 개별 세포 또는 세포 개체군으로부터 핵산을 분석하는 방법
AU2015305570C1 (en) * 2014-08-19 2020-07-23 President And Fellows Of Harvard College RNA-guided systems for probing and mapping of nucleic acids
WO2016034591A2 (en) 2014-09-01 2016-03-10 Vib Vzw Mutant pores
WO2016055778A1 (en) 2014-10-07 2016-04-14 Oxford Nanopore Technologies Limited Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
EP3212807B1 (en) 2014-10-29 2020-09-02 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US20170349926A1 (en) * 2014-12-22 2017-12-07 DNAe Group Holdings LTD. Bubble primers
MX367432B (es) 2015-01-12 2019-08-08 10X Genomics Inc Procesos y sistemas para la preparación de bibliotecas de secuenciación de ácido nucleico y bibliotecas preparadas con estos.
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
KR20170119710A (ko) 2015-02-24 2017-10-27 10엑스 제노믹스, 인크. 표적화된 핵산 서열 커버리지 방법
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
CN107735686B (zh) 2015-04-14 2021-06-11 鲁汶天主教大学 具有内部蛋白质衔接子的纳米孔
PT3882357T (pt) 2015-12-04 2022-09-05 10X Genomics Inc Métodos e composições para análise de ácidos nucleicos
EP3387432B1 (en) 2015-12-08 2022-09-28 Katholieke Universiteit Leuven KU Leuven Research & Development Modified nanopores, compositions comprising the same, and uses thereof
FR3045669B1 (fr) 2015-12-16 2019-04-05 Laboratoires Expanscience Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant
CN116356000A (zh) 2016-03-02 2023-06-30 牛津纳米孔科技公开有限公司 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔
JP7364333B2 (ja) 2016-04-06 2023-10-18 オックスフォード ナノポール テクノロジーズ ピーエルシー 変異体ポア
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
FR3053053B1 (fr) 2016-06-23 2018-07-13 Laboratoires Expanscience Modeles de la dermatite atopique juvenile
US10443098B2 (en) 2016-08-15 2019-10-15 Omniome, Inc. Method and system for sequencing nucleic acids
FR3059550B1 (fr) 2016-12-01 2020-01-03 Universite De Rouen Normandie Traitement des troubles causes par l'alcoolisation foetale (tcaf)
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG11201901822QA (en) 2017-05-26 2019-03-28 10X Genomics Inc Single cell analysis of transposase accessible chromatin
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
FR3068045B1 (fr) 2017-06-22 2021-06-04 Expanscience Lab Modeles de peau sensible reconstituee
AU2018294660B2 (en) 2017-06-30 2022-05-19 Oxford Nanopore Technologies Plc Novel protein pores
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
US10982260B2 (en) * 2017-11-29 2021-04-20 Xgenomes Corp. Sequencing by emergence
EP3775271A1 (en) 2018-04-06 2021-02-17 10X Genomics, Inc. Systems and methods for quality control in single cell processing
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
FR3081707A1 (fr) 2018-05-30 2019-12-06 Universite De Rouen Normandie Traitement des troubles neurologiques causes par l'alcoolisation foetale
CN112243462A (zh) 2018-06-06 2021-01-19 加利福尼亚大学董事会 产生核酸文库的方法以及用于实践所述方法的组合物和试剂盒
MA53160A (fr) 2018-07-20 2021-05-26 Pf Medicament Récepteur pour vista
JP2022500015A (ja) 2018-09-07 2022-01-04 セクエノム， インコーポレイテッド 移植片拒絶を検出する方法およびシステム
CN109517722B (zh) * 2018-09-28 2022-04-01 德拜至臻医学科技(杭州)有限公司 一种捕获特定微量细胞的装置及其制作和使用方法
WO2020113237A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
EP3927845A1 (en) 2019-02-19 2021-12-29 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
FR3098405B1 (fr) 2019-07-12 2021-06-25 Expanscience Lab Composition comprenant des polyphénols de graines de passiflore, des peptides d’avocat et un extrait d’hamamélis et utilisation pour traiter et/ou prévenir les vergetures
AU2020397802A1 (en) 2019-12-02 2022-06-16 Caris Mpi, Inc. Pan-cancer platinum response predictor
JP2023516299A (ja) 2020-02-28 2023-04-19 ラボラトリー コーポレイション オブ アメリカ ホールディングス 父子判定のための組成物、方法、およびシステム
EP3922641A1 (en) 2020-06-09 2021-12-15 Institut Gustave-Roussy Methods for detecting and treating covid patients requiring intensive care
FR3133198A1 (fr) 2022-03-04 2023-09-08 Pierre Fabre Dermo-Cosmetique Modele de peau reconstituee

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6082063A (ja) * 1983-10-07 1985-05-10 Toshiba Corp 電力変換装置
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US4966848A (en) * 1988-02-08 1990-10-30 The General Hospital Corporation Isolation, purification, characterization, cloning and sequencing of N α-acetyltransferase
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5068191A (en) * 1989-08-31 1991-11-26 The Biomembrane Institute Purified histo-blood group a glycosyltransferase and antibodies thereto
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
CA2036946C (en) * 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5227288A (en) * 1990-10-01 1993-07-13 Blattner Frederick R DNA sequencing vector with reversible insert
US6007980A (en) * 1990-11-30 1999-12-28 Yale University Alpha-3 chain type IV collagen polypeptides
US5843667A (en) * 1991-03-22 1998-12-01 Amoco Corporation Nucleic acid probes for the detection for genital mycoplasmas
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
WO1994019480A1 (en) 1993-02-18 1994-09-01 United States Biochemical Corporation Dna sequencing with non-radioactive label
US5714320A (en) * 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
AU694146B2 (en) * 1993-09-27 1998-07-16 Arch Development Corporation Methods and compositions for efficient nucleic acid sequencing
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5491069A (en) * 1994-02-18 1996-02-13 The Regents Of The University Of California Biomarkers of cell senescence
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5753462A (en) * 1995-06-07 1998-05-19 Zymogenetics, Inc. Secretion leader trap cloning method
CN1153825A (zh) * 1995-09-18 1997-07-09 株式会社日立制作所 Dna碱基序列的测序方法及用于该方法的样品调制方法
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5780232A (en) * 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
JP3051826B2 (ja) * 1996-06-03 2000-06-12 花王株式会社 脱墨方法
JP4124377B2 (ja) * 1996-06-06 2008-07-23 ソレクサ・インコーポレイテッド コードアダプターの連結による配列決定
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
US5994068A (en) * 1997-03-11 1999-11-30 Wisconsin Alumni Research Foundation Nucleic acid indexing
US5888737A (en) * 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
WO1999053102A1 (en) * 1998-04-16 1999-10-21 Packard Bioscience Company Analysis of polynucleotide sequence
US7272507B2 (en) * 1999-10-26 2007-09-18 Michael Paul Strathmann Applications of parallel genomic analysis
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6458493B2 (en) * 1999-06-04 2002-10-01 International Business Machines Corporation Method to control nested to isolated line printing

Also Published As

Publication number Publication date
ATE302286T1 (de) 2005-09-15
NO996331D0 (no) 1999-12-20
US20040076998A1 (en) 2004-04-22
NO996334D0 (no) 1999-12-20
IL143732A (en) 2006-12-31
CN1334879A (zh) 2002-02-06
ES2247848T3 (es) 2006-03-01
EP1619259A3 (en) 2007-08-08
DK1141399T3 (da) 2005-12-12
EP1619259A2 (en) 2006-01-25
EP1141399A1 (en) 2001-10-10
US9458493B2 (en) 2016-10-04
DE69926797T2 (de) 2006-07-06
US20150247181A1 (en) 2015-09-03
AU1881000A (en) 2000-07-31
JP4741079B2 (ja) 2011-08-03
CN101240330A (zh) 2008-08-13
NO986133D0 (no) 1998-12-23
NO996425L (no) 2000-06-26
JP2011172573A (ja) 2011-09-08
US20170016061A1 (en) 2017-01-19
EP1141399B1 (en) 2005-08-17
US20020028458A1 (en) 2002-03-07
CA2354635A1 (en) 2000-07-06
CA2354635C (en) 2009-03-24
JP2003503007A (ja) 2003-01-28
NO996336D0 (no) 1999-12-20
NO996339D0 (no) 1999-12-20
NO996335D0 (no) 1999-12-20
NO996330D0 (no) 1999-12-20
NO996337D0 (no) 1999-12-20
CN100351391C (zh) 2007-11-28
NO996333D0 (no) 1999-12-20
NO996338D0 (no) 1999-12-20
AU774389B2 (en) 2004-06-24
US6723513B2 (en) 2004-04-20
NO996425D0 (no) 1999-12-23
NO996332D0 (no) 1999-12-20
DE69926797D1 (de) 2005-09-22

Similar Documents

Publication Publication Date Title
EE200100340A (et) Meetod signaali võimendamiseks, meetod kogu sihtnukleiinhappemolekuli või selle osa sekveneerimiseks, reaktiivikomplekt ja meetod sihtnukleiinhappemolekuli kaardistamiseks
ATE322558T1 (de) Sensible und multiplexe diagnostische tests zur proteinanalyse
DE69739465D1 (de) Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung
DE60029092D1 (de) Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
ATE393228T1 (de) Fusionsproteine und deren verwendung zur messung von protease-aktivität
DE60041355D1 (de) Verfahren zur detektion von erkrankungen
ES2173670T3 (es) Procedimiento de identificacion de acidos nucleicos mediante espectrometria de masas laser de desorcion/ionizacion asistidas por matriz.
DE60236262D1 (de) Elektrophorese mit doppelstrang-dna-marker
DE60029413D1 (de) Enzymatische messung von mycophenolsäure
ATE333522T1 (de) Verfahren zur bestimmung von mehrere analyten
DE69902796D1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
DE60033420D1 (de) Verfahren zur quantifizierung von oxidiertes glutathion
DE50204680D1 (de) Verfahren zur detektion von nukleinsäuremolekülen
ATE449868T1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
ATE330037T1 (de) Verfahren zur altersbestimmung von individuen
DE59814032D1 (de) Nucleinsäuremolekül, kit und verwendung
ATE333519T1 (de) Electrochemisches verfahren zum nachweis von nukleinsäuren
ATE386140T1 (de) Methoden und reagenzien zur in situ amplifizierung
ATE513061T1 (de) Diagnostisches verfahren und kit zur bestimmung des kell-blutgruppengenotyps
FR2786789B1 (fr) Methode de detection in vitro d'une sequence d'acide nucleique cible dans un echantillon d'acide nucleique
ATE474932T1 (de) Methode zur analyse doppelsträngiger dna
ATE307905T1 (de) Verfahren zur detektion von nukleinsäuremolekülen