DE69926797D1 - Sequenzierungsverfahren mit signalverstärkern - Google Patents

Sequenzierungsverfahren mit signalverstärkern

Info

Publication number
DE69926797D1
DE69926797D1 DE69926797T DE69926797T DE69926797D1 DE 69926797 D1 DE69926797 D1 DE 69926797D1 DE 69926797 T DE69926797 T DE 69926797T DE 69926797 T DE69926797 T DE 69926797T DE 69926797 D1 DE69926797 D1 DE 69926797D1
Authority
DE
Germany
Prior art keywords
sequencing method
signal amplifiers
sequencing
nucleic acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69926797T
Other languages
English (en)
Other versions
DE69926797T2 (de
Inventor
Preben Lexow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/GB1999/004417 external-priority patent/WO2000039333A1/en
Publication of DE69926797D1 publication Critical patent/DE69926797D1/de
Application granted granted Critical
Publication of DE69926797T2 publication Critical patent/DE69926797T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Saccharide Compounds (AREA)
DE69926797T 1998-12-23 1999-12-23 Sequenzierungsverfahren mit Verstärkungsmarkierungen Expired - Lifetime DE69926797T2 (de)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
NO986133 1998-12-23
NO986133A NO986133D0 (no) 1998-12-23 1998-12-23 FremgangsmÕte for DNA-sekvensering
NO996330A NO996330D0 (no) 1998-12-23 1999-02-26 Metode for sekvensanalyse
NO996330 1999-02-26
NO996331A NO996331D0 (no) 1998-12-23 1999-03-19 Metode for sekvensanalyse
NO996331 1999-03-19
NO996332 1999-04-13
NO996332A NO996332D0 (no) 1998-12-23 1999-04-13 Metode for sekvensanalyse
NO996333A NO996333D0 (no) 1998-12-23 1999-04-14 Metode for sekvensanalyse
NO996333 1999-04-14
NO996334A NO996334D0 (no) 1998-12-23 1999-04-16 Metode for sekvensanalyse
NO996334 1999-04-16
NO996335 1999-04-19
NO996335A NO996335D0 (no) 1998-12-23 1999-04-19 Metode for sekvensanalyse
NO996336 1999-06-11
NO996336A NO996336D0 (no) 1998-12-23 1999-06-11 Metode for sekvensanalyse
NO996337 1999-06-15
NO996337A NO996337D0 (no) 1998-12-23 1999-06-15 Metode for sekvensanalyse
NO996338A NO996338D0 (no) 1998-12-23 1999-08-26 Metode for sekvensanalyse
NO996338 1999-09-10
PCT/GB1999/004417 WO2000039333A1 (en) 1998-12-23 1999-12-23 Sequencing method using magnifying tags

Publications (2)

Publication Number Publication Date
DE69926797D1 true DE69926797D1 (de) 2005-09-22
DE69926797T2 DE69926797T2 (de) 2006-07-06

Family

ID=19902782

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69926797T Expired - Lifetime DE69926797T2 (de) 1998-12-23 1999-12-23 Sequenzierungsverfahren mit Verstärkungsmarkierungen

Country Status (13)

Country Link
US (4) US6723513B2 (de)
EP (2) EP1141399B1 (de)
JP (2) JP4741079B2 (de)
CN (2) CN101240330A (de)
AT (1) ATE302286T1 (de)
AU (1) AU774389B2 (de)
CA (1) CA2354635C (de)
DE (1) DE69926797T2 (de)
DK (1) DK1141399T3 (de)
EE (1) EE200100340A (de)
ES (1) ES2247848T3 (de)
IL (1) IL143732A (de)
NO (12) NO986133D0 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6777187B2 (en) * 2001-05-02 2004-08-17 Rubicon Genomics, Inc. Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates
US20040197791A1 (en) * 2001-06-29 2004-10-07 Makarov Vladimir L. Methods of using nick translate libraries for snp analysis
GB0308851D0 (en) * 2003-04-16 2003-05-21 Lingvitae As Method
US20050095599A1 (en) * 2003-10-30 2005-05-05 Pittaro Richard J. Detection and identification of biopolymers using fluorescence quenching
JP2007524410A (ja) * 2004-01-23 2007-08-30 リングヴィテ エーエス ポリヌクレオチドライゲーション反応の改良
SE0401270D0 (sv) * 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
US20060019259A1 (en) * 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
EP1784754A4 (de) * 2004-08-13 2009-05-27 Harvard College Opti-nanopore dna-ableseplattform mit ultrahochdurchsatz
GB0422733D0 (en) * 2004-10-13 2004-11-17 Lingvitae As Method
GB0422730D0 (en) * 2004-10-13 2004-11-17 Lingvitae As Method
KR101159072B1 (ko) * 2005-01-20 2012-06-25 삼성전자주식회사 나노포어를 이용한 생분자의 분리방법
GB0504182D0 (en) * 2005-03-01 2005-04-06 Lingvitae As Method
GB0504184D0 (en) * 2005-03-01 2005-04-06 Lingvitae As Method
EP1856293A2 (de) * 2005-03-16 2007-11-21 Compass Genetics, Llc Verfahren und zusammensetzungen zum ablesen von assays auf mehrfachen analytischen plattformen
KR100707198B1 (ko) * 2005-06-27 2007-04-13 삼성전자주식회사 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법
WO2007041621A2 (en) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Hybridization assisted nanopore sequencing
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
ES2374788T3 (es) * 2005-12-23 2012-02-22 Nanostring Technologies, Inc. Nanoinformadores y métodos para su producción y uso.
US7932029B1 (en) * 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US20100291548A1 (en) 2006-03-12 2010-11-18 Applera Corporation Methods of Detecting Target Nucleic Acids
US8679741B2 (en) 2006-05-31 2014-03-25 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
WO2007146158A1 (en) * 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by nanopore using modified nucleotides
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US7892739B2 (en) * 2007-03-27 2011-02-22 Lehigh University Systems, compositions and methods for nucleic acid detection
JP5745842B2 (ja) * 2007-06-19 2015-07-08 ストラトス ゲノミクス インコーポレイテッド 拡張によるハイスループット核酸配列決定
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
EP2201136B1 (de) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Sequenzierung mittels nanoporen und hybridisierung von sonden zur bildung ternärer komplexe und ausrichtung mit variablem bereich
GB2453377A (en) * 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
US8852864B2 (en) * 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
AU2009223671B2 (en) 2008-03-11 2014-11-27 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
CA2991818C (en) 2008-03-28 2022-10-11 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8628940B2 (en) 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
CN102245760A (zh) 2008-07-07 2011-11-16 牛津纳米孔技术有限公司 酶-孔构建体
CA2730068A1 (en) * 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Base-detecting pore
US20100092960A1 (en) * 2008-07-25 2010-04-15 Pacific Biosciences Of California, Inc. Helicase-assisted sequencing with molecular beacons
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
CN102186989B (zh) * 2008-09-03 2021-06-29 纳伯塞斯2.0有限责任公司 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
ES2599967T3 (es) 2008-09-16 2017-02-06 Sequenom, Inc. Procedimientos y composiciones para el enriquecimiento basado en metilación de ácido nucleico fetal de una muestra materna útiles para diagnósticos prenatales no invasivos
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010048605A1 (en) * 2008-10-24 2010-04-29 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US9080211B2 (en) * 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
WO2010053820A1 (en) * 2008-10-29 2010-05-14 Trustees Of Boston University Sequence preserved dna conversion
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
CN102482330A (zh) 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
CA2750879C (en) 2009-01-30 2018-05-22 Oxford Nanopore Technologies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
WO2010093465A1 (en) 2009-02-11 2010-08-19 Caris Mpi, Inc. Molecular profiling of tumors
WO2010107946A2 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
US8455260B2 (en) * 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US20100243449A1 (en) * 2009-03-27 2010-09-30 Oliver John S Devices and methods for analyzing biomolecules and probes bound thereto
EP3514244B1 (de) 2009-04-03 2021-07-07 Sequenom, Inc. Verfahren für die herstellung von nukleinsäuren
US8246799B2 (en) * 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US8298767B2 (en) 2009-08-20 2012-10-30 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
CA2779223A1 (en) 2009-10-27 2011-05-12 Caris Mpi, Inc. Molecular profiling for personalized medicine
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US9605307B2 (en) * 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
EP3933402A1 (de) 2010-02-23 2022-01-05 University of Washington Herstellungsverfahren für ungestützte künstliche mycolsäuremembranen
EP3072968A1 (de) * 2010-02-25 2016-09-28 Advanced Liquid Logic, Inc. Verfahren zur herstellung von nukleinsäure-bibliotheken
CN103154265A (zh) 2010-05-11 2013-06-12 波士顿大学董事会 纳米孔阵列用于核酸多重测序的用途
EP2390351A1 (de) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Verfahren zur DNA-Sequenzierung durch Hybridisierung
EP2390350A1 (de) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Verfahren zur DNA-Sequenzierung durch Polymerisation
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
WO2012061726A2 (en) * 2010-11-05 2012-05-10 University Of Utah Research Foundation Compositions and methods for sequencing dna
EP2640849B1 (de) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Verfahren zur sequenzierung von biomolekülen durch nachweis der relativen positionen von hybridisierten sonden
GB2500360B (en) 2010-12-22 2019-10-23 Genia Tech Inc Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
KR101939420B1 (ko) 2011-02-11 2019-01-16 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 세공
WO2012135658A2 (en) * 2011-03-30 2012-10-04 Noblegen Biosciences, Inc. Sequence preserved dna conversion for optical nanopore sequencing
CA2834218C (en) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification of a minority nucleic acid species using inhibitory oligonucleotides
KR20140050067A (ko) 2011-07-25 2014-04-28 옥스포드 나노포어 테크놀로지즈 리미티드 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법
PT3623481T (pt) 2011-09-23 2021-10-15 Illumina Inc Composições para sequenciação de ácidos nucleicos
EP2807476A4 (de) * 2012-01-20 2015-12-09 Genia Technologies Inc Nachweis und sequenzierung von molekülen auf nanoporenbasis
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
JP6271505B2 (ja) 2012-04-10 2018-01-31 オックスフォード ナノポール テクノロジーズ リミテッド 変異体ライセニンポア
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
CN104350162A (zh) 2012-06-15 2015-02-11 吉尼亚科技公司 芯片设置和高精确度核酸测序
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014013259A1 (en) 2012-07-19 2014-01-23 Oxford Nanopore Technologies Limited Ssb method
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA3120521A1 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
EP2931919B1 (de) 2012-12-14 2019-02-20 10X Genomics, Inc. Verfahren und systeme zur verarbeitung von polynukleotiden
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
EP2956550B1 (de) 2013-01-18 2020-04-08 Nabsys 2.0 LLC Verbesserte sondenanbindung
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
FR3001889B1 (fr) 2013-02-11 2021-02-12 Expanscience Lab Utilisation d'une composition comprenant un perseose d'avocat dans la protection des cellules souches epidermiques .
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
CN105209634B (zh) 2013-03-08 2020-05-12 牛津纳米孔技术公司 酶停滞方法
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
US10443092B2 (en) * 2013-03-13 2019-10-15 President And Fellows Of Harvard College Methods of elongating DNA
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
US10329614B2 (en) * 2013-08-02 2019-06-25 Stc.Unm DNA sequencing and epigenome analysis
FR3011008B1 (fr) 2013-09-24 2017-12-29 Expanscience Lab Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
EP3640349A3 (de) 2013-10-23 2020-07-29 Roche Sequencing Solutions, Inc. Schnelle molekulare erfassung mit nanoporen
EP2886663A1 (de) 2013-12-19 2015-06-24 Centre National de la Recherche Scientifique (CNRS) Nanoporensequenzierung mit replikativen Polymerasen und Helicasen
FR3016373B1 (fr) 2014-01-10 2018-01-19 Laboratoires Expanscience Modele de peau de mammelon reconstitue
CN111534504B (zh) 2014-01-22 2024-06-21 牛津纳米孔科技公开有限公司 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
FR3019186B1 (fr) 2014-03-31 2019-06-07 Laboratoires Expanscience Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US10934581B2 (en) 2014-04-30 2021-03-02 International Business Machines Corporation Bow tie DNA compositions and methods
CN106459159B (zh) 2014-05-02 2021-11-30 牛津纳米孔技术公司 突变孔
WO2016028843A2 (en) 2014-08-19 2016-02-25 President And Fellows Of Harvard College Rna-guided systems for probing and mapping of nucleic acids
CN114605507A (zh) 2014-09-01 2022-06-10 弗拉芒区生物技术研究所 突变csgg孔
US10266885B2 (en) 2014-10-07 2019-04-23 Oxford Nanopore Technologies Ltd. Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
EP3212807B1 (de) 2014-10-29 2020-09-02 10X Genomics, Inc. Verfahren und zusammensetzungen zur gezielten nukleinsäuresequenzierung
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US20170349926A1 (en) * 2014-12-22 2017-12-07 DNAe Group Holdings LTD. Bubble primers
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
CN107735686B (zh) 2015-04-14 2021-06-11 鲁汶天主教大学 具有内部蛋白质衔接子的纳米孔
CN115369161A (zh) 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
CA3011830A1 (en) 2015-12-08 2017-06-15 Katholieke Universiteit Leuven Ku Leuven Research & Development Modified nanopores, compositions comprising the same, and uses thereof
FR3045669B1 (fr) 2015-12-16 2019-04-05 Laboratoires Expanscience Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant
WO2017149317A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pore
CN118256605A (zh) 2016-04-06 2024-06-28 牛津纳米孔科技公开有限公司 突变体孔
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
FR3053053B1 (fr) 2016-06-23 2018-07-13 Laboratoires Expanscience Modeles de la dermatite atopique juvenile
CA3033741A1 (en) 2016-08-15 2018-02-22 Omniome, Inc. Method and system for sequencing nucleic acids
FR3059550B1 (fr) 2016-12-01 2020-01-03 Universite De Rouen Normandie Traitement des troubles causes par l'alcoolisation foetale (tcaf)
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10161003B2 (en) * 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
EP4230746A3 (de) 2017-05-26 2023-11-01 10X Genomics, Inc. Einzelzellanalyse von transposase-zugänglichem chromatin
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
FR3068045B1 (fr) 2017-06-22 2021-06-04 Expanscience Lab Modeles de peau sensible reconstituee
SG11201913174PA (en) 2017-06-30 2020-01-30 Vib Vzw Novel protein pores
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
SG11202004649SA (en) * 2017-11-29 2020-06-29 Xgenomes Corp Sequencing of nucleic acids by emergence
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
FR3081707A1 (fr) 2018-05-30 2019-12-06 Universite De Rouen Normandie Traitement des troubles neurologiques causes par l'alcoolisation foetale
JP7537748B2 (ja) 2018-06-06 2024-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 核酸ライブラリを生成する方法ならびにそれを実施するための組成物およびキット
CA3106418A1 (en) 2018-07-20 2020-01-23 Pierre Fabre Medicament Receptor for vista
CA3107467A1 (en) 2018-09-07 2020-03-12 Sequenom, Inc. Methods, and systems to detect transplant rejection
CN109517722B (zh) * 2018-09-28 2022-04-01 德拜至臻医学科技(杭州)有限公司 一种捕获特定微量细胞的装置及其制作和使用方法
EP3888021B1 (de) 2018-11-30 2024-02-21 Caris MPI, Inc. Molekulare profilierung der nächsten generation
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
CA3128894A1 (en) 2019-02-19 2020-08-27 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
FR3098405B1 (fr) 2019-07-12 2021-06-25 Expanscience Lab Composition comprenant des polyphénols de graines de passiflore, des peptides d’avocat et un extrait d’hamamélis et utilisation pour traiter et/ou prévenir les vergetures
CA3163319A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
JP7344786B2 (ja) * 2019-12-19 2023-09-14 株式会社日立製作所 溶液中の任意のdna配列を同定する方法
US20230120825A1 (en) 2020-02-28 2023-04-20 Laboratory Corporation Of America Holdings Compositions, Methods, and Systems for Paternity Determination
EP3922641A1 (de) 2020-06-09 2021-12-15 Institut Gustave-Roussy Verfahren zum nachweis und zur behandlung von covid-patienten, die intensivpflege benötigen
FR3133198A1 (fr) 2022-03-04 2023-09-08 Pierre Fabre Dermo-Cosmetique Modele de peau reconstituee

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6082063A (ja) * 1983-10-07 1985-05-10 Toshiba Corp 電力変換装置
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US4966848A (en) * 1988-02-08 1990-10-30 The General Hospital Corporation Isolation, purification, characterization, cloning and sequencing of N α-acetyltransferase
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5068191A (en) * 1989-08-31 1991-11-26 The Biomembrane Institute Purified histo-blood group a glycosyltransferase and antibodies thereto
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
CA2036946C (en) * 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5227288A (en) * 1990-10-01 1993-07-13 Blattner Frederick R DNA sequencing vector with reversible insert
US6007980A (en) * 1990-11-30 1999-12-28 Yale University Alpha-3 chain type IV collagen polypeptides
US5843667A (en) * 1991-03-22 1998-12-01 Amoco Corporation Nucleic acid probes for the detection for genital mycoplasmas
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
WO1994019480A1 (en) 1993-02-18 1994-09-01 United States Biochemical Corporation Dna sequencing with non-radioactive label
US5714320A (en) * 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
WO1995009248A1 (en) * 1993-09-27 1995-04-06 Arch Development Corp. Methods and compositions for efficient nucleic acid sequencing
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5491069A (en) * 1994-02-18 1996-02-13 The Regents Of The University Of California Biomarkers of cell senescence
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5753462A (en) * 1995-06-07 1998-05-19 Zymogenetics, Inc. Secretion leader trap cloning method
CN1153825A (zh) * 1995-09-18 1997-07-09 株式会社日立制作所 Dna碱基序列的测序方法及用于该方法的样品调制方法
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5780232A (en) * 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
JP3051826B2 (ja) * 1996-06-03 2000-06-12 花王株式会社 脱墨方法
JP4124377B2 (ja) * 1996-06-06 2008-07-23 ソレクサ・インコーポレイテッド コードアダプターの連結による配列決定
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
US5994068A (en) * 1997-03-11 1999-11-30 Wisconsin Alumni Research Foundation Nucleic acid indexing
US5888737A (en) * 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
AU3567099A (en) * 1998-04-16 1999-11-01 Packard Bioscience Company Analysis of polynucleotide sequence
US7272507B2 (en) * 1999-10-26 2007-09-18 Michael Paul Strathmann Applications of parallel genomic analysis
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6458493B2 (en) * 1999-06-04 2002-10-01 International Business Machines Corporation Method to control nested to isolated line printing

Also Published As

Publication number Publication date
CN100351391C (zh) 2007-11-28
AU774389B2 (en) 2004-06-24
US20170016061A1 (en) 2017-01-19
EP1141399A1 (de) 2001-10-10
IL143732A (en) 2006-12-31
US6723513B2 (en) 2004-04-20
NO996339D0 (no) 1999-12-20
EP1141399B1 (de) 2005-08-17
NO996335D0 (no) 1999-12-20
NO996425L (no) 2000-06-26
JP2003503007A (ja) 2003-01-28
ES2247848T3 (es) 2006-03-01
US20040076998A1 (en) 2004-04-22
EP1619259A2 (de) 2006-01-25
EE200100340A (et) 2002-10-15
NO996332D0 (no) 1999-12-20
NO996338D0 (no) 1999-12-20
NO996333D0 (no) 1999-12-20
CA2354635A1 (en) 2000-07-06
DK1141399T3 (da) 2005-12-12
JP2011172573A (ja) 2011-09-08
NO986133D0 (no) 1998-12-23
AU1881000A (en) 2000-07-31
US20020028458A1 (en) 2002-03-07
NO996337D0 (no) 1999-12-20
CN1334879A (zh) 2002-02-06
NO996334D0 (no) 1999-12-20
DE69926797T2 (de) 2006-07-06
NO996336D0 (no) 1999-12-20
CA2354635C (en) 2009-03-24
JP4741079B2 (ja) 2011-08-03
EP1619259A3 (de) 2007-08-08
NO996330D0 (no) 1999-12-20
NO996425D0 (no) 1999-12-23
US9458493B2 (en) 2016-10-04
ATE302286T1 (de) 2005-09-15
NO996331D0 (no) 1999-12-20
CN101240330A (zh) 2008-08-13
US20150247181A1 (en) 2015-09-03

Similar Documents

Publication Publication Date Title
DE69926797D1 (de) Sequenzierungsverfahren mit signalverstärkern
DE69739465D1 (de) Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung
DE60040335D1 (de) Derivatisierte nukleinsäuren und deren verwendung
DE60029092D1 (de) Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
DE69835143D1 (de) Selektion von proteinen mittels rns-protein fusionen
ATE319855T1 (de) Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
SE0003286D0 (sv) Method and kit for human identification
DE69333289D1 (de) Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
DE60039037D1 (de) Methode zur direkten sequenzierung von nukleinsäuren
DE60031007D1 (de) Selektion von Bindungs-Bereichen für Zinkfingerproteine und Design-Methoden für Zinkfingerproteine, geeignet zur Bindung an solche vorselektierte Bereiche
DE60120806D1 (de) Server zur Bereitstellung von Navigationsinformationen
DE69915932D1 (de) Verfahren zur Bestimmung von Ziel-Nukleinsäuren
DE60041355D1 (de) Verfahren zur detektion von erkrankungen
CY1107660T1 (el) Μεθοδοι επισημανσης υλικων
DE69838538D1 (de) Verfahren zur erkennung von zielnukleinsäuren
BR9812783A (pt) "sistemas de detecção para o registro de interações e as relações funcionais de proteìnas"
DE69822685D1 (de) Verfahren zur Bestimmung von Nukleinsäuresequenzen
DE60140139D1 (de) Auf nukleinsäurenamplifizierung basierendes verfahren zur bestimmung von methylierungsprofil und reagenzien dafür
DE69902796D1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
DE50204680D1 (de) Verfahren zur detektion von nukleinsäuremolekülen
DE59712415D1 (de) Verfahren zur amplifikation von nukleinsäure
CY1105034T1 (el) Ελαχιστοι υποκινητες και οι χρησεις τους
DK1129191T3 (da) Fremgangsmåder til diagnosticering eller behandling af neurologiske sygdomme
DE60038029D1 (de) Methoden und reagenzien zur in situ amplifizierung
DE60121547D1 (de) Electrochemisches verfahren zum nachweis von nukleinsäuren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition