DK0941244T3 - Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistoffer - Google Patents
Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistofferInfo
- Publication number
- DK0941244T3 DK0941244T3 DK97912577T DK97912577T DK0941244T3 DK 0941244 T3 DK0941244 T3 DK 0941244T3 DK 97912577 T DK97912577 T DK 97912577T DK 97912577 T DK97912577 T DK 97912577T DK 0941244 T3 DK0941244 T3 DK 0941244T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- autoantibodies
- rheumatoid arthritis
- patients
- antigen recognized
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1004539A NL1004539C2 (nl) | 1996-11-15 | 1996-11-15 | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
PCT/NL1997/000624 WO1998022503A2 (en) | 1996-11-15 | 1997-11-14 | Peptide derived from an antigen recognized by autoantibodies from patients with rheumatoid arthritis, antibody directed against said peptide, a combinatorial antigen, and a method of detecting auto-immune antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0941244T3 true DK0941244T3 (da) | 2007-04-30 |
Family
ID=19763876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97912577T DK0941244T3 (da) | 1996-11-15 | 1997-11-14 | Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistoffer |
Country Status (13)
Country | Link |
---|---|
US (5) | US6858438B2 (da) |
EP (1) | EP0941244B1 (da) |
JP (1) | JP4197743B2 (da) |
AT (1) | ATE352560T1 (da) |
AU (1) | AU741850B2 (da) |
BR (1) | BR9712955A (da) |
CA (1) | CA2272573C (da) |
DE (1) | DE69737292T2 (da) |
DK (1) | DK0941244T3 (da) |
ES (1) | ES2281095T3 (da) |
NL (1) | NL1004539C2 (da) |
PT (1) | PT941244E (da) |
WO (1) | WO1998022503A2 (da) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
WO1999028344A2 (en) * | 1997-11-28 | 1999-06-10 | Innogenetics N.V. | Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment |
FR2773078B1 (fr) * | 1997-12-30 | 2000-05-26 | Univ Toulouse | Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide |
FR2795735B1 (fr) * | 1999-07-01 | 2001-09-07 | Univ Toulouse | Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide |
WO2001046222A2 (en) * | 1999-12-21 | 2001-06-28 | Innogenetics N.V. | Peptides designed for the diagnosis and treatment of rheumatoid arthritis |
NL1019540C2 (nl) | 2001-12-11 | 2003-07-01 | Stichting Tech Wetenschapp | Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit. |
CA2527916A1 (en) * | 2003-03-14 | 2004-09-30 | Aaron B. Kantor | Biological markers for diagnosing rheumatoid arthritis |
DK1882946T3 (da) | 2003-12-23 | 2010-05-31 | Hoffmann La Roche | Fremgangsmåde til at bedømme rheumatold arthritis ved at måle anti-CCP og interleukin 6 |
CA2552420A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Method of assessing rheumatoid arthritis by measuring anti-ccp and serum amyloid a |
US20060141547A1 (en) * | 2004-11-16 | 2006-06-29 | Das Hasi R | Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis |
WO2008037420A1 (en) | 2006-09-29 | 2008-04-03 | Roche Diagnostics Gmbh | Assessing the risk of disease progression for a patient with rheumatoid arthritis |
ES2307421B1 (es) * | 2007-04-30 | 2009-09-28 | Consejo Superiorde Investigaciones Cientificas (Csic) | Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide. |
US8323656B2 (en) * | 2007-06-25 | 2012-12-04 | Yijun Xu | Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof |
ES2390394T3 (es) | 2007-12-03 | 2012-11-12 | Sqi Diagnostics Systems Inc. | Péptidos sintéticos inmunorreactivos con los autoanticuerpos de la artritis reumatoide |
GB0803107D0 (en) * | 2008-02-20 | 2008-03-26 | Axis Shield Diagnostics Ltd | Method |
EP2307451B1 (en) * | 2008-03-21 | 2016-05-25 | Universiteit Hasselt | Biomarkers for rheumatoid arthritis |
JP5528436B2 (ja) | 2008-06-04 | 2014-06-25 | モディクエスト べー.フェー. | 抗炎症剤 |
EP2204655A1 (en) | 2008-12-23 | 2010-07-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnostic prediction of rheumatoid arthritis and systemic lupus erythematosus |
EP2325195A1 (en) | 2009-11-23 | 2011-05-25 | Toscana Biomarkers S.r.l. | Viral citrullinated peptides and uses thereof |
EP2332987A1 (en) | 2009-12-10 | 2011-06-15 | ModiQuest B.V. | Anti-inflammatory agents directed against citrullinated epitopes |
EP2336769A1 (en) | 2009-12-18 | 2011-06-22 | F. Hoffmann-La Roche AG | Trigger assay for differentiating between rheumatic and non-rheumatic disorders |
EP2402368A1 (en) | 2010-07-02 | 2012-01-04 | Toscana Biomarkers S.r.l. | Histone citrullinated peptides and uses thereof |
WO2012096893A2 (en) * | 2011-01-10 | 2012-07-19 | Opko Pharmaceuticals, Llc | Antigen surrogates in autoimmune disease |
EP2527841A1 (en) | 2011-05-25 | 2012-11-28 | Toscana Biomarkers S.r.l. | Methods for the diagnosis of rheumatoid arthritis |
WO2013014312A1 (es) * | 2011-07-28 | 2013-01-31 | Consejo Superior De Investigaciones Científicas (Csic) | Polipeptidos quimericos derivados de la proteina vimentina con utilidad para el diagnostico de la artritis reumatoide |
EP3056903A1 (en) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-Casp8 |
EP3056904A1 (en) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3 |
EP3256854A1 (en) | 2015-02-13 | 2017-12-20 | F. Hoffmann-La Roche AG | Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd |
KR101758354B1 (ko) * | 2015-03-26 | 2017-07-17 | 한국과학기술연구원 | 신규한 시클릭 시트룰리네이티드 펩티드, 이를 포함하는 류마티스 관절염 진단용 조성물 및 이를 이용한 진단 방법, 및 류마티스 관절염 마커 스크리닝 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE511116T1 (de) * | 1991-04-26 | 1993-04-29 | Clonatec S.A., Paris | Antigene, die von polyarthritis rheumatoide antikoerpern erkannt werden, ihre herstellung und ihre anwendungen. |
US6100377A (en) * | 1994-06-10 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Constrained peptides |
FR2752842B1 (fr) | 1996-08-30 | 1998-11-06 | Biomerieux Sa | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
FR2773405B1 (fr) * | 1998-01-08 | 2000-09-29 | France Telecom | Procede et systeme de controle d'acces a une ressource limite a certaines plages horaires |
-
1996
- 1996-11-15 NL NL1004539A patent/NL1004539C2/nl not_active IP Right Cessation
-
1997
- 1997-11-14 PT PT97912577T patent/PT941244E/pt unknown
- 1997-11-14 US US09/308,150 patent/US6858438B2/en not_active Expired - Lifetime
- 1997-11-14 JP JP52350198A patent/JP4197743B2/ja not_active Expired - Lifetime
- 1997-11-14 DK DK97912577T patent/DK0941244T3/da active
- 1997-11-14 AU AU49707/97A patent/AU741850B2/en not_active Expired
- 1997-11-14 ES ES97912577T patent/ES2281095T3/es not_active Expired - Lifetime
- 1997-11-14 BR BR9712955-0A patent/BR9712955A/pt not_active Application Discontinuation
- 1997-11-14 CA CA002272573A patent/CA2272573C/en not_active Expired - Lifetime
- 1997-11-14 EP EP97912577A patent/EP0941244B1/en not_active Expired - Lifetime
- 1997-11-14 DE DE69737292T patent/DE69737292T2/de not_active Expired - Lifetime
- 1997-11-14 WO PCT/NL1997/000624 patent/WO1998022503A2/en active IP Right Grant
- 1997-11-14 AT AT97912577T patent/ATE352560T1/de active
-
2005
- 2005-02-16 US US11/059,775 patent/US7335724B2/en not_active Expired - Fee Related
- 2005-06-23 US US11/165,085 patent/US7288634B2/en not_active Expired - Fee Related
-
2007
- 2007-08-06 US US11/834,557 patent/US8772448B2/en not_active Expired - Fee Related
-
2014
- 2014-05-22 US US14/285,577 patent/US20140342378A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2272573C (en) | 2010-02-02 |
ES2281095T3 (es) | 2007-09-16 |
US20060039924A1 (en) | 2006-02-23 |
US20140342378A1 (en) | 2014-11-20 |
US20080050841A1 (en) | 2008-02-28 |
NL1004539C2 (nl) | 1998-05-20 |
US7288634B2 (en) | 2007-10-30 |
ATE352560T1 (de) | 2007-02-15 |
EP0941244B1 (en) | 2007-01-24 |
CA2272573A1 (en) | 1998-05-28 |
JP2001513753A (ja) | 2001-09-04 |
BR9712955A (pt) | 1999-12-07 |
US20050186201A1 (en) | 2005-08-25 |
US6858438B2 (en) | 2005-02-22 |
WO1998022503A3 (en) | 1998-08-27 |
US20020137092A1 (en) | 2002-09-26 |
AU4970797A (en) | 1998-06-10 |
US7335724B2 (en) | 2008-02-26 |
EP0941244A2 (en) | 1999-09-15 |
DE69737292D1 (de) | 2007-03-15 |
WO1998022503A2 (en) | 1998-05-28 |
AU741850B2 (en) | 2001-12-13 |
US8772448B2 (en) | 2014-07-08 |
DE69737292T2 (de) | 2007-06-28 |
PT941244E (pt) | 2007-02-28 |
JP4197743B2 (ja) | 2008-12-17 |
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